LOCUS       BGC0001021             23821 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv complete genome.
ACCESSION   BGC0001021
VERSION     BGC0001021
KEYWORDS    .
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
COMMENT     On or before Feb 1, 2013 this sequence version replaced BX842572.1,
            BX842573.1, BX842574.1, BX842575.1, BX842576.1, BX842577.1,
            BX842578.1, BX842579.1, BX842580.1, BX842581.1, BX842582.1,
            BX842583.1, BX842584.1, AL123456.2.
            On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 22:04:41
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 23821
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23821
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1500:19638]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1501..19638
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..23821
                     /SMILES="NC(CCCCN)C(=O)NC(CCCCN)C(=O)C(C)C(O)NC(C([*])O)C(=
                     O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..23821
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001021"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23821
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(16..231)
                     /gene="mbtH"
                     /locus_tag="Rv2377c"
     CDS             complement(16..231)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2377c"
                     /db_xref="EnsemblGenomes-Tr:CCP45165"
                     /db_xref="InterPro:IPR005153"
                     /db_xref="PDB:2KHR"
                     /gene="mbtH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009:mbtH-like protein (Score: 119.4; E-value:
                     6.7e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Rv2377c"
                     /note="Rv2377c, (MT2445.1, MTCY27.03), len: 71 aa. Putative
                     mbtH, conserved protein with no function assigned (see
                     Quadri et al., 1998; De Voss et al., 1999), similar to
                     hypothetical proteins or proteins found in several gene
                     clusters for biosynthesis or transport of siderophores and
                     other nonribosomally synthesized peptides e.g.
                     Q9Z388|SCE8.11c putative small conserved hypothetical
                     protein from Streptomyces coelicolor (71 aa), FASTA scores:
                     opt: 345, E(): 1.4e-19, (68.2% identity in 66 aa overlap);
                     Q9F8V3|CUMB COUY protein (probably involved in the
                     biosynthesis of aminocoumarin antibiotic coumermycin a(1))
                     (see Wang et al., 2000) from Streptomyces rishiriensis (71
                     aa), FASTA scores: opt: 329, E(): 2.2e-18, (63.2% identity
                     in 68 aa overlap); Q9F5J2|SIM-CB MBTH-like protein
                     (probably protein involved in the biosynthesis of
                     aminocoumarin antibiotic coumermycin a(1)) from
                     Streptomyces antibioticus (70 aa), FASTA scores: opt:
                     308,E(): 8.4e-17, (65.6% identity in 64 aa overlap); Q9FB14
                     MBTH-like protein (involved in the biosynthesis of the
                     antitumor drug bleomycin) (see Du et al., 2000) from
                     Streptomyces verticillus FASTA scores: opt: 220, E():
                     8.8e-10, (41.2% identity in 68 aa overlap); etc."
                     /product="Putative conserved protein MbtH"
                     /protein_id="CCP45165.1"
                     /transl_table=11
                     /translation="MSTNPFDDDNGAFFVLVNDEDQHSLWPVFADIPAGWRVVHGEASR
                     AACLDYVEKNWTDLRPKSLRDAMVED"
     gene            complement(209..1504)
                     /gene="mbtG"
                     /locus_tag="Rv2378c"
     CDS             complement(209..1504)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2378c"
                     /db_xref="EnsemblGenomes-Tr:CCP45166"
                     /db_xref="GOA:P9WKF7"
                     /gene="mbtG"
                     /locus_tag="Rv2378c"
                     /note="Rv2378c, (MTCY27.02), len: 431 aa.
                     MbtG,lysine-N-oxygenase (hydroxylase) (EC 1.13.12.10 or
                     1.14.13.59; depending if enzyme is NADPH dependent or
                     independent) (see citations below), showing some similarity
                     with various proteins including ornithine and
                     lysine-N-oxygenases, e.g. Q9K6Q1|TRKA|BH3677 potassium
                     uptake protein from Bacillus halodurans (350 aa), FASTA
                     scores: opt: 153, E(): 0.016, (25.2% identity in 246 aa
                     overlap); P56584|SID1_USTMA L-ornithine 5-monooxygenase
                     from Ustilago maydis (Smut fungus) (570 aa), FASTA scores:
                     opt: 136, E(): 0.31, (22.85% identity in 127 aa overlap);
                     Q9HHV0|HXYA|VNG6214G monooxygenase from Halobacterium sp.
                     strain NRC-1 (477 aa), FASTA scores: opt: 119, E():
                     3.4,(40.0% identity in 70 aa overlap); O69828|SC1A6.23
                     putative lysine N-hydroxlase (fragment) from Streptomyces
                     coelicolor (134 aa), blast score: 76 (similarity in part
                     for this one); etc. Cofactors: FAD (by similarity)."
                     /product="Lysine-N-oxygenase MbtG (L-lysine
                     6-monooxygenase) (lysine N6-hydroxylase)"
                     /protein_id="CCP45166.1"
                     /transl_table=11
                     /translation="MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGAN
                     WQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAE
                     WIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQADALM
                     ITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNELFRHR
                     VSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEA
                     LLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTS
                     LFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSC
                     LGLLSDRVLGAGIFTPTKHNDTRRSGEHQSFR"
     gene            complement(1501..5886)
                     /gene="mbtF"
                     /locus_tag="Rv2379c"
     CDS             complement(1501..5886)
                     /NRPS_PKS="Domain: Condensation_DCL (16-316). E-value:
                     1e-107. Score: 351.5. Matches aSDomain:
                     nrpspksdomains_Rv2379c_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (476-862). E-value: 4.8e-96.
                     Score: 313.6. Matches aSDomain:
                     nrpspksdomains_Rv2379c_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (969-1031). E-value: 4.9e-11.
                     Score: 34.9. Matches aSDomain:
                     nrpspksdomains_Rv2379c_PP-binding.1"
                     /NRPS_PKS="Domain: Epimerization (1046-1337). E-value:
                     4.7e-77. Score: 251.1. Matches aSDomain:
                     nrpspksdomains_Rv2379c_Epimerization.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2379c"
                     /db_xref="EnsemblGenomes-Tr:CCP45167"
                     /db_xref="GOA:O05819"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="UniProtKB/TrEMBL:O05819"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mbtF"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 322;
                     E-value: 9e-98)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PROSITE:PS00455"
                     /locus_tag="Rv2379c"
                     /note="Rv2379c, (MTCY27.01), len: 1461 aa. MbtF, peptide
                     synthetase (see citations below), similar in part to
                     several synthases e.g. O52820|PCZA363.4 protein from
                     Amycolatopsis orientalis (4077 aa), FASTA scores: opt:
                     1873, E(): 1.1e-99, (35.55% identity in 1522 aa overlap);
                     O07944|SNBDE pristinamycin I synthase 3 and 4 from
                     Streptomyces pristinaespiralis (4848 aa), FASTA scores:
                     opt: 1817, E(): 2.1e-96, (33.65% identity in 1463 aa
                     overlap); O52821 protein similar to peptide synthetase from
                     Amycolatopsis orientalis (1860 aa) FASTA scores: opt:
                     1705,E(): 2.9e-90, (34.75% identity in 1344 aa overlap);
                     Q9XCF2|PSTB putative peptide synthetase (similar to
                     Mycobacterium tuberculosis nrp protein) from Mycobacterium
                     avium (2552 aa), FASTA scores: opt: 1687, E():
                     4e-89,(35.45% identity in 1058 aa overlap); Q9ZET7 peptide
                     synthetase (fragment) from Mycobacterium smegmatis (1438
                     aa), FASTA scores: opt: 1479, E(): 2.5e-77, (30.45%
                     identity in 1507 aa overlap); etc. Contains PS00455
                     putative AMP-binding domain signature. Belongs to the
                     ATP-dependent AMP-binding enzyme family."
                     /product="Peptide synthetase MbtF (peptide synthase)"
                     /protein_id="CCP45167.1"
                     /sec_met_domain="Condensation (E-value: 5.2e-60, bitscore:
                     192.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 5.3e-98, bitscore:
                     317.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.9e-12, bitscore:
                     34.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPVAVTRADARGAIDDVMALSPLQQGLFSRATLVAAESGSEAAE
                     ADPYVIAMAADAAGPLDIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSAEVLW
                     RHVRAHPSEVGALAAEERRRRFDVGRGPLIRFLLIELPDECWHLVIVAHHIVIDGWSLP
                     LFVSELLALYRAGGHVAALPAAPRPYRDYIGWLAGRDQTASRAMWADHLNGLDGPTLLS
                     PALADTPVQPGIPGRTEVRLDREATAELADAARTRGVTISTLVQMAWATTLSAFTGRGD
                     VTFGVTVSGRPSELSGVETMIGLFINTVPLRVRLDARATVGGQCAVLQRQFAMLRDHSY
                     LGFNEFRAIAGIGEMFDTLLVYENFPPGEVVGTAEFVANGVTFRPVALESLSHFPVTVA
                     AHRSTGELTLLVEVLDGALGTMAPESLGRRVLAVLQRLVSRWDRPLRDVDILLDGEHDP
                     TAPGLPDVTTSAPAVHTRFAEIAAAQPDSVAVSWADGQLTYRELDALADRLATGLRRAD
                     VSRETPVAVALSRGPRYVAAMLAVLKAGGMIVPLDPAMPGERVAEILRQTSAPVVIDEG
                     VFAASVGADILEEDRAITVPVDQAAYVIFTSGTTGTPKGVIGTHRALSAYADDHIERVL
                     RPAAQRLGRPLRIAHAWSFTFDAAWQPLVALLDGHAVHIVDDHRQRDAGALVEAIDRFG
                     LDMIDTTPSMFAQLHNAGLLDRAPLAVLALGGEALGAATWRMIQQNCARTAMTAFNCYG
                     PTETTVEAVVAAVAEHARPVIGRPTCTTRAYVMDSWLRPVPDGVAGELYLAGAQLTRGY
                     LGRPAETAARFVAEPNGRGSRMYRTGDVVRRLPDGGLEFLGRSDDQVKIRGFRVEPGEI
                     AAVLNGHHAVHGCHVTARGHASGPRLTAYVAGGPQPPPVAELRAMLLERLPRYLVPHHI
                     VVLDELPLTPHGKIDENALAAINVTEGPATPPQTPTELVLAEAFADVMETSNVDVTAGF
                     LQMGLDSIVALSVVQAARRRGIALRARLMVECDTIRELAAAIDSDAAWQAPANDAGEPI
                     PVLPNTHWLYEYGDPRRLAQTEVIRLPDRITRERLDAVLAAVVDGHEVLRCRFDRDAMA
                     LVAQPKTDILSEVWVSGELVTAVAEQTLGALASLDPQAGRLLSAVWLREPDGPGVLVLT
                     AHVLAMDPASWRIVLGELDAGLHALAAGRAPSPARENTSYRQWSRLLAQRAKALDSVDF
                     WVAELEGADPPLGARRVAPQTDRVGELAITMSISDADLTARLLSTGRSMTDLLATAAAR
                     MVTAWRRQRGQQTPAPLLALETHGRADVHVDKTADTSDTVGLLSAIYPLRIHCDGATDF
                     ARIPGSGIDYGLLRYLRADTAERLRAHREPQLLLNYLGSLHVGVGDLAVDRALLADVGQ
                     LPEPEQPVRHELTVLAALLGPADAPVLATRWRTLPDILSADDVATLQSLWQGALAEITA
                     "
     CDS_motif       complement(1810..1854)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0014"
                     /evalue="1.50E-05"
                     /label="NRPS-E6"
                     /locus_tag="Rv2379c"
                     /protein_end="1359"
                     /protein_start="1344"
                     /score="17.5"
                     /tool="antismash"
                     /translation="RIPGSGIDYGLLRYL"
     aSDomain        complement(1876..2748)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2379c_Epimerization.1"
                     /evalue="4.70E-77"
                     /label="Rv2379c_Epimerization.1"
                     /locus_tag="Rv2379c"
                     /protein_end="1337"
                     /protein_start="1046"
                     /score="251.1"
                     /tool="antismash"
                     /translation="PIPVLPNTHWLYEYGDPRRLAQTEVIRLPDRITRERLDAVLAAVV
                     DGHEVLRCRFDRDAMALVAQPKTDILSEVWVSGELVTAVAEQTLGALASLDPQAGRLLS
                     AVWLREPDGPGVLVLTAHVLAMDPASWRIVLGELDAGLHALAAGRAPSPARENTSYRQW
                     SRLLAQRAKALDSVDFWVAELEGADPPLGARRVAPQTDRVGELAITMSISDADLTARLL
                     STGRSMTDLLATAAARMVTAWRRQRGQQTPAPLLALETHGRADVHVDKTADTSDTVGLL
                     SAIYPLRIHC"
     aSModule        1876..5838
                     /complete
                     /domains="nrpspksdomains_Rv2379c_Condensation_DCL.1"
                     /domains="nrpspksdomains_Rv2379c_AMP-binding.1"
                     /domains="nrpspksdomains_Rv2379c_PP-binding.1"
                     /domains="nrpspksdomains_Rv2379c_Epimerization.1"
                     /locus_tags="Rv2379c"
                     /monomer_pairings="lys -> D-lys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(1882..1932)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0013"
                     /evalue="4.40E-03"
                     /label="NRPS-E5"
                     /locus_tag="Rv2379c"
                     /protein_end="1335"
                     /protein_start="1318"
                     /score="9.9"
                     /tool="antismash"
                     /translation="DTSDTVGLLSAIYPLRI"
     CDS_motif       complement(2335..2400)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0012"
                     /evalue="6.40E-07"
                     /label="NRPS-E2"
                     /locus_tag="Rv2379c"
                     /protein_end="1184"
                     /protein_start="1162"
                     /score="21.9"
                     /tool="antismash"
                     /translation="LVLTAHVLAMDPASWRIVLGEL"
     CDS_motif       complement(2584..2676)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0011"
                     /evalue="4.40E-05"
                     /label="C2_LCL_024-062"
                     /locus_tag="Rv2379c"
                     /protein_end="1101"
                     /protein_start="1070"
                     /score="15.9"
                     /tool="antismash"
                     /translation="VIRLPDRITRERLDAVLAAVVDGHEVLRCRF"
     aSDomain        complement(2794..2979)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2379c_PP-binding.1"
                     /evalue="4.90E-11"
                     /label="Rv2379c_PP-binding.1"
                     /locus_tag="Rv2379c"
                     /protein_end="1031"
                     /protein_start="969"
                     /score="34.9"
                     /tool="antismash"
                     /translation="LAEAFADVMETSNVDVTAGFLQMGLDSIVALSVVQAARRRGIALR
                     ARLMVECDTIRELAAAI"
     misc_feature    complement(3079..3081)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(3274..3336)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0010"
                     /evalue="6.40E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="Rv2379c"
                     /protein_end="871"
                     /protein_start="850"
                     /score="37.4"
                     /tool="antismash"
                     /translation="FLGRSDDQVKIRGFRVEPGEI"
     aSDomain        complement(3301..4458)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2379c_AMP-binding.1"
                     /evalue="4.80E-96"
                     /label="Rv2379c_AMP-binding.1"
                     /locus_tag="Rv2379c"
                     /protein_end="862"
                     /protein_start="476"
                     /score="313.6"
                     /specificity="consensus: lys"
                     /tool="antismash"
                     /translation="FAEIAAAQPDSVAVSWADGQLTYRELDALADRLATGLRRADVSRE
                     TPVAVALSRGPRYVAAMLAVLKAGGMIVPLDPAMPGERVAEILRQTSAPVVIDEGVFAA
                     SVGADILEEDRAITVPVDQAAYVIFTSGTTGTPKGVIGTHRALSAYADDHIERVLRPAA
                     QRLGRPLRIAHAWSFTFDAAWQPLVALLDGHAVHIVDDHRQRDAGALVEAIDRFGLDMI
                     DTTPSMFAQLHNAGLLDRAPLAVLALGGEALGAATWRMIQQNCARTAMTAFNCYGPTET
                     TVEAVVAAVAEHARPVIGRPTCTTRAYVMDSWLRPVPDGVAGELYLAGAQLTRGYLGRP
                     AETAARFVAEPNGRGSRMYRTGDVVRRLPDGGLEFLGRSDDQVKIR"
     CDS_motif       complement(3337..3372)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0009"
                     /evalue="1.50E+00"
                     /label="NRPS-E6"
                     /locus_tag="Rv2379c"
                     /protein_end="850"
                     /protein_start="838"
                     /score="1.8"
                     /tool="antismash"
                     /translation="DVVRRLPDGGLE"
     CDS_motif       complement(3418..3507)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0008"
                     /evalue="2.60E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="Rv2379c"
                     /protein_end="823"
                     /protein_start="793"
                     /score="48.5"
                     /tool="antismash"
                     /translation="PDGVAGELYLAGAQLTRGYLGRPAETAARF"
     CDS_motif       complement(4027..4086)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0007"
                     /evalue="7.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="Rv2379c"
                     /protein_end="620"
                     /protein_start="600"
                     /score="27.7"
                     /tool="antismash"
                     /translation="AYVIFTSGTTGTPKGVIGTH"
     CDS_motif       complement(4231..4272)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0006"
                     /evalue="9.40E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="Rv2379c"
                     /protein_end="552"
                     /protein_start="538"
                     /score="12.7"
                     /tool="antismash"
                     /translation="LAVLKAGGMIVPLD"
     misc_feature    complement(4585..4587)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(4789..4902)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0005"
                     /evalue="4.30E-13"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="Rv2379c"
                     /protein_end="366"
                     /protein_start="328"
                     /score="41.6"
                     /tool="antismash"
                     /translation="QRQFAMLRDHSYLGFNEFRAIAGIGEMFDTLLVYENFP"
     aSDomain        complement(4939..5838)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2379c_Condensation_DCL.1"
                     /domain_subtype="Condensation_DCL"
                     /evalue="1.00E-107"
                     /label="Rv2379c_Condensation_DCL.1"
