LOCUS       BGC0001085             10646 bp    DNA     linear   BCT 07-AUG-2014
DEFINITION  Streptomyces blastmyceticus DNA, teleocidin B biosynthetic gene
            cluster, its upstream and downstream region, strain: NBRC 12747.
ACCESSION   BGC0001085
VERSION     BGC0001085
KEYWORDS    .
SOURCE      Streptomyces blastmyceticus
  ORGANISM  Streptomyces blastmyceticus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 22:51:30
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10646
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1197)
                     /gene="tleB"
     CDS             complement(1..1197)
                     /codon_start=1
                     /gene="tleB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 455.5; E-value:
                     2.5e-138)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P-450"
                     /protein_id="BAP27940.1"
                     /sec_met_domain="p450 (E-value: 3.7e-31, bitscore: 96.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDERAPLSYPFNEAVALDVDPLYAKLRAEEPVVRVSCPFGEDAW
                     LVTSHADMKTILADPRFSRALAAEHDESRLTPLPIHTSILGMDSPDHTRLRRLLAKVFT
                     MRRVELLRPRIEQEADRLIDALIAEGPPGDLMEGFAVPFAGTVVCDLLGVPFEDREQFR
                     GWLDAFSATTVMTEEEIEADTERLHGYIAQLMVRRRAEPQDDLISAMVKASDEEEKLSE
                     KELVELASVLLIAGHETVSSQLIDSLHVLFTHPEQLRLLKDRPELMPGTVEELMRFVPL
                     ISHVTFARYATEDVELSGTLVRAGESVLPAIPSANRDESVFENADRFDLTREHNPHLGF
                     GYGIHRCLGAPLARLEMQVALDSLLRRLPELRCAVPAESLEWKDGMQVRSLLELPVLW"
     misc_feature    1..10646
                     /note="contains teleocidin B biosynthetic gene cluster"
     protocluster    1..10646
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[9470:10646]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9471..10646
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     protocluster    1..10646
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1496:9014]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1497..9014
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="2"
     cand_cluster    1..10646
                     /SMILES="NC(C(C)C)C(=O)NC(Cc1ccccc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="indole"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10646
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001085"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10646
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="indole"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(1194..1424)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009:mbtH-like protein (Score: 110.8; E-value:
                     3.4e-34)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf5"
                     /product="MbtH"
                     /protein_id="BAP27941.1"
                     /transl_table=11
                     /translation="MNNPWDDTEGTFLVLVNDEGQHSLWPSFTTVPAGWTAVRGPATRQ
                     ECLAYVEENWTDMRPKSLVEHQSRLSEVRSA"
     misc_feature    complement(1353..1355)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1497..9014)
                     /gene="tleA"
     CDS             complement(1497..9014)
                     /NRPS_PKS="Domain: AMP-binding (41-443). E-value: 1.5e-107.
                     Score: 351.6. Matches aSDomain:
                     nrpspksdomains_tleA_AMP-binding.1"
                     /NRPS_PKS="Domain: nMT (532-751). E-value: 4.5e-111. Score:
                     363.0. Matches aSDomain: nrpspksdomains_tleA_nMT.1"
                     /NRPS_PKS="Domain: PCP (953-1022). E-value: 6.9e-25. Score:
                     78.9. Matches aSDomain: nrpspksdomains_tleA_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1036-1338). E-value:
                     2.1e-115. Score: 376.7. Matches aSDomain:
                     nrpspksdomains_tleA_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1508-1912). E-value:
                     1.1e-104. Score: 342.0. Matches aSDomain:
                     nrpspksdomains_tleA_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2020-2087). E-value: 4e-26. Score:
                     82.9. Matches aSDomain: nrpspksdomains_tleA_PCP.2"
                     /NRPS_PKS="Domain: TD (2129-2373). E-value: 1.7e-85. Score:
                     278.0. Matches aSDomain: nrpspksdomains_tleA_TD.1"
                     /codon_start=1
                     /gene="tleA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     381.5; E-value: 1.1e-115)"
                     /gene_kind="biosynthetic"
                     /product="nonribosomal peptide synthetase"
                     /protein_id="BAP27942.1"
