BGC0001064: cylindrocyclophane D biosynthetic gene cluster from Cylindrospermum licheniforme UTEX B 2014
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 26,219 nt. (total: 26,219 nt).
This entry is originally from NCBI GenBank JX477167.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001064
Short description cylindrocyclophane D biosynthetic gene cluster from Cylindrospermum licheniforme UTEX B 2014
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: JX477167.1
Compounds
  • cylindrocyclophane D
  • cylindrocyclophane E
  • cylindrocyclophane F
Species Cylindrospermum licheniforme UTEX B 2014 [taxonomy]
References
Chemical products information
cylindrocyclophane D
Copy SMILES
C40H60O8
Chemical database entries
PubCHEM
cylindrocyclophane E
Copy SMILES
C38H58O6
Chemical database entries
PubCHEM
cylindrocyclophane F
Copy SMILES
C36H56O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV96135.1
 1069 - 2886 (+) AMP-dependent synthetase/ligase
  • Precursor biosynthesis
Activity assay
copy AA seq
copy Nt seq
  • AFV96136.1
 3419 - 3745 (+) acyl carrier protein
  • Precursor biosynthesis
Activity assay
copy AA seq
copy Nt seq
  • AFV96137.1
 4003 - 5418 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AFV96138.1
 5656 - 9342 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AFV96139.1
 9332 - 10573 (+) beta-ketoacyl synthase
  • Tailoring (Methylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • AFV96140.1
 10578 - 11837 (+) HMG-CoA synthase-like enzyme
  • Tailoring (Methylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • AFV96141.1
 11840 - 12604 (+) enoyl-CoA hydratase/isomerase
  • Tailoring (Methylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • AFV96142.1
 12592 - 19266 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AFV96143.1
 19362 - 20483 (+) type III polyketide synthase
  • Scaffold biosynthesis
Activity assay
copy AA seq
copy Nt seq
  • AFV96144.1
 20495 - 21094 (+) phospholipid methyltransferase
copy AA seq
copy Nt seq
  • AFV96145.1
 21475 - 23430 (+) hemolysin-type calcium-binding region
copy AA seq
copy Nt seq
  • AFV96146.1
 23972 - 25579 (+) choline dehydrogenase-like flavoprotein
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Ketide length 4
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
AFV96135.1
+
AFV96142.1
+
AFV96138.1
+
AFV96143.1 		Synthase subclass: Modular type I/Type III
Thioesterases:
  • AFV96142.1 (Unknown)
Module 0
Specificity: Decanoyl-CoA
Evidence for specificity: Activity assay
Genes: AFV96135.1
Core domains: CoA-ligase
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: AFV96138.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Activity assay
Genes: AFV96142.1
Core domains: Enoylreductase, Ketosynthase, Acyltransferase, Thiolation (ACP/PCP), Thioesterase
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AK6U5FV25F7Z3GQ43DVTSAVK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for cylindrocyclophane D
  • Linked new PubChem id for cylindrocyclophane D (pubchem:10258912)
  • Update compound structure (SMILES) for cylindrocyclophane E
  • Linked new PubChem id for cylindrocyclophane E (pubchem:102306484)
  • Update compound structure (SMILES) for cylindrocyclophane F
  • Linked new PubChem id for cylindrocyclophane F (pubchem:11757351)
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.