LOCUS       BGC0001154             16561 bp    DNA     linear   BCT 10-SEP-2019
DEFINITION  Catenulispora acidiphila DSM 44928 chromosome, complete genome.
ACCESSION   BGC0001154
VERSION     BGC0001154
KEYWORDS    .
SOURCE      Catenulispora acidiphila DSM 44928
  ORGANISM  Catenulispora acidiphila DSM 44928
            Bacteria; Actinobacteria; Catenulisporales; Catenulisporaceae;
            Catenulispora.
COMMENT     URL -- http://www.jgi.doe.gov
            JGI Project ID: 4082785
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Jonathan A. Eisen (jaeisen@ucdavis.edu)
            David Bruce (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Finishing done by JGI-LANL
            Annotation by JGI-ORNL and JGI-PGF
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 23:30:37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16561
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1320)
                     /codon_start=1
                     /db_xref="InterPro:IPR006153"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 360.7; E-value:
                     1.5e-109)"
                     /gene_kind="transport"
                     /inference="protein motif:PFAM:PF00999"
                     /locus_tag="Caci_2714"
                     /note="PFAM: sodium/hydrogen exchanger; KEGG: fal:FRAAL1809
                     Na+/H+ antiporter"
                     /product="sodium/hydrogen exchanger"
                     /protein_id="ACU71629.1"
                     /transl_table=11
                     /translation="MAFAVAPDAVLAGEVAVAIVAAWAARTAARPLRQSAVVVEILAGV
                     ALGPSLLGLLPGDPTGRLFPASGRGTLTSVAELGLLLFMFAIGWELDVSVVRARRTATI
                     AMTAANFVVPFAVGAALAFALYPAYAGTRSGHRVTEAVFVVYIGVALAITAFPVLARIL
                     GDSPLRNTPVGQTAMAMAAGTDLCGWLGLALVVIAASATGSAASWTTLPLVVVYLAAMF
                     LIVRPLLRTALAHVRAVGSGGTLPLVVAAVLASSYVSSAAGLHAAFGAFLLGLVMPRDS
                     RAVLMLDIAEPLERTGAILMPVYFVATGLSADFHTLGWAGFELGFGVVALASTAKIGAV
                     AAAARICGTDRREALILGVLMNTRGLTEIVVLDIGLSIGIIDAHLFTALLLMAVATTAV
                     TTPVLHRLTSAASPATPAPWRPGSRPDRDAPSPSGPARTA"
     protocluster    1..16561
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5485:10877]"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5486..10877
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="1"
     cand_cluster    1..16561
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /kind="single"
                     /product="aminocoumarin"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..16561
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001154"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..16561
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="aminocoumarin"
                     /region_number="1"
                     /rules="(novK or novJ or novI or novH or SpcDK_cou)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1320)
                     /locus_tag="Caci_2714"
     gene            complement(1327..2601)
                     /locus_tag="Caci_2715"
     CDS             complement(1327..2601)
                     /codon_start=1
                     /db_xref="InterPro:IPR006076"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103:FAD dependent oxidoreductase (Score: 244.8;
                     E-value: 2.6e-74)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF01266"
                     /locus_tag="Caci_2715"
                     /note="PFAM: FAD dependent oxidoreductase; KEGG:
                     sen:SACE_2961 fructosyl-amino acid oxidase, putative"
                     /product="FAD dependent oxidoreductase"
                     /protein_id="ACU71630.1"
                     /transl_table=11
                     /translation="MRNRPRVVVVGGGVLGTCIAGACAARSARVTLLDAAVPGSGTSST
                     SFAWANAQKKRPESYFRLNAEGLAEYHRLARAGVGSGWFHAVGNVEVAVDAASAEALEA
                     NVADLAARGYAAENVSARRAADLEPLIDPDRIAAAAYFPDEGWVDAEEMVSDALADVRA
                     GTGVIRTHHAVVGFEPAGAGTKVLLADGEELLADYVVCATGTATEALLAGSGIAVPMIS