                     /sec_met_domain="Condensation (E-value: 9e-71, bitscore:
                     226.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.4e-122, bitscore:
                     395.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.4e-18, bitscore:
                     53.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.2e-69, bitscore:
                     220.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAQHHSAPLRPTAGAPRSASPTDPATPSDGDALPATLPEAFARQ
                     AALTPDAPALVSGAAGAGTAEISLTYRELDARADRLARRLTAEGVEPGGTVAVLMDRSA
                     ELVVSLLAIVKSGGAYVPLDPRQPVSRLRWILDQTGAELVLTAGGSPDAQLTAGRKVLA
                     VSVGDADERIPTVPVHPCEPRQLAYVMFTSGSTGTPKGVAVTHENVVGLARDQAWRGGA
                     HGRVLLHSPHAFDASTYELWVPLLCGGTVVVAPPGDLDARGIAAAVTDAEITGLWVTAG
                     LFSVLAEEAPRCFLGVREVWTGGDAVSPAAVRRVLRACPETAVVNGYGPTETTTFATCH
                     RVADPGVLGTVVPIGAAMAGMRAEVLDPRLAPVPPGEVGELYLGGSGLARGYWNRPALT
                     AERFVADPLGEPGARLFRTGDLVRRGPDGLLEFVGRSDDQVKIRGFRVEPGEVEAVLAG
                     HPGVAQAAVVVREDRPGQKRLVGYVVPAEESAAEAPSDGADRVGEWQEIYDSLYSDVAR
                     ARFGEDFSGWNSSYDGEPIPAAQMREWRDATVARIRELRPRRVLEIGVGTGLLMSRLAP
                     HCDAYWGTDLSGQVIEALRHLVRQDPELADRVELRAGAADDTAELPTGFFDTVVVNSVT
                     QYFPDAHYLADVLAKAVGLLVPGGSVFIGDVRNLRLLRCFHTDVRLRQDGLPADPAAVR
                     AAVEHGMVREKELLVDPAFFAELAAGLPGAVGSEVRVKRGRSVNELTRYRYDAVLRKLS
                     PGEQDPLPVRELSWGRDVQSPDELAALLRAEPPAGDVRLTGLPDSRLAPVAEALRELDG
                     GTGRIRALGARDDAGTDELERLHELADRLGLRASATWSADEDGTLDVFLTPRQPGSAVD
                     GPAPGVPLTSLVNAPAAARDTGALVSSVRAFLRERLPEYLVPAATVVLESLPLTANGKV
                     DRRRLPEPGTGSAEDGRAPRNPLEELLCGLFADILGVSGVTIDDSFFTLGGHSLSATRL
                     STRLRSVLGLELPVRAVFETPTVAGLAEAVREASAGDRPPLVPAERPEEVPLSFAQRRL
                     WFLDHLQGPGAAYNVPLVLDLDGELDRAALEAALGDVLARHESLRTVFPETAGVPRQLV
                     LDGAAVRPRLEVSAVAPEELDAAVAATVRRPFDLAAEIPVRARLFTAGPGRHVLALAVH
                     HIACDGWSLAPLWRDLATAYAARRDGGAAPDVAPLPVQYADYALWQHRLLGDEDDPASL
                     ASRQIDYWTKALADLPECAELPVDRPRPQVASHRGDTLHFTVDADLHRRITELAGRCGA
                     SPFMVVHAALVTLLTKLGAGPDIAVGTPVAGRTDHALDGLVGFFVNTLVLRTDTSGNPA
                     FRDLLARVRETDLAAYAHQDVPFERLVDALAPARGLAHHPLFQVLLALQNAPQGAAELP
                     GLAVAERAVGTGACRFDLSLSLRERHGADQRPGGMDGVAEYSTDLFDRSTVERLVHRFL
                     RLLDAVTADPGRRLGSLEVLLPDERERLLARSGDGTPGTELGHLPELFEAQVRRTPNAT
                     ALIHDDGTGPVRTLTFRELNARANQLARYLIGCGAGPERFVAIALPRDADSVVATLAVL
                     KAGAAYLPLDAGYPAARLAHMTEDARPTILLTDSGTSLPLPDGTGMRTVVLDRDETRRA
                     VALCWETDVADGERLAPLSCGAPAYVIYTSGSTGRPKGVVVTHAGVSGVVEAQVRRFGV
                     TAASRILQFASHSFDGAVWELCGGLLTGATLVMAPAELTAPGPELAALVERHRVTHATL
                     PPAALSVMEPGELPSLRWLITSGEAPSAETVRRWSAGRRFLNGYGPTETTVCATLSAPL
                     SGGGTPPIGRPTVGARAYVLDRDLCLVPPGVPGELHVSGAGLARGYLHRSGLTAERFVA
                     DPFGAPGDRMYKTGDTVRWNADGELEFIGRTDGQIKIRGFRIEPGEVEAVLGGHPGVAQ
                     AVVVPRKDARGGTYLAAYAVPAGDSPGLDGAELRDGLTGLLPGYMVPSAVVVLDSLPVT
                     ATGKVDRSALPEPDFGALSTGREPRNPRERILCELFAEVLGVPRVTIDDGFFDLGGHSL
                     LVTRVISGLRRRLGVELPVRTLFERQSVAALLEAVDGPAVPGGTYTPARADLAAEAVLD
                     PAITVGRAADGTRAEGRETILLTGATGFLGAFLLRELLDRTSADIHCLVRAEDAAQADR
                     RIRRNMAEYGLWNEFSRNRIVAVPGDLEKPLLGLSPERFDALAARLDAVYHNGARVSAV
                     DPYDRLRAANVAGTREVLRLAARFATPVHHISTAAVSVGTDEHPGPVPESHRVAPEAVL
                     PGGYTETKWVAEQLVWAAAGRGLPVTVHRCGRISGHTVSGAGSARDVFWQLVRAMLVLG
                     AAPRAADDGTAPVVDLIPADWAAAAIVHLSRTPGTEGLAHHLTCPSPVPFETVLGHLRA
                     YGYRLDTLDLDDWTATLRQRADAAADGGPGAGEGLLDAAVLLTDTLPALARVGRIHLDR
                     ANTIAGLAGSGPAFPPLDGELIRTYADFFVSSGFFPPPAAH"
     aSDomain        complement(1896..2627)
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tleA_TD.1"
                     /evalue="1.70E-85"
                     /label="tleA_TD.1"
                     /locus_tag="tleA"
                     /protein_end="2373"
                     /protein_start="2129"
                     /score="278.0"
                     /tool="antismash"
                     /translation="ILLTGATGFLGAFLLRELLDRTSADIHCLVRAEDAAQADRRIRRN
                     MAEYGLWNEFSRNRIVAVPGDLEKPLLGLSPERFDALAARLDAVYHNGARVSAVDPYDR
                     LRAANVAGTREVLRLAARFATPVHHISTAAVSVGTDEHPGPVPESHRVAPEAVLPGGYT
                     ETKWVAEQLVWAAAGRGLPVTVHRCGRISGHTVSGAGSARDVFWQLVRAMLVLGAAPRA
