LOCUS       BGC0001151             19936 bp    DNA     linear   BCT 18-APR-2012
DEFINITION  Streptomyces antibioticus strain Tu 1718 clone 6J11 genomic
            sequence.
ACCESSION   BGC0001151
VERSION     BGC0001151
KEYWORDS    .
SOURCE      Streptomyces antibioticus
  ORGANISM  Streptomyces antibioticus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 23:28:55
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..19936
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[8510:12050]"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8511..12050
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
     cand_cluster    1..19936
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(BLS or CAS or tabtoxin)"
                     /kind="single"
                     /product="blactam"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..19936
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001151"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19936
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="blactam"
                     /region_number="1"
                     /rules="(BLS or CAS or tabtoxin)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..2532
                     /gene="psr"
     CDS             1..2532
                     /codon_start=1
                     /gene="psr"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     259.4; E-value: 1.3e-78)"
                     /gene_kind="regulatory"
                     /product="SanG"
                     /protein_id="AFH74309.1"
                     /transl_table=11
                     /translation="MLPVDNVVSNAVDPLTPSIEAFGHMRVRIGQREVALGSPRQRALF
                     AVLLISVGKTVPVHDIINCIWGPAPPSAVTGTLHSYVSRLRKAISDVLTTRHEILVSMR
                     HAAPGYQLDISPEGTDVHRFEQLVESGRTHFSAGDLPEARRDLDRAMALWTDTPYSELA
                     SYDFAALEASRLDQLRLQALQIWADACLHLGAHDEVVRELSKEIRRNPMLERLGSQLML
                     AQYHSGSPAEALMTYERIRSHVSAELGADTSKELQEIHQSILRQDLPVVPPRPLLESRP
                     VVLTAPSVRTNPVQANPVQAGPVQATPVQADPVHARPVGTSPAVPAPVSADVPVRPRPR
                     PRPAGAVPPIGSLIGREREMEQLRSMVTGDFPRRTVLITGEQGIGKTRLLKELARELGP
                     DRPEVIWAHCTGRGSRRTWGQVVQKVLRVRGNALHGCSSGAGPGTPPPHECHRPSDGDL
                     GQAHLDDTAYQQAVVHLLLTAAADEPLVIVLEDLHLADTHTLELLRLLTMEGQEAHLVV
                     LATVQEHSLARLPDLRRATADLLRTDGVGNLHLTALSPVQAHALIHELHEAPVPWHHVS
                     FLHRATGGNPYLLTALARHEDLTNVHKDLLASLSFDVRTVLLSRLAEHPLEAIAVLEVC
                     AVMGPVIDHYLLTSVLDQRGMTGTVKEALDTGLLTRNPADPGDLRFSQYLIRDYLLAGL
                     DAVLKAQLHLSIAQALAERTAHSSRSVVGPDLTHHCTQAAVALDPHEAVQPMIALADRA
                     EALKRWGEVVMWLAQASAVLRSRPLRGEAVHADRALQERLARVRATCFRCPTSRPCPKA
                     ENSNAILRRNLPGACYTPRPATMITAARQET"
     misc_feature    4..6
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2714..4117
                     /gene="atr"
     CDS             2714..4117
                     /NRPS_PKS="Domain: Aminotran_3 (71-403). E-value: 4.1e-107.
                     Score: 349.9. Matches aSDomain:
                     nrpspksdomains_atr_Aminotran_3.1"
                     /codon_start=1
                     /gene="atr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 429.1;
                     E-value: 2.9e-130)"
                     /gene_kind="biosynthetic-additional"
                     /product="4-aminobutyrate aminotransferase"
                     /protein_id="AFH74310.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.2e-123, bitscore:
                     402.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPVPSPWQPAARTDRRNPLTTSMPTVRPDRRHLASGIPGPLSSA
                     FEARRRAAVARGVGSAVPVYAAAADPGLLHDIDGNAFIDLASGLGVTAVGNAAPDVVAA
                     VREQVGLFTHTCFLTSPYSGYVEVCEELSNLTPGRHEKRSVLLSTGAEAVENAVKVARA
                     ATGRSAIVVLDHAYHGRTNLALGMTAKNAPFKQGFGPFAPDIHRVPTSYPYRDPQGMTG
                     EEAAQRALEALERQVGGENVAAIVVEPVQGEGGFIVPAPGFLPALQSWCREHGALFVAD
                     EIQSGFCRTGAWFASEHEDLVPDLVITAKALAGGLPLSAVTGRAEIMDAVQLGGFGGTY
                     GGNPVACAAALASIEVMRTGHLVDSARAIGDTLFTRLRALAVRHPAIGEVRGRGAMVGV
                     EIVEPGGRRPGAEAAQRLAKACQQRGVLLLTAGTHSNVLRFLPPLVIPPALLNDAVDVI
                     EECCDELLA"
     aSDomain        2927..3922
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_atr_Aminotran_3.1"
                     /evalue="4.10E-107"
                     /label="atr_Aminotran_3.1"
                     /locus_tag="atr"
                     /protein_end="403"
                     /protein_start="71"
                     /score="349.9"
                     /tool="antismash"
                     /translation="GLLHDIDGNAFIDLASGLGVTAVGNAAPDVVAAVREQVGLFTHTC
                     FLTSPYSGYVEVCEELSNLTPGRHEKRSVLLSTGAEAVENAVKVARAATGRSAIVVLDH
                     AYHGRTNLALGMTAKNAPFKQGFGPFAPDIHRVPTSYPYRDPQGMTGEEAAQRALEALE
                     RQVGGENVAAIVVEPVQGEGGFIVPAPGFLPALQSWCREHGALFVADEIQSGFCRTGAW
                     FASEHEDLVPDLVITAKALAGGLPLSAVTGRAEIMDAVQLGGFGGTYGGNPVACAAALA
                     SIEVMRTGHLVDSARAIGDTLFTRLRALAVRHPAIGEVRGRGAMVGVEIVE"
     gene            4098..5120
                     /gene="akr"
     CDS             4098..5120
                     /codon_start=1
                     /gene="akr"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     295.3; E-value: 7.9e-90)"