                     /locus_tag="Rv2379c"
                     /protein_end="316"
                     /protein_start="16"
                     /score="351.5"
                     /tool="antismash"
                     /translation="DVMALSPLQQGLFSRATLVAAESGSEAAEADPYVIAMAADAAGPL
                     DIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSAEVLWRHVRAHPSEVGALAAE
                     ERRRRFDVGRGPLIRFLLIELPDECWHLVIVAHHIVIDGWSLPLFVSELLALYRAGGHV
                     AALPAAPRPYRDYIGWLAGRDQTASRAMWADHLNGLDGPTLLSPALADTPVQPGIPGRT
                     EVRLDREATAELADAARTRGVTISTLVQMAWATTLSAFTGRGDVTFGVTVSGRPSELSG
                     VETMIGLFINTVPLRVRLD"
     CDS_motif       complement(4951..5046)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0004"
                     /evalue="4.10E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="Rv2379c"
                     /protein_end="312"
                     /protein_start="280"
                     /score="64.2"
                     /tool="antismash"
                     /translation="DVTFGVTVSGRPSELSGVETMIGLFINTVPLR"
     CDS_motif       complement(5092..5148)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0003"
                     /evalue="1.30E+01"
                     /label="C5_DCL_263-294"
                     /locus_tag="Rv2379c"
                     /protein_end="265"
                     /protein_start="246"
                     /score="-1.6"
                     /tool="antismash"
                     /translation="TAELADAARTRGVTISTLV"
     misc_feature    complement(5224..5226)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(5368..5430)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0002"
                     /evalue="1.80E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="Rv2379c"
                     /protein_end="173"
                     /protein_start="152"
                     /score="36.4"
                     /tool="antismash"
                     /translation="HHIVIDGWSLPLFVSELLALY"
     CDS_motif       complement(5629..5745)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2379c_0001"
                     /evalue="3.40E-12"
                     /label="C2_DCL_024-062"
                     /locus_tag="Rv2379c"
                     /protein_end="86"
                     /protein_start="47"
                     /score="38.6"
                     /tool="antismash"
                     /translation="PYVIAMAADAAGPLDIALLRDCAAAMLTRHPNLRASFLH"
     gene            complement(5868..10916)
                     /gene="mbtE"
                     /locus_tag="Rv2380c"
     CDS             complement(5868..10916)
                     /NRPS_PKS="Domain: Condensation_LCL (0-280). E-value:
                     1.5e-67. Score: 219.6. Matches aSDomain:
                     nrpspksdomains_Rv2380c_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (446-828). E-value:
                     1.2e-106. Score: 348.5. Matches aSDomain:
                     nrpspksdomains_Rv2380c_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (941-1009). E-value: 1.7e-24. Score:
                     77.7. Matches aSDomain: nrpspksdomains_Rv2380c_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1026-1321). E-value:
                     1.9e-97. Score: 317.7. Matches aSDomain:
                     nrpspksdomains_Rv2380c_Condensation_LCL.2"
                     /NRPS_PKS="Domain: PCP (1578-1645). E-value: 8.4e-22.
                     Score: 69.0. Matches aSDomain:
                     nrpspksdomains_Rv2380c_PCP.2"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2380c"
                     /db_xref="EnsemblGenomes-Tr:CCP45168"
                     /db_xref="GOA:I6Y0L1"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="UniProtKB/TrEMBL:I6Y0L1"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mbtE"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     335.3; E-value: 1.2e-101)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PROSITE:PS00012"
                     /inference="protein motif:PROSITE:PS00455"
                     /locus_tag="Rv2380c"
                     /note="Rv2380c, (MTCY22H8.05), len: 1682 aa. MbtE, peptide
                     synthetase (see citations below), similar in part to
                     several synthases e.g. O07944|SNBDE pristinamycin I
                     synthase 3 and 4 from Streptomyces pristinaespiralis (4848
                     aa), FASTA scores: opt: 2635, E(): 1.9e-146, (36.8%
                     identity in 1657 aa overlap); O05647|SNBDE virginiamycin S
                     synthetase (fragment) from Streptomyces virginiae (1997 aa)
                     FASTA scores: opt: 2580, E(): 1.6e-143, (40.65% identity in
                     1163 aa overlap); Q9R9I2|DHBF protein involved in
                     siderophore production from Bacillus subtilis (2378
                     aa),FASTA scores: opt: 2388, E(): 3.6e-132, (33.9% identity
                     in 1579 aa overlap); O68487|ACMB actinomycin synthetase II
                     from Streptomyces chrysomallus (2611 aa), FASTA scores:
                     opt: 2165, E(): 4.9e-119, (35.0% identity in 1634 aa
                     overlap); etc. Equivalent to AAK46743 from Mycobacterium
                     tuberculosis strain CDC1551 (1787 aa) but shorter 105 aa.
                     Contains PS00455 putative AMP-binding domain signature, and
                     PS00012 Phosphopantetheine attachment site. Belongs to the
                     ATP-dependent AMP-binding enzyme family."
                     /product="Peptide synthetase MbtE (peptide synthase)"
                     /protein_id="CCP45168.1"
                     /sec_met_domain="Condensation (E-value: 4e-54, bitscore:
                     173.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-107, bitscore:
                     348.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.6e-18, bitscore:
                     56.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRIL
                     RTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDA
                     PLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAA
                     SGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMA
                     KNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQ
                     SAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGG
                     FNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVL
                     LDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV
                     VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYV
                     PVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYT
                     SGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGA
                     RMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEP
                     LPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLD
                     DSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNAD
                     GDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPA
                     AGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIAS
                     DTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDV
                     GVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNA
                     VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCA
                     AGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLF
                     TDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAG
                     ETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKA
                     GGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYA
                     HQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFD
                     AAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVE
                     MVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSET
                     ATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETE
                     RALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCE
                     LAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQWP"
     aSDomain        complement(5982..6182)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2380c_PCP.2"
                     /evalue="8.40E-22"
                     /label="Rv2380c_PCP.2"
                     /locus_tag="Rv2380c"
                     /protein_end="1645"
                     /protein_start="1578"
                     /score="69.0"
                     /tool="antismash"
                     /translation="ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGI
                     PLTARMVFEHPVLCELAAAVDA"
     aSModule        5982..7838
                     /domains="nrpspksdomains_Rv2380c_Condensation_LCL.2"
                     /domains="nrpspksdomains_Rv2380c_PCP.2"
                     /incomplete
                     /locus_tags="Rv2380c"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(6345..6434)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0014"
                     /evalue="2.10E+00"
                     /label="NRPS-A_a6"
                     /locus_tag="Rv2380c"
                     /protein_end="1524"
                     /protein_start="1494"
                     /score="1.0"
                     /tool="antismash"
                     /translation="PVGVVGDVYYGGGPAVGARLARPSETATRF"
     CDS_motif       complement(6804..6914)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0013"
                     /evalue="3.40E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="Rv2380c"
                     /protein_end="1371"
                     /protein_start="1334"
                     /score="67.7"
                     /tool="antismash"
                     /translation="RQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV"
     aSDomain        complement(6954..7838)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2380c_Condensation_LCL.2"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.90E-97"
                     /label="Rv2380c_Condensation_LCL.2"
                     /locus_tag="Rv2380c"
                     /protein_end="1321"
                     /protein_start="1026"
                     /score="317.7"
                     /tool="antismash"
                     /translation="PVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAI
                     TDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLE
                     TDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV
                     QYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEF
                     RLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQL
                     IGFFINIVVLRNDL"
     CDS_motif       complement(6963..7052)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0012"
                     /evalue="2.60E-12"
                     /label="C5_LCL_267-296"
                     /locus_tag="Rv2380c"
                     /protein_end="1318"
                     /protein_start="1288"
                     /score="39.1"
                     /tool="antismash"
                     /translation="DVPIGAPVAGRSEANLDQLIGFFINIVVLR"
     misc_feature    complement(7074..7076)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(7314..7349)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0011"
                     /evalue="1.60E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="Rv2380c"
                     /protein_end="1201"
                     /protein_start="1189"
                     /score="14.3"
                     /tool="antismash"
                     /translation="QYADYSVWQSAL"
     CDS_motif       complement(7398..7463)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0010"
                     /evalue="9.90E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="Rv2380c"
                     /protein_end="1173"
                     /protein_start="1151"
                     /score="27.7"
                     /tool="antismash"
                     /translation="VHHIAGDHWSAGVLFTDLLTAY"
     CDS_motif       complement(7659..7772)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0009"
                     /evalue="1.50E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="Rv2380c"
                     /protein_end="1086"
                     /protein_start="1048"
                     /score="43.1"
                     /tool="antismash"
                     /translation="VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR"
     aSDomain        complement(7890..8093)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2380c_PCP.1"
                     /evalue="1.70E-24"
                     /label="Rv2380c_PCP.1"
                     /locus_tag="Rv2380c"
                     /protein_end="1009"
                     /protein_start="941"
                     /score="77.7"
                     /tool="antismash"
                     /translation="ERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFG
                     VDVGVREIFEFATVTALAGHIDT"
     aSModule        7890..10916
                     /complete
                     /domains="nrpspksdomains_Rv2380c_Condensation_LCL.1"
                     /domains="nrpspksdomains_Rv2380c_AMP-binding.1"
                     /domains="nrpspksdomains_Rv2380c_PCP.1"
                     /locus_tags="Rv2380c"
                     /monomer_pairings="lys -> lys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(8406..8468)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0008"
                     /evalue="7.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="Rv2380c"
                     /protein_end="837"
                     /protein_start="816"
                     /score="34.0"
                     /tool="antismash"
                     /translation="FVGRADEQVKIRGFRIELGDV"
     aSDomain        complement(8433..9578)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2380c_AMP-binding.1"
                     /evalue="1.20E-106"
                     /label="Rv2380c_AMP-binding.1"
                     /locus_tag="Rv2380c"
                     /protein_end="828"
                     /protein_start="446"
                     /score="348.5"
                     /specificity="consensus: lys"
                     /tool="antismash"
                     /translation="EQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDR
                     VAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAG
                     YRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDT
                     DRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPS
                     LLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRF
                     KVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTA
                     ERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIR"
     CDS_motif       complement(8550..8639)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0007"
                     /evalue="4.50E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="Rv2380c"
                     /protein_end="789"
                     /protein_start="759"
                     /score="41.3"
                     /tool="antismash"
                     /translation="PTGVIGEIYIGGTHVAYGYHRRAGLTAERF"
     CDS_motif       complement(9147..9206)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0006"
                     /evalue="6.60E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="Rv2380c"
                     /protein_end="590"
                     /protein_start="570"
                     /score="27.9"
                     /tool="antismash"
                     /translation="AYLIYTSGTTGLPKGVAVPH"
     CDS_motif       complement(9357..9398)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0005"
                     /evalue="5.50E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="Rv2380c"
                     /protein_end="520"
                     /protein_start="506"
                     /score="13.4"
                     /tool="antismash"
                     /translation="LGVVKSGAVYVPVD"
     CDS_motif       complement(9918..10037)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0004"
                     /evalue="1.30E-09"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="Rv2380c"
                     /protein_end="333"
                     /protein_start="293"
                     /score="30.3"
                     /tool="antismash"
                     /translation="RDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGF"
     aSDomain        complement(10077..10916)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2380c_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.50E-67"
                     /label="Rv2380c_Condensation_LCL.1"
                     /locus_tag="Rv2380c"
                     /protein_end="280"
                     /protein_start="0"
                     /score="219.6"
                     /tool="antismash"
                     /translation="MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRIL
                     RTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDA
                     PLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAA
                     SGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMA
                     KNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRP"
     CDS_motif       complement(10086..10172)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0003"
                     /evalue="2.00E-09"
                     /label="C5_LCL_267-296"
                     /locus_tag="Rv2380c"
                     /protein_end="277"
                     /protein_start="248"
                     /score="29.8"
                     /tool="antismash"
                     /translation="DFLVAAPVLNRGAGTEDAIGYFGNTVAMR"
     CDS_motif       complement(10482..10544)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0002"
                     /evalue="1.10E-06"
                     /label="C3_LCL_132-143"
                     /locus_tag="Rv2380c"
                     /protein_end="145"
                     /protein_start="124"
                     /score="21.2"
                     /tool="antismash"
                     /translation="HHIAWDDGSWRVFFTDLTQAY"
     CDS_motif       complement(10767..10877)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2380c_0001"
                     /evalue="8.10E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="Rv2380c"
                     /protein_end="50"
                     /protein_start="13"
                     /score="47.2"
                     /tool="antismash"
                     /translation="LNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYP"
     misc_feature    complement(10878..10880)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11056..14070)
                     /gene="mbtD"
                     /locus_tag="Rv2381c"
     CDS             complement(11056..14070)
                     /NRPS_PKS="Domain: PKS_AT (99-401). E-value: 5.3e-73.