                     ADDGTAPVVDLIPADWAAAAIV"
     aSModule        1896..5906
                     /complete
                     /domains="nrpspksdomains_tleA_Condensation_LCL.1"
                     /domains="nrpspksdomains_tleA_AMP-binding.2"
                     /domains="nrpspksdomains_tleA_PCP.2"
                     /domains="nrpspksdomains_tleA_TD.1"
                     /final_module
                     /locus_tags="tleA"
                     /monomer_pairings="phe -> phe"
                     /tool="antismash"
                     /type="nrps"
     aSDomain        complement(2754..2954)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tleA_PCP.2"
                     /evalue="4.00E-26"
                     /label="tleA_PCP.2"
                     /locus_tag="tleA"
                     /protein_end="2087"
                     /protein_start="2020"
                     /score="82.9"
                     /tool="antismash"
                     /translation="ERILCELFAEVLGVPRVTIDDGFFDLGGHSLLVTRVISGLRRRLG
                     VELPVRTLFERQSVAALLEAVD"
     CDS_motif       complement(3006..3032)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0018"
                     /evalue="5.10E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="tleA"
                     /protein_end="2003"
                     /protein_start="1994"
                     /score="3.8"
                     /tool="antismash"
                     /translation="GKVDRSALP"
     CDS_motif       complement(3249..3314)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0017"
                     /evalue="6.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="tleA"
                     /protein_end="1922"
                     /protein_start="1900"
                     /score="34.2"
                     /tool="antismash"
                     /translation="FIGRTDGQIKIRGFRIEPGEVE"
     aSDomain        complement(3279..4490)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tleA_AMP-binding.2"
                     /evalue="1.10E-104"
                     /label="tleA_AMP-binding.2"
                     /locus_tag="tleA"
                     /protein_end="1912"
                     /protein_start="1508"
                     /score="342.0"
                     /specificity="consensus: phe"
                     /tool="antismash"
                     /translation="FEAQVRRTPNATALIHDDGTGPVRTLTFRELNARANQLARYLIGC
                     GAGPERFVAIALPRDADSVVATLAVLKAGAAYLPLDAGYPAARLAHMTEDARPTILLTD
                     SGTSLPLPDGTGMRTVVLDRDETRRAVALCWETDVADGERLAPLSCGAPAYVIYTSGST
                     GRPKGVVVTHAGVSGVVEAQVRRFGVTAASRILQFASHSFDGAVWELCGGLLTGATLVM
                     APAELTAPGPELAALVERHRVTHATLPPAALSVMEPGELPSLRWLITSGEAPSAETVRR
                     WSAGRRFLNGYGPTETTVCATLSAPLSGGGTPPIGRPTVGARAYVLDRDLCLVPPGVPG
                     ELHVSGAGLARGYLHRSGLTAERFVADPFGAPGDRMYKTGDTVRWNADGELEFIGRTDG
                     QIKIR"
     CDS_motif       complement(3399..3488)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0016"
                     /evalue="2.50E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="tleA"
                     /protein_end="1872"
                     /protein_start="1842"
                     /score="51.7"
                     /tool="antismash"
                     /translation="PPGVPGELHVSGAGLARGYLHRSGLTAERF"
     CDS_motif       complement(3591..3617)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0015"
                     /evalue="2.00E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="tleA"
                     /protein_end="1808"
                     /protein_start="1799"
                     /score="7.9"
                     /tool="antismash"
                     /translation="YGPTETTVC"
     CDS_motif       complement(3972..4031)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0014"
                     /evalue="8.30E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="tleA"
                     /protein_end="1681"
                     /protein_start="1661"
                     /score="33.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVVVTH"
     CDS_motif       complement(4248..4289)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0013"
                     /evalue="1.40E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="tleA"
                     /protein_end="1589"
                     /protein_start="1575"
                     /score="18.2"
                     /tool="antismash"
                     /translation="LAVLKAGAAYLPLD"
     CDS_motif       complement(4842..4961)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0012"