                     /gene_kind="biosynthetic-additional"
                     /product="Cvm1-like aldo/keto reductase"
                     /protein_id="AFH74311.1"
                     /transl_table=11
                     /translation="MTNSSHEAPRAGAPLPVSRLGELKVPAQGLGCLSMSSFYGLSDRD
                     EAIATVHRAVDRGVTLIDTADVQGLGEGERLVGAAIAGRRERVLIATKVGLERSASGEF
                     LGVRGDRTYIRDRCEGSLRRLGVDRLDLYTKHWAAPGERIEEAMEAMAELVAEGKVRHV
                     CLSEVSADTIRRAHAVHPVTAVQSEWSLWTRGIEREVLATCRELGIGIIANCPLGRGFL
                     TGGVTSAAELRPEDFRHTLPRFTEGNIGRNRALVERLRSVARRLEITPAQLALAWLHHQ
                     GDDVVPIPGTARRDHLDENLAAAFISLTPQDLRETEAAVAPGAVHGERYGSFLMELVDN
                     "
     gene            complement(5224..6474)
                     /gene="hmt"
     CDS             complement(5224..6474)
                     /codon_start=1
                     /gene="hmt"
                     /product="OrfA-like hydroxymethyltransferase"
                     /protein_id="AFH74312.1"
                     /transl_table=11
                     /translation="MKESPPVPPRPSQECPMDVLEVLRRKPSLNLFPIENRLSPRAREA
                     LASDANNRYPYVEGPVSHYGDVMGLGEVYDYCVDLAKEFYGARHGCVHFLSGLHTMYTV
                     ITALVPAGSRVMVLHPEDGGHYATITICEGLGHSVSRLPFDRKTLLIDYEELAVQLAES
                     PVDVIYLDASSMLRLPDARLLRQAAPDTLLCLDASHLMGILPAAPKTLVFDGGFDTVSG
                     STHKTLPGPQKGLMVTNDATLAGKVMERIPFTASSSHAGNVGALAITLEELMPCRVEHA
                     QQIIANARELAAQLAQRGFSVAGEEFGWTETHQVWAYIPEEQGPHGWGRVLTRANVRST
                     TVPLPSSDGLPALRLGTQELTRSGMKEAEMTEVADILERLLLRGEAPEQVIGTVRDLAL
                     RFPGVSWIGSADTTSVD"
     gene            6793..8508
                     /gene="ceaS3"
     CDS             6793..8508
                     /codon_start=1
                     /gene="ceaS3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 501.4;
                     E-value: 5.5e-152)"
                     /gene_kind="biosynthetic-additional"
                     /product="carboxyethylarginine synthase 3"
                     /protein_id="AFH74297.1"
                     /transl_table=11
                     /translation="MSRVSTSPSTSPTTAHALLQRLRDHGVRTVFGVVGREAASILFDE
                     AEGIDFVLTRHEFTAGVAADVVARITGRPQACWATLGPGMTNLSTGVATSILDRSPVIA
                     LAAQSESHDIFPNDTHQCLDSVSVMEPMTKYAVELQRPDDIVDLVDSAVSAAMTEPVGP
                     SFISLPVDLLGSEIDASVEHPAAKMPSKPIGAFEEGWEKEADKAAELLRSAQHPVLVVG
                     AAAIRSGAVPTIRALAERLRIPVITTYIAKGVLPQGHELSYGAVTGYMDGILSFPALET
                     LFGPADLILTVGYDYAEDLRPSMWQRGGAKKTVRVSPTANPIPRVYRPDLDVVTDVQAF
                     MTHLDERTAGFDAKTPHDITPLRERISEFLADPAQYDDGMRVHQVIDCMNTVMSETAES
                     GEGTIVSDIGFFRHYGVLFARADQPFGFLTSAGCSSFGYGLPAAMGAQIARPGQPTMLI
                     AGDGGFHSNSADLETIARLNLPIVTVVVNNDTNGLIELYQNIGHHRSHDPAVKFGGVDF
                     VGLARANGIEAIKAGTREELLAALRKGAGLGRPFLVEVPVNYDFQAGGFGALSI"
     gene            8511..10034
                     /gene="bls3"
     CDS             8511..10034
                     /codon_start=1
                     /gene="bls3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: BLS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 339.3; E-value: 7.4e-103)"
                     /gene_kind="biosynthetic"
                     /product="beta-lactam synthetase 3"
                     /protein_id="AFH74298.1"
                     /sec_met_domain="BLS (E-value: 5.5e-159, bitscore: 519.2,
                     seeds: 11, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 3.4e-29, bitscore:
                     92.4, seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 1.1e-15, bitscore:
                     47.6, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGSLPAAVGFLAEIRPDGGPPLRPDFASLGGRTELAEDTGGQSL
                     RAVLLHSGAPDGAHARDRGRTVVFAGELYNRDELARLLPAGLSPDSDAALVLALFGSYD
                     VHAFRLLNGRFAALVAAGERVVLATDHAGSVPLYASVAAGRVLAATEAKALRAATGGQP
                     LPARPVRRLTGVHQVPAGTVLDVRVSTAECVAHRTWAPPLARRIVSENEAVETVRQVLD
                     RAVRVRTGPDTPLVVLSGGIDSSSVAALSAHRSAGRIETVSMGTEEADEFPQARVVATH
                     LGSAHREITVSMADLLRQLPHAVWAAESLDPDIVEYLLPLTALYLRLEGSGRRILTGYG
                     ADIPLGGMHREDRLPQLDTAVCHDMATFDGLNEMTPVLSQISGHWSTHPYWDRDVLDVL
                     VALEAGLKRRYGQDKWVLRAAMGDLLPHEVVIRPKLGVHEGSGVTAAFTRLLTDAGVPD
                     QQVHRAKELVVQELFDHVVVAGRHPDEVKTGEVVEQVAERLASGATAAL"
     gene            10117..11079
                     /gene="pah3"
     CDS             10117..11079
                     /codon_start=1
                     /gene="pah3"
                     /product="proclavaminate amidinohydrolase 3"
                     /protein_id="AFH74299.1"
                     /transl_table=11
                     /translation="MNDPGQRLDINVSPRYAQIPTFMRLPHDPSPQGKDVVVIGAPYDG
                     GTSYRPGARFGPRAVRNESGLIHGVGIDRGPGTFDLIDCVDAGDIDLTPFNMHIAMDTA
                     QRRLSELLADNAAFLMIGGDHSLTLAALRAVAAKHGPVAVLHLDAHSDTNPAFYGGEYH
                     HGTPFRHAIDEKLVDPQRMLQIGIRGHNPQPDSLDYARGHGVRIMTSDEFCGLGPQAAT
                     ALVREHLGDAPVYVSVDVDVVDPAFAPGTGTPAPGGPSSREVLALLRGVGDLRPVGFDV
                     MEVSPLYDHGGITSVLATEIGAELLYQYARSTTRERQSS"
     gene            11076..12050
                     /gene="cas3"
     CDS             11076..12050