                     Score: 237.8. Matches aSDomain:
                     nrpspksdomains_Rv2381c_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (668-840). E-value: 9.1e-29.
                     Score: 92.5. Matches aSDomain:
                     nrpspksdomains_Rv2381c_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (918-972). E-value: 1.3e-14. Score:
                     46.1. Matches aSDomain: nrpspksdomains_Rv2381c_ACP.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2381c"
                     /db_xref="EnsemblGenomes-Tr:CCP45169"
                     /db_xref="GOA:P71719"
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR013968"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR020801"
                     /db_xref="UniProtKB/TrEMBL:P71719"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mbtD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 140.6; E-value: 1.3e-42)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PROSITE:PS00012"
                     /locus_tag="Rv2381c"
                     /note="Rv2381c, (MTCY22H8.04), len: 1004 aa.
                     MbtD,polyketide synthase (see citations below), similar in
                     part to several synthases e.g. Q03132|ERY2_SACER|ERYA
                     erythronolide synthase, modules 3 and 4 from
                     Saccharopolyspora erythraea (Streptomyces erythraeus) (3567
                     aa), FASTA scores: opt: 971, E(): 1e-46, (29.35% identity
                     in 1043 aa overlap); Q9F829|megaii megalomicin
                     6-deoxyerythronolide B synthase 2 from Micromonospora
                     megalomicea subsp. nigra (3562 aa), FASTA scores: opt:
                     787,E(): 2.4e-36, (29.35% identity in 1032 aa overlap);
                     Q9L4W4|NYSB polyketide synthase from Streptomyces noursei
                     (3192 aa), FASTA scores: opt: 761, E(): 6.6e-35, (29.55%
                     identity in 1086 aa overlap); O30764|NIDA1 polyketide
                     synthase modules 1 and 2 from Streptomyces caelestis (4340
                     aa), FASTA scores: opt: 726, E(): 7.8e-33, (27.3% identity
                     in 1052 aa overlap); etc. Contains PS00012
                     Phosphopantetheine attachment site."
                     /product="Polyketide synthetase MbtD (polyketide synthase)"
                     /protein_id="CCP45169.1"
                     /sec_met_domain="PP-binding (E-value: 2.7e-12, bitscore:
                     36.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 9.6e-74, bitscore: 237.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 4.3e-34, bitscore:
                     107.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEV
                     ARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQ
                     GGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIE
                     GAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGR
                     LPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSG
                     HFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYW
                     YANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSA
                     RRGERFVDALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEP
                     LPPVSGLTIAVERWERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSA
                     ARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVD
                     AADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETA
                     LRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRI
                     VLLSRRAADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSV
                     ISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSA
                     ANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQ
                     QAIEASLHEFTVDPLVFAADAARLQMLLDSRQFERYEGPTDPNLTIVDAVRTQLAAVLG
                     IPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDA
                     DERSHTAQKVDISRD"
     aSDomain        complement(11155..11316)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2381c_ACP.1"
                     /evalue="1.30E-14"
                     /label="Rv2381c_ACP.1"
                     /locus_tag="Rv2381c"
                     /protein_end="972"
                     /protein_start="918"
                     /score="46.1"
                     /tool="antismash"
                     /translation="DAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRS
                     IGATVSLAT"
     aSModule        11155..13773
                     /complete
                     /domains="nrpspksdomains_Rv2381c_PKS_AT.1"
                     /domains="nrpspksdomains_Rv2381c_PKS_KR.1"
                     /domains="nrpspksdomains_Rv2381c_ACP.1"
                     /locus_tags="Rv2381c"
                     /monomer_pairings="mmal -> Me-ohmal"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(11551..12066)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2381c_PKS_KR.1"
                     /evalue="9.10E-29"
                     /label="Rv2381c_PKS_KR.1"
                     /locus_tag="Rv2381c"
                     /protein_end="840"
                     /protein_start="668"
                     /score="92.5"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: A1"
                     /tool="antismash"
                     /translation="VVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ
                     HGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAA
                     KVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHC
                     VAVKWGLWQ"
     CDS_motif       complement(11596..11694)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2381c_0005"
                     /evalue="2.90E-09"
                     /label="PKSI-KR_m4"
                     /locus_tag="Rv2381c"
                     /protein_end="825"
                     /protein_start="792"
                     /score="29.5"
                     /tool="antismash"
                     /translation="LLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLR"
     CDS_motif       complement(11971..12063)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2381c_0004"
                     /evalue="2.10E-13"
                     /label="PKSI-KR_m1"
                     /locus_tag="Rv2381c"
                     /protein_end="700"
                     /protein_start="669"
                     /score="42.8"
                     /tool="antismash"
                     /translation="VVTGGAGAIGMHYARYLAEHGARRIVLLSRR"
     aSDomain        complement(12868..13773)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2381c_PKS_AT.1"
                     /evalue="5.30E-73"
                     /label="Rv2381c_PKS_AT.1"
                     /locus_tag="Rv2381c"
                     /protein_end="401"
                     /protein_start="99"
                     /score="237.8"
                     /specificity="consensus: mmal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPY
                     LIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGS
                     ITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVA
                     VSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQF
                     IGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQ
                     NCEGAANLPDGPAVLVGSARR"
     CDS_motif       complement(13021..13059)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2381c_0003"
                     /evalue="1.60E-04"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="Rv2381c"
                     /protein_end="350"
                     /protein_start="337"
                     /score="14.0"
                     /tool="antismash"
                     /translation="DYWYANLRHTVRF"
     misc_feature    complement(13156..13158)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(13417..13530)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2381c_0002"
                     /evalue="7.80E-14"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="Rv2381c"
                     /protein_end="218"
                     /protein_start="180"
                     /score="43.7"
                     /tool="antismash"
                     /translation="GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARAN"
     CDS_motif       complement(13732..13776)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2381c_0001"
                     /evalue="8.80E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="Rv2381c"
                     /protein_end="113"
                     /protein_start="98"
                     /score="18.1"
                     /tool="antismash"
                     /translation="FVFPGQGGHWPGMGA"
     gene            complement(14070..15404)
                     /gene="mbtC"
                     /locus_tag="Rv2382c"
     CDS             complement(14070..15404)
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (6-427). E-value:
                     3.5e-144. Score: 472.6. Matches aSDomain:
                     nrpspksdomains_Rv2382c_PKS_KS.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2382c"
                     /db_xref="EnsemblGenomes-Tr:CCP45170"
                     /db_xref="GOA:P71718"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:P71718"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mbtC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 282.3; E-value:
                     1.2e-85)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Rv2382c"
                     /note="Rv2382c, (MTCY22H8.03), len: 444 aa. MbtC,polyketide
                     synthase (see citations below), similar in part to several
                     synthases e.g. Q9F7T9 avermectin polyketide synthase
                     (fragment) from Streptomyces avermitilis (3626 aa), FASTA
                     scores: opt: 1458, E(): 7e-82, (50.65% identity in 446 aa
                     overlap); AAG23264|SPNA polyketide synthase loading and
                     extender module 1 from Saccharopolyspora spinosa (2595 aa)
                     FASTA scores: opt: 1441, E(): 6e-81,(49.1% identity in 446
                     aa overlap); O33954|TYLG tylactone synthase starter module
                     and modules 1 & 2 from Streptomyces fradiae (4472 aa) FASTA
                     scores: opt: 1439, E(): 1.2e-80,(51.0% identity in 447 aa
                     overlap); O30764|NIDA1 polyketide synthase modules 1 and 2
                     from Streptomyces caelestis (4340 aa) FASTA scores: opt:
                     1432, E(): 3.3e-80, (50.9% identity in 442 aa overlap);
                     etc."
                     /product="Polyketide synthetase MbtC (polyketide synthase)"
                     /protein_id="CCP45170.1"
                     /sec_met_domain="mod_KS (E-value: 6.6e-166, bitscore:
                     541.7, seeds: 217, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRG
                     WALRELFDGSRRNGFKPIHNLGGFLSSATTFDPEFFRISPREATAMDPQQRVGLRVAWR
                     TLENSGINPDDLAGHDVGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIAYTL
                     DLAGPALTVDTSCSSALAAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALS
                     DDGHCRPYSAHASGTAWAEGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTA
                     PSGDAQTRLLRRAIAQAAVVPADVGMVEGHGTATRLGDRTELRSLAASYGTAPAGRGPL
                     LGSVKSNIGHAQAAAGGLGLVKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLT
                     PWRAVDGWRTAAVSAFGMSGTNSHVIVSMPDTVSAPERGPECGEV"
     aSDomain        complement(14124..15386)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2382c_PKS_KS.1"
                     /domain_subtype="Modular-KS"
                     /evalue="3.50E-144"
                     /label="Rv2382c_PKS_KS.1"
                     /locus_tag="Rv2382c"
                     /protein_end="427"
                     /protein_start="6"
                     /score="472.6"
                     /tool="antismash"
                     /translation="VVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRGWALREL
                     FDGSRRNGFKPIHNLGGFLSSATTFDPEFFRISPREATAMDPQQRVGLRVAWRTLENSG
                     INPDDLAGHDVGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIAYTLDLAGPA
                     LTVDTSCSSALAAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALSDDGHCR
                     PYSAHASGTAWAEGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTAPSGDAQ
                     TRLLRRAIAQAAVVPADVGMVEGHGTATRLGDRTELRSLAASYGTAPAGRGPLLGSVKS
                     NIGHAQAAAGGLGLVKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLTPWRAVD
                     GWRTAAVSAFGMSGTNSHVIVS"
     CDS_motif       complement(14337..14381)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2382c_0004"
                     /evalue="2.00E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="Rv2382c"
                     /protein_end="356"
                     /protein_start="341"
                     /score="13.5"
                     /tool="antismash"
                     /translation="GSVKSNIGHAQAAAG"
     CDS_motif       complement(14439..14483)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2382c_0003"
                     /evalue="8.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="Rv2382c"
                     /protein_end="322"
                     /protein_start="307"
                     /score="9.1"
                     /tool="antismash"
                     /translation="VEGHGTATRLGDRTE"
     CDS_motif       complement(14685..14711)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2382c_0002"
                     /evalue="7.70E+01"
                     /label="PKSI-KS_m5"
                     /locus_tag="Rv2382c"
                     /protein_end="240"
                     /protein_start="231"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="AHASGTAWA"
     CDS_motif       complement(14859..14906)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2382c_0001"
                     /evalue="1.40E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="Rv2382c"
                     /protein_end="182"
                     /protein_start="166"
                     /score="17.2"
                     /tool="antismash"
                     /translation="GPALTVDTSCSSALAA"
     gene            complement(15394..19638)
                     /gene="mbtB"
                     /locus_tag="Rv2383c"
     CDS             complement(15394..19638)
                     /NRPS_PKS="Domain: PP-binding (9-74). E-value: 3.1e-12.