                     /evalue="1.60E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="tleA"
                     /protein_end="1391"
                     /protein_start="1351"
                     /score="68.7"
                     /tool="antismash"
                     /translation="RETDLAAYAHQDVPFERLVDALAPARGLAHHPLFQVLLAL"
     aSDomain        complement(5001..5906)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tleA_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="2.10E-115"
                     /label="tleA_Condensation_LCL.1"
                     /locus_tag="tleA"
                     /protein_end="1338"
                     /protein_start="1036"
                     /score="376.7"
                     /tool="antismash"
                     /translation="EEVPLSFAQRRLWFLDHLQGPGAAYNVPLVLDLDGELDRAALEAA
                     LGDVLARHESLRTVFPETAGVPRQLVLDGAAVRPRLEVSAVAPEELDAAVAATVRRPFD
                     LAAEIPVRARLFTAGPGRHVLALAVHHIACDGWSLAPLWRDLATAYAARRDGGAAPDVA
                     PLPVQYADYALWQHRLLGDEDDPASLASRQIDYWTKALADLPECAELPVDRPRPQVASH
                     RGDTLHFTVDADLHRRITELAGRCGASPFMVVHAALVTLLTKLGAGPDIAVGTPVAGRT
                     DHALDGLVGFFVNTLVLRTDT"
     CDS_motif       complement(5010..5099)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0011"
                     /evalue="7.40E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="tleA"
                     /protein_end="1335"
                     /protein_start="1305"
                     /score="50.5"
                     /tool="antismash"
                     /translation="DIAVGTPVAGRTDHALDGLVGFFVNTLVLR"
     CDS_motif       complement(5367..5405)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0010"
                     /evalue="3.20E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="tleA"
                     /protein_end="1216"
                     /protein_start="1203"
                     /score="16.5"
                     /tool="antismash"
                     /translation="QYADYALWQHRLL"
     CDS_motif       complement(5457..5522)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0009"
                     /evalue="3.90E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="tleA"
                     /protein_end="1186"
                     /protein_start="1164"
                     /score="35.4"
                     /tool="antismash"
                     /translation="VHHIACDGWSLAPLWRDLATAY"
     CDS_motif       complement(5724..5840)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0008"
                     /evalue="3.20E-19"
                     /label="C2_LCL_024-062"
                     /locus_tag="tleA"
                     /protein_end="1097"
                     /protein_start="1058"
                     /score="61.3"
                     /tool="antismash"
                     /translation="AAYNVPLVLDLDGELDRAALEAALGDVLARHESLRTVFP"
     aSDomain        complement(5949..6155)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tleA_PCP.1"
                     /evalue="6.90E-25"
                     /label="tleA_PCP.1"
                     /locus_tag="tleA"
                     /protein_end="1022"
                     /protein_start="953"
                     /score="78.9"
                     /tool="antismash"
                     /translation="EELLCGLFADILGVSGVTIDDSFFTLGGHSLSATRLSTRLRSVLG
                     LELPVRAVFETPTVAGLAEAVREA"
     aSModule        5949..8891
                     /complete
                     /domains="nrpspksdomains_tleA_AMP-binding.1"
                     /domains="nrpspksdomains_tleA_nMT.1"
                     /domains="nrpspksdomains_tleA_PCP.1"
                     /locus_tags="tleA"
                     /monomer_pairings="val -> NMe-val"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(6207..6233)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0007"
                     /evalue="4.50E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="tleA"
                     /protein_end="936"
                     /protein_start="927"
                     /score="3.9"
                     /tool="antismash"
                     /translation="GKVDRRRLP"
     aSDomain        complement(6762..7418)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tleA_nMT.1"
                     /domain_subtype="nMT"
                     /evalue="4.50E-111"
                     /label="tleA_nMT.1"
                     /locus_tag="tleA"
                     /protein_end="751"
                     /protein_start="532"
                     /score="363.0"
                     /tool="antismash"
