BGC0001027: nocobactin NA biosynthetic gene cluster from Nocardia farcinica IFM 10152
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Location: 820,180 - 840,689 nt. (total: 20,510 nt).
This entry is originally from NCBI GenBank AP006618.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001027
Short description nocobactin NA biosynthetic gene cluster from Nocardia farcinica IFM 10152
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AP006618.1
Compounds
  • nocobactin NA
  • nocobactin NA 10152B
Species Nocardia farcinica IFM 10152 [taxonomy]
References
Chemical products information
nocobactin NA
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C36H53N5O10
Chemical database entries
PubCHEM
nocobactin NA 10152B
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C38H57N5O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • NFA_7610
  • BAD55606.1
  • nbtG
 820180 - 821469 (+) putative lysine-N-oxygenase
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  • NFA_7620
  • BAD55607.1
  • nbtH
 821524 - 822204 (-) putative N6-hydroxylysine acetyltransferase
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  • NFA_7630
  • BAD55608.1
  • nbtA
 822348 - 823103 (+) thioesterase
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  • NFA_7640
  • BAD55609.1
  • nbtB
 823100 - 824410 (+) putative polyketide synthase
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  • NFA_7650
  • BAD55610.1
  • nbtC
 824403 - 827489 (+) putative polyketide synthase
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  • NFA_7660
  • BAD55611.1
  • nbtD
 827508 - 832613 (+) putative non-ribosomal peptide synthetase
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  • NFA_7670
  • BAD55612.1
  • nbtE
 832610 - 837178 (+) non-ribosomal peptide synthetase
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  • NFA_7680
  • BAD55613.1
  • nbtF
 837186 - 840689 (+) putative non-ribosomal peptide synthetase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
nbtD
Module ?
Specificity: N6-hydroxylysine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
nbtE
Module ?
Specificity: N6-hydroxylysine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
nbtF
Module ?
Specificity: threonine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for nocobactin NA
  • Add new compound: nocobactin NA 10152B
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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