                     Score: 38.7. Matches aSDomain:
                     nrpspksdomains_Rv2383c_PP-binding.1"
                     /NRPS_PKS="Domain: Heterocyclization (96-393). E-value:
                     1.1e-124. Score: 407.5. Matches aSDomain:
                     nrpspksdomains_Rv2383c_Heterocyclization.1"
                     /NRPS_PKS="Domain: AMP-binding (557-951). E-value: 6.6e-94.
                     Score: 306.6. Matches aSDomain:
                     nrpspksdomains_Rv2383c_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1063-1133). E-value: 1.9e-18.
                     Score: 58.3. Matches aSDomain:
                     nrpspksdomains_Rv2383c_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1189-1411). E-value:
                     5.8e-53. Score: 172.5. Matches aSDomain:
                     nrpspksdomains_Rv2383c_Thioesterase.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2383c"
                     /db_xref="EnsemblGenomes-Tr:CCP45171"
                     /db_xref="GOA:P9WQ63"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001031"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR013624"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="InterPro:IPR029058"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mbtB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     133.8; E-value: 1.6e-40)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PROSITE:PS00012"
                     /inference="protein motif:PROSITE:PS00455"
                     /locus_tag="Rv2383c"
                     /note="Rv2383c, (MTCY22H8.02), len: 1414 aa.
                     MbtB,phenyloxazoline synthase (see citations below),
                     similar to the N-terminal region of several synthetases
                     e.g. Q9EWP5|SC4C2.17 putative non-ribosomal peptide
                     synthase from Streptomyces coelicolor (2229 aa), FASTA
                     scores: opt: 2878, E(): 4.1e-156, (46.85% identity in 1138
                     aa overlap); Q9Z399|IRP2 yersiniabactin biosynthetic from
                     Yersinia pestis (2041 aa), FASTA scores: opt: 2297, E():
                     5.3e-123,(38.55% identity in 1069 aa overlap);
                     P48633|HMP2_YEREN|IRP2 high-molecular-weight protein 2 (may
                     be involved in the nonribosomal synthesis of small
                     peptides) from Yersinia enterocolitica (2035 aa), FASTA
                     scores: opt: 2275, E(): 9.4e-122, (38.45% identity in 1069
                     aa overlap); O85739|PCHE|PA4226 dihydroaeruginoic acid
                     synthetase from Pseudomonas aeruginosa (1438 aa) FASTA
                     scores: opt: 2236, E(): 1.2e-119, (38.2% identity in 1330
                     aa overlap); Q9RFM8|PCHE pyochelin synthetase from
                     Pseudomonas aeruginosa (1438 aa), FASTA scores: opt:
                     2229,E(): 3e-119, (38.0% identity in 1329 aa overlap); etc.
                     Contains PS00455 Putative AMP-binding domain signature, and
                     PS00012 Phosphopantetheine attachment site. Belongs to the
                     ATP-dependent AMP-binding enzyme family."
                     /product="Phenyloxazoline synthase MbtB (phenyloxazoline
                     synthetase)"
                     /protein_id="CCP45171.1"
                     /sec_met_domain="Condensation (E-value: 5.7e-43, bitscore:
                     136.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-102, bitscore:
                     332.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-16, bitscore:
                     50.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSL
                     VGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAP
                     MQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGT
                     QRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGER
                     TRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRD
                     ADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPA
                     MTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTA
                     AARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTE
                     QFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLA
                     AGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSG
                     DLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVD
                     QPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAY
                     VLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATLECDMSVLDIFAAL
                     RSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVG
                     GDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFP
                     NNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLA
                     RYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHAAAATVLPGGSDVLAAAV
                     CVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERS
                     GDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRW
                     LDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPI
                     EQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQR
                     ADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHCMGAIVAFEFARLAERNGVPVRA
                     LWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRA
                     LSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHL
                     DAVARMVSADVR"
     aSDomain        complement(15406..16071)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2383c_Thioesterase.1"
                     /evalue="5.80E-53"
                     /label="Rv2383c_Thioesterase.1"
                     /locus_tag="Rv2383c"
                     /protein_end="1411"
                     /protein_start="1189"
                     /score="172.5"
                     /tool="antismash"
                     /translation="VLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAA
                     DSIEALALELFEAGDWHLTAPLTLFGHCMGAIVAFEFARLAERNGVPVRALWASSGQAP
                     STVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPD
                     VRIRANIHAVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSA
                     "
     aSModule        15406..19350
                     /complete
                     /domains="nrpspksdomains_Rv2383c_Heterocyclization.1"
                     /domains="nrpspksdomains_Rv2383c_AMP-binding.1"
                     /domains="nrpspksdomains_Rv2383c_PCP.1"
                     /domains="nrpspksdomains_Rv2383c_Thioesterase.1"
                     /final_module
                     /locus_tags="Rv2383c"
                     /monomer_pairings="ser-thr -> ser-thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(15817..15876)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0015"
                     /evalue="1.70E-06"
                     /label="NRPS-te1"
                     /locus_tag="Rv2383c"
                     /protein_end="1274"
                     /protein_start="1254"
                     /score="20.6"
                     /tool="antismash"
                     /translation="PLTLFGHCMGAIVAFEFARL"
     misc_feature    complement(16009..16011)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(16192..16194)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(16240..16449)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2383c_PCP.1"
                     /evalue="1.90E-18"
                     /label="Rv2383c_PCP.1"
                     /locus_tag="Rv2383c"
                     /protein_end="1133"
                     /protein_start="1063"
                     /score="58.3"
                     /tool="antismash"
                     /translation="RALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWL
                     DSPSLMVADMFAARTIAALAQLLTG"
     CDS_motif       complement(16561..16587)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0014"
                     /evalue="2.20E+01"
                     /label="afterCy4"
                     /locus_tag="Rv2383c"
                     /protein_end="1026"
                     /protein_start="1017"
                     /score="-1.1"
                     /tool="antismash"
                     /translation="VTLLDRIPF"
     CDS_motif       complement(16756..16821)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0013"
                     /evalue="6.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="Rv2383c"
                     /protein_end="961"
                     /protein_start="939"
                     /score="31.2"
                     /tool="antismash"
                     /translation="FVGRADHRVKISGYRVELGEIE"
     aSDomain        complement(16786..17967)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2383c_AMP-binding.1"
                     /evalue="6.60E-94"
                     /label="Rv2383c_AMP-binding.1"
                     /locus_tag="Rv2383c"
                     /protein_end="951"
                     /protein_start="557"
                     /score="306.6"
                     /specificity="consensus: ser-thr"
                     /tool="antismash"
                     /translation="FFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVG
                     DTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQ
                     VRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVE
                     TFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDT
                     YEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGG
                     ATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSG
                     RGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKIS"
     CDS_motif       complement(16894..16983)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0012"
                     /evalue="5.60E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="Rv2383c"
                     /protein_end="915"
                     /protein_start="885"
                     /score="50.6"
                     /tool="antismash"
                     /translation="PDWVAGELWVSGRGIARGYRGRPELTAERF"
     CDS_motif       complement(17350..17391)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0011"
                     /evalue="1.80E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="Rv2383c"
                     /protein_end="763"
                     /protein_start="749"
                     /score="2.9"
                     /tool="antismash"
                     /translation="FAALRSGGAIVVVD"
     CDS_motif       complement(17503..17562)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0010"
                     /evalue="3.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="Rv2383c"
                     /protein_end="712"
                     /protein_start="692"
                     /score="28.7"
                     /tool="antismash"
                     /translation="AYVLFTSGSTGEPKGVEVAH"
     misc_feature    complement(17683..17685)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(17743..17781)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0009"
                     /evalue="1.30E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="Rv2383c"
                     /protein_end="632"
                     /protein_start="619"
                     /score="9.3"
                     /tool="antismash"
                     /translation="LGILAAGGVYLPI"
     CDS_motif       complement(18166..18240)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0008"
                     /evalue="1.40E-05"
                     /label="Cy7"
                     /locus_tag="Rv2383c"
                     /protein_end="491"
                     /protein_start="466"
                     /score="18.0"
                     /tool="antismash"
                     /translation="ISQGPQVLLDAQVTEFDGGVLVNWD"
     CDS_motif       complement(18298..18327)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0007"
                     /evalue="9.30E-03"
                     /label="Cy6"
                     /locus_tag="Rv2383c"
                     /protein_end="447"
                     /protein_start="437"
                     /score="9.0"
                     /tool="antismash"
                     /translation="APVVFTSALG"
     CDS_motif       complement(18355..18393)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0006"
                     /evalue="3.40E-03"
                     /label="afterCy5"
                     /locus_tag="Rv2383c"
                     /protein_end="428"
                     /protein_start="415"
                     /score="10.4"
                     /tool="antismash"
                     /translation="HSAYPGLSVLRDL"
     aSDomain        complement(18460..19350)
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2383c_Heterocyclization.1"
                     /evalue="1.10E-124"
                     /label="Rv2383c_Heterocyclization.1"
                     /locus_tag="Rv2383c"
                     /protein_end="393"
                     /protein_start="96"
                     /score="407.5"
                     /tool="antismash"
                     /translation="GEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLR
                     AAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDA
                     KSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALG
                     YTYREYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWH
                     WLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVD
                     LLVGDFTSSLLLDVDL"
     CDS_motif       complement(18463..18522)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0005"
                     /evalue="2.80E-09"
                     /label="Cy5"
                     /locus_tag="Rv2383c"
                     /protein_end="392"
                     /protein_start="372"
                     /score="29.0"
                     /tool="antismash"
                     /translation="HPDVDLLVGDFTSSLLLDVD"
     CDS_motif       complement(18523..18561)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0004"
                     /evalue="6.40E-03"
                     /label="afterCy4"
                     /locus_tag="Rv2383c"
                     /protein_end="372"
                     /protein_start="359"
                     /score="9.5"
                     /tool="antismash"
                     /translation="FLLNLPLFSRQAL"
     CDS_motif       complement(18574..18633)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0003"
                     /evalue="2.20E-09"
                     /label="Cy4"
                     /locus_tag="Rv2383c"
                     /protein_end="355"
                     /protein_start="335"
                     /score="29.9"
                     /tool="antismash"
                     /translation="GITPAMTLAAAFANVLARWS"
     CDS_motif       complement(18925..18969)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0002"
                     /evalue="1.50E-04"
                     /label="Cy3"
                     /locus_tag="Rv2383c"
                     /protein_end="238"
                     /protein_start="223"
                     /score="15.0"
                     /tool="antismash"
                     /translation="RLHVDLDMQAADAMS"
     misc_feature    complement(18985..18987)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18988..18990)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(19147..19197)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv2383c_0001"
                     /evalue="3.10E-07"
                     /label="Cy2"
                     /locus_tag="Rv2383c"
                     /protein_end="164"
                     /protein_start="147"
                     /score="22.7"
                     /tool="antismash"
                     /translation="ALRHPMLRVQFLPDGTQ"
     misc_feature    complement(19360..19362)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(19417..19611)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2383c_PP-binding.1"
                     /evalue="3.10E-12"
                     /label="Rv2383c_PP-binding.1"
                     /locus_tag="Rv2383c"
                     /protein_end="74"
                     /protein_start="9"
                     /score="38.7"
                     /tool="antismash"
                     /translation="IIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGI
                     AVDFATLAATPTIEAWSQLV"
     gene            19737..21434
                     /gene="mbtA"
                     /locus_tag="Rv2384"
     CDS             19737..21434
                     /NRPS_PKS="Domain: AMP-binding (47-456). E-value: 3.4e-82.
                     Score: 268.0. Matches aSDomain:
                     nrpspksdomains_Rv2384_AMP-binding.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2384"
                     /db_xref="EnsemblGenomes-Tr:CCP45172"
                     /db_xref="GOA:P71716"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="UniProtKB/TrEMBL:P71716"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mbtA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     466.1; E-value: 1.9e-141)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PROSITE:PS00455"
                     /locus_tag="Rv2384"
                     /note="Rv2384, (MTCY22H8.01, MTCY253.37c), len: 565 aa.
                     mbtA, bifunctional enzyme, including salicyl-AMP ligase
                     (Sal-AMP ligase) and salicyl-S-ArCP synthetase (see Quadri
                     et al., 1998; De Voss et al., 1999), highly similar to
                     other ligases e.g. Q9F638|MXCE from Stigmatella aurantiaca
                     2,3-DHBA-AMP ligase (protein involved in the biosynthesis
                     of 2,3-dihydroxybenzoic acid, contains the AMP binding
                     signature) (543 aa), FASTA scores: opt: 1683, E():
                     2.8e-90,(48.25% identity in 545 aa overlap) (see Silakowski
                     et al.,2000); P40871|DHBE_BACSU|ENTE
                     2,3-dihydroxybenzoate-AMP ligase from Bacillus subtilis
                     (539 aa), FASTA scores: opt: 1569, E(): 1.2e-83, (44.9%
                     identity in 532 aa overlap); O07899|VIBE_VIBCHVC0772
                     vibriobactin-specific 2,3-dihydroxybenzoate-AMP ligase from
                     Vibrio cholerae (543 aa), FASTA scores: opt: 1457, E():
                     3.7e-77, (44.6% identity in 545 aa overlap); etc. Also
                     similar to P95819|SNBA pristinamycin I synthetase I from
                     Streptomyces pristinaespiralis (582 aa), FASTA scores: opt:
                     1532, E(): 1.7e-81, (46.35% identity in 548 aa overlap);
                     and Q9RFM9|PCHD salicyl-AMP ligase from Pseudomonas
                     aeruginosa (547 aa), FASTA scores: opt: 1415, E(): 1e-74,
                     (45.95% identity in 533 aa overlap). Contains PS00455
                     Putative AMP-binding domain signature. Belongs to the
                     ATP-dependent AMP-binding enzyme family."