                     /translation="GEPIPAAQMREWRDATVARIRELRPRRVLEIGVGTGLLMSRLAPH
                     CDAYWGTDLSGQVIEALRHLVRQDPELADRVELRAGAADDTAELPTGFFDTVVVNSVTQ
                     YFPDAHYLADVLAKAVGLLVPGGSVFIGDVRNLRLLRCFHTDVRLRQDGLPADPAAVRA
                     AVEHGMVREKELLVDPAFFAELAAGLPGAVGSEVRVKRGRSVNELTRYRYDAVLRK"
     CDS_motif       complement(7290..7325)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0006"
                     /evalue="9.20E+00"
                     /label="C3_starter_134-155"
                     /locus_tag="tleA"
                     /protein_end="575"
                     /protein_start="563"
                     /score="-0.3"
                     /tool="antismash"
                     /translation="GVGTGLLMSRLA"
     CDS_motif       complement(7656..7721)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0005"
                     /evalue="5.60E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="tleA"
                     /protein_end="453"
                     /protein_start="431"
                     /score="37.5"
                     /tool="antismash"
                     /translation="FVGRSDDQVKIRGFRVEPGEVE"
     aSDomain        complement(7686..8891)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tleA_AMP-binding.1"
                     /evalue="1.50E-107"
                     /label="tleA_AMP-binding.1"
                     /locus_tag="tleA"
                     /protein_end="443"
                     /protein_start="41"
                     /score="351.6"
                     /specificity="consensus: val"
                     /tool="antismash"
                     /translation="FARQAALTPDAPALVSGAAGAGTAEISLTYRELDARADRLARRLT
                     AEGVEPGGTVAVLMDRSAELVVSLLAIVKSGGAYVPLDPRQPVSRLRWILDQTGAELVL
                     TAGGSPDAQLTAGRKVLAVSVGDADERIPTVPVHPCEPRQLAYVMFTSGSTGTPKGVAV
                     THENVVGLARDQAWRGGAHGRVLLHSPHAFDASTYELWVPLLCGGTVVVAPPGDLDARG
                     IAAAVTDAEITGLWVTAGLFSVLAEEAPRCFLGVREVWTGGDAVSPAAVRRVLRACPET
                     AVVNGYGPTETTTFATCHRVADPGVLGTVVPIGAAMAGMRAEVLDPRLAPVPPGEVGEL
                     YLGGSGLARGYWNRPALTAERFVADPLGEPGARLFRTGDLVRRGPDGLLEFVGRSDDQV
                     KIR"
     CDS_motif       complement(7806..7895)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0004"
                     /evalue="6.90E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="tleA"
                     /protein_end="403"
                     /protein_start="373"
                     /score="56.7"
                     /tool="antismash"
                     /translation="PPGEVGELYLGGSGLARGYWNRPALTAERF"
     CDS_motif       complement(8010..8033)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0003"
                     /evalue="2.80E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="tleA"
                     /protein_end="335"
                     /protein_start="327"
                     /score="4.7"
                     /tool="antismash"
                     /translation="YGPTETTT"
     CDS_motif       complement(8397..8456)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0002"
                     /evalue="5.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="tleA"
                     /protein_end="206"
                     /protein_start="186"
                     /score="31.2"
                     /tool="antismash"
                     /translation="AYVMFTSGSTGTPKGVAVTH"
     CDS_motif       complement(8643..8684)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tleA_0001"
                     /evalue="8.50E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="tleA"
                     /protein_end="124"
                     /protein_start="110"
                     /score="15.8"
                     /tool="antismash"
                     /translation="LAIVKSGGAYVPLD"
     gene            9471..10646
                     /gene="tleC"
     CDS             9471..10646
                     /codon_start=1
                     /experiment="in vitro assay by using a recombinant enzyme;
                     enzymatic activity was confirmed"
                     /gene="tleC"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /product="tryptophan dimethylallyltransferase"
                     /protein_id="BAP27943.1"
                     /sec_met_domain="indole_PTase (E-value: 8.8e-79, bitscore:
                     253.1, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESAGPGTGPQPPRTSGDFTPDTGVIAEMTGRPMRFDSDRYRPTD
                     TYAEVACDKVCRAYEGLGADGGDRESLLAFLRDLTDPWGELPVGTPPEDACWVSIDGMP