                     /codon_start=1
                     /gene="cas3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: CAS"
                     /gene_kind="biosynthetic"
                     /product="clavaminate synthase 3"
                     /protein_id="AFH74300.1"
                     /sec_met_domain="CAS (E-value: 1.4e-189, bitscore: 619.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVVDCSEYSADLLALASRLPRIPRQDLYGFLDAAHEAAGDLPEG
                     LGTALDRFNADGSHDGYLMLRGLPVEDDDDLPATPTSTPAPVDRPLQNMEAMLAVIGRR
                     LGLHTGYRELRSGTVYHDVYPSPGAHHLSSETSETLLEFHTEMAYHVLQPNYVMLACSR
                     ADHERKAATLVGSIRKALPLIPEEVRARLFDRPMPCCVDVAFRGGVENPGAIANVKPLY
                     GDPRDPFLGYDRELLAPREPDDVEAVAVLSKALDEVSEAVRLTPGDLLVVDNFRTTHAR
                     TPFSPRWDGKDRWLHRVYIRTDRNDQLSGGERAGDVVDFSPRR"
     gene            12190..13374
                     /gene="oat3"
     CDS             12190..13374
                     /codon_start=1
                     /gene="oat3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1220:bifunctional ornithine (Score: 504.3; E-value:
                     2.9e-153)"
                     /gene_kind="biosynthetic-additional"
                     /product="ornithine acetyltransferase 3"
                     /protein_id="AFH74301.1"
                     /transl_table=11
                     /translation="MTDSAAFDPRGFAVHTAPVGLADDGRDDFTVLTSTEPAVVSAVFT
                     RSLFAGPSVVLSRAAVRDRSARGVVVLARNANVATGSEGERNAREVRDTVARAVGVAED
                     ELLIASTGVIGRQYPMESIRDHVKTLTAPEPGHDGFQRAARAIMTTDTRPKVARARVGD
                     AVITGIAKGVGMMEPDMATLLTFFATDARLDPEEQDRIFRRVMDRTFNAVSIDTDTSTS
                     DTAALFANGLAGDVDPAEFENALYEVALTLVKDIASDGEGASKLIEVQVSGARDTAQAK
                     RVGKAVVNSPLVKTAVHGGDPNWGRVAMAIGKCSDDTDIDQDKVAIRFGEVTVYPPGRP
                     GAQDEDAVRAAVADEMRGDHVVIGIDLAVADGAFTVYGCDLTEGYVRLNADYST"
     gene            complement(13451..14095)
                     /gene="oxr"
     CDS             complement(13451..14095)
                     /codon_start=1
                     /gene="oxr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /product="oxidoreductase"
                     /protein_id="AFH74302.1"
                     /sec_met_domain="PF00881 (E-value: 1.7e-23, bitscore: 73.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALLNLNPDELLTTTRSVRKRLDLTRPVPLELVKECIEIALQAPT
                     GSNRQTWHWLVITDPDQRAAIGEFYRRAVDTYLSSEGACGTLYPEDPQRHAVQKRVGDS
                     VAYLGERMSEVPVLVIPCLDANEAPEYNEAGMWGSIVQAGWSYMLAARARRLGTAWTTL
                     HLMYEKEIAELLKIPDGVVQAALIPTAYSIGTDFKPARRQPLDQVLHLDSW"
     gene            complement(14197..15414)
                     /gene="trn"
     CDS             complement(14197..15414)
                     /codon_start=1
                     /gene="trn"
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 292.7; E-value: 5e-89)"
                     /gene_kind="transport"
                     /product="major facilitator superfamily MFS_1 protein"
                     /protein_id="AFH74303.1"
                     /transl_table=11
                     /translation="MKRRSAQQGGGLPRTFWWLWGGTLITSAGGFVVPYLAIYLTSVRD
                     YSVSFTGLVMTVFGIGSGLAAFVGGILADRLGRRAVLLWSEALSVIGMAGLGFADTKAL
                     VVAGTLVVGVGLNATRPARAAAVADLVSEEDRPRAYSLLYWATNLGFSVAAVSAGAAAD
                     QSFALLFLVNAIANTVAGAVAYRFVPETRPESARPHRERAGGRGSAVLRDRPFTVLLGS
                     VLLLGLMFQQPLVALPLTMTEQGRSPAEYGLVMMVNGLVIAAFQLPLSRLGDRFRPEHA
                     LAVATLFSGIGFGLTGVVQSLPGYAATVVLWSLGEIVVLPRCMTLVALLAPAHAQGSYQ
                     GRLLLVWSSAVALAPLLSSQLIEASGTTAVWVACTALGLLAAALHLVLGRLRRKPVHEE
                     AEPLPS"
     gene            complement(15452..16720)
                     /gene="lig"
     CDS             complement(15452..16720)
                     /codon_start=1
                     /gene="lig"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 73.6; E-value: 2.9e-22)"
                     /gene_kind="biosynthetic-additional"
                     /product="ligase"
                     /protein_id="AFH74304.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.6e-10,
                     bitscore: 30.7, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.7e-08, bitscore:
                     24.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQRPKIVLVGQLVTAPWVFEAAQRVGVDVVLIPWTGTDLDVARR
                     AAAVTEVLPLDVETDPDGALAALVERFRSDPFDGIMAGNELVVPFTARAARTLGLPGLS
                     EQGAAVVRDKRSMRQRLAEAGLAVPGLAALERKEDWADALTLRFPVVVKPARGFSSLGV
                     IRVDDKEQLEQAVSSTWELVEARSHKPAETGGGSGVLVEEYLDGPEISAESLVHRGRVR
                     VCAVSWKGELTGPYFEETTLRAPARLPAEILAAVEAEVVAAHHAFGVDEGATHTELRLV
                     GGVRPVLLEMGARIGGGGFMHHLVRGSSGIDFAAETVRIHLGQEPRCWSQEPVAAGHAA
                     AYLVPVGTGGTFRRIRGLDEVRADPRVDHVAQAVAPGAVLRPYPAWTAYPAIVLSHHAS
                     DEEAVQFREHLERTLHIEYEEQG"
     gene            complement(16885..17799)
                     /gene="pah4"
     CDS             complement(16885..17799)
                     /codon_start=1
                     /gene="pah4"
                     /product="proclavaminate amidinohydrolase 4"
                     /protein_id="AFH74305.1"
                     /transl_table=11
                     /translation="MEQNYAQNLTFMGIPRHASPRGRDLVVIGAPYDAGTSHRPGTQLG