                     /product="Bifunctional enzyme MbtA: salicyl-AMP ligase
                     (SAL-AMP ligase) + salicyl-S-ArCP synthetase"
                     /protein_id="CCP45172.1"
                     /sec_met_domain="AMP-binding (E-value: 9.2e-90, bitscore:
                     290.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTV
                     LSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITPGDRVLLQLPN
                     GCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPMARE
                     LVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKL
                     IPRTHDDYVFNATASAALCRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPD
                     PSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTPKSLRLLQVGGSKLEPEDARR
                     VRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPG
                     EEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICR
                     AGETIAASDLEEQLLSHPAIFSAAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDR
                     RGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH"
     aSDomain        19878..21104
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv2384_AMP-binding.1"
                     /evalue="3.40E-82"
                     /label="Rv2384_AMP-binding.1"
                     /locus_tag="Rv2384"
                     /protein_end="456"
                     /protein_start="47"
                     /score="268.0"
                     /specificity="consensus: sal"
                     /tool="antismash"
                     /translation="DAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGI
                     TPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADV
                     ASGFDYRPMARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALL
                     LVSGGTTGMPKLIPRTHDDYVFNATASAALCRLSADDVYLVVLAAGHNFPLACPGLLGA
                     MTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTPKSLRLLQV
                     GGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELR
                     IVNADGEPVGPGEEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNL
                     VVTGRVKDVI"
     misc_feature    20079..20081
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21530..22450
                     /gene="mbtJ"
                     /gene_synonym="lipK"
                     /locus_tag="Rv2385"
     CDS             21530..22450
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2385"
                     /db_xref="EnsemblGenomes-Tr:CCP45173"
                     /db_xref="GOA:Q79FE8"
                     /db_xref="InterPro:IPR013094"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:Q79FE8"
                     /gene="mbtJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 216; E-value: 1.1e-65)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="lipK"
                     /locus_tag="Rv2385"
                     /note="Rv2385, (MTCY253.36c), len: 306 aa. Putative
                     mbtJ,acetyl hydrolase (see citations below), showing some
                     similarity with various hydrolases including acetyl
                     hydrolases e.g. Q9ZBM4|MLCB1450.08|ML0314 putative
                     hydrolase/esterase from Mycobacterium leprae (335 aa),FASTA
                     scores: opt: 449, E(): 6.7e-21, (33.85% identity in 313 aa
                     overlap); AAK47950|MT3591 Esterase from M. tuberculosis
                     strain CDC1551 (327 aa), FASTA scores: opt: 469, E():
                     3.6e-22, (35% identity in 283 aa overlap); Q9X8J4|SCE9.22
                     putative esterase from Streptomyces coelicolor (266 aa),
                     FASTA scores: opt: 430,E(): 8.5e-20,(38% identity in 245 aa
                     overlap); Q01109|BAH_STRHY acetyl-hydrolase from
                     Streptomyces hygroscopicus (299 aa),FASTA scores: opt: 420,
                     E(): 4e-19, (35.1% identity in 265 aa overlap). Equivalent
                     to AAK46748 from Mycobacterium tuberculosis strain CDC1551
                     (327 aa) but shorter 21 aa. Note that previously known as
                     lipK."
                     /product="Putative acetyl hydrolase MbtJ"
                     /protein_id="CCP45173.1"
                     /transl_table=11
                     /translation="MVLRPITGAIPPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVN
                     SVLPDGRRVVGEWVYGPHNNAINAGPGGGAIYYVHGSGYTMCSPRTHRRLTSWLSSLTG
                     LPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAAEHMVIAADSAGGHLTVDMLLQ
                     PEVAARPPAAVVLFSPLIDLTFRLGASRELQRPDPVVRADRAARSVALYYTGVDPAHHR
                     LALDVAGGPPLPPTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHVFQALPR
                     MTPEAAKAMTYVAQFIRSTTARGDL"
     misc_feature    21929..21931
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21947..21949
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(22454..23806)
                     /gene="mbtI"
                     /gene_synonym="trpE2"
                     /locus_tag="Rv2386c"
     CDS             complement(22454..23806)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv2386c"
                     /db_xref="EnsemblGenomes-Tr:CCP45174"
                     /db_xref="GOA:P9WFX1"
                     /db_xref="InterPro:IPR005801"
                     /db_xref="InterPro:IPR015890"
                     /db_xref="InterPro:IPR019996"
                     /db_xref="InterPro:IPR019999"
                     /db_xref="PDB:2G5F"
                     /db_xref="PDB:2I6Y"
                     /db_xref="PDB:3LOG"
                     /db_xref="PDB:3RV6"
                     /db_xref="PDB:3RV7"
                     /db_xref="PDB:3RV8"
                     /db_xref="PDB:3RV9"
                     /db_xref="PDB:3ST6"
                     /db_xref="PDB:3VEH"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mbtI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 350.7; E-value:
                     2.7e-106)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="trpE2"
                     /locus_tag="Rv2386c"
                     /note="Rv2386c, (MTCY253.35), len: 450 aa.
                     mbtI,isochorismate synthase (see citations below), similar
                     to Q9X9I8|IRP9 salicylate synthetase from Yersinia
                     enterocolitica (434 aa), FASTA scores: opt: 887, E():
                     7.5e-48, (37.45% identity in 422 aa overlap); and similar
                     in C-terminal region to many anthranilate synthases
                     component I e.g. Q9Z4W7|TRPE_STRCO|SCE8.07c from
                     Streptomyces coelicolor (511 aa), FASTA scores: opt:
                     509,E(): 3e-24, (40.4% identity in 255 aa overlap);
                     P33975|TRPE_HALVO from Halobacterium volcanii (Haloferax
                     volcanii) (523 aa) FASTA scores: opt: 488, E():
                     6.2e-23,(34.2% identity in 298 aa overlap); and similar to
                     Q08653|TRPE_THEMA|TM0142 anthranilate synthase component I
                     from Thermotoga maritima (461 aa), FASTA scores: opt:
                     478,E(): 2.3e-22, (28.4% identity in 440 aa overlap); etc.
                     Could be belong to the anthranilate synthase component I
                     family. Note that previously known as trpE2, an
                     anthranilate synthase component I."
                     /product="Isochorismate synthase MbtI"
                     /protein_id="CCP45174.1"
                     /transl_table=11
                     /translation="MSELSVATGAVSTASSSIPMPAGVNPADLAAELAAVVTESVDEDY
                     LLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETD
                     QAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDR
                     LLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPL
                     TYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGRGPAID
                     RLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIR
                     ARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLD
                     AALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ"
     misc_feature    complement(23315..23317)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gctgtgagcg agcggtcagt cctcgaccat ggcgtcacgc aggctcttcg gccgcagatc
       61 ggtccagttc ttttccacgt agtccaggca ggcggcacgg ctggcttcgc cgtgcaccac
      121 gcgccagccg gccgggatat cggcgaacac cggccacagg ctgtgctggt cttcgtcgtt
      181 gaccagcacg aagaatgcgc cgttgtcgtc atcgaaagga ttggtgctca ccgcttctcc
      241 ttgtgtcgtt gtgtttggtc ggcgtaaaga tgccggcgcc gagcacccgg tccgacaaca
      301 agccgaggca gctcaggttg gggaacccgg gcccctgggt gagtccggac agggtgggca
      361 ggaacagctt gggcgtgacg tcggtgactg ccaagtcgta gccgatcgct tcctgcaggc
      421 ggtcggcggt cagcggtcca cccagtccca gctcgagcag gtcgagggtg tgctgactga
      481 acagtgaggt gaaccacagc ggatcggcgc ccgagccgtc gatgacgaga tcgaatccgt
      541 gcacggtctc gaagttctcg ctgccccggt tggtgctcag cgtcaaccgg atctgcccct
      601 gacggcccac cgcgtgggcg acccggccac gcagatgatg gatgcggtca tcggccagca
      661 gcgcttcctg cacggtcgcc gagaacactc ctcggtcggt gcgggccagc gcgtcgcgcc
      721 gttcgtcgaa cgtcaaggcc gcccagtcgg tcggatcgga aaacagtgag ttctcgaaga
      781 atccctcgcc gcgggtgaac agggttacct gcggggagat gacggtgatg gttgagaccc
      841 gatgccggaa cagctcgttg agcatcgatg cggccgtctc tccgccaccg atcaccgcga
      901 cccgctcggc gttgatccgg tcgtggccgg cggcacggtc ccagaactgt gcgattgaga