                     LETSVAWAGRKAGVRLSLESPRGPAKRRMEDGMALTRRLAGRPGVSVDPCLRVEDLFTD
                     DDPQGYFTIAHAVAWTPGGHPRYKIFLNPAVRGREQAAARTEEAMIRLGLEQPWRALTE
                     HLGGAYGPEHEPAALAMDLVPGDDFRVQVYLAHSGVSAEAIDAKSAVAADHVPGSFARA
                     LRGINGADDTPEWKRKPPVTAFSFGPGRAVPGATLYVPMIPVHGSDAAARDRVAAFLRS
                     EGMDAVGYEAVLDAISDRSLPESHTQNFISYRGGDSPRFSVYLAPGVYREA"
ORIGIN
        1 tcaccagagg accggcagct ccagcaggct ccgcacctgc atgccgtcct tccattccag
       61 cgattccgcc ggaaccgcgc accgcagctc gggaagccgc cgcagcagcg aatccagcgc
      121 cacctgcatt tccagccggg cgagcggcgc gcccaggcag cggtggattc cgtaaccgaa
      181 tcccagatgc ggattgtgct cccgcgtgag gtcgaaccgg tcggcattct cgaagaccga
      241 ttcatcgcgg ttcgcggacg gaatcgcggg cagtacggat tcgcccgcgc gcaccagcgt
      301 cccgctcagt tcgacgtcct ccgtggcata gcgcgcgaag gtcacatggg aaatgagcgg
      361 tacgaagcgc atcagctcct cgaccgtccc gggcatcagc tcgggcctgt ccttgagcag
      421 ccggagctgt tcggggtggg tgaacagcac gtgcagggag tcgatcagct gggaggagac
      481 cgtctcgtgc ccggcgatca gcagcacgct cgccagctcc acgagctcct tctcggagag
      541 cttctcctcc tcgtcgctgg ccttgaccat ggcgctgatg aggtcgtcct gcggctccgc
      601 gcgcctgcgc accatcagct gcgcgatata gccgtgcagc cgctcggtgt ccgcctcgat
      661 ctcctcctcc gtcatcaccg tcgtggcgga gaaggcgtcc agccagccgc ggaactgctc
      721 ccggtcctcg aagggcacgc cgagcaggtc gcacacgacg gtgcccgcga agggcaccgc
      781 gaagccctcc atgaggtcgc ccggtgggcc ctcggcgatc agcgcgtcga tcagccggtc
      841 ggcctcctgc tcgatgcgcg ggcgcagcag ctcgacccgg cgcatggtga agaccttggc
      901 caggagccgg cgcagccggg tgtggtcggg ggagtccatg cccaggatgc tggtgtggat
      961 gggcagcggg gtcaggcggg actcgtcgtg ctcggcggcc agcgcccggc tgaaccgggg
     1021 gtccgcgagg atcgtcttca tgtccgcgtg cgaggtgacc agccaggcgt cttcgccgaa
     1081 agggcagctg acccgtacga cgggttcctc ggcgcgcagc ttcgcgtaga gcgggtcgac
     1141 gtccagggcg accgcttcgt tgaacgggta gctgaggggc gcgcgttcgt ccttcatgcg
     1201 gaccgcacct ccgagagccg cgactggtgc tcgacgaggc tcttgggccg catgtcggtc
     1261 cagttctcct cgacgtaggc gaggcactcc tgccgggtgg cggggccgcg gacggccgtc
     1321 cacccggcgg ggacagtggt gaaggacggc cataaggagt gctgtccctc gtcgttgacc
     1381 agcacgagga aggtgccctc ggtgtcgtcc caggggttgt tcacgatgtt cggcctttcc
     1441 gtgaaggggt gtggaggcgt gccggggccg gggccccggc acggtcgcgg cgccgctcag
     1501 tgcgcggcgg gcggcgggaa gaagcccgac gagacgaaga agtcggcgta cgtacggatc
     1561 agctcgccgt ccagcggcgg gaacgccgga cccgaaccgg ccagccctgc aatggtgttg
     1621 gcgcggtcga ggtggatccg gcccacgcgg gcgagcgcgg gcagggtgtc ggtgaggagc
     1681 acggccgcgt ccagcagccc ctcgcccgcc cccggcccgc cgtccgccgc cgcgtcggcc
     1741 cgctgccgca gggtggccgt ccagtcgtcg aggtccaggg tgtccagccg gtagccgtac
     1801 gcccgcagat ggccgaggac ggtctcgaag gggacggggg acgggcaggt gaggtggtgc
     1861 gcgaggccct cggtgcccgg ggtgcgggag aggtggacga tagcggccgc ggcccagtcg
     1921 gcggggatca ggtcgacgac cggggccgtg ccgtcgtccg ccgcgcgggg cgccgcgccg
     1981 aggacgagca tggcgcggac gagctgccag aacacgtccc gggccgaccc cgcaccgctg
     2041 acggtgtgtc cgctgatgcg cccgcaccgg tggacggtca ccggcagtcc gcgcccggcc
     2101 gccgcccaga cgagctgctc ggccacccac ttggtctcgg tgtagccgcc cggcaggacc
     2161 gcctccggcg cgacccggtg cgactcgggc accggaccgg ggtgttcgtc ggtccccacc
     2221 gacacggcgg ccgtggagat gtggtgcacc ggcgtcgcga acctggcggc cagccgcagc
     2281 acttcccggg tgcccgcgac gttcgccgcg cgcagccggt cgtacgggtc gaccgcgctg
     2341 acccgcgcgc cgttgtggta gaccgcgtcg agccgggccg cgagggcgtc gaagcgctcg
     2401 ggggagagcc cgagcagcgg cttctccagg tcgccgggga cggcgacgat ccggttgcgg
     2461 gagaactcgt tccacagccc gtactccgcc atgttccgcc ggatccggcg gtccgcctgc
     2521 gcggcgtcct cggcgcgcac caggcagtgg atgtcggcgc tcgtgcggtc gaggagctcg
     2581 cgcagcagga acgccccgag gaagccggtc gcaccggtca gcaggatggt ctcccgtccc
     2641 tccgcccggg tgccgtccgc cgcccggccc acggtgatcg ccgggtcgag cacggcctcc
     2701 gcggcgaggt cggcccgcgc cggcgtgtac gtcccgccgg gtacggccgg accgtcgacg
     2761 gcctccagca gcgcggccac cgactgccgc tcgaagaggg tgcggacggg cagctccacg
     2821 ccgaggcggc ggcgcagccc gctgatcacc cgggtcacca gcagcgagtg cccgcccagg
     2881 tcgaagaagc cgtcgtcgat ggtcacccgg ggcacgccca gcacctcggc gaacagctcg
     2941 cacaggatcc gctcgcgcgg gttgcggggc tcgcggcccg tggacagcgc cccgaagtcg
     3001 ggctcgggga gcgccgagcg gtccaccttg cccgtggccg tcaccggcag cgagtccagg
     3061 accacgaccg cggacggcac catatagccg ggcagcagac cggtcagccc gtcgcgcagc
     3121 tccgccccgt ccaggcccgg cgagtcaccg gcgggcaccg cgtacgccgc caggtacgta
     3181 ccgccgcggg cgtccttgcg ggggacgacg accgcctggg ccacccccgg gtgaccgccc
     3241 agcaccgcct cgacctcgcc gggctcgatc cggaagccgc ggatcttgat ctgcccgtcg
     3301 gtgcggccga tgaactccag ctcgccgtcg gcgttccagc ggaccgtgtc gccggtcttg