                     PRAIRQGSDLLLGTGFGRGPAASDIIDCADAGDIDLGPCDARTVLEVAQRSLQSLLEHN
                     DAFLMLGGDHALTLAALRAVVRRHGMVAAVHLDAHCDTQPDVYGTEYHHGTTFRQAIEE
                     RLIDPRRLVQIGVRGPRVEPDPQDGARRHGTRVITAADMVAVGPSATARLIREIIGDVP
                     VYVSVGMDVVDPRFAPGTAAPAPDGPSSLDVLEVLRCVGDLEPVGFDVMGVCPPYDHGG
                     VTSLLATEVGAELLYQFARSRCR"
     gene            complement(18566..19936)
                     /gene="ctr"
     CDS             complement(18566..19936)
                     /codon_start=1
                     /gene="ctr"
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 68; E-value: 2.2e-20)"
                     /gene_kind="other"
                     /product="transcriptional regulator"
                     /protein_id="AFH74306.1"
                     /transl_table=11
                     /translation="MSRRPESEHTAVTADVGARIRRLRRAAGMSQADLAGDGLSPSYIS
                     LVEAGKRSPSPEVLAQLAARLHCDVAELGGEPAVSVTGLAVELSFAETALNAGDAQAAR
                     EAYLAVRAKVGKSSQPESWYKATYGLARALENLGELEEAVVHLEELHATAVAQPDSVPR
                     LTTVIALCRCYRELGDLSHAIEVAEDTLAELDELGLAPTVVGVELLSTLVGVHMERGDL
                     HRASYLAGKAIEQADSVTDARARGAAYWNASVVLHRNGKTADALVLIEKALACYAEGED
                     TRALARLRNAYAMLLLESGSTEPEPVREMLQQSYASLREVGSSVDVAYCLSALARMELR
                     LGDPLSAVRNAEEALELLGTQHRLQSARNYLVLAAAHLAMGRTEACQEAYERGALMLEA
                     SEANRQAGFAWAELAEIFRLCGEEARAVWAYRQSVRCLGHREAFSEDALEQSPTTGG"
ORIGIN
        1 gtgttaccgg tagataacgt tgtcagcaat gccgtcgatc ccctcacacc ctccattgag
       61 gctttcggcc atatgagagt ccgcatcgga cagcgtgaag tcgccctggg ctcccctcgg
      121 cagcgtgccc tgttcgcggt tctgctcatc agcgtcggca agaccgtgcc cgtacacgac
      181 atcatcaatt gcatatgggg gccggctccc ccatcggccg tgaccggcac gctccactcc
      241 tatgtctccc ggctccgcaa agccatctcc gatgtcctga cgacacggca cgagatcctc
      301 gtcagcatgc gtcacgcggc tcccggatat cagctggaca tctcaccgga aggcaccgac
      361 gtccaccggt tcgaacagct cgtggagtcc ggccgcaccc acttctccgc cggagacctg
      421 cccgaggcac gcagggacct cgatcgggcg atggcgctgt ggacggacac gccctacagc
      481 gaactggcgt cgtacgactt cgcggctctg gaagcgagcc gtctggacca actgcgcctc
      541 caggccctgc agatctgggc cgacgcgtgc ctgcacctcg gggcgcacga cgaggtggtc
      601 cgggaactga gcaaggagat ccgccgcaac cccatgctgg agcggctggg cagccagttg
      661 atgctggcgc agtaccacag tggttcaccc gcggaagccc tcatgacgta cgagcggatc
      721 cgctcccatg tctccgccga actcggcgcc gacaccagca aggaactcca ggagatccac
      781 cagtcgatcc tgcgccagga cctgccggtc gtaccacccc ggcccctgct cgaaagccgg
      841 cctgtggtac tcaccgcacc ttcggtccgg acgaatccgg tccaggcgaa tccggttcag
      901 gcaggtcccg ttcaggcaac tccggttcag gcggatccgg tccacgcgcg tccggtcggc
      961 acgtcccccg cggtcccggc gcccgtctcc gcggacgtcc cggtccgacc ccggccccgg
     1021 ccacggccgg ccggagcggt acccccgatc ggcagcctca tcgggcggga gcgcgagatg
     1081 gagcaactgc gctcgatggt gacgggcgac ttcccccggc ggaccgtgct gatcaccggt
     1141 gaacagggaa tcggcaagac ccgtctgctc aaggaactgg cacgcgaact cgggccggac
     1201 aggccggagg tgatctgggc gcactgcacc ggccgtggca gccgccggac ttggggccag
     1261 gtcgttcaga aagtgctccg ggtgcgcggg aacgcgctgc acggctgttc gtcgggcgcc
     1321 gggcccggga cgcctccccc gcacgagtgc caccggccct cggacggcga cctcgggcag
     1381 gcgcacctcg acgacacggc ctaccagcaa gccgtggtgc atctgctgct caccgccgcg
     1441 gcggacgagc cgctggtgat cgtgctggag gacctccacc tggccgacac ccacaccctc
     1501 gaactactgc gtctgctcac catggagggc caggaagccc acctcgtggt cctcgcgacc
     1561 gtgcaggaac actccctcgc tcgccttccc gatctgcggc gcgcgacggc cgacctgctg
     1621 cgcacggacg gcgtggggaa cctccatctg accgcgctct ccccggtcca ggcgcacgcg
     1681 ctgatccacg aactgcatga agcgcccgtc ccctggcacc acgtgtcgtt cctccaccgg
     1741 gccaccgggg gcaacccgta cctgctcacc gcgctcgcca gacacgagga tctgaccaac
     1801 gtccacaagg acctcctcgc gtccctctcg ttcgacgtca ggacggtgct gctcagccgg
     1861 ctcgccgagc atccgctcga ggcgatcgcc gtgctggagg tgtgcgcggt catggggccg
     1921 gtcatcgacc actacctgct cacctctgtc ctcgaccagc ggggtatgac cggtaccgtc
     1981 aaggaagcac tggacaccgg tctcctcacc cgcaaccccg ccgatcccgg cgatctgcgg
     2041 ttcagccagt acctgatacg ggactatctg ctcgcgggac tggacgccgt gctgaaggca
     2101 cagttgcacc tgagcatcgc ccaggcactg gccgagcgga ccgcgcacag ttcccggtcg
     2161 gtcgtcggcc ccgacctgac gcatcactgc acgcaggccg ccgtggccct ggatccgcat
     2221 gaggcggtgc agccgatgat cgcactcgcc gaccgggccg aggccctcaa gcgttggggc
     2281 gaggtggtga tgtggctggc gcaggcctcc gccgtcctcc gctcccgtcc gctgcgcggt
     2341 gaggccgtgc atgccgaccg cgcactgcag gaacggctgg cccgcgtgag ggccacctgt
     2401 ttccgctgcc cgaccagcag gccgtgtccg aaggcggaga acagcaacgc tatcctccgg
     2461 cggaatctgc cgggcgcgtg ctacacgccc cggcccgcga cgatgatcac agcggcccgg
     2521 caggaaactt gacgtctttc ttgagttttt cttgacacgt gccgtcaccc gccctgcgag
     2581 gcgaagtccg gacccgtcac gcatgacttc cggccttcgc cgcgcacccc tccccaggaa
     2641 ttcttgacgc attcttgcat tcctcgaagg cggcgcgatc agtggtgttg ccgggccttt
     2701 cgcgagcgct agcgtgaatc ccgtcccgtc gccgtggcag cccgcagctc gaacggacag
     2761 gagaaatcct ttgaccactt ccatgcccac cgtacggccg gaccggcgcc accttgcgtc
     2821 cgggattccc ggtccccttt ccagcgcctt cgaggcacgg cgtcgcgccg cggtcgccag
     2881 gggcgtcggc agcgccgttc ccgtgtacgc ggcagcggcg gatcccggtc tgctgcacga
     2941 catagacggg aacgcgttca tcgacctcgc gtccggtctc ggtgtgacgg cggtgggcaa
     3001 cgcggccccg gacgtcgtcg cggcggtccg cgagcaagtg gggctgttca cccacacctg
