BGC0001105: onnamide A biosynthetic gene cluster from Uncultured bacterium
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 36,513 nt. (total: 36,513 nt).
This entry is originally from NCBI GenBank AY688304.2.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001105
Short description onnamide A biosynthetic gene cluster from Uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The gene cluster encodes for all onnamides, theopederins and pseudoonnamides."
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AY688304.2
Compounds
  • onnamide A
Species Uncultured bacterium [taxonomy]
References
Chemical products information
onnamide A
Copy SMILES
C39H63N5O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAV97868.1
3 - 422 (+) putative transposase
copy AA seq
copy Nt seq
  • AAV97869.1
  • onnA
459 - 1721 (+) OnnA
copy AA seq
copy Nt seq
  • AAV97870.1
  • onnB
1783 - 14913 (+) OnnB
copy AA seq
copy Nt seq
  • AAV97871.1
  • onnC
14930 - 16090 (+) OnnC
copy AA seq
copy Nt seq
  • AAV97872.1
  • onnD
16120 - 17073 (+) OnnD
copy AA seq
copy Nt seq
  • AAV97873.1
  • onnE
17124 - 18194 (+) OnnE
copy AA seq
copy Nt seq
  • AAV97874.1
  • onnF
18213 - 19235 (+) OnnF
copy AA seq
copy Nt seq
  • AAV97875.1
  • onnG
19409 - 20374 (+) OnnG
copy AA seq
copy Nt seq
  • AAV97876.1
  • onnH
20462 - 21268 (+) OnnH
copy AA seq
copy Nt seq
  • AAV97877.1
  • onnI
21358 - >36513 (+) OnnI
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
onnI
+
onnB
Synthase subclass: Trans-AT type I
Module 0
Genes: onnB
Core domains: Thiolation (ACP/PCP)
Scaffold-modifying domains: GNAT
Module 1
Genes: onnB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 2
Genes: onnB
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: 2x Crotonase / Enoyl-CoA dehydratase
Module 3
Genes: onnB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 4
Genes: onnI
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: onnI
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: onnI
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 8
Genes: onnI
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Pyran synthase
KR-domain stereochemistry: D-OH
Module 9
Genes: onnI
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 10
Genes: onnI
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: onnI
Core domains: Ketosynthase
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
onnI
Module 5
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for onnamide A
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Removed invalid PKS modules
  • Sorted modules by module number
  • Removed invalid NRPS modules
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.