                     ETARKPRASGGEGREGSPDERYTAVGGLAFTAPLRSPLRRIVHTPDMGLRPSAYGRAVL
                     GGDGAGSRVPRNDPAVFENGPRLLERARRLFPAMAEVTLDAVRVGVRPMPADGLTVAGF
                     TESVPGLYVVVTHSGITLAQYLARLVAGEVLGSKEAAALADFRPGRFAAARLEDVAPAD
                     KGSAEKGSAEKAPVEEGLVGDRKRG"
     sig_peptide     complement(2527..2601)
                     /locus_tag="Caci_2715"
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 0.987) with cleavage site probability 0.420 at
                     residue 25"
     gene            complement(2598..3881)
                     /locus_tag="Caci_2716"
     CDS             complement(2598..3881)
                     /codon_start=1
                     /db_xref="InterPro:IPR001926"
                     /inference="protein motif:PFAM:PF00291"
                     /locus_tag="Caci_2716"
                     /note="PFAM: Pyridoxal-5'-phosphate-dependent protein beta
                     subunit; KEGG: hsl:OE1807R threonine synthase"
                     /product="Pyridoxal-5'-phosphate-dependent protein beta
                     subunit"
                     /protein_id="ACU71631.1"
                     /transl_table=11
                     /translation="MAEFIGNYESLIRKVRGSAGDGTSGAGDTNSAGEAGSAKVIRYFC
                     VRCEHEFIEPAFNKCTECGGAIDAIYDLDQVQIPAEKQGPDPLQHYFSLLPVRERSSLH
                     WGGEGNTPCFQVPELASALGIAQLYFKNEAVNPTSSTKDRVASVCLSRFGELGVRDLVL
                     SSTGNSSTAYARAVSLVPGFTLHIFVGREFVSRLNYADHPRIVTHVVDGEFVTAGRVGE
                     RFAQDNGFFWEGGFFNLGRREGLKLAYLEAYDEMQAEPDYVFQAVSSGMGLVGAYKGAV
                     EYRELGRLGKVPSFMAVQQASCSPMAQAFAEDADQIAPRHVVRDPKGLAYAILRGDPTG
                     TYPYIRDLCLTSGGRILAAGEERIRHARRVLAETVGVDVCFASSTAFAGVLEAAEAGLL
                     APDSVVLVNLTGADRPAAQVATIGRTHA"
     gene            complement(3848..5482)
                     /locus_tag="Caci_2717"
     CDS             complement(3848..5482)
                     /NRPS_PKS="Domain: AMP-binding (15-429). E-value: 6e-68.
                     Score: 221.1. Matches aSDomain:
                     nrpspksdomains_Caci_2717_AMP-binding.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR000873"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     259.9; E-value: 6e-79)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF00501"
                     /locus_tag="Caci_2717"
                     /note="PFAM: AMP-dependent synthetase and ligase; KEGG:
                     fra:Francci3_4204 AMP-dependent synthetase and ligase"
                     /product="amide synthetase"
                     /protein_id="ACU71632.1"
                     /sec_met_domain="AMP-binding (E-value: 4e-72, bitscore:
                     232.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDPGHYVARILDQLALDDDRPVIRWQDTVVPAAELRSALIRVAT
                     ALRRLDVGSDDTVAVLTSVNSPWMLATRYAVHLVGATVVYVSGSNHGTTTHGLTRQTRA
                     RMVHETGASVLLFDEDNAAEADGIRALLASRSEVRLCALGTPLSGPVSIDGSPVAEPTT
                     TTATGSAASTIDLTPHTPTRAMVIYTSGSTGSPKGVVKPFVAWNNVVLNEATFTSAKTF
                     LAVSAVSHTGGLLTDMAIASGGSALLRTAFEPAAFLRDIAEYRVTDTLIGVPLLYQLTN
                     HPDAPTTDLSSLRRLLYIGCAASPERVREAVKVFPGVLHHSYGTTETGQIAMLTAADHD
                     VAELLDTVGRPRTDLTVAVRDPRTGRGLPAGQLGEVVVRGANNMLGYAADPDLTARVLR
                     DGWVHTGDLGRIGDNGYLRLFGRMDDVVKVHDTRVHPIEVEKVLAGHPGVADACVWGRQ
                     GPDLLGELHAAVVLREDDPPAREALRGHVAALMTPTHVPATLTRWRAFPINVNGKVDRV
                     LVREQSSHPEAGRDEPAWPNSSETTKA"
     CDS_motif       complement(4163..4225)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2717_0003"
                     /evalue="1.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="Caci_2717"
                     /protein_end="440"
                     /protein_start="419"
                     /score="14.2"
                     /tool="antismash"
                     /translation="FGRMDDVVKVHDTRVHPIEVE"
     aSDomain        complement(4196..5437)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2717_AMP-binding.1"