     3061 ttttctgacc agcccctact ccgggtacgt ggaggtgtgc gaggagctgt cgaacctcac
     3121 gcccggccgt catgagaagc gcagcgttct gctgagcacg ggtgccgaag cggtggagaa
     3181 cgccgtcaag gtcgcccggg ccgccaccgg ccgcagcgcc atcgtggtgc tggaccacgc
     3241 ctaccacgga cgcaccaacc tcgctctggg catgaccgcg aagaacgcgc cgttcaagca
     3301 gggcttcggc ccgttcgccc ccgacatcca ccgggtcccc acctcgtacc cgtaccgcga
     3361 cccgcagggc atgaccggcg aggaagcggc ccagcgcgcc cttgaggctc tggaacgcca
     3421 ggtcggcggg gagaacgtgg ccgccatcgt cgtcgaaccg gtgcagggcg agggcgggtt
     3481 catcgtgccg gctcccggtt tcctgcccgc gctccagagc tggtgccggg agcacggagc
     3541 cctgttcgtc gccgacgaga tccagagcgg gttctgccgt accggcgcct ggttcgccag
     3601 cgagcacgag gacctcgtac cggacctggt gatcaccgcc aaggcactgg ccggcgggct
     3661 gcccctgtcc gccgtgaccg ggcgggccga gatcatggac gcggtgcaac tcggtggctt
     3721 cggcggtacc tacggtggca acccggtcgc ctgcgccgcc gctctggcgt ccatcgaggt
     3781 gatgcgcacc gggcacctcg tcgacagcgc acgtgcgatc ggcgacaccc tgttcacccg
     3841 cctgcgcgcc ctcgccgtgc ggcatccggc catcggcgag gtccgggggc gcggggcgat
     3901 ggtgggtgtc gagatcgtcg agcccggcgg caggcggccc ggcgccgagg cggcccagcg
     3961 gctggccaag gcctgtcagc agcgcggggt gctgctcctg accgccggga cccacagcaa
     4021 cgtcctgcgg ttcctgcctc ctctcgtcat tcctccggcc ctgctgaacg acgcggtcga
     4081 cgtcatcgag gagtgctgtg acgaactcct cgcatgaggc accccgggcc ggcgctccgc
     4141 tgccggtgag cagactggga gagctgaagg tcccggccca gggactgggc tgtctgagca
     4201 tgagctcctt ctacgggctc tcggaccgcg acgaggcgat cgccaccgtg caccgcgcgg
     4261 tggaccgggg cgtgaccctg atcgacacgg ccgacgtgca gggcctcgga gagggcgagc
     4321 ggctggtcgg cgcggccatc gccgggcgac gcgagcgcgt gctgatcgcc acgaaggtcg
     4381 gtctggagcg ttcggcaagc ggcgagttcc tcggtgtgcg gggcgaccgg acatacatcc
     4441 gtgaccggtg cgagggctcg ctgcgccggc tgggcgtgga ccggctggac ctgtacacca
     4501 agcactgggc cgctcccggc gagcggatcg aggaggccat ggaggccatg gccgaactcg
     4561 tggccgaggg caaggtgcgc catgtgtgcc tgtccgaggt ctccgccgac acgatccgca
     4621 gggcccacgc ggtgcacccc gtcaccgcgg tccagagtga atggtccctg tggacccgcg
     4681 gcatcgagcg ggaggtgctg gccacctgcc gggagctggg catcggcatc atcgccaact
     4741 gcccgctggg ccgcgggttc ctcaccggtg gcgtgacctc ggcggcggag ttgcggccgg
     4801 aggacttccg gcacacgctg ccccgcttca ccgagggcaa catcgggcgc aaccgggctc
     4861 tcgtcgagag gctgcggtcc gtcgcacgcc ggctggagat cactcccgcc cagctcgcgc
     4921 tggcctggct ccaccaccag ggcgacgacg tcgtccccat tcccggcacg gctcgccggg
     4981 accatctcga cgagaacctg gccgcggcct tcatctccct caccccgcag gacctacggg
     5041 agacggaggc ggcggtggct cccggcgcgg tgcacggtga acgctacggc tcgttcctca
     5101 tggagctggt ggacaactga acccgggtcc gcacaggcct cgcgggccgc acaagggcgc
     5161 cgcttcccgt cacgggaagc ggcgcccttg tcgctggtgg gttcgtcgta cgacccgccg
     5221 gggtcaatcg acggacgtgg tgtccgcgga acctatccag gacacgcccg ggaaccggag
     5281 cgcgaggtcg cggacggtgc cgatcacctg ctcgggcgcc tcaccgcgca gcaggagccg
     5341 ctccaggatg tcggccacct cggtcatctc ggcctccttc atgccgctgc gggtgagctc
     5401 ctgcgtgccc agccgcaggg ccggcaagcc gtcgctgctg ggcaggggaa ccgtcgtact
     5461 gcgtacgttc gcccgggtca gcaccctgcc ccagccgtgc ggcccctgct cctcggggat
     5521 gtacgcccag acctggtgcg tctcggtcca gccgaactcc tcgcccgcca cgctgaaccc
     5581 gcgctgcgcc aactgggctg ccagctcacg ggcgttggcg atgatctgct gcgcgtgctc
     5641 cacccggcag ggcatcagct cctccagggt gatcgcgagt gcgccgacgt tcccggcgtg
     5701 cgagctggag gcggtgaacg ggatccgctc catgaccttc ccggccagcg tcgcgtcgtt
     5761 cgtgaccatc aggcccttct gcgggccggg cagtgtcttg tgggtgctgc ccgagacggt
     5821 gtcgaacccg ccgtcgaaga ccagggtctt gggagcggcc ggcaggatgc ccatgaggtg
     5881 ggaggcgtcc aggcacagga gggtgtccgg tgccgcctgg cgcagcagcc gggcgtcggg
     5941 caggcgcagc atgctggagg cgtcgaggta gatgacgtcg acgggggact ccgcgagctg
     6001 gacggcgagt tcctcgtagt cgatcagcag ggtcttcctg tcgaacggca ggcgtgagac
     6061 ggagtgtccc aggccctcgc agatcgtgat ggtggcgtag tggccgccgt cctctgggtg
     6121 caggaccatg acgcggctgc cggctggcac cagggcggtg atgacggtgt acatggtgtg
     6181 caggccggac aggaagtgca cgcacccgtg gcgggcgccg tagaactcct tggccaggtc
     6241 gacgcagtag tcgtacacct cccccagccc catgacgtcc ccgtagtgcg agaccgggcc
     6301 ctcgacgtag gggtagcggt tgttcgcgtc gctggccagt gcctcccggg ccctcgggga
     6361 aagcctgttc tcgatgggga acaagttgag gctgggcttg cgccgcagga cttccagtac
     6421 gtccatggga cactcctgtg atggccgggg cgggacaggc ggagattctt tcaacgcgcc
     6481 cttgccgccc ccttgtcgtc cgctggcgaa gagcggcggc cgaaatgaag ccccctgcgg
     6541 ccgaaagctt ttgacgaggc attggcacgg ctgtgggccg ccattgacga ggggaaagcg
     6601 tgggtcaatg cggaccgcat tcgcggcttt ccggccggag ccgccttttc cgaagggtca
     6661 caagggatcg tccatttcgc tgcaagaggc gttggacagc atgtgccatg tccggccggc
     6721 cttttggccc gtgccgcagg tacgcctttc accggcccgg acgcggagac ccttccccac
     6781 cgaggagctg ccatgtcacg cgtgtccacc agcccttcca cttcccccac caccgcacac
     6841 gccctgctcc agcgcctccg tgatcacggc gtgcgcaccg tgttcggtgt ggtcggccgg
     6901 gaggcggcgt cgatcctctt cgacgaggcg gagggcatcg acttcgtgct gacccggcac
     6961 gagttcaccg ccggggtcgc cgccgacgtg gtggcccgca tcaccggccg gccgcaggca
     7021 tgctgggcca ccctgggccc gggtatgacc aacctgtcca ccggcgtcgc cacctccata
     7081 ctcgaccggt cgcccgtcat cgcgctggcg gcccagtcgg agtcgcacga catcttcccc
     7141 aacgacaccc accagtgcct ggactcggtg tcggtgatgg agccgatgac caagtacgcg
     7201 gtggaacttc agcggccgga cgacatcgtc gacctggtgg actccgcggt gtcggccgcg