      961 gcacgcgcgg gtttccgggc agtagcgact tttcagcctg gccgggcccg gtgatcatca
     1021 acgcgtcggc ctgcacggtg gtctcgtggg tgcacaacgc ccagcggtca ccggtgacgg
     1081 cgagccgttc gacctcgccg tggatcacct tgaggccaat gtgatcggcc acccaggcta
     1141 ggtactgact ccacctgcga tgggtgggcg ccgggcggcc ccggtcgatc cattccgcga
     1201 acgacgcggt ggcgatcaga tacgactgcc agctgtagcg ggtcatccgc tcgtccaatt
     1261 ctgcgttgcg ccgtggcacc agcgccgacc ggtagggaaa accgacatcc ttttctgggc
     1321 tggtgcccag ccggtgggct ccgtcggtcc agccaccgct ggcctgccag ttggccccga
     1381 ccccgatgcg ttcgacggcg atcacgtcgg gcacgtcgac ccccatgtca cgcagcacgg
     1441 atgccttggc cgcgaccgcc accgccttgg ctccagcgcc caggaccgcg agcgtcggat
     1501 tcatgctgtt atctccgcca gcgcgccctg ccacagtgat tgcagcgtgg cgacgtcgtc
     1561 ggcggacagg atgtcgggca gcgtgcgcca ccgcgtggct agcacgggag cgtcggcggg
     1621 cccgaggagc gccgccagca ccgtcagttc gtggcgcacc ggctgttcgg gttcaggcag
     1681 ttgccccaca tcagccagta gtgcgcggtc gaccgccaga tctcccaccc cgacgtgcag
     1741 gctacccaga tagttcagca gcagctgggg ttcgcggtgg gcgcgtagtc gctccgcggt
     1801 atcggcgcgc aggtaccgca gcaggccgta atcgatgccg ctgccgggta tccgcgcgaa
     1861 gtcggtcgcg ccgtcgcagt ggatgcgcag cggatagatc gcgctgagca gcccgaccgt
     1921 gtcgctggtg tcggcagtct tatcgacgtg gacgtccgcg cggccatgcg tctccaacgc
     1981 caacagcggt gctggtgttt gttgaccgcg ttgccggcgc caggcggtca ccatccgcgc
     2041 agcggcggta gccagcagat cggtcatcga ccgtcccgtc gaaagcagcc gcgcggtcag
     2101 atcggcgtcg gagatcgaca tggtgatcgc tagctcacca acccggtcgg tctgcggcgc
     2161 caccctgcgg gcacccaacg gcggatcggc gccctcgagt tcggcgaccc agaaatcaac
     2221 gctatccagc gccttagccc gctgcgccag cagccgcgac cactgccggt agctggtgtt
     2281 ctcgcgcgct gggctgggcg cgcgcccggc cgccagcgcg tgcaggccgg cgtcgagttc
     2341 acccagcaca atccgccagg aggctgggtc catcgccagc acatgggcgg tcagcaccag
     2401 aacaccgggc ccgtcgggtt cgcgcagcca caccgccgag agcagtcggc cggcctgggg
     2461 gtcgagactc gccagcgcgc caagagtctg ctcggccacc gcggtgacca gttcaccgct
     2521 gacccaaacc tcgctgagaa tgtccgtttt cggttgtgcg acaagggcca tcgcatcccg
     2581 gtcgaaccgg caccgcaaca cctcgtgtcc gtcgacgacc gcggccaaca cggcatccag
     2641 gcgttcgcgg gtgatccggt cgggcaacct gatgacctcg gtttgtgcca gccggcgcgg
     2701 gtcgccgtac tcgtagagcc aatgagtgtt gggtagcacc gggatcggct cgccggcatc
     2761 gttggccggt gcctgccatg cggcatcgga gtcaatggcc gccgcgagtt cacggatggt
     2821 gtcgcactcc accatcagcc tggcccgcaa cgcaatccca cgacggcgcg cggcctgcac
     2881 caccgacagc gccacgatgc tgtctagacc catctgcaaa aagcccgcgg tgacatcgac
     2941 gttcgaggtt tccatgacat cggcgaacgc ctcggccagc accagctcgg tcggtgtctg
     3001 cggcggagtt gccggtcctt cggtgacatt gattgccgcc aaagcgtttt cgtcgatctt
     3061 gccgtgtgga gtcagcggta actcgtcgag gacgacgata tggtgcggga ctagataacg
     3121 cggcaaccgc tctagcagca tcgcccgcaa ttcggccacc ggtggcggtt gtggtccgcc
     3181 tgccacatac gccgtcagcc gggggccact ggcatggccg cgggccgtca catggcaacc
     3241 gtgcaccgca tggtggccgt tgagcaccgc ggcaatctca cccggctcga cgcggaaacc
     3301 gcggatcttc acctggtcat cgctgcgccc gaggaactcc agtccaccgt cgggcaggcg
     3361 gcgcaccaca tctccggtgc ggtacattcg gctaccgcgc ccgtttggct cagcgacaaa
     3421 gcgcgccgca gtctcggccg ggcggccgag gtaaccgcgg gtcaactggg cgcccgccag
     3481 atacagctcg ccggcgacgc catcgggcac cggccgcagc caggagtcca tgacgtaggc
     3541 gcgggtggtg caggtcggac gtccgatgac cggtcgcgca tgctcagcaa cggcggcgac
     3601 cacggcttcg accgtggtct cggtaggccc gtagcagttg aaggccgtca tggccgtgcg
     3661 cgcgcagttc tgctggatca tccgccacgt cgcggcgccc aaggcttcgc cgccgagcgc
     3721 aagcaccgcc aacggcgccc ggtcgagcag tccagcgttg tgcagctggg cgaacatcga
     3781 cggcgtggtg tcaatcatgt ccagaccgaa tcggtcgatc gcttcgacca gcgcccctgc
     3841 gtcccgctga cgatggtcgt cgacaatgtg caccgcgtgg ccgtcaagca gtgcgaccaa
     3901 cggctgccac gccgcgtcga aggtgaacga ccaggcatgc gcgattcgca gcgggcgccc
     3961 gagccgctgg gccgccggcc gcaacacgcg ctcgatgtgg tcgtcggcgt aggccgacag
     4021 cgcccgatgg gtgccgatga cacctttcgg ggtaccggtg gtgccggagg tgaaaatcac
     4081 gtaggccgcc tggtccaccg gcaccgtgat ggcacggtcc tcctcgagta tgtcagcgcc
     4141 aaccgaagcg gcgaacacgc cctcatcgat gaccaccgga gccgatgtct ggcgcaagat
     4201 ctcggcgaca cgctcaccgg gcatcgccgg gtccagcggc acgatcatgc cacccgcctt
     4261 gaggaccgcc agcatggcgg ccacgtagcg cggaccacgg gacagcgcga cggccaccgg
     4321 ggtctcgcga ctcacgtccg cgcggcgcag cccagtggcc agccggtcgg ccaatgcatc
     4381 cagctcccgg tacgtcagct gaccatccgc ccaactgacc gccaccgagt caggctgtgc
     4441 cgcagcgatt tcggcgaacc gggtatgcac cgcgggtgcc gacgtcgtca catccggcag
     4501 gccgggtgcg gtcggatcgt gctcgccgtc cagcagaatg tcgacgtcgc gcagcggccg
     4561 atcccaccgg ctgaccaagc gctgtaacac agccagcacc cgcctgccga ggctttcggg
     4621 cgccatcgtg cccagcgcac cgtcgagcac ctccactagc agcgtgagct caccggtgct
     4681 gcggtgcgcg gcgacggtca ccggaaagtg cgacaaactc tctagcgcca ccggacggaa
     4741 cgtcaccccg tttgcgacga actccgcggt gcccaccacc tcgccgggcg ggaagttctc
     4801 atacaccagt agggtgtcga acatctcacc gataccggcg atggcacgaa actcgttgaa
     4861 accgagatag ctgtggtcgc gcaacatggc gaattgacgt tgtaggacag cgcattgccc
     4921 gccgacggta gcgcgggcgt ccaggcggac ccgcagtggc accgtattga tgaacaggcc
     4981 gatcatcgtt tccacgccgg acagttcgct gggcctgccg gacaccgtca caccgaacgt
     5041 cacatcgcca cgaccggtga atgctgaaag cgtggtagcc caagccattt gaacaagtgt
     5101 gctgatcgtg acgccacggg tgcgggcggc atcggccagc tccgcggtgg cttcacggtc
     5161 aaggcgcact tcggtgcgtc ccggaatacc cggctgcaca ggagtgtcgg cgagtgccgg
     5221 cgataacaga gtcgggccgt ccaggccatt gaggtggtcc gcccacattg cgcggctagc
     5281 cgtctgatcg cggccggcca gccagccgat gtagtcgcga tacggccgcg gcgctgccgg
     5341 caacgcggcg acgtgaccac cagcccgata caaggcgagc agctcggaga cgaacagcgg
     5401 caacgaccat ccgtcgatga cgatgtggtg cgcgacgatg accagatgcc aacattcgtc
     5461 cggtagttcg atgagcagga accggatgag tggtccgcgg ccgacgtcga agcggcgccg
     5521 gcgctcttcg gctgccagcg ccccgacctc actggggtgg gcgcgcacgt gacgccaaag
     5581 cacctcggca ctggatggta ttacctgcac gggccggctc aggttcccgt gtaggaagct
     5641 cgcccgcagg ttggggtgcc gggtcagcat cgcggcagcg cagtcgcgaa gcaaggcgat
     5701 gtcgagcggg ccggccgcgt cggccgccat cgcgatcaca tacgggtcgg cctctgcggc
     5761 ctcagagccg gactccgcgg cgaccagtgt cgccctagaa aacagtccct gttgcaatgg
     5821 gctgagcgcc atcacatcgt cgatggcgcc ccgcgcgtcg gctcgcgtca cggccactgg
     5881 tcccatgacg cggtcagggc cgacagttcg tctggggaaa gccctgatgt gctcatcggc
     5941 gcgtgatgct tgtcgtccgg ctcggcctcg acgtgaggct tggcgtcgac cgcggcggcg
     6001 agctcacaca aaacgggatg ctcgaaaacc atccgcgcgg tcagcggtat cccgccatct
     6061 cgagcccggg cagccacctg agtcgcgagg atgctgtcgc cgccgaggtt gaagaagtcg
     6121 tcgtagcgtc cgacctcccc cacctcgagc acgtcggcga ggatggcagc cagcgcgcgc
     6181 tcggtttcgg tgtcggcggg ctcggccggc accggtgccg cctgcgccgt tggcagccgt
     6241 tcgatttcgg ccagcagctc cagttggccg tcggccttcc acactccgcg ctcgccgttg
     6301 cggtagagcc gagaacccgg ttgcgcggcg aacggatcgg caacgaatcg ggtcgcggtc
     6361 tccgatggcc gggccaaccg ggcaccgacg gcgggaccgc caccgtaata aacgtcaccc
     6421 accacgccta ccggaacggg cttaagtgcg tcgtcaagca ggtacacccg ggccgttccg
     6481 gcgcccgcat tggaccggtc caaaatgcgc cgtctggctt gcgcgctgac catctcgacc
     6541 tcgcgcagcg gttggtccgg acggtcggcg aacgcctcga cgacacggac tagccagtcg
     6601 gcgaagcgtt gtgcggtggc gcgctcatac aactcggtgc ggtagatgac gtggccgcgg
     6661 tactcgtcgc cgcaggcgaa gaagttgacc gatagatcgg cttgcgcggc atcgaatgtc
     6721 ggctccagca cgcgcaacgt ggtgtcaccg tcgggcccgg tgtcgatgac gtggtcttgc
     6781 ggcatttgtt cgcgaacgtg cacaacaatg tcgaacaacg gattgcggga cagcgaccgc
     6841 tgggggttga ccgcctccac cacctggtcg aacggcaggt cctgatgtgc atacgctgcc
     6901 agcgccatct gcctggtgcg ctgcagcacc tcgcgcagcg tggggttccc gcgcaggtcg
     6961 ttgcgcaaca ccacgatgtt gatgaagaac ccgatgagct ggtccaggtt ggcctcgctg
     7021 cgaccggcca ccggggcgcc gatggggacg tctaccccgc cgccggcctt gtgtaacacc
     7081 accgcgacgg cggcctgtag cagcatgaac tcggtgacac cgaggtctcg gctcacggca
     7141 gccaatttgt cgcggatcgc ggcgccgaga cgaaattcga ccgcgtcacc ggcaccgctg
     7201 agcagggccg ggcgcgggaa gtccgggcgc agaccggttt cgcctgccag gccccccagc
     7261 tggcggatcc agtagtcgcg ttgcggaccg acgatgcccg caccgtcgtc gagtagcgcc
     7321 gactgccaca cgctgtagtc ggcgtactgc accggcagcg gtgcccacga cggccgttgt
     7381 ccggtgctgc gggcccggta tgcggtcagc agatcggtga acaacacccc agccgaccag
     7441 tggtcgccgg cgatgtgatg caccaccagc gacaacacgg tctgctccgg cgtgctcagc
     7501 agcgccgccc ggatcggcca gtcggtttcc aggtcgaaaa cgtaacctcg ctcgttgttc
     7561 agttcggctc gcagccacgc ggcgtcggac ccggcggcgc accgcaccgg cacctcggcg
     7621 ggcggctgga tgatctggtg tggcacgccg ccgatctcgc ggtagacggt gcgcaggatc
     7681 tcgtggcgtg ccaccacatc ggtgatggcc gccgcgaacg cgttggtgtc gcagggccca
     7741 tgcaatgccg cggcgaaggg aatgttgttg acggcgttgg gcccgtcgaa gcgatagttg
     7801 aaccagctac gcatttgaga cgacgacaat cgcactggcc cgtcatgatc cacccgggtc
     7861 agccgcggcc tcgccgaatc cgaatccaac gtatcgatgt gtccggccaa cgcggtcacc
     7921 gtggcgaatt cgaagatctc ccgcacaccg acatcgacgc cgaacgcgtt gcgcacggcc
     7981 gcaacgagtt tggttgccag cagcgagtga ccgccgaggt cgaagaacga gtcgtcagca
     8041 cccactcggt cgcggccgag cagctcaccg aacagttggg caaggcgccg ctcggtggcg
     8101 gtctgcggcg cgcggaactc ggtgtccgac gcgatctgcg gttccggcag cgcggcgcgg
     8161 tcgattttgc catgcgcggt gatcggaatc tcatccagca caacataggc cgcgggcagc
     8221 atatattcag gcagtgccgc ggccacccgg gcgcggatgc ggtcgagatc gacgccgaca
     8281 tcggcgggtc cgtcgccgcc cgcggcgggt gtcacgtagc ccaccagact cttgcccagc
     8341 cgcggcaggt cgctaaccac cacaacggcc tgcccgaccg tagggtcgac cgcgatggcc
     8401 gctgctacgt caccgagttc gattcggaat ccgcgaatct tgacctgctc gtcggcacgg
     8461 cccacgaact cgatgtcacc gtcagcattg cggcgcgcca gatccccgga ccggtacatg
     8521 cgggaaccgg gattaaacgg gtcggcaacg aatcgctccg cggtcagccc ggcgcggcga
