BGC0000992: fusaridione A biosynthetic gene cluster from Fusarium heterosporum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 60,504 nt. (total: 60,504 nt).
This entry is originally from NCBI GenBank AY700570.3.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000992
Short description fusaridione A biosynthetic gene cluster from Fusarium heterosporum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AY700570.3
Compounds
  • fusaridione A
  • (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
Species Fusarium heterosporum [taxonomy]
References
Chemical products information
fusaridione A
Copy SMILES
C27H31N1O4
Chemical database entries
PubCHEM
PubCHEM
(3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
Copy SMILES
C27H33N1O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGO65982.1
  • gFH322
668 - 3063 (-) putative multicopper oxidase
copy AA seq
copy Nt seq
  • AGO65983.1
  • gFH333
4026 - 5939 (+) putative multicopper oxidase
copy AA seq
copy Nt seq
  • AAV66104.2
  • fsdR
7974 - 9584 (-) putative fungal transcription factor
copy AA seq
copy Nt seq
  • AAV66105.2
  • gFH335
10850 - 12987 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AGO65984.1
  • gFH336
13533 - 15211 (+) putative CoA-transferase-like protein
copy AA seq
copy Nt seq
  • AGO65985.1
  • gFH337
15393 - 17174 (-) putative nucleoside phosphorylase-like protein
copy AA seq
copy Nt seq
  • AGO65986.1
  • gFH339
19676 - 21919 (-) putative monooxygenase
copy AA seq
copy Nt seq
  • AGO65987.1
  • gFH340
21245 - 23847 (+) putative metal-dependent hydrolase
copy AA seq
copy Nt seq
  • AAV66102.1
  • fsdK
24673 - 26095 (-) putative dimethylallyltransferase
copy AA seq
copy Nt seq
  • AAV66107.2
  • fsdD
26408 - 27370 (-) putative methyltransferase
copy AA seq
copy Nt seq
  • AGO65988.1
  • fsdH
28230 - 30412 (+) putative cytochrome p450
copy AA seq
copy Nt seq
  • AGO65989.1
  • fsdG
30795 - 32428 (+) putative MFS transporter
copy AA seq
copy Nt seq
  • AAV66110.2
  • fsdS
33544 - 45616 (+) fusaridione A synthetase
copy AA seq
copy Nt seq
  • AGO65990.1
  • gFH438
48948 - 50693 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AGO65991.1
  • fsdC
50751 - 51896 (-) putative enoylreductase-like protein
copy AA seq
copy Nt seq
  • AGO65992.1
  • gFH350
52150 - 59922 (-) putative ankyrin-repeat containing protein
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
fsdS
Module ?
Specificity: tyrosine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for fusaridione A
  • Linked new PubChem id for fusaridione A (pubchem:91819845)
  • Add new compound: (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
  • Added NRP substrate specificities
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.