     7261 atgaccgagc cggtcggccc cagcttcatc tccctgccgg tcgacctgct cggcagcgag
     7321 atcgacgcct ccgtcgagca ccccgcggcg aagatgccgt ccaagcccat cggtgccttc
     7381 gaggagggct gggagaagga ggcggacaag gccgccgaac tcctccgctc ggcgcagcac
     7441 ccggtgctgg tcgtcggtgc cgccgcgatc cgttccggcg cggtgcccac catccgcgcc
     7501 ctggccgagc gcctgcgcat ccccgtcatc accacctaca tcgccaaggg cgtcctgccc
     7561 cagggccacg agctgagcta cggcgcggtc accggctaca tggacggcat cctgtccttc
     7621 ccggccctgg agaccctgtt cggcccggcg gacctcatcc tgacggtcgg gtacgactac
     7681 gccgaggacc tgcggccgtc gatgtggcag cgcggcggcg cgaagaagac cgtgcgggtg
     7741 tcgccgacgg ccaacccgat cccgcgggtc taccgtcccg acctcgacgt cgtgaccgac
     7801 gtgcaggcgt tcatgacgca cctggacgag cggacggccg gattcgacgc gaagaccccg
     7861 cacgacatca ccccgctgcg cgagcggatc agcgagttcc tggccgaccc ggcccagtac
     7921 gacgacggca tgcgcgtgca ccaggtcatc gactgcatga acaccgtcat gtcggagacc
     7981 gcggagtccg gcgagggcac gatcgtctcc gacatcggtt tcttccggca ctacggggtc
     8041 ctcttcgccc gtgccgacca gccgttcggc ttcctcacct cggccggctg ctccagcttc
     8101 ggatacggtc tgcccgcggc gatgggcgcc cagatcgccc ggcccggaca gcccaccatg
     8161 ctcatcgcgg gcgacggcgg cttccactcc aacagcgccg acctggagac catcgcccgg
     8221 ctcaacctgc cgatcgtcac cgtcgtcgtc aacaacgaca ccaacggcct gatcgagctg
     8281 taccagaaca tcggccacca ccgctcccac gacccggcgg tgaagttcgg cggcgtcgac
     8341 ttcgtcgggc tcgcccgcgc caacggcatc gaggcgatca aggccggcac gcgcgaggag
     8401 ctcctggccg cgctgcgcaa gggagcggga ctgggccggc cgttcctggt cgaggtgccg
     8461 gtcaactacg acttccaggc gggcggcttc ggcgccctga gcatctgatc atggcgggat
     8521 ccctcccggc agccgtcggt ttcctcgccg agatccgccc ggacggcggc ccacccctgc
     8581 ggcccgactt cgcgtccctc ggcgggcgca ccgaactggc cgaggacacc ggcggtcaga
     8641 gtctgcgagc cgtgctgctg cactcgggcg cgccggacgg cgcccacgcc cgtgaccggg
     8701 gccggacggt ggtcttcgcc ggcgagctgt acaaccggga cgaacttgcc cggctgctgc
     8761 ccgccgggct gtcaccggac agcgacgccg ccctggtgct ggccctcttc ggcagctacg
     8821 acgtgcacgc cttccggctg ctcaacggcc gtttcgcggc gctggtcgcg gccggggaac
     8881 gcgtcgtgct cgccacggac cacgcgggat ccgtgcccct gtacgcgtcc gtcgccgccg
     8941 gccgggtgct ggcggcgacc gaggcgaagg cgctgcgcgc agccacgggc gggcagccgc
     9001 tgcccgcccg cccggtgcgg cgactgacag gtgtccatca ggtgcccgcg gggaccgtcc
     9061 tggacgtacg ggtgagcacc gcggagtgtg tcgcccaccg gacctgggcg cccccgctgg
     9121 cccggcggat cgtctccgag aacgaagccg tcgagacagt ccggcaggtc ctggaccgtg
     9181 ccgtgcgggt gcggacggga ccggacaccc cgctcgtggt gctctccggg gggatcgact
     9241 cctccagtgt cgcggcgctg tccgcccacc gttcggcggg acggatcgag acggtgtcca
     9301 tggggacgga ggaagccgac gagttcccgc aggcacgtgt ggtggccacc catctgggct
     9361 ccgcccaccg cgagatcacc gtgtcaatgg ccgatctgct gcgccagttg ccgcacgcgg
     9421 tctgggcggc ggagtccctg gacccggaca tcgtcgagta cctgctcccg ctgacggccc
     9481 tgtacctgcg gctggagggc agcggccggc gcatcctcac cgggtacggc gccgacatac
     9541 cgctcggcgg tatgcaccgc gaggaccggc tgccccagct cgacacggcc gtctgccacg
     9601 acatggcgac cttcgacggc ctcaacgaga tgacaccggt cctctcccag atcagcggcc
     9661 actggtccac ccacccgtac tgggaccgtg acgtcctcga cgtgctggtg gcgctggagg
     9721 ccggtctcaa acggcgctac ggccaggaca agtgggtgct gcgcgccgcc atgggtgacc
     9781 tcctgcccca cgaggtcgtc atccgtccca agctcggcgt ccacgagggg tcaggggtca
     9841 ccgccgcgtt cacccggctg ctgacggacg ccggcgtccc ggaccaacag gtgcaccggg
     9901 ccaaggagtt ggtggtgcag gagctgttcg accacgtcgt cgtcgccggc cgccacccgg
     9961 acgaggtgaa gaccggggag gtggtggagc aggttgccga gcggctggcg tccggcgcca
    10021 cggccgccct gtgacgggcc acggctgccc cggcctcgtc cacaccccgt accgacccca
    10081 cgaaaccgtc cactcgcagc gaagaggggc caccccgtga acgaccccgg acaacggctc
    10141 gacatcaacg tctctcctcg ttacgcacag atccccacct tcatgcgcct tccgcacgat
    10201 ccgtcgccgc agggcaagga cgtcgtggtc atcggcgccc cgtacgacgg gggtaccagc
    10261 taccggccgg gggcccgctt cggtccgcgc gccgtacgca acgaatccgg gctcatccac
    10321 ggcgtcggca tcgaccgcgg gcccggcacc ttcgacctca tcgactgcgt ggacgccggg
    10381 gacatcgacc tgaccccgtt caacatgcac atcgcgatgg acacggcgca gcggcgcctg
    10441 agcgaactcc tggccgacaa cgccgccttc ctgatgatcg gcggtgacca ctcgctgacg
    10501 ctggccgccc tccgcgcggt cgccgccaag cacggtccgg tggccgtcct gcacctcgac
    10561 gcccactcgg acaccaaccc cgccttctac ggcggggagt accaccacgg caccccgttc
    10621 cggcacgcca tcgacgagaa gctcgtcgac ccgcagcgca tgctgcagat cgggatccgg
    10681 ggccacaacc cgcagcccga ctcactggac tacgcccgtg gacacggggt gcggatcatg
    10741 acctccgacg agttctgcgg cctcggtccc caggccgcca cggccctggt ccgcgaacac
    10801 ctcggcgacg cacccgtcta cgtgtcggtg gacgtcgacg tggtggatcc ggcgttcgcc
    10861 ccgggcaccg gcacccccgc cccgggcggc ccgagctcgc gtgaggtgct cgccctgctg
    10921 cgcggggtcg gagacctgcg cccggtgggc ttcgacgtca tggaggtctc ccccctgtac
    10981 gaccacggcg gcatcacctc ggtgctggcg accgagatag gggccgaact cctctaccag
    11041 tacgcacgct ccacaacccg agaaaggcag agctcgtgac cgtagtcgac tgctcggagt
    11101 actccgccga cctgctcgcg ttggcctcgc ggctgccgcg gatcccccgc caggacctgt
    11161 acggcttcct cgacgccgcg cacgaagccg ccggcgacct gcccgagggc ctgggcacgg
    11221 cgctcgaccg gttcaacgcc gacggcagcc acgacggcta cctcatgctg cggggcctgc
    11281 cggtggagga cgacgacgac ctgccggcca cccccaccag caccccggct ccggtggacc
    11341 gccccctgca gaacatggag gcgatgctgg cggtcatcgg ccgccgcctg ggcctgcaca
    11401 ccgggtaccg ggagctgcgg tccggcaccg tctaccacga cgtgtacccg tcgccgggcg
    11461 cccaccacct gtcctccgag acctccgaga ccctgctcga attccacacg gagatggcct
