BGC0001053: tubulysin A biosynthetic gene cluster from Archangium disciforme
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Location: 1 - 82,868 nt. (total: 82,868 nt).
This entry is originally from NCBI GenBank AJ620477.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001053
Short description tubulysin A biosynthetic gene cluster from Archangium disciforme
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AJ620477.1
Compounds
  • tubulysin A
Species Archangium disciforme [taxonomy]
References
Chemical products information
tubulysin A
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C43H65N5O10S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF05629.1
 1 - 3308 (-) hypothetical protein
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  • CAF05630.1
 3453 - 4706 (-) hypothetical protein
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  • CAF05631.1
 5719 - 7164 (+) hypothetical protein
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  • CAF05632.1
 7317 - 9557 (-) hypothetical protein
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  • CAF05633.1
 10550 - 12193 (-) hypothetical protein
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  • CAF05634.1
 12841 - 13881 (+) hypothetical protein
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  • CAF05635.1
 13835 - 14833 (-) hypothetical protein
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  • CAF05636.1
 14942 - 15586 (+) hypothetical protein
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  • CAF05637.1
 15847 - 16983 (+) hypothetical protein
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  • CAF05638.1
 18809 - 21154 (-) hypothetical protein
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  • CAF05639.1
 22366 - 23532 (+) hypothetical protein
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  • CAF05640.1
 24591 - 26513 (+) hypothetical protein
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  • CAF05641.1
 26597 - 27517 (+) hypothetical protein
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  • CAF05642.1
 29858 - 30400 (+) hypothetical protein
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  • CAF05643.1
  • tubA
 31220 - 32392 (+) TubA protein
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  • CAF05644.1
 32397 - 33056 (-) hypothetical protein
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  • CAF05645.1
  • tubZ
 33074 - 34195 (-) TubZ protein
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  • CAF05646.1
 34205 - 35422 (-) hypothetical protein
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  • CAF05647.1
  • tubB
 35522 - 40147 (+) TubB protein
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  • CAF05648.1
  • tubC
 40144 - 48021 (+) TubC protein
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  • CAF05649.1
  • tubD
 48011 - 58558 (+) TubD protein
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  • CAF05650.1
  • tubE
 58551 - 62096 (+) TubE protein
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  • CAF05651.1
  • tubF
 62103 - 70616 (+) TubF protein
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  • CAF05652.1
 70585 - 71640 (-) patatin-like protein
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  • CAF05653.1
 71731 - 72786 (-) patatin-like protein
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  • CAF05654.1
 74655 - 75359 (-) hypothetical protein
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  • CAF05655.1
 75488 - 76645 (+) hypothetical protein
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  • CAF05656.1
  • tubG
 76787 - 77545 (+) TubG protein
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  • CAF05657.1
 77769 - 78695 (+) hypothetical protein
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  • CAF05658.1
 79138 - 80019 (+) hypothetical protein
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  • CAF05659.1
 80057 - 81493 (-) hypothetical protein
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  • CAF05660.1
 81721 - 82797 (-) pyrroline carboxylate reductase-like protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
tubB
Module ?
Specificity: pipecolic acid
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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