     3361 tacatccggt cgcccggtgc cccgaacggg tcggccacga accgctccgc ggtcagcccc
     3421 gaccggtgca gatagccgcg ggccagcccg gcgcccgaca catggagctc cccgggcacc
     3481 cccggcggca ccaggcacag gtcacggtcc aggacgtagg cgcgcgcacc cacggtgggc
     3541 cggccgatcg ggggcgttcc gccgccggac agcggggcgc tgagcgtcgc gcacaccgtc
     3601 gtctcggtcg ggccgtagcc gttgaggaac ctgcgccccg cagaccagcg gcgcaccgtc
     3661 tccgccgacg gcgcctcgcc cgaggtgatc agccagcgca gcgacggcag ttcgcccggc
     3721 tccatcaccg acagcgcggc cgggggcagc gtcgcgtgcg tgacccggtg ccgctcgacc
     3781 agcgcggcca gctccgggcc cggcgcggtg agctccgcgg gcgccatcac cagggtggcc
     3841 ccggtcagca gcccgccgca cagctcccac accgcgccgt cgaagctgtg cgaggcgaac
     3901 tgcaggatcc ggctcgccgc tgtcaccccg aaccgccgca cctgcgcctc gaccacgccg
     3961 gagacccccg cgtgggtgac gacgacgccc ttgggccggc cggtggaccc ggaggtgtag
     4021 atgacgtagg cgggcgcccc gcagctcagc ggcgctagcc gctcgccgtc ggcgacgtcc
     4081 gtctcccagc acagggccac ggcccgccgg gtctcgtccc ggtccagcac gaccgtgcgc
     4141 atccccgtgc cgtcgggcag cggcaaggag gtgccggagt cggtgagcag gatcgtgggc
     4201 cgggcgtcct cggtcatatg ggcgaggcgg gccgccggat agcccgcgtc cagcggcaga
     4261 taggcggccc ccgccttcag caccgcgagc gtcgcgacga ccgagtcggc gtcgcgcggc
     4321 agggcgatcg ccacgaaccg ctccggcccg gcaccgcagc cgatcagata ccgggccagc
     4381 tggttcgccc gcgcgttcag ctcacggaac gtcagcgtgc gtacgggccc ggtgccgtcg
     4441 tcgtggatca gcgcggtcgc gttcggtgtc cgcctcacct gcgcctcgaa cagctccggc
     4501 agatggccga gttccgtgcc gggggtgccg tcgccgctgc gcgcaagcag ccgctcccgc
     4561 tcgtcgggga gcagcacctc cagcgagccg agccggcggc cggggtcggc ggtgaccgcg
     4621 tcgaggagcc gtaggaaacg gtggacgagg cgctcgacgg tggaccggtc gaacaggtcg
     4681 gtgctgtact ccgcgacccc gtccatgccc cccggccgct ggtccgcgcc gtgccgctcc
     4741 cgcaggctca gcgacaggtc gaaccggcac gccccggtgc ccaccgcccg ctccgcgacg
     4801 gccaggcccg gcagctccgc cgcgccctgc ggggcgttct gcagcgccag cagcacctgg
     4861 aacagcgggt ggtgggcgag gccgcgcgcc ggggcgaggg cgtcgaccag ccgctcgaag
     4921 ggcacgtcct gatgggcgta cgcggccagg tcggtctccc ggacccgggc cagcaggtcg
     4981 cggaacgcgg ggttgccgga ggtgtccgtg cgcagcacca gcgtgttgac gaagaacccg
     5041 accaggccgt ccagcgcgtg gtcggtgcgg cccgcgaccg gggtgccgac cgcgatgtcc
     5101 gggcccgcgc ccagcttcgt cagcagcgtc accagcgcgg cgtgcacgac catgaacggg
     5161 ctggccccgc accgcccggc cagctccgtg atccgccggt gcagatcggc gtcgaccgtg
     5221 aagtgcaggg tgtcgccgcg gtgcgaggcc acctgcggcc ggggccggtc cacgggcagc
     5281 tccgcgcact cgggcaggtc ggccaacgcc ttggtccagt agtcgatctg acgggacgcc
     5341 aggcttgcgg gatcatcctc gtcgcccagc agccggtgct gccacagcgc gtagtcggcg
     5401 tactgcaccg gcagcggtgc gacgtcgggt gccgcgccgc cgtcgcggcg ggcggcgtag
     5461 gcggtggcga ggtcgcgcca cagcggcgcc agcgaccagc cgtcgcacgc gatgtggtgg
     5521 acggccagcg ccaggacgtg ccggccggga cccgcggtga acagccgcgc gcgcaccggt
     5581 atctcggccg cgaggtcgaa gggccggcgg accgtggcgg ccaccgccgc gtccagctcc
     5641 tccggcgcga ccgcgctcac ctccaggcgc ggccggacgg cggcaccgtc caggaccagc
     5701 tgccggggca ccccggccgt ctccgggaag accgtccgca ggctctcgtg ccgggccagc
     5761 acatcgccca gcgccgcttc gagcgccgcg cggtccagct cgccgtccag gtcgagcacg
     5821 agcgggacgt tgtacgcggc gcccggcccc tggaggtggt cgaggaacca cagccgccgc
     5881 tgggcgaacg acagcggcac ctcctcgggc cgctccgcgg gcaccagcgg cgggcggtcc
     5941 ccggccgacg cctcgcgcac cgcctcggcg agaccggcga cggtcggcgt ctcgaagacg
     6001 gcgcgcaccg gcagctccag gcccaggacg gaccgcagcc gggtgctgag ccgggtggcc
     6061 gacagcgagt gcccgcccag cgtgaagaag ctgtcgtcga tggtgacccc ggacaccccg
     6121 aggatgtcgg cgaacagccc gcacagcagc tcttcgagcg gattgcgcgg cgcccggccg
     6181 tcctcggcgg acccggtgcc gggctccggc agccggcgcc ggtcgacctt gccgttcgcg
     6241 gtcagtggca ggctctccag caccaccgtc gccgcgggca ccagatactc gggcaaccgc
     6301 tcgcgcagga acgcccggac cgaggacacc agcgcaccgg tgtcccgcgc ggccgccggg
     6361 gcgttgacca gcgaggtgag cggcacccca ggcgccgggc cgtcgaccgc cgaaccgggt
     6421 tgacgtggcg tcaaaaatac gtccagcgtg ccgtcctcgt cggccgacca ggtggccgag
     6481 gcgcgcagcc ccagcctgtc cgccagctcg tggaggcgct ccagctcgtc ggttccggcg
     6541 tcgtcgcgag cgcccagggc gcggatccgg cccgtacccc cgtccagctc ccgcagggcc
     6601 tcggccaccg gcgcgagcct gctgtccggc aaccccgtca gccgtacgtc gcccgccggc
     6661 ggctccgcgc gcagcagcgc ggccagctcg tccggcgatt ggacgtcccg cccccacgac
     6721 aactcccgta cgggcaatgg atcctgctcg ccgggggaca gcttgcgcag cacggcgtcg
     6781 tagcggtagc gcgtcagctc gttcacggac cgcccgcgct tcacccgcac ctcgctgccg
     6841 accgcgcccg gcaggccggc cgccagctcg gcgaagaacg ccgggtcgac cagcagctcc
     6901 ttctcccgca ccatgccgtg ctcgacggcc gcccggacgg cggcggggtc cgccggcaac
     6961 ccgtcctgcc ggagccggac gtcggtgtgg aagcagcgca gcagccgcag attgcggacg
