BGC0000969: chondramide A biosynthetic gene cluster from Chondromyces crocatus
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Location: 1 - 49,145 nt. (total: 49,145 nt).
This entry is originally from NCBI GenBank AM179409.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000969
Short description chondramide A biosynthetic gene cluster from Chondromyces crocatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AM179409.1
via Knock-out studies
Compounds
  • chondramide A
Species Chondromyces crocatus [taxonomy]
References
Chemical products information
chondramide A Evidence:
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C36H46N4O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ46687.1
 531 - 1877 (+) hypothetical protein
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    • CAJ46688.1
    		 2262 - 3953 (+) putative phosphoenol pyruvate synthase
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      • CAJ46689.1
      • cmdA
      		 3967 - 16515 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAJ46690.1
      • cmdB
      		 16512 - 23108 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAJ46691.1
      • cmdC
      		 23105 - 26461 (+) non-ribosomal peptide synthase
      • Scaffold biosynthesis
      • Knock-out
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      • CAJ46692.1
      • cmdD
      		 26668 - 38406 (+) non-ribosomal peptide synthase
      • Scaffold biosynthesis
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      • CAJ46693.1
      • cmdE
      		 38459 - 40027 (+) tryptophan halogenase
      • Tailoring
      • Knock-out
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      • CAJ46694.1
      • cmdF
      		 40179 - 41774 (+) tyrosine aminomutase
      • Precursor biosynthesis
      • Knock-out
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      • CAJ46695.1
      		 41795 - 42673 (+) putative phosphoenol pyruvate synthase
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        • CAJ46696.1
        		 42765 - 44243 (-) putative nucleotidase-2',3'-cyclic phosphodiesterase
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          • CAJ46697.1
          		 44408 - 45397 (+) hypothetical protein
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            • CAJ46698.1
            		 45410 - 46171 (+) putative cephalosporin hydroxylase
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              • CAJ46699.1
              		 46182 - 48533 (-) putative heavy metal translocating P-type ATPase
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                Biosynthesis information

                Biosynthetic modules

                Name
                4
                Type
                nrps-type1
                Genes
                cmdC
                Substrates
                alanine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                5
                Type
                nrps-type1
                Genes
                cmdD
                Substrates
                tryptophan (evidence: Structure-based inference, Knock-out studies)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation, epimerase, methyltransferase
                Name
                6
                Type
                nrps-type1
                Genes
                cmdD
                Substrates
                R-beta-tyrosine, tyrosine, phenylalanine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                condensation (DCL), adenylation
                Name
                0
                Type
                pks-modular
                Genes
                cmdA
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                Name
                1
                Type
                pks-modular-starter
                Genes
                cmdA
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketoreductase, carrier (ACP)
                Name
                2
                Type
                pks-modular
                Genes
                cmdA
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                Name
                3
                Type
                pks-modular
                Genes
                cmdB
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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