BGC0001108: pederin biosynthetic gene cluster from Uncultured bacterium
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Location: 1 - 75,778 nt. (total: 75,778 nt).
This entry is originally from NCBI GenBank AY328023.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001108
Short description pederin biosynthetic gene cluster from Uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Pederin is most likely not released by the TE domain but by PedG."
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AY328023.1
Compounds
  • pederin
  • pseudopederin
  • pederone
Species Uncultured bacterium [taxonomy]
References
Chemical products information
pederin
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C25H45N1O9
Chemical database entries
PubCHEM
pseudopederin
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C24H43N1O9
Chemical database entries
PubCHEM
pederone
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C25H43N1O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • AAS47548.1
 1 - 520 (-) putative isocitrate dehydrogenase kinase/phosphatase
  • Other enzymatic
Sequence-based prediction
AY328023 and AY850690\n together build up the pederin gene cluster (BGC0001108\n and BGC0000255\n) BGC0001109\n is not complete.
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  • AAS47549.1
 1911 - 2654 (+) putative dioxygenase
  • Tailoring (Dioxygenation)
Sequence-based prediction
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  • AAS47557.1
  • pedA
 6372 - 7310 (-) putative methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AAS47558.1
  • pedB
 7324 - 8718 (-) putative FMN-dependent oxidoreductase
  • Tailoring (Monooxygenation)
Sequence-based prediction
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  • AAS47559.1
  • pedC
 8894 - 9898 (-) putative acyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS47563.1
  • pedD
 10062 - 11111 (+) putative acyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS47560.1
  • pedE
 11341 - 12162 (+) putative methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AAS47564.1
  • pedF
 12407 - 38212 (+) mixed type I polyketide synthase/nonribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS47561.1
  • pedG
 38240 - 39541 (+) putative FAD-dependent monooxygenase
  • Tailoring (Monooxygenation)
Sequence-based prediction
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  • AAS47562.1
  • pedH
 39565 - 58365 (+) mixed type I polyketide synthase - peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS47550.1
 61329 - 61637 (-) putative acyl carrier protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS47551.1
 66565 - 68511 (-) putative DNA helicase
  • Other enzymatic
Sequence-based prediction
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  • AAS47552.1
 69647 - 70096 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • AAS47553.1
 70095 - 70571 (+) putative RNA methylase
  • Other enzymatic
Sequence-based prediction
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  • AAS47554.1
 72053 - 72415 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • AAS47555.1
 72966 - 74459 (+) putative aldehyde dehydrogenase
  • Other enzymatic
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
pedC
+
pedD 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: pedC, pedD
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
pedH
Module ?
Specificity: arginine
Evidence for specificity:
pedF
Module ?
Specificity: glycine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Corrected duplicated gene annotation
  • Removed duplicate gene name
  • Added NRP substrate specificities
  • Fixed biosynthetic classes
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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