     8581 tggtatccgt atgcgacatg cgtccctcca atatagatct cgccgatcac accggtcggc
     8641 accggctgca acgaatcgtc gagcaggtgc atggtggtgt tgatcttggg ccggccgatg
     8701 ggcacgatgc gggtgccctg tgggcccacc actttaaacc ggctggcgtt gatcacggtt
     8761 tcggttggac cgtagaagtt gtgcagcagc gcatcgaatg tcgcgtggaa cttgtcggcc
     8821 acctcaccgg gtagcggctc cccgccgatg ggtacccgct gcaacgtccg ccactggctc
     8881 acacccggca gcgacaggaa cagcccgagt agggacggca cgaaatgcat tgccgtgatg
     8941 ccctcgtcgc gcaacagggc ggtgagatat ccaatgtcgg tgagtccccc ggggcgtggt
     9001 atcaccatcc gcgcgccaca ggccagcgtg ccgaagatct cggcgatcga gacgtcgaag
     9061 ctgggtgagg cgacctgcag tagccggtcg gtgtcgtcga cgtcgtattc gcccttgaac
     9121 cagacgaagt actcggcgac ggggcggtgt ggcaccgcga cacctttggg caatccggtg
     9181 gtaccggacg tgtagatgag ataggccgtg ttgtctggcc gtagcggccg gattcgatcg
     9241 gcgtcggtgg ggtcgtcgct gcggtatccg gccagctcac gtactggcgt gcgcagcacc
     9301 agtttcgcgt cgcagtcggc gaggatgaaa tccagccggt cttgcgggta gctgggatcc
     9361 acgggcacat acaccgcccc ggacttgacc acccccaagg ccgtgacgat caggtccggc
     9421 gatttgtcaa gaagtaccgc gacccggtct tcgctgccta tcccctgctc gatcagccag
     9481 tgccccaacc ggttcgacgc ctcattgagg tcgtggtagg tgaagtgttg gccctcatac
     9541 accacggcgg tggcgtcggg agtccgcgtg gtctgctcgt tcaccaggtc cacgagggtt
     9601 ttgacagggg tatcgaaccg ctcgccgcgc gacacctcgc gcagcctggc ggcgtcgcgc
     9661 tcatccatca gcgccagccc cgacaacgtg ttgtcggggg cggccagcgc attgtcgagc
     9721 agcacaccga agtgtcgaag catctgcttg gccagggcgg gttccaggat ctccaccagg
     9781 tgttcggcct cgaccagcac acccgcgcgg tcgaattcga ccatgaagcc caacggcagc
     9841 tgcgtgatgt tgctgcgcag gtcgtagcgc tcgcactcga tgcctggcgg gttgaatccg
     9901 ccgccgtcgg gctcccggaa accgaagctg acccgggtca tgcgctcggc accgtgccgg
     9961 cgatcggggt tcagttccct taccacgcgg tcgaggttga tccgttggtg tgcgaacgcc
    10021 ccgctggcga tgtcgcgggt ggcggtcagc aactcccgga aactcatcgc cgattgcggt
    10081 cgcagccgca tcgctaccgt gttgccgaaa tagccgatgg catcttcggt tccggcgcca
    10141 cggttgagca ccggagccgc cacgaggaag tcgtcactgt gggtgtagcg atgcaccagg
    10201 gcaccgaacg cggccagcag caccatgtag ggagtgcaac cggtgttctt cgccatcgtg
    10261 gccacccgcg cagcggtgtc ggcgggcagc cgcaacgtgg cgcgcgcggc acgccaactg
    10321 gtcggcacac acgttccggc tgggccggga agttccagcg gctctggcgg atcggccatg
    10381 atcgcgcgcc aatagttgag gtcggcctcg gtagtgtcgg gtccggatgc ggccgacgga
    10441 cggtgttctg gccccagatc ggcccctagg tcagctcgcg agtacgcctg ggtgagatcg
    10501 gtgaagaaca cccgccacga accatcatcc caggcgatgt ggtgggccac caacagcagc
    10561 acgtgttcgt cggcagccgt gcgcaccacc gtgattcgca atggcgcgtc gcgggaaagc
    10621 tcgaagggag cgcagaattc gcgctgagcc aacacctcca ggcgcagccg ctgggcgcgt
    10681 tgggacaggt ccgtcaggtc gtattgtgtc cagccggggc gaagatccgc gtgcacggtc
    10741 ggctgggcga ctccgtcgtc gccgacaggg taggtggtac gcagtatccg atggcgacgg
    10801 gcgacggcgt tgactgcgtc gcgcaacctg gccagatcga tgtcaccggt gatgcggtag
    10861 gacacacaga tgttgagtaa cgcaccgctg gggtcggcca tctgcacgaa ccacatccgg
    10921 gcctggccgt cggagagccg atcgtcagtg tgcgggccaa tgtcctgcgc agccgaggac
    10981 aggccgcggt cggcgagcct gcgacgcagc agctccaatc gggcctcgtc gaggcgggcg
    11041 ccgatgtcgg cggtattagt cacgcgaaat gtccactttc tgtgcggtgt gtgagcgctc
    11101 gtcggcatct tcgagtttcg cgacaagtcc atcaccggtg atgtcgccca tgagcgtggc
    11161 cagcgacacc gtcgcgccga ttgatcgttt gagtcggtta cgcaagtcca gtgccagcat
    11221 ggaatcgaca ccgagatcga acagcgattc ctgcaggttc acctcgccgg cctgcgggat
    11281 cccgagcacg gccgccaatt gggtgcgcac cgcgtccacg atcgtcaggt tggggtcggt
    11341 tggaccctcg taccgttcga attgcctgct gtccaacaac atctgcaacc gggccgcgtc
    11401 ggcggcgaac actagcgggt cgacagtgaa ttcgtgcagg ctcgcctcga tcgcctgctg
    11461 gggcgccatc tggcggagtc cagaccgctc gacgcgggcg atcgtaaccg catccgcgat
    11521 tccccgagct ggttcgccgg ccttgggggc ctgccatagg ccccatttca ccgccacgca
    11581 gtgcctgccc tgggcgcgca gctgggcggc catcacgtcg agcagccggt tggccgccga
    11641 gtacgcgacc accccgtgtc caccccacac ccccatcacc gaggaacaca gcagggttcg
    11701 cacatccggg cgcagcggcc acagctcgat catctgggcc aggccgagca ccttggccgc
    11761 gaagttgtca acgacggcgg ccgacgtcac ccccggtgcg gtaccagaga tcacgctgcc
    11821 tgccgcgtgc acgatcaacg aggcgccgac gccaccgtat tcggctgcaa tcgctgacaa
    11881 ctgggtggga tcggtgatat cgcacggcgg cgacacgatc acggtgccat gttgctttct
    11941 gagcatggcc accgtcgcct gatccgcggc gcgccggctg agcagcacga tgcgccgtgc
    12001 gccatgctcg gcgagatacc gcgcgtagtg catcccgatg gcacccgcgc caccggtgac
    12061 gacgacatcg tcgagcacgc cggagtccaa cgaccagttc gggacggccg gggcatcggc
    12121 gagggttcgc tcgaacagcg tgtacccgtt taccgagccg cgtagcgcgg tctcaccgaa
    12181 gccccgcagt accgccgtta tgaccgagac gccgaggacc gggtccaagt cccacgacgg
    12241 caagtccagg tggctgaaag tctgttcggg atgctcgaat ccgatgcttc gatgcatcgc
    12301 ggccagcgcg gcctggccgg ccgacggcac cgcgtccgct gcgtcgacct gctcggcgcc
    12361 gacggtgacc agacataccg attggcaacg ggcaccgata tgcatcggat agtccagcaa
    12421 accggccccg acgaggtcgg cgagtgcacc ggcggcccgg acggcgtcgg tgtgttcgaa
    12481 gtcgggcgcg atcaccagga tcaactcggc gtcccgcgca gcactcagct cggtatcggg
    12541 gtgcgaatca attgctgcgc acagtgtttg agccagcgcg cggtgagcac cgagatcgag
    12601 cactgcgagg tgacggtgcc gcccagcgac cggtgtcgac ggcaccatcc gttcccaccg
    12661 ctcaaccgca atggtcagtc cggacaccgg cggcagcggt tcggggtgcg cccacatcgg
    12721 caccgcacgc atcggcgcgt tcgggaaccc ggacagatcg acgtcgccgt cgagtgggtc
    12781 accgcccagg tcaccccacg ggtagccagg gtcagcgacc gccgcgctaa caatattcgc
    12841 cgacaacgca tcaacaaacc gctcgccacg acgtgccgac ccgaccagca cagcgggacc
    12901 gtccggcagg ttggcggcgc cctcacagtt ctgaccgatc gcaaacaaca gcgcgggatg
    12961 ggccgatatc tcgatgaacg cccgtgctcc acagcggatt gccgattcga cagcgcggtc
    13021 gaaacgcacc gtatggcgca ggtttgcgta ccagtagtcg ccgaaagtgg tgcctggcgc
    13081 caccacgtcg ccggtggttc cgccgatgaa ttgcactggc gcttccataa attcggagtc
    13141 aggcagctgc tcgcataatt catcgcggag cgattcgagc acgctggtat gcaccgggaa
    13201 gcccacggtg atcccgcggg cgaagtgacc gctggaccgg actgtgtcaa cgatggccgc
    13261 taccgcttgg cgctcaccgg acacggcgac ggtcgaggag gcattgacca cagacagttc
    13321 cagccagccg ccggtggtcg cgatcagcgc gctcgcgtcc tgttcaccga tgcccagcgc
    13381 cgccaccgca tagcgaccag gcaagcggcc caccacgttg gcgcgggccg ccaccacggc
    13441 cacagcatcc gacaaggtga tacttcctgc gagataggcc gccgctactt cgccgaggct
    13501 atgaccgact gttagatcgg gcagcacacc gcaggaacgc catacctccg ccagcgcaac
    13561 ggcatggacg aactgcgcgc cttcgatctc gatctcgcag aacgcttgcc gctcatcggt
    13621 tccgggcggg gcgatcaggt atggcagcgg cgagtcgaca ccagcggccg caaatgcggc
    13681 ggcgcacgtg tcggtcgcgg tccgataggt cggcagctcg cggtaggcga cggcgcccat
    13741 gcccggccaa tgaccaccct ggccgggaaa gacgaacgcc tggcgcgggg ccgagcccaa
    13801 cgacgaccgc gcgatgagcg gatgctcgcg tccggcggcc agcgcgcgca agccctcggc
    13861 gagttccagc cggtcggcgg cccgaagcac cgcccgatgc cgacggaccc gtcgggtctt
    13921 gcgcagctgc cgagccactt cggtcacggt cgtagccgga aagcgctcga ggtagtcggc
    13981 gatggcccga gcgtccggcc cgatcagttc ctcggcatgg gcgctgagca aaaccgcaac
    14041 ccgcccatcg ggcagctgtt tgggggccat cacacctccc cacactcggg gccacgctcg
    14101 ggcgcggaaa cggtgtccgg catcgaaacg atcacgtggc tattggtacc gctcatcccg
    14161 aacgcggaca ccgccgcggt gcgccatccg tcaacggccc gccacggcgt gagtttgtcg
    14221 gccagccgca gaccctgttt ctcccaatcg atttcgcggc tgggctcgtc gacgtgcagt
    14281 gtcggcggga tcgcggcgtg ctgggcggcc agaatgacct tcacaaggcc cagcccgccc
    14341 gccgccgcct gagcatgccc gatgtttgac ttgaccgatc ccaacagcgg cccgcgtccg
    14401 gccggggcgg tgccgtagct ggctgccagt gaccgcaatt cggtgcgatc gccgagccgg
    14461 gtcgcggtgc cgtgcccttc gaccatcccg acatcggcgg gcacaactgc tgcctgcgcg
    14521 atggcgcgcc ggagcagtcg cgtttgcgcg tcgccgctgg gcgcggtcag cccgtcgcta
    14581 agtccatcgg agttcaggca actggcacgc acctcggcga ggacacgacg ccggtcagcg
    14641 gttgcccgcg accggcgctg caggaggaac atggcggcgc cctctgccca ggcggttccg
    14701 ctggcgtgcg cgctgtaggg ccggcagtgg ccgtcgtcgg atagcgcgtg ctgcttggag
    14761 aactcgacga aatagccggg cgtacccatc acgcacacgc cgccggcgag tgccaggtcg
    14821 cagtcgccgg cccggatagc ttgaaccgcg gtgtgaaagg ccgccagcgc cgacgaacac
    14881 gaggtatcga cggtcagcgc cggcccggcc aggtcaaggg tgtaggcgat gcgcccggag
    14941 atgacaccca gcgacgtccc ggtgatcaga tggccactgt ggtgggagaa ttcggtcaaa
    15001 gcgggaccgt attcgagcgc cgaggcaccg acataacagc ccacatcgtg accggccagg
    15061 tcatcgggat tgatcccgct gttctccagg gtgcgccatg ctactcgcag ccccacccgc
    15121 tgctgcgggt ccatcgccgt cgcctcgcgc ggtgagatgc ggaagaactc aggatcgaat
    15181 gtagttgcgc tggaaaggaa tccgccaagg ttgtggatcg gtttgaatcc gtttcgacgc
    15241 gacccgtcga acagctcgcg aagtgcccaa cctcgatcgg tggggaacgg tccgagtccc
    15301 tcgcgctgtt cggagagcag tgtccagtag tcgtcggcgg tttcgacacc accgggtgcc
    15361 tcgatggcca gcccgacgat gacgaccggg tcgttatcgg acatcggcac tcaccatccg
    15421 ggccacggcg tcgaggtgat cgttgagata gaagtgacca ccatcaaagt gcgacagcgt
    15481 gaagcgaccg gaggtgtgag tctcccaact ggtcaacatc tcccggctga tgcggtggtc
    15541 gcggttgccg ccgaccgcgt ggatgttggc gcggatgcgc acgtcgggtg gacatgaata
    15601 gccgctgagg gcccgatagt cggccttgac cgccggcacc agcagttcaa cgaattcctc
    15661 gtcctcgagc agcacgggat cggtgccgcc aagatccacc atgtcggcca ggacgtcacg
    15721 gtcggcggtc ggcaacggtc cggacgcggc caccgtcgac ggagcctgac cggaggaagc
    15781 ccacagtgca cgtaccggca cgccattgcg ctcggcgagg cgagcgaact cgaaggccac
    15841 tatcgcaccc atgcaatggc cgaacagcgt cagcggagcc gtcaggtgcc agtcgcccgc
    15901 ctcgaacagc tcgagcgcca gcgcctcgat gctgtctgcc gccgggtggc tgcgccggtc
    15961 agcccgctgc gggtactgca ccacgaacgt gtcaacgtcg ttggccacta acgattttgc
    16021 caaccaccgg taagccgcgg cagcgccgcc ggcgtgtgga aacaccagca ccgcgccggg
    16081 cttgtcagta ccggtgaacc gcttcaccca cggtttgaag gctggctgtg cgggctgctc
    16141 gatcggatcg agcgccgcca tcacgtcggc acttgtcata ttcgcgattt ctaagtacac