                     /evalue="6.00E-68"
                     /label="Caci_2717_AMP-binding.1"
                     /locus_tag="Caci_2717"
                     /protein_end="429"
                     /protein_start="15"
                     /score="221.1"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="ALDDDRPVIRWQDTVVPAAELRSALIRVATALRRLDVGSDDTVAV
                     LTSVNSPWMLATRYAVHLVGATVVYVSGSNHGTTTHGLTRQTRARMVHETGASVLLFDE
                     DNAAEADGIRALLASRSEVRLCALGTPLSGPVSIDGSPVAEPTTTTATGSAASTIDLTP
                     HTPTRAMVIYTSGSTGSPKGVVKPFVAWNNVVLNEATFTSAKTFLAVSAVSHTGGLLTD
                     MAIASGGSALLRTAFEPAAFLRDIAEYRVTDTLIGVPLLYQLTNHPDAPTTDLSSLRRL
                     LYIGCAASPERVREAVKVFPGVLHHSYGTTETGQIAMLTAADHDVAELLDTVGRPRTDL
                     TVAVRDPRTGRGLPAGQLGEVVVRGANNMLGYAADPDLTARVLRDGWVHTGDLGRIGDN
                     GYLRLFGRMDDVVKV"
     CDS_motif       complement(4295..4378)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2717_0002"
                     /evalue="1.10E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="Caci_2717"
                     /protein_end="396"
                     /protein_start="368"
                     /score="17.9"
                     /tool="antismash"
                     /translation="PAGQLGEVVVRGANNMLGYAADPDLTAR"
     CDS_motif       complement(4883..4933)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2717_0001"
                     /evalue="6.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="Caci_2717"
                     /protein_end="200"
                     /protein_start="183"
                     /score="24.8"
                     /tool="antismash"
                     /translation="AMVIYTSGSTGSPKGVV"
     gene            complement(5486..6268)
                     /locus_tag="Caci_2718"
     CDS             complement(5486..6268)
                     /codon_start=1
                     /db_xref="InterPro:IPR002347"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     82.7; E-value: 5e-25)"
                     /gene_kind="biosynthetic"
                     /inference="similar to AA sequence:KEGG:MAV_1395"
                     /locus_tag="Caci_2718"
                     /note="KEGG: mav:MAV_1395 2-hydroxycyclohexanecarboxyl-CoA
                     dehydrogenase"
                     /product="b-ketotyrosyl-reductase"
                     /protein_id="ACU71633.1"
                     /sec_met_domain="novK (E-value: 3.6e-117, bitscore: 380.0,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLTAAAGQTGALSRMAVVAGGACDTGLAAALQLAELGLDVALI
                     GADVAVPVEVTERFFAGGRHCLAIRADLADGRSFAAALGGARSVLGSPSVLVNCVPLGG
                     PEPLSAEERYADARRSLRALFACCRAVCAHMVRNRWGRIVNIAQPAVADGAADREWRDG
                     QTVLGGLVGFTRSAALELAAYGVTANYIAPSSCYPAGPAHAPAPPPAAAAGGGGTGPSY
                     AAGVAALTGFLISDQASAITGQGGYLAGRPAAPSARWE"
     gene            complement(6265..6759)
                     /locus_tag="Caci_2719"
     CDS             complement(6265..6759)
                     /codon_start=1
                     /inference="similar to AA sequence:KEGG:NCU05096"
                     /locus_tag="Caci_2719"
                     /note="KEGG: hypothetical protein"
                     /product="conserved hypothetical protein"
                     /protein_id="ACU71634.1"
                     /transl_table=11
                     /translation="MSRRSVLCGGASRFGSASRFGEASRFGGASRFSGASEFGGASFSG
                     GASRFGGASRFGGASRFGGASRFSGASEFGEVSLFGGRLVGGASTAGEASVSGGSLFGG
                     ANSATEASLFGKSLIGGASTVGGASFSGESLFGGASTVGKASISGARRRLPAACGEGGS
                     R"
     sig_peptide     complement(6694..6759)
                     /locus_tag="Caci_2719"
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 0.735) with cleavage site probability 0.655 at
                     residue 22"
     gene            complement(6756..7523)
                     /locus_tag="Caci_2720"
     CDS             complement(6756..7523)
                     /NRPS_PKS="Domain: PKS_KR (10-183). E-value: 3.8e-23.
