BGC0001083: merochlorin A biosynthetic gene cluster from Streptomyces sp. CNH189
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 60,157 nt. (total: 60,157 nt).
This entry is originally from NCBI GenBank JX186999.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
Terpene
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001083
Short description merochlorin A biosynthetic gene cluster from Streptomyces sp. CNH189
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "An unusual terpene cyclization catalyzed by chloroperoxidases not by classic terpene synthase/cyclases"
Biosynthetic class(es)
  • Polyketide (Other)
  • Terpene (Sesquiterpene/Unknown)
Loci NCBI GenBank: JX186999.1
Compounds
  • merochlorin A
  • merochlorin B
  • deschloro-merochlorin A
  • deschloro-merochlorin B
  • isochloro-merochlorin B
  • dichloro-merochlorin B
  • merochlorin D
  • merochlorin C
Species Streptomyces sp. CNH189 [taxonomy]
References
Chemical products information
merochlorin A
Copy SMILES
C25H31Cl1O4
Chemical database entries
NPAtlas
merochlorin B
Copy SMILES
C25H29Cl1O4
Chemical database entries
NPAtlas
deschloro-merochlorin A
Copy SMILES
C25H30O4
deschloro-merochlorin B
Copy SMILES
C25H30O4
isochloro-merochlorin B
Copy SMILES
C25H29Cl1O4
dichloro-merochlorin B
Copy SMILES
C25H28Cl2O4
merochlorin D
Copy SMILES
C26H33Cl1O5
Chemical database entries
NPAtlas
merochlorin C
Copy SMILES
C26H32Cl2O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGH68886.1
  • mcl1
 1 - 858 (-) methylenetetrahydrofolate reductase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68887.1
  • mcl2
 1096 - 2169 (-) isoprenyl diphosphate synthase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68888.1
  • mcl3
 2291 - 3268 (-) ketoacyl-ACP synthase III
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68889.1
  • mcl4
 3403 - 4578 (-) HMG-CoA synthase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68890.1
  • mcl5
 4582 - 5643 (-) HMG-CoA reductase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68891.1
  • mcl6
 5636 - 6730 (-) isopentenyldiphosphate isomerase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68892.1
  • mcl7
 6727 - 7839 (-) phosphomevalonate kinase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68893.1
  • mcl8
 7836 - 8876 (-) mevalonate diphosphate decarboxylase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68894.1
  • mcl9
 8866 - 9903 (-) mevalonate kinase
  • Precursor biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68895.1
  • mcl10
 10838 - 11023 (-) MerR-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68896.1
  • mcl11
 11020 - 11649 (-) hypothetical protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68897.1
  • mcl12
 12224 - 14245 (+) oxidoreductase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68898.1
  • mcl13
 14242 - 15681 (+) 3-carboxymuconate cycloisomerase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68899.1
  • mcl14
 16151 - 17692 (+) FAD-dependent oxidoreductase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68900.1
  • mcl15
 18104 - 19804 (+) cytochrome B-like protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68901.1
  • mcl16
 20057 - 20416 (+) hypothetical protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68902.1
  • mcl17
 21073 - 22149 (+) type-III polyketide synthase
  • Scaffold biosynthesis
Activity assay
copy AA seq
copy Nt seq
  • AGH68903.1
  • mcl18
 22146 - 22706 (+) monooxygenase
  • Tailoring (Monooxygenation)
Knock-out
copy AA seq
copy Nt seq
  • AGH68904.1
  • mcl19
 22712 - 23878 (+) aminotransferase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68905.1
  • mcl20
 24166 - 25752 (+) AMP-dependent synthetase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68906.1
  • mcl21
 25749 - 26882 (+) methyltransferase
  • Tailoring (Methylation)
Knock-out
copy AA seq
copy Nt seq
  • AGH68907.1
  • mcl22
 27097 - 27750 (+) isosesquilavandulyl diphosphate synthase
  • Precursor biosynthesis
Activity assay
copy AA seq
copy Nt seq
  • AGH68908.1
  • mcl23
 28223 - 29140 (+) aromatic prenyltransferase
  • Tailoring (Prenylation)
Activity assay
copy AA seq
copy Nt seq
  • AGH68909.1
  • mcl24
 29301 - 30854 (+) vanadium-dependent chloroperoxidase
  • Tailoring (Halogenation)
Activity assay
copy AA seq
copy Nt seq
  • AGH68910.1
  • mcl25
 30953 - 32515 (+) MFS-like transporter
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68911.1
  • mcl26
 32659 - 33612 (-) aromatase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68912.1
  • mcl27
 33703 - 34425 (-) thioesterase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68913.1
  • mcl28
 34587 - 35408 (-) SARP-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68914.1
  • mcl29
 35748 - 36416 (-) TetR-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68915.1
  • mcl30
 36568 - 38886 (-) iron-sulfur-binding oxidoreductase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68916.1
  • mcl31
 39033 - 39902 (-) SARP-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68917.1
  • mcl32
 40410 - 41057 (-) TetR-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68918.1
  • mcl33
 41565 - 43022 (-) NRPS-like condensation domain
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68919.1
  • mcl34
 43295 - 44236 (-) SARP-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68920.1
  • mcl35
 44736 - 45551 (+) SARP-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68921.1
  • mcl36
 45645 - 46487 (-) SARP-like transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68922.1
  • mcl37
 47593 - 48585 (+) AfsA-like gamma-butyrolactone synthase
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68923.1
  • mcl38
 48730 - 49494 (+) oxidoreductase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68924.1
  • mcl39
 51650 - 53245 (+) MFS-like transporter
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • AGH68925.1
  • mcl40
 54769 - 56364 (+) vanadium-dependent chloroperoxidase
  • Tailoring (Halogenation)
Other in vivo study
copy AA seq
copy Nt seq
  • AGH68926.1
  • mcl41
 56801 - 57523 (+) thioredoxin-like oxidoreductase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Malonamyl-CoA
Ketide length 5
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
mcl17 Synthase subclass: Type III
Module 1
Genes: mcl17
Core domains: Ketosynthase
Terpene-specific information
Carbon count subclass Sesquiterpene
Structural subclass Unknown
Isoprenoid precursor DMAPP
Prenyltransferases mcl23
Terpene synthases/cyclases mcl22
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: MQCAQSV425YQGLSERITRLP7K, no GDPR consent given).
  • Hidden contributor (ID: 7PXJSJT7IBMNIYLGG3GUM5VC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected polyketide synthase gene entries
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.