    16201 ctcggcgacc agttcgagtc ggtcggcgtt ggcttcccga ccggtgagca actgggccaa
    16261 cgcggcaatg gtcctggcgg caaacatgtc ggcgaccatc aggctcggcg aatccagcca
    16321 ccgccggata ccggcgacga cctgggtcgc aagcacggaa tcgccgccca gggcaaagaa
    16381 gtcgtcgtgc acgcccacgg catcgttggc acggcccagg atgtccgcga cgatgcggcg
    16441 cagtgcccgc tgaagcaccg ttcgcggcgc cgcatagggt gccgatctgt cgccagaccg
    16501 ctcgacctcg gcggcaagca gggcgccaac ctccgcgcgg tcgatcttgc cgctgtcggt
    16561 aaaggggatg cggtctagca gcgtgacgtg gcgcggaatc atgtgcgcgg gcaccagatc
    16621 ggcgagctgc tgtcgaatcg actccgcggt cacgccggca tcgtcgacgc agaccgccgc
    16681 ggccagcaca tcggacccgc caggaagcac ggtggccgcc gccgcgtgca caccgggcaa
    16741 gcgctgcagc gcggcttcga tctcgccgag ttcgacgcgg tacccgctga tcttgacgcg
    16801 gtgatcggca cggccgacga actccagggt gccgtcgtgc cagtagcggg ccagatcacc
    16861 ggtgcgatac caggtgcggc cgtcatgctc gacgaagcgc tccgcggtca gctcgggacg
    16921 gccacggtaa ccccgggcga ttccgcgacc ggacacccac aactcaccgg ccacccaatc
    16981 ggggcagtcg tcgccgctgt cggccactac ccggcaggcg ttgttgggaa acgggacgcc
    17041 gtatggcacc gaggcccagt ccggtggcag attggccgcg tcctggacct cgaaaatggt
    17101 tgcgtggacc gcggtttcgg tggctccacc caaccccgcg aaccgtgcgc tcggcgcttg
    17161 cacctgcagg cggcgggcca ggtcgggacg cacccagtcg ccgccgacgg ccaccgctcg
    17221 cagcgacgac agccggcccc cgccgacttc gagcagcatg tccaaccagc ccggcatgaa
    17281 attcaacgcc gtgacctcgt aagtgtcgat aagccgggcc caggcgtcgg gatcgcggcg
    17341 ctgcgcttcg tcgaccacca cgatcgctcc gccggagcgc agggcggcga agatgtccag
    17401 caccgacatg tcgcactcca gcgtcgccag ggcaagccag cgatctgcgg cgcctagctc
    17461 gaagtgccgg atgaaggtct ccacggtgtt catcgcggcg tcgtgcgcca cctcgacacc
    17521 cttgggttcc ccggttgagc ccgaggtgaa caacacatag gcgagcgcgg tgggatcgct
    17581 aggcccgggc acgaattctg ccggcgcggc ggcaagcacg tcagccagca acagcgtcgg
    17641 gaccggcacc cgcacttggc atggcgggcc gcaaacgagc gctaagttga ccgaaccggt
    17701 cgccaggatg cgctccgcgc ggtcgcgggg ctggtcgacg ccgatcggca gatagacccc
    17761 gccggcggcc aaaatcccca gcacagccgc cacttgttcg cccgttttcg gacccagcac
    17821 cgcgacggtg tcgccgactc gtaggcccgc agcacgcagc gccgcggcca ccgccgatgc
    17881 ctggtcgcgc agttgggcgt agctcaagtc gccggaactg gcgaacaccg ccggcgcgtc
    17941 gggctgctgt tgggcctggc ggaaaaaccc gtcgtgcagc gcctcggtgc tgggggcggc
    18001 ggtgcgaccg ttcagcgccg cgcgcaccgc gcgttgcgcg gcgggtagcg cggacgggct
    18061 cggcgcatcc caggcgtcgt ccccggcggc caaccggagc aattcgtcga cctggtgggt
    18121 gaacatggcg tcgatgacgc cgggtgcaaa gaccccctcg cggacatccc agttcaccag
    18181 cacaccgccg tcgaactcgg tgacctgggc gtcgagcagc acctggggcc cctgcgaaat
    18241 gatccatccg ggtgtgccga attgctcggt gacgtccggg cagaaaaggt cgccgagccc
    18301 cagcgcgctg gtgaatacca ccggtgccag cacctgggtg ccacggtggc ggctgaggtc
    18361 acgcagcaca gacagcccgg ggtatgcact gtggcctgcg gcgctgcgca gggcttcctg
    18421 caccgcctgc gcccgcgccg ccgccgtgcg cgcaccggtc agatcgacgt cgagcaacag
    18481 cgaggaggtg aagtcaccga ccagcaggtc gacgtctgga tgcagggcct ggcgactgaa
    18541 caacggcagg ttcagcagga accgcgacga cgctgaccaa cgcgccagca cgttggcaaa
    18601 ggccgcggcc agcgtcatcg ccggggtgat gccgcgggcc cgggctcggg cgaacaacgc
    18661 gtcgcgggtc tgcgggtcta gccagtgcca gcgccgggtg ctgcggcgcc ggtcgcgttc
    18721 gccgccggcc cgggtaggca gcgcgggcgg atccggcagc tgcgggatgc gctgcgccca
    18781 ccagtcccgg tcggcgtcgc gaaccggttg gggcagcgtc tcctccgcct cgatagcctg
    18841 ccggtattcc cggtaggtgt agcccagtgc cggcggttca cggccgtcat agagggccgc
    18901 caggtcggcc agcaagatgc ggtagctcat cgcgtcagcg gcctgcatgt ccaggtcgac
    18961 atgtaggcgg gtgcgctccc ccggtaataa cgtcaacgca agttcgaata ccgcaccgtc
    19021 gagctgctgg tgcgatttgg cgtcgcggat ccccgccaac cgctgatcga cgacatccgg
    19081 ggccacgtga cgcaggtcgg caacactgat gggaaagtcg cgagatcccg ccgccggcgg
    19141 gatgcgctgg gtgccgtcgg gcaagaactg cacccgcagc atcgggtgcc gcagcgccaa
    19201 ccgggtggcc gccgcgcgga gcctgtccgg atcgacccgg gcaccatcga actcgacgta
    19261 gaggtgccca gctaccccgc cgagctgttg gtggtcgtgg cggccgaccc acatcgcgtg
    19321 ctgcatcggc gccagcggga aaggctcgcc ttcctgggat aacccggcat cccctggtgc
    19381 ggcaactgcc gtgggcgcga cgccggtgcc ggcggacacc agttgggacc aggcctcgat
    19441 tgtgggtgtg gcggccagtg tggcgaagtc gacggcgatg cccttccggc gccagcgccc
    19501 caccagcgac atcatccgga tcgagtccag gccctgacca acgaggttgg cgccggggtg
    19561 cagagcatcg gcgcggacac cgagcaactc tgcgacctcg gcgcgaatga tctccgagca
    19621 cgccgtagca tgcaccacaa accctcccct gttagcacag gctgccctaa ttttagtggt
    19681 taccctatct tcgaaccacg cacctgcgct accagccccc ctgttaagga gcccacatgc
    19741 caccgaaggc ggcagatggc cgccgaccca gtcccgacgg cggactgggt ggctttgtac
    19801 cgttccccgc ggatcgggcc gcgtcgtacc gggcggccgg ctattggtcg gggcgaaccc
    19861 tggacaccgt gctctccgat gccgcgcggc gctggcctga ccgcctcgcg gtggccgacg
    19921 ccggtgatcg tcccggccac ggcggcctca gttacgccga actcgaccag cgggccgacc
    19981 gggccgccgc ggcgctgcac ggcctgggca tcacgccagg cgaccgggta ctgctccagc
    20041 tgccaaacgg ctgccagttc gcggttgccc tgttcgcgtt attgcgggcg ggagcgatcc
    20101 cagtgatgtg cctgcccggt caccgcgccg ccgaattggg ccacttcgcc gccgtcagcg
    20161 cggccaccgg gctggtggtc gccgatgtgg ccagcgggtt cgactatcgg ccgatggcgc
    20221 gcgaacttgt tgccgatcac cccaccctgc gccatgtcat cgtcgatggc gatccgggac
    20281 cgttcgtgtc gtgggcgcag ctgtgcgccc aggccggcac cggttcgccg gcaccgccgg
    20341 ccgatcccgg atcgccagcg ctgctgctgg tctccggcgg caccactggc atgcccaaac
    20401 tcattccacg cacccacgac gactacgtgt tcaacgcgac ggccagcgcc gcactctgtc
    20461 ggcttagcgc cgacgacgtc tatctggtgg tgctggccgc cggccacaat ttcccgctgg
    20521 cctgcccggg cctgctcggc gcgatgaccg tcggggccac cgccgtgttc gcccccgatc
    20581 ccagcccgga ggccgccttc gccgccatcg agcgccacgg tgtcaccgtc accgcgttgg
    20641 ttccggcact ggccaaactg tgggcccaat cctgtgagtg ggagccggtg acaccgaagt
    20701 cactgcggtt gttgcaggtt ggcgggtcca agctagaacc cgaggacgct cgccgggtac
    20761 gcaccgcgct caccccgggc ctgcagcagg tgttcggcat ggcggagggg ctgctgaact
    20821 tcacccgcat cggcgaccca cccgaagtgg tggagcacac ccaggggcgg ccactatgcc
    20881 cggccgacga actgcgcatc gtcaacgccg atggtgagcc ggtggggccc ggggaggaag
    20941 gcgaactctt ggtgcgcggg ccctacacgc tgaacggcta ttttgctgcc gaacgcgaca
    21001 acgagcgctg cttcgatccg gacggcttct accgcagcgg cgacctggtc cgccgccgcg
    21061 acgacggcaa tctggtggtc accgggcgcg tcaaggatgt catctgccgt gcgggagaaa
    21121 ccatcgccgc cagcgacctc gaagaacagc tgctgagcca tccggcgatc ttctcggccg
    21181 cggcggtggg actacctgac cagtatctgg gggaaaaaat ctgcgctgca gtcgttttcg
    21241 ctggagctcc gattacgctt gcggagttga acggctacct tgaccggcgt ggtgtggccg
    21301 cgcatacgcg acccgaccag ctggtcgcga tgccggcgct gcccacaacg ccgatcggga
    21361 agatcgacaa acgagcgatc gtccgccagc tcggcatcgc gacgggtccc gtgacgaccc
    21421 agcgctgcca ttgactgacg tcaacaagtt gaattgactg cgttgcatga ccgacggtgt
    21481 tccggcccgc gggtcacttc gatcacgcgg cgcggtagcg gtgagctcga tggtgttgcg
    21541 gcccatcacc ggggcgattc cgccagacgg gccgtggggg atatgggcct cgcgccggat
    21601 catcgccgga ctcatgggca cgttcgggcc ctcgctcgcg ggcacccgag tggaacaagt
    21661 caactccgtt ctgccggacg gacgccgggt cgtcggcgaa tgggtgtatg gaccgcacaa
    21721 caacgcgatc aatgccggac ccggtggcgg cgccatctat tacgtacacg gcagcggtta
    21781 cacgatgtgt tcgccccgaa cccaccggcg gctgacatcc tggctgtcgt cattgaccgg
    21841 gctaccggta ttcagtgtcg attaccgact ggcgccgcgc taccgtttcc cgaccgcggc
    21901 caccgacgtg cgggcagcct gggattggtt agcgcacgta tgcggcttag ccgcggagca
    21961 catggtgatc gccgcggatt ccgcgggtgg ccatctgacc gtcgacatgc tgctgcaacc
    22021 cgaggtcgcc gcccgacctc cggcggcggt ggtgttgttt tcgccgctga tcgacctcac
    22081 cttccggctg ggcgccagtc gtgagctgca gcgccccgat cctgtcgtgc gcgctgaccg
    22141 tgcggcccgg tcggttgcgc tgtactacac cggagtcgat cccgcccacc accggctggc
    22201 gctcgatgtt gccggcgggc caccgctgcc accgacgctg atccaggtgg gtggagccga
    22261 gatactcgag gccgatgcga gacaactcga tgccgacatc cgcgctgccg gcggcatatg
    22321 cgagttgcaa gtgtggcctg atcagatgca tgtgttccag gccctgccgc ggatgacgcc
    22381 cgaagcggcc aaagccatga cctatgttgc ccagttcatc cgcagtacaa cagcacgtgg
    22441 agacctctga acgttactgg cgtgcaacca gataaggcgt caatgtggat agcttttcgc
    22501 aagtctcctc gaattcgcgc tctggctccg attcttcgat gatgccggcg ccggcccgca
    22561 gccaagtccg cccgccgacc tggtatgccg cccgcagcgt cagcgcggcg tctagcccgc
    22621 catccgccga aagcatcacc accgcaccgg aatacagccc acgtgggcac tcatcgaggc
    22681 gaaagatggc ctcaacgcca gctgctttcg ggattccgga tgcagtgaca gcaggaaaaa
    22741 gggcttccag ggcggccatc cggtcgctcg atggatccaa ccgtgctctg atggtggagc
    22801 cgaggtgctg cacactgccg cgctcgcgca ccgtcatgaa atcgatgacc gcagcactcc
    22861 ctggttcggc gatgtcggta atctcctcaa gcgaagagcg cactgaaatg gcgtgctcga
    22921 caatttcttt ggagtttgat tccaggtcat cacgagccag tcggtcaatg gcgggaccac
    22981 ggcccaaggc gcgggtaccg gccaacggct cggtgatcac cactccgtcg gcgcgcaccg
    23041 ccgtgacgag ttcggggctg taacccagag cacggattcc gcccaactgc aacaaaaacg
    23101 acctcaccgg ggtgttgtgc cgacgcccca gccggtaggt caacggaaag tcgatcgcga
    23161 aaggcacttc gacacaacgg gacagaatca ccttgtggta gcggccggca gcgatttcat
    23221 cgacggctac cgccacccga cggcggaagc cggatggatc gtcggagacg tcgacggagc
    23281 gggactgcgg cacctctcgc accccggtgg cgagtaatcg gtcgatggcc tcgcggtggc
    23341 gaatcccagc atcgaacagg cgaatctcct tttcgctcac catgatccgg gttcggggcg
    23401 aaaacacccg ggccagtggg gtgtgcggcg ccagccgctg ctgcaaccca tagcggtgca
    23461 cgccgaattc gaaggcgacc cagccaaaag cttgatcggt ttccagcaac agccgatcga
    23521 cggcttcgcc cagggccgct cccgggcgac ccgaccattg ctgtcgccgc gtaacgccat
    23581 cacggatgac gcgcagttcg tcgctgtcta gctccaccat cgcctgcaca ccggcggcca
    23641 ggacccattg gccgtcgcac tcgtagagca ggtaatcctc gtcgacggac tcggtaacca
    23701 ccgccgccag ctccgctgcc aggtcggcgg ggttgacacc ggcgggcatc gggatggacg
    23761 acgacgcggt gctgacggcg cctgtcgcga cgctgagctc ggacacagct agtaaatgta
    23821 g
//