    11521 accacgtcct ccagccgaac tacgtgatgc tcgcatgctc acgcgcggac cacgagcgca
    11581 aggcggccac cctggtcggc tcgatccgca aggcgctgcc cctgataccc gaggaagtcc
    11641 gcgcccgcct gttcgaccgg cccatgccgt gctgcgtgga cgtcgcgttc cgcggcggcg
    11701 tcgagaaccc gggcgccatc gccaacgtca agccgctgta cggcgatccc cgggatccct
    11761 tcctaggcta cgaccgtgag ctgctcgcgc cgcgcgaacc cgacgacgtg gaggccgtcg
    11821 ccgtgctgtc gaaggcgctc gacgaggtga gcgaggcggt gcggctgacc cccggggacc
    11881 ttctggtcgt cgacaacttc cgcaccacgc acgcccgtac gccgttctcc ccgcgctggg
    11941 acggcaagga ccgctggctg caccgcgtct acatccgcac ggaccgcaac gaccagctgt
    12001 ccggcggtga acgcgccggt gacgtcgtgg acttctcgcc acgccgctag cacccgcgca
    12061 gaaccctgtg ggcgtgggac cgccggaacg ccggcggtcc cacgcccacg gcacgctccg
    12121 cacgaccctg acctccggtg attgccggta cggtgggatc ccatccgctt gctggggaga
    12181 tgattgacct tgacagacag cgcagccttc gacccgcgag gtttcgcggt gcacacggca
    12241 ccggtcgggc tggcggacga cgggcgcgac gacttcaccg tcctgacatc gaccgaaccg
    12301 gcggtcgtca gcgcggtctt cacccgttcc ctcttcgcgg gccccagcgt ggtgctcagc
    12361 cgcgcggcgg tccgcgaccg cagcgcccgg ggcgtcgtcg tcctggcccg caacgcgaac
    12421 gtggccaccg gctcggaggg cgaacgcaac gcgcgcgagg tgcgcgacac ggtggcccgg
    12481 gcggtgggcg tggccgagga cgaactcctc atcgcctcca cgggtgtgat cggccgtcag
    12541 tacccgatgg aatccatccg ggaccacgtc aagaccctca ccgcgcccga gccgggccat
    12601 gacggtttcc agcgggcggc tcgcgccatc atgaccacgg acacccggcc caaggtggcg
    12661 cgggcccgcg tcggcgacgc cgtgatcacc ggcatcgcca agggtgtcgg gatgatggag
    12721 cccgacatgg ccaccctgct gaccttcttc gccaccgacg cccggctcga cccggaggaa
    12781 caggaccgga tcttccgccg ggtcatggac cggacgttca acgcggtcag catcgacacg
    12841 gacacctcca ccagcgacac ggcggcgctc ttcgccaacg gactggcggg cgacgtggac
    12901 cccgcggagt tcgagaacgc cctgtacgag gtggcgctca ccctggtcaa ggacatcgcg
    12961 tccgacggag agggcgcgag caagctgatc gaggtgcagg tgagcggggc ccgcgacacc
    13021 gcgcaggcca aacgcgtggg caaggccgtg gtcaactcac ccctggtgaa gaccgcggtc
    13081 cacgggggtg acccgaactg gggccgggtg gcgatggcca tcggcaagtg ctccgacgac
    13141 acggacatcg accaggacaa ggtcgccatc cgcttcggtg aggtcacggt ctacccgccc
    13201 ggccggcccg gggcacagga cgaggacgcg gtgcgcgccg ccgtcgccga cgagatgcgc
    13261 ggcgatcacg tggtcatcgg catcgacctg gccgtcgcgg acggcgcctt caccgtctac
    13321 ggctgcgatc tgacggaggg gtacgtccgc ctcaacgccg actactccac ctgaccgcgc
    13381 ccctcaccca ccccgctcat gacgaagacc gccgcttgcg gagcggcggt cttcgtcatg
    13441 agcggccgtg tcaccagctg tcgaggtgga ggacctggtc cagcggctgc cgccgggcgg
    13501 gcttgaagtc cgtgccgatc gagtacgccg tcggaatcag cgccgcctgc acgacaccgt
    13561 cgggaatctt cagcagctcg gcgatctcct tctcgtacat caggtgcagc gtggtccagg
    13621 cggtgcccag cctccgcgcc cgggccgcga gcatgtaact ccacccggcc tggacgatgg
    13681 agccccacat gcccgcctcg ttgtactcgg gggcctcgtt cgcgtccagg caggggatga
    13741 cgagcacggg tacctcgctc atccgctccc ccaggtaggc gacgctgtca cccacccgct
    13801 tctgcaccgc gtggcgttgc gggtcctccg ggtagagcgt gccgcaggcc ccctcggacg
    13861 agaggtaggt gtcgaccgcc cggcggtaga actcgccgat cgcggcacgc tggtccgggt
    13921 ccgtgatgac gagccagtgc caggtctggc ggttgcttcc ggtgggagcc tggagcgcga
    13981 tctcgatgca ctccttgacg agttccaggg gcaccgggcg ggtcaggtcc agccgcttgc
    14041 gtaccgatcg ggtggtcgtg agcagttcgt cggggttcag gttcagcaga gccatggcaa
    14101 ttcctcggtg tcggcggtcc gtggaccggc ttgggtgcgg ggaacagacg tgacggtggt
    14161 cttggggtgg cgggcggcgc aacgggcgcg gcccggtcag gaaggcaggg gttcggcttc
    14221 ctcgtgcacc ggcttgcggc gcagccggcc caggacgagg tggagggcgg cggccagcag
    14281 gcccagcgcc gtacaggcga cccagaccgc ggtggtgccg gacgcctcga tcagctggct
    14341 gctcaggagc ggggccaggg ccacggcgga gctccacacc agcaacaggc gtccctggta
    14401 actgccttgg gcgtgcgccg gggccaggag ggcgacgagt gtcatgcacc gcggcaggac
    14461 gacgatctct cccaggctcc acagcaccac ggtcgccgcg tatcccggaa ggctctggac
    14521 cactccggtg aggccgaagc cgatgccgga gaacagggtc gccaccgcca gggcgtgctc
    14581 cgggcggaac cggtcgccca gccggctcag cggcagctgg aacgccgcga tgaccaggcc
    14641 gttcaccatc atgacgaggc cgtactccgc cggtgaacgc ccttgctccg tcatcgtcaa
    14701 gggcagggcc accagcggct gctggaacat caggcccagc aggagcaccg atccgagcag
    14761 gaccgtgaac ggccggtccc ggagcacggc cgagccccgt ccacccgccc gctcacgatg
    14821 tggccgggcc gactccgggc gggtctccgg gacaaagcga taggcgacgg cgcccgcgac
    14881 cgtgttggcg atcgcgttga ccaggaacag cagggcgaag ctctggtcgg ccgcggcacc
    14941 ggcgctgacc gccgccacgg agaatcccag gttggtcgcc cagtacagca acgagtaggc
    15001 gcgcggccgg tcctcctcac tcaccaggtc ggcgacggcc gcggcgcgag ccggccgtgt
    15061 ggcgttgagc ccgaccccca cgaccagtgt ccccgcgacc acgagggcct tggtgtcggc
    15121 gaagcccagc cctgccatgc cgatgacact cagcgcctcg ctccacagca gcaccgcccg
    15181 acgccccagg cggtcggcga ggatcccgcc gacgaaggcg gcaaggccgc tgccgatgcc
    15241 gaacaccgtc atgacgaggc cggtgaagga caccgagtag tcacgcacgc tggtcaggta
    15301 gatcgccagg tacggcacga cgaacccgcc cgcggacgtg atgagcgttc caccccacag
    15361 ccaccagaag gtgcgcggca ggccgccgcc ctgctgggcg gagcgtcgtt tcacgagccg
    15421 ttcaccggcc tgcggtggcg gacgagcggg gtcacccctg ctcctcgtac tcgatgtgca
    15481 gggtcctttc gaggtgctcg cggaactgca cggcctcctc gtccgacgcg tggtgggaca
    15541 gcacgatcgc cggatacgcg gtccacgccg ggtacgggcg cagcaccgct ccgggggcga
    15601 cggcctgtgc cacgtggtcg acccgggggt cggcacggac ctcgtccagg ccccggatgc
    15661 gccggaaggt gccgccggtg ccgaccggga ccaggtaggc ggccgcgtgt ccggccgcca
