BGC0001073: kosinostatin biosynthetic gene cluster from Micromonospora sp. TP-A0468
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Location: 1 - 82,504 nt. (total: 82,504 nt).
This entry is originally from NCBI GenBank JN038178.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0001073
Short description kosinostatin biosynthetic gene cluster from Micromonospora sp. TP-A0468
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: JN038178.1
Compounds
  • kosinostatin
Species Micromonospora sp. TP-A0468 [taxonomy]
References
Chemical products information
kosinostatin
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C33H32N2O10
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFJ52719.1
 6446 - 7069 (-) response regulator
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  • AFJ52718.1
 7229 - 8578 (+) hypothetical protein
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  • AFJ52659.1
 9140 - 9946 (+) 2,3-rRing cyclase
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  • AFJ52660.1
 9943 - 11505 (+) nonribosomal peptide synthetase
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  • AFJ52661.1
 11507 - 11770 (+) peptidyl carrier protein
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  • AFJ52662.1
 11773 - 12807 (+) anthranilate phosphoribosyltransferase
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  • AFJ52663.1
 12800 - 13621 (+) alpha-tryptophan synthase
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  • AFJ52664.1
 13618 - 13992 (+) L-ectoine synthase
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  • AFJ52665.1
 14017 - 15156 (+) acyl-CoA dehydrogenase
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  • AFJ52666.1
 15160 - 15855 (+) phosphoribosylanthranilate isomerase
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  • AFJ52667.1
 15920 - 16618 (+) indoleglycerol phosphate synthase
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  • AFJ52668.1
 16669 - 17553 (-) transcriptional activator
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  • AFJ52669.1
 18678 - 19574 (-) dTDP-glucose synthase
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  • AFJ52670.1
 19786 - 20775 (+) dTDP-glucose 4,6-dehydratase
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  • AFJ52671.1
 20823 - 21602 (+) ketoreductase
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  • AFJ52672.1
 21699 - 22658 (-) aromatase
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  • AFJ52673.1
 22696 - 23481 (-) C-9 ketoreductase
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  • AFJ52717.1
 23591 - 24049 (+) monooxygenase
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  • AFJ52674.1
 24046 - 25314 (+) ketoacyl synthase alpha-subunit
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  • AFJ52675.1
 25311 - 26519 (+) chain length factor
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  • AFJ52676.1
 26548 - 26805 (+) acyl carrier protein
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  • AFJ52677.1
 26861 - 27295 (+) cyclase
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  • AFJ52679.1
 28260 - 29156 (+) monooxygenase
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  • AFJ52678.1
 29233 - 30021 (+) transcriptional regulator
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  • AFJ52716.1
 30224 - 31300 (+) ABC transporter
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  • AFJ52715.1
 31297 - 32130 (+) ABC transporter
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  • AFJ52680.1
 32267 - 33358 (+) carboxylesterase
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  • AFJ52714.1
 34109 - 35584 (-) efflux protein
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  • AFJ52713.1
 35625 - 36608 (-) transporter
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  • AFJ52681.1
 36816 - 37268 (+) Cylase
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  • AFJ52682.1
 37360 - 37944 (-) 3,5-epimerase
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  • AFJ52683.1
 38165 - 39175 (+) glycosyl transferase associated protein
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  • AFJ52684.1
 39198 - 40496 (+) glycosyl transferase
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  • AFJ52685.1
 40496 - 41992 (+) 2,3-hexose dehydratase
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  • AFJ52686.1
 41989 - 43014 (+) pyruvate dehydrogenase alpha-subunit
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  • AFJ52687.1
 43034 - 44068 (+) pyruvate dehydrogenase beta-subunit
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  • AFJ52712.1
 44236 - 47025 (+) SNF2/RAD54 family helicase
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  • AFJ52711.1
 47037 - 48338 (+) hypothetical protein
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  • AFJ52710.1
 48388 - 48822 (+) hypothetical protein
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  • AFJ52688.1
 49112 - 50317 (-) regulator
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  • AFJ52709.1
 50304 - 50774 (-) hypothetical protein
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  • AFJ52708.1
 50785 - 51216 (-) hypothetical protein
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  • AFJ52689.1
 51422 - 51649 (+) regulator
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  • AFJ52690.1
 51685 - 52203 (-) dehydorgenase
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  • AFJ52691.1
 52361 - 53344 (-) sugar 3-ketoreductase
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  • AFJ52692.1
 53452 - 54495 (-) enoyl reductase
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  • AFJ52693.1
 54498 - 54953 (-) hydroxylase
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  • AFJ52694.1
 55088 - 55924 (+) Hydroxylase
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  • AFJ52695.1
 56007 - 56840 (+) Regulator
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  • AFJ52707.1
 56853 - 57431 (-) Resistance protein
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  • AFJ52696.1
 57470 - 58555 (-) Dioxygenase
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  • AFJ52697.1
 58579 - 60078 (-) FAD-dependent/BBE domain-containing oxidoreductase
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  • AFJ52698.1
 60258 - 61118 (+) methyltransferase
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  • AFJ52699.1
 61163 - 61852 (+) aminotransferase
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  • AFJ52700.1
 61849 - 63372 (+) carboxylyase
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  • AFJ52701.1
 63435 - 64280 (+) deformylase
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  • AFJ52702.1
 64303 - 65265 (-) regulator
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  • AFJ52706.1
 65262 - 66122 (-) regulator
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  • AFJ52703.1
 66185 - 66745 (-) reductase
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  • AFJ52704.1
 66777 - 67835 (-) AHBA kinase
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  • AFJ52705.1
 67842 - 68195 (-) membrane protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new NPAtlas id for kosinostatin (npatlas:NPA05118)
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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