BGC0001050: thalassospiramide A biosynthetic gene cluster from Tistrella bauzanensis
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Location: 1 - 19,730 nt. (total: 19,730 nt).
This entry is originally from NCBI GenBank KC181865.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001050
Short description thalassospiramide A biosynthetic gene cluster from Tistrella bauzanensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Modules 1 and 5 are missing adenylation domains completely. Module 6 is spread over the two genes, with the condensation domain on ttbA and the remainder of the module on ttbB. The PKS portion is a trans AT system but to date no AT domain has been identified in the rest of the genome."
Biosynthetic class(es)
  • NRP (Other lipopeptide)
  • Polyketide (Other)
Loci NCBI GenBank: KC181865.1
Compounds
  • thalassospiramide A
Species Tistrella bauzanensis [taxonomy]
References
Chemical products information
thalassospiramide A
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C48H75N7O13
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGC65516.1
  • ttbA
1 - 16158 (+) NRPS/PKS hybrid
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGC65517.1
  • ttbB
16164 - 19730 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
ttbA Synthase subclass: Trans-AT type I
Module 4
Genes: ttbA
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
Release type
  • Macrolactonization
Lipid moiety cis-3-decenoic acid
Thioesterase genes
  • ttbB (Type I)
NRP-synthases
Gene Modules
ttbA
Module 1
Condensation domain type: Starter
Module 2
Specificity: valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 3
Specificity: serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 5
Condensation domain type: Unknown
ttbB
Module 6
Specificity: tyrosine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Modification domains: Methylation
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CCA4OQJBG74OWG57XELOC2J2, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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