    15721 ccggctcctg cgaccagcac cggggctcct gccccagatg gatgcgtacg gtctcggccg
    15781 cgaagtcgat gccgctgctc ccccggacga ggtggtgcat gaacccgccg cctccgatgc
    15841 gcgcgcccat ctccagcagc accggacgca ccccgccgac caggcgcagc tcggtgtggg
    15901 tggcaccctc gtcgacgccg aaggcgtggt gggcggcgac cacttccgct tcgacggcgg
    15961 ccaggatctc ggccggcagc cgggccggtg cgcgcagcgt ggtctcctcg aagtaggggc
    16021 cggtgagttc ccccttccag gagaccgcgc acacccgcac ccggccccgg tggaccaggg
    16081 actcggctga gatctccggt ccgtccaggt actcctcgac cagcactccg ctgccgccac
    16141 ccgtttcggc gggcttgtgc gaacgggcct ccacgagctc ccaggtactg ctgacggcct
    16201 gttcgagctg ctccttgtcg tcgacccgga tgacgccgag gctggagaag ccgcgcgccg
    16261 gcttcaccac gaccgggaac cgcagtgtca gtgcgtcggc ccagtcctcc ttgcgctcca
    16321 gggcggcaag accggggacc gccaggcccg cctccgccag gcgctgccgc atgctgcgct
    16381 tgtcgcgcac caccgccgcg ccctgttcgg acagaccggg gagaccgagg gtgcgtgcgg
    16441 cacgcgcggt gaaggggacg accagttcgt tgcccgccat gatcccgtcg aaggggtccg
    16501 accgaaagcg ctcgaccaga gccgccagcg ccccgtccgg atccgtctcc acgtccaggg
    16561 gcaggacctc cgtcaccgcg gcggcccgcc gtgccacgtc caggtcggtg cccgtccagg
    16621 ggatgagcac cacgtcgacg cccacacgct gggcggcctc gaacacccag ggggcggtga
    16681 cgagttggcc gacgagaaca atcttcgggc gttgcggcat ggtgatctcc gtgagaaagg
    16741 tgcgggcaag ccaggaagcg atgcgacgag tccgggccga ccaccggtgg cccgccgtgc
    16801 agtgttgcgc acgggccttg ccgtgctctt gcaccgggca tgacgccccg gaactgcccg
    16861 gcctggacgt gtggagcgtc cccgtcaccg gcaacgggac cgtgcgaact ggtagagcag
    16921 ctccgcgccc acctcggtgg ccaggaggga cgtgacaccg ccgtggtcgt agggcgggca
    16981 gacgcccatc acgtcgaagc cgacgggctc cagatcaccg acacagcgca gcacttcgag
    17041 gacgtcgagc gaggagggcc cgtccggtgc cggcgccgcg gtgccgggcg cgaacctcgg
    17101 atccacgacg tccatgccga ccgacacgta gaccggtacg tctccgatga tctcgcggat
    17161 caggcgagcg gtggcggagg ggcccacggc gaccatgtcg gcggcggtga tgacccgtgt
    17221 gccgtgtctt cgggcgccgt cctgcgggtc gggttcgacc cgagggccgc ggaccccgat
    17281 ctgcacgagt cgccgagggt cgatcagcct ctcctcgatg gcctgacgga acgtcgtgcc
    17341 gtggtggtat tcggtgccgt agacgtccgg ttgggtgtcg cagtgcgcgt cgagatgcac
    17401 cgcggcgacc atcccgtgcc tgcggacgac tgcccgcagc gccgcaagcg tgagcgcgtg
    17461 gtcgcccccc agcatcagga acgcgtcgtt gtgctccagc agggactgca ggctccgctg
    17521 cgcaacctcc aagaccgtgc gcgcgtcgca cgggcccagg tcgatgtccc cggcgtccgc
    17581 gcagtcgatg atgtcggagg ccgcgggccc ccggccgaaa cctgtgccga gaaggaggtc
    17641 cgagccctgc cgaatggccc gcgggcccag ctgggtcccg ggccgatgac tggtgccggc
    17701 atcgtacggg gcgccgatca ccaccaggtc ccggccgcgc ggagaagcat ggcgagggat
    17761 tcccatgaag gtcagattct gcgcgtagtt ctgttccact gctccactgc tcatcgattg
    17821 tcatgaggac ttcactgagt gtgcctattt ccgcgccccg tcacgcgcgc ccgcgaggag
    17881 acggcattct gcatgtgttc gcttgcaatc cactgaacaa cgccttgcag gcttcttggc
    17941 gtagggccac cgagtacggt tcaagcctgc atgtgacagc agatgagcag gtcagaagcc
    18001 ttgcaatcgg ccaacactcg accgctcttg tctcatttcc tccggtcgat aactggccac
    18061 gtcgagttct ggttcctgcc gctgggaatt gttggaattt ccgcgacatg aagtgcgcgc
    18121 gccagatttg actcccgccc gcgagtgctc ctaccgtttc gtaccaccgc cccttcacaa
    18181 gcccgtcacg tgtatgcata aaggcttggg gggagttcag aaagacagcg cggcgggttc
    18241 tgcccaccgt cgcctggcgt accgctcgga gagaaaatgg aacaggatca catacgcagc
    18301 ctctcgcgtg ccgtcgcgtt ggccttggcc gccaccgccc tggcagtgac agggatctac
    18361 gccccactgg cacaggcatc gatggtcagc accgcaggcc agacactcac gtccccgacc
    18421 ggggccgagg ggatgctcac tgaggaggac aacgacattc ccgtctgctg ctagggaaga
    18481 cggacgtgcg gacgccggcc gtcccgacgt ccgcgcgcag ggtgccggtc atggggcgcc
    18541 ggcacctcgg atccggtgcc ggccctcagc cccccgtcgt cggtgactgc tcaagcgcat
    18601 cctcggaaaa tgcctcccgg tgtcccaggc agcgcacgct ctgccggtac gcccacaccg
    18661 cacgcgcctc ctccccgcac aaccggaaga tctccgccaa ctcggcccag gcgaaacctg
    18721 cctgacggtt ggcctcggaa gcctccagca tcaaagcgcc ccgctcatag gcctcctgac
    18781 aggcttcggt ccgccccatc gcgaggtgag cggcggcgag caccaggtag ttccgcgcgc
    18841 tttgcagacg gtgctgcgtg ccgaggagct ccagcgcctc ctccgcgttg cggacggccg
    18901 acaggggatc gcccagccgc aactccatcc gggccagggc cgacaggcag taggcgacgt
    18961 ccacgctgct gcccacctcg cgcaaggacg cgtagctctg ctggagcatc tcgcgcaccg
    19021 gctccggctc cgtgctcccg gactccagca gcagcatggc gtaggcgttg cgcagccgcg
    19081 cgagcgcacg cgtgtcctct ccttcggcgt aacacgccag cgccttctcg atcagcacca
    19141 gggcgtcggc cgtcttgccg ttgcggtgca ggacgacact ggcgttccag tacgccgcgc
    19201 cccgggcgcg ggcgtcggtg accgagtcgg cctgctcgat ggcctttccg gccaggtacg
    19261 aggcacggtg caggtctccg cgctccatgt ggacgccgac gagcgtcgac agcagttcga
    19321 cgcctacgac cgtgggcgcc aggccgagct cgtccagttc ggcgagcgtg tcctcggcca
    19381 cctcgatggc gtgggagaga tcgccgagtt cccggtagca gcggcacagc gcgatcaccg
    19441 tggtcagacg gggcaccgag tcgggctggg ccaccgcggt ggcgtggagc tcctccaggt
    19501 gcacgaccgc ctcctccagc tcgccgaggt tctccagggc acgggccaga ccgtaggtcg
    19561 ccttgtacca ggactcgggc tgcgaggact tgcccacttt ggcgcgcacg gccaggtacg
    19621 cctcacgcgc cgcctgggca tcgccggcgt tcaacgccgt ctccgcgaag ctcagttcca
    19681 ccgcgagccc ggtgacggac accgcgggct caccccccag ctccgccacg tcacagtgaa
    19741 gtcgcgcggc cagctgcgcg agcacctcgg gcgacggcga ccgcttgccc gcctcgacga
    19801 gggagatgta gctgggtgac agtccgtcac ctgccagatc cgcctgggac atgcccgccg
    19861 cccgacgcag ccgccgaatc cgcgcaccga catccgccgt gacagccgtg tgctccgatt
    19921 cgggacgtcg gctcac
//
