BGC0000954: ajudazol A biosynthetic gene cluster from Chondromyces crocatus
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Location: 1 - 83,663 nt. (total: 83,663 nt).
This entry is originally from NCBI GenBank AM946600.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000954
Short description ajudazol A biosynthetic gene cluster from Chondromyces crocatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AM946600.1
via Knock-out studies
Compounds
  • ajudazol A
Species Chondromyces crocatus [taxonomy]
References
Chemical products information
ajudazol A Evidence:
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C34H42N2O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ18827.1
 6976 - 11652 (+) putative Trp
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    • CAQ18828.1
    • ajuA
    		 11896 - 18414 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18829.1
    • ajuB
    		 18436 - 28647 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18830.1
    • ajuC
    		 28650 - 35318 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18831.1
    • ajuD
    		 35383 - 39609 (+) nonribosomal polypetide synthetase
    • Scaffold biosynthesis
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    • CAQ18832.1
    • ajuE
    		 39630 - 46166 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18833.1
    • ajuF
    		 46163 - 50905 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18834.1
    • ajuG
    		 50902 - 59742 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18835.1
    • ajuH
    		 59739 - 64601 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18836.1
    • ajuI
    		 64641 - 66017 (+) putative cytochrome P450
    • Tailoring
    • Knock-out
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    • CAQ18837.1
    • ajuJ
    		 66033 - 67502 (-) putative cytochrome P450
    • Tailoring
    • Knock-out
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    • CAQ18838.1
    • ajuK
    		 67689 - 73346 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CAQ18839.1
    • ajuL
    		 73351 - 82734 (+) hybrid polyketide synthase/nonribosomal polypetide synthetase
    • Scaffold biosynthesis
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    Biosynthesis information

    Biosynthetic modules

    Name
    8
    Type
    nrps-type1
    Genes
    ajuD
    Substrates
    serine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (LCL), adenylation
    Name
    2
    Type
    nrps-type1
    Genes
    ajuL
    Substrates
    glycine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (DCL), adenylation, methyltransferase
    Name
    1
    Type
    pks-modular
    Genes
    ajuK
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, methyltransferase, carrier (ACP)
    Name
    3
    Type
    pks-modular
    Genes
    ajuL
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
    Name
    4
    Type
    pks-modular
    Genes
    ajuA
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
    Name
    5
    Type
    pks-modular
    Genes
    ajuB
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
    Name
    6
    Type
    pks-modular
    Genes
    ajuB
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
    Name
    7
    Type
    pks-modular
    Genes
    ajuC
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
    Name
    9
    Type
    pks-modular
    Genes
    ajuE
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
    Name
    10
    Type
    pks-modular
    Genes
    ajuF
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
    Name
    11
    Type
    pks-modular
    Genes
    ajuG
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
    Name
    12
    Type
    pks-modular
    Genes
    ajuG
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
    Name
    13
    Type
    pks-modular
    Genes
    ajuH
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
    Annotation changelog

    Entry version: 4

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Corrected NRP module activity
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Sorted modules by module number
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Updated bioactivity data
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Updated NRP substrate specificities
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2019-10-16
    Updated compound(s) information (NPAtlas curation)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2015-06-12
    Submitted
    • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Detailed domain annotation
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