BGC0001034: pellasoren biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 61,485 nt. (total: 61,485 nt).
This entry is originally from NCBI GenBank HE616533.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001034
Short description pellasoren biosynthetic gene cluster from Sorangium cellulosum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "DH of module 7 is inactive as inferred from the structure of pellasoren. Active site alignment showed two aa being different to the other active DHs within the cluster. I don't know how to mark this DH as inactive."
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: HE616533.1
Compounds
  • pellasoren
  • pellasoren B
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
pellasoren
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C26H41N1O4
Chemical database entries
PubCHEM
pellasoren B
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C26H41N1O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCE88383.1
  • pelT
 1478 - 3736 (+) ABC transporter protein
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  • CCE88382.1
  • pelG
 4808 - 7192 (+) polyketide synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • CCE88386.1
  • pelH
 7189 - 8040 (+) hydroxyacyl-CoA dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • CCE88387.1
  • pelI
 8044 - 8325 (+) Ppant binding-site containing protein
  • Precursor biosynthesis
Sequence-based prediction
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  • CCE88384.1
  • pelJ
 8375 - 9529 (+) acyl-CoA dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • CCE88385.1
  • pelK
 9581 - 10711 (+) HAD superfamily phosphatase
  • Precursor biosynthesis
Sequence-based prediction
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  • CCE88377.1
  • pelA
 10735 - 22728 (+) non-ribosomal peptide synthetase/polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CCE88381.1
  • pelB
 22730 - 28303 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CCE88380.1
  • pelC
 28317 - 33929 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CCE88376.1
  • pelD
 33926 - 45976 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CCE88379.1
  • pelE
 45973 - 51621 (+) polyketide synthase
  • Scaffold biosynthesis
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  • CCE88378.1
  • pelF
 51618 - 58979 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Propionyl-CoA
Cyclic? no
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
pelE
+
pelF
+
pelA
+
pelC
+
pelB
+
pelD 		Synthase subclass: Modular type I
Module 1
Specificity: Methoxymalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pelA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 2
Genes: pelA
Core domains: Ketoreductase
KR-domain stereochemistry: Inactive
Non-canonical activity:
  • Skipped
Evidence for non-canonical activity:
  • Structure-based inference
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pelB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pelC
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pelD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pelD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 7
Specificity: Methylmalonyl-CoA
Genes: pelE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pelF
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Macrolactonization
NRP-synthases
Gene Modules
pelA
Module 2
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RZRTXUKFH6LMF4VTOZ22YQ5Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for pellasoren
  • Linked new PubChem id for pellasoren (pubchem:60145150)
  • Add new compound: pellasoren B
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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