BGC0001000: hectochlorin biosynthetic gene cluster from Lyngbya majuscula
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Location: 1 - 41,964 nt. (total: 41,964 nt).
This entry is originally from NCBI GenBank AY974560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001000
Short description hectochlorin biosynthetic gene cluster from Lyngbya majuscula
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The phylogeny/classification of the producing organism for this molecule has been updated from Lyngbya majuscula JHB to Moorea producens JHB. "
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AY974560.1
via
Compounds
  • hectochlorin
Species Lyngbya majuscula [taxonomy]
References
Chemical products information
hectochlorin Evidence: NMR [1], [2]
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C27H34Cl2N2O9S2
Chemical database entries
CyanoMetDB CyanoMetDB_1362
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAY42393.1
 2444 - 4264 (+) Acyl-ACP synthetase
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    • AAY42394.1
    		 5267 - 6721 (+) Putative halogenase
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      • AAY42395.1
      		 6964 - 8190 (+) Putative transposase
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        • AAY42396.1
        		 8248 - 14022 (+) Polyketide synthase
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          • AAY42397.1
          		 14019 - 24089 (+) Nonribosomal peptide synthetase
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            • AAY42398.1
            		 24086 - 35923 (+) Nonribosomal peptide synthetase
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              • AAY42399.1
              		 36589 - 37932 (+) Cytochrome P450 monooxygenase
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                • AAY42400.1
                		 38547 - 39881 (+) Cytochrome P450 monooxygenase
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  2
                  Type
                  nrps-type1
                  Genes
                  AAY42397.1
                  Substrates
                  2-ketoisovaleric acid (evidence: Activity assay)
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  3
                  Type
                  nrps-type1
                  Genes
                  AAY42397.1
                  Substrates
                  cysteine (evidence: Activity assay)
                  Integrated Monomers
                  Domains
                  condensation (Heterocyclization), adenylation, oxidase
                  Name
                  4
                  Type
                  nrps-type1
                  Genes
                  AAY42398.1
                  Substrates
                  2-ketoisovaleric acid (evidence: Activity assay)
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  5
                  Type
                  nrps-type1
                  Genes
                  AAY42398.1
                  Substrates
                  cysteine (evidence: Activity assay)
                  Integrated Monomers
                  Domains
                  condensation (Heterocyclization), adenylation, oxidase
                  Name
                  1
                  Type
                  pks-modular
                  Genes
                  AAY42396.1
                  Substrates
                  Integrated Monomers
                  Domains
                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
                  Annotation changelog

                  Entry version: next

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2024-06-11
                  MIBiG v4 annotathon
                  • (ID: GLNIA6HUGFRXN2FRDQ7ILDE7)
                  • (ID: CDYCL6EXTYWWVPBEB3X7HZS2)
                  • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Corrected NRP module activity
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Updated NRP substrate specificities
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: AFDKNJ3M7IY2EN7OLH4KRCAV)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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