BGC0001152: fusaricidin B biosynthetic gene cluster from Paenibacillus polymyxa
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Location: 10,739 - 42,549 nt. (total: 31,811 nt).
This entry is originally from NCBI GenBank EF451155.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001152
Short description fusaricidin B biosynthetic gene cluster from Paenibacillus polymyxa
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
  • Polyketide
Loci NCBI GenBank: EF451155.3
Compounds
  • fusaricidin B
Species Paenibacillus polymyxa [taxonomy]
References
Chemical products information
fusaricidin B [synonyms: gatavalin]
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C42H76N10O11
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACA34357.1
  • fusG
 10739 - 11473 (+) enoyl-acyl carrier protein reductase
  • Tailoring (Unknown)
Sequence-based prediction
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  • ACA34358.1
  • fusF
 11534 - 12946 (+) acyl-CoA ligase
  • Tailoring (Unknown)
Sequence-based prediction
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  • ACA34359.1
  • fusE
 12991 - 14214 (+) aldehyde dehydrogenase
  • Tailoring (Unknown)
Sequence-based prediction
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  • ACA34360.1
  • fusD
 14211 - 15911 (+) acetolactate synthase large subunit
  • Tailoring (Unknown)
Sequence-based prediction
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  • ACA34361.1
  • fusC
 16118 - 17176 (+) 3-oxoacyl-acyl carrier protein synthase
  • Tailoring (Unknown)
Sequence-based prediction
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  • ACA34362.1
  • fusB
 17181 - 17588 (+) (3R)-hydroxymyristoyl-acyl carrier protein dehydratase
  • Tailoring (Unknown)
Sequence-based prediction
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  • ABQ96384.2
  • fusA
 17682 - 41408 (+) fusaricidin synthetase
  • Scaffold biosynthesis
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  • ACA34363.1
  • fusTE
 41926 - 42549 (-) alpa/beta hydrolase-thioesterase
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
fusC Synthase subclass:
Module 1
Genes: fusC
Core domains: Ketosynthase
NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
Release type
  • Macrolactonization
Lipid moiety guanidinylated b-hydroxy fatty acid
NRP-synthases
Gene Modules
fusF
Module 0
fusA
Module 2
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Starter
Module 3
Specificity: valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 4
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
Module 5
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 6
Specificity: asparagine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 7
Specificity: D-alanine
Evidence for specificity:
  • Activity assay
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SDHXYXULZ6ZTMHSITTYHRAHA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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