BGC0001021: mycobactin biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 2,656,200 - 2,680,020 nt. (total: 23,821 nt).
This entry is originally from NCBI GenBank AL123456.3.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001021
Short description mycobactin biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AL123456.3
Compounds
  • mycobactin
Species Mycobacterium tuberculosis H37Rv [taxonomy]
References
Chemical products information
mycobactin
Copy SMILES
C46H76Fe1N5O10
Chemical database entries
PubCHEM
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Rv2377c
  • CCP45165.1
  • mbtH
2656215 - 2656430 (-) Putative conserved protein MbtH
copy AA seq
copy Nt seq
  • Rv2378c
  • CCP45166.1
  • mbtG
2656408 - 2657703 (-) Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
copy AA seq
copy Nt seq
  • Rv2379c
  • CCP45167.1
  • mbtF
2657700 - 2662085 (-) Peptide synthetase MbtF (peptide synthase)
copy AA seq
copy Nt seq
  • Rv2380c
  • CCP45168.1
  • mbtE
2662067 - 2667115 (-) Peptide synthetase MbtE (peptide synthase)
copy AA seq
copy Nt seq
  • Rv2381c
  • CCP45169.1
  • mbtD
2667255 - 2670269 (-) Polyketide synthetase MbtD (polyketide synthase)
copy AA seq
copy Nt seq
  • Rv2382c
  • CCP45170.1
  • mbtC
2670269 - 2671603 (-) Polyketide synthetase MbtC (polyketide synthase)
copy AA seq
copy Nt seq
  • Rv2383c
  • CCP45171.1
  • mbtB
2671593 - 2675837 (-) Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)
copy AA seq
copy Nt seq
  • Rv2384
  • CCP45172.1
  • mbtA
2675936 - 2677633 (+) Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
copy AA seq
copy Nt seq
  • Rv2385
  • CCP45173.1
  • mbtJ
2677729 - 2678649 (+) Putative acetyl hydrolase MbtJ
copy AA seq
copy Nt seq
  • Rv2386c
  • CCP45174.1
  • mbtI
2678653 - 2680005 (-) Isochorismate synthase MbtI
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
mbtF
Module ?
Specificity: lysine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for mycobactin
  • Linked new PubChem id for mycobactin (pubchem:136041711)
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.