     7021 tcgccgatga acaccgaccc gccggggacg agcagcccga cggccttggc caggacgtcc
     7081 gcgaggtagt gggcgtcggg gaagtactgc gtcacggagt tgacgacgac ggtgtcgaag
     7141 aagccggtgg gcagttcagc cgtgtcgtcg gctgcaccgg cccgcagctc gacccggtcc
     7201 gccagttcgg ggtcctgtcg caccagatgg cgcagcgcct cgatgacctg gccggagagg
     7261 tccgttcccc agtaggcgtc gcagtgcggg gccagccggg acatcagcag cccggtgccg
     7321 acgccgatct ccagcacccg gcgcggccgg agttcacgga tccgggccac ggtggcatcg
     7381 cgccactccc gcatctgcgc cgccggtatc ggctcgccgt cgtagctgct gttccagccg
     7441 gagaagtcct cgccgaagcg cgcccgcgcc acgtcgctgt acagcgagtc gtagatctcc
     7501 tgccactcgc cgacccggtc cgcgccgtcc gagggcgcct cggccgcgct ctcctccgcc
     7561 ggtacgacat agccgacgag ccgcttctgg cccggcctgt cctcgcgcac caccacggcc
     7621 gcctgggcga ccccggggtg cccggcgagg acggcctcga cctcgcccgg ctcgacccgg
     7681 aagccgcgga tcttcacctg gtcgtcgctg cggccgacga actccaggag cccgtccggg
     7741 ccgcgccgca ccaggtcacc ggtgcggaac agccgggcac cgggctcgcc cagcgggtcg
     7801 gcgacgaagc gctcggcggt gagcgccggg cggttccagt agccacgggc cagccccgag
     7861 ccgccgagat agagctcgcc gacctccccg ggcggcaccg gcgccagccg tggatcgagc
     7921 acctccgcgc gcatcccggc catcgccgcg ccgatgggca cgaccgtgcc caggacaccg
     7981 gggtcggcca cccggtggca ggtggcgaac gtggtggtct cggtcggccc gtagccgttg
     8041 acgaccgcgg tctccgggca tgcccgcagc acccgccgga cggccgcggg ggagaccgcg
     8101 tccccgcccg tccacacctc ccgcaccccg aggaagcacc gcggcgcctc ctcggccagc
     8161 accgagaaca ggcccgccgt cacccacagc ccggtgatct ccgcgtccgt gacggcggcg
     8221 gcgatgccgc gtgcgtccag gtccccgggc ggtgcgacca ccaccgtccc cccgcacagc
     8281 agcggcaccc acagctcgta cgtcgaggcg tcgaacgcgt gcggcgagtg cagcagcacc
     8341 cggccgtggg cgccgccgcg ccacgcctgg tcgcgggcga gacccaccac gttctcatgg
     8401 gtcaccgcga cgcccttggg cgtgccggtc gagccggagg tgaacatcac atacgccaac
     8461 tggcgcggtt cacaggggtg tacggggacg gtcggtatcc gttcgtccgc gtcgcccacg
     8521 gacacggcca gcaccttgcg ccccgccgtg agctgcgcgt ccggggatcc gccggccgtc
     8581 aggacgagct ccgcgccggt ctggtccagg atccaccgca accgggatac gggctgccgc
     8641 ggatccaacg ggacgtaggc gccaccggac ttgacgatcg cgagcaggga gacgacgagc
     8701 tcggccgaac ggtccatcag caccgccacg gtgccgcccg gctccacgcc ctccgccgtc
     8761 agccgccggg ccagccggtc cgcgcgtgcg tcgagctccc ggtaggtcag ggagatctcc
     8821 gccgttcccg ctcccgcggc gccgctcacc agcgccggcg cgtcgggggt gagcgccgcc
     8881 tgccgggcga acgcctccgg gagcgtcgcg gggagagcgt ccccgtcgga tggggtggcg
     8941 gggtcggtgg gggatgcgga acgcggagca ccggcggtgg gccggagtgg ggcggagtgg
     9001 tgctgtgcgg acacgcgtca acaactcctc tgcacaggct tcccggagca cggcggcgcc
     9061 gactctcccc ggttggccgc gtgtggacag ggcacaccga ttcgcgagcg ccgtgcacca
     9121 gcgagcgatg tgtagcgatc gtgtcgcgga acgtcgtgat gcggaccacc gccgtgcatg
     9181 atccggccgt tcttgcaaag ccgatgcccg agcctgaccg taaccagcgg taatgcgcag
     9241 gtgcggctgg cggtcccggg cattccgcca ccgcggaccg gccgaatccc cggtcgggct
     9301 ccggcgcgga ctgaggcgga tcgaccgtac gcgcgaaggg cggcaagttg gccggaacat
     9361 aggcccgata acgggatccc gggcaattgt cgggcaaagc tctgacagcg cccgccgcac
     9421 ggtgggaaga tcgcgctcgt ttttgccgtc accacgcaca gggagtcacg atggagtccg
     9481 caggtcccgg aaccggcccc caaccgcccc gcacatcagg cgatttcacc ccggacacgg
     9541 gcgtcatagc cgagatgacc ggccgcccga tgcgcttcga ctccgaccgc taccggccca
     9601 ccgacaccta cgcggaggtc gcctgcgaca aggtgtgccg cgcctacgag ggcctcgggg
     9661 ccgacggcgg ggaccgggag tcgctcctcg cgttcctgcg cgacctcacc gacccctggg
     9721 gcgaactccc cgtcggcaca ccccccgagg acgcctgctg ggtctccatc gacggcatgc
     9781 ccctggagac ctcggtcgcc tgggccgggc gcaaggcagg ggtccggctc tccctggagt
     9841 cccccagggg cccggcgaag cgccggatgg aggacggcat ggccctcacc cggcggctgg
     9901 ccggccgccc cggtgtctcc gtcgacccct gcctccgggt cgaggacctc ttcaccgacg
     9961 acgacccgca ggggtacttc accatcgccc acgcggtggc ctggaccccc ggcggccacc
    10021 cccgctacaa gatcttcctc aaccccgcgg tccgtggccg ggaacaggcc gccgcccgca
    10081 cggaagaggc catgatccgc ctcggcctgg aacagccctg gcgcgccctc accgaacacc
    10141 tcggcggcgc gtacggcccg gagcacgaac ccgccgccct ggccatggac ctcgtgcccg
    10201 gcgacgactt ccgcgtccag gtctacctcg cgcactccgg ggtgtccgcc gaagccatcg
    10261 acgcgaagtc ggccgtcgcc gcggaccacg taccgggctc cttcgcccgc gcgctgcgcg
    10321 gcatcaacgg cgcggacgac acccccgaat ggaagcggaa gccgccggtg acggccttct
    10381 ccttcggccc gggaagggcc gtgcccggtg cgacgctgta cgtcccgatg atccctgtgc
    10441 acgggagcga tgcggcggcg cgggatcggg tggcggcgtt tctgcgctct gaggggatgg
    10501 atgcggtggg gtacgaggcg gtgctcgacg cgatctccga ccgttcgctg ccggagtcgc
    10561 acacgcagaa cttcatctcg taccggggcg gtgactcacc gcgcttctcg gtgtacctcg
    10621 cgccgggggt ctaccgggag gcgtag
//