                     Score: 74.2. Matches aSDomain:
                     nrpspksdomains_Caci_2720_PKS_KR.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR013968"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     231.1; E-value: 2.4e-70)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF00106"
                     /locus_tag="Caci_2720"
                     /note="PFAM: short-chain dehydrogenase/reductase SDR; KR
                     domain protein; KEGG: sen:SACE_5381 putative
                     3-oxoacyl-[acyl- carrier protein] reductase"
                     /product="b-ketotyrosyl-reductase"
                     /protein_id="ACU71635.1"
                     /sec_met_domain="adh_short (E-value: 3.4e-36, bitscore:
                     114.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-32, bitscore:
                     103.4, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="novJ (E-value: 6.5e-139, bitscore: 451.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTPDGTGTVAVVTGAARGIGAAVALRLAAGGATVVVVDREERD
                     TAGTVAAVRRAGGRALGIGCDVAVAAEVRTAMLRIAAAYGRLDILVNCAGVTRDRLLLA
                     MDDPEWDTVLDVSLGGTMRWSLAAAELMKHRGTGRIVTFSSVAADGNPGQSNYATAKAA
                     LAGFTRALASELGPHGITVNAVAPGFVATPMVAELADRLGVDREAFLKEAASHAAVGRV
                     GTVDDIAAVVAFLTGRDSGYLTGQTVSVDGGRR"
     aSDomain        complement(6975..7493)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2720_PKS_KR.1"
                     /evalue="3.80E-23"
                     /label="Caci_2720_PKS_KR.1"
                     /locus_tag="Caci_2720"
                     /protein_end="183"
                     /protein_start="10"
                     /score="74.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAARGIGAAVALRLAAGGATVVVVDREERDTAGTVAAVRR
                     AGGRALGIGCDVAVAAEVRTAMLRIAAAYGRLDILVNCAGVTRDRLLLAMDDPEWDTVL
                     DVSLGGTMRWSLAAAELMKHRGTGRIVTFSSVAADGNPGQSNYATAKAALAGFTRALAS
                     ELGPHGITVN"
     CDS_motif       complement(7017..7103)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2720_0002"
                     /evalue="2.30E-07"
                     /label="PKSI-KR_m4"
                     /locus_tag="Caci_2720"
                     /protein_end="169"
                     /protein_start="140"
                     /score="23.3"
                     /tool="antismash"
                     /translation="VTFSSVAADGNPGQSNYATAKAALAGFTR"
     CDS_motif       complement(7401..7487)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2720_0001"
                     /evalue="3.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="Caci_2720"
                     /protein_end="41"
                     /protein_start="12"
                     /score="16.3"
                     /tool="antismash"
                     /translation="VVTGAARGIGAAVALRLAAGGATVVVVDR"
     gene            complement(7520..7834)
                     /locus_tag="Caci_2721"
     CDS             complement(7520..7834)
                     /codon_start=1
                     /db_xref="InterPro:IPR005153"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009:mbtH-like protein (Score: 61.6; E-value:
                     7.7e-19)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF03621"
                     /locus_tag="Caci_2721"
                     /note="PFAM: MbtH domain protein; KEGG: cvi:CV_2232
                     MbtH-like protein"
                     /product="MbtH-like protein"
                     /protein_id="ACU71636.1"
                     /transl_table=11
                     /translation="MNVLDDEAAPFLVLGNAAQEYSLWPAAGDVPVPGGWRAVFGPAER
                     HACLAEIGRVWVDRAGAESAGGESSGTGSAGGESAGTESTGTESARAQSTAATGSGGPR
                     "
     gene            complement(7877..9100)
                     /locus_tag="Caci_2722"
     CDS             complement(7877..9100)
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 337.9; E-value:
                     1.3e-102)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF00067"
                     /locus_tag="Caci_2722"
                     /note="PFAM: cytochrome P450; KEGG: sgr:SGR_3267 putative
                     cytochrome P450"
                     /product="cytochrome P450"
                     /protein_id="ACU71637.1"
                     /sec_met_domain="p450 (E-value: 1.9e-15, bitscore: 46.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="novI (E-value: 2e-248, bitscore: 813.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRPVVQPDDLDRVDLASPVLHAENNLDEVWRHLRANDPVHWHR
                     PVDGRPGFWVITRHADVHKVYQDKGHFTTAGGNALATLLTGGDSASGTMLAVTDGPRHQ
                     QIRNVMTRGLNPRTLEAVRHSLQQTVDRLLKNALDMGECDAAHDVAANVPLGAICDLLE
                     IPESDRHHLLGLTSHAWSTDHADEPPQEAWVAKSEILLYFSRLAKERRGAEYDDMVTLL
                     ANCRIKGEPLSATELMANCYGLMIGGDETGRHAITGTILALTENPDQWRALKNGDVDIK
                     TATEEALRWTVPSLHGGRTATGDVELGGKLIKAGDVASVWIYSANRDEEVFDEPDRFLL
                     GRTPNNHFTFAYGMHYCLGHYLGRMEVHAVLDGLRRLVGNVEQIGEEKWIYSSILHGMH
                     SMPVRMTA"
     gene            complement(9102..10877)
                     /locus_tag="Caci_2723"
     CDS             complement(9102..10877)
                     /NRPS_PKS="Domain: AMP-binding (9-406). E-value: 5.9e-104.
                     Score: 339.7. Matches aSDomain:
                     nrpspksdomains_Caci_2723_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (522-589). E-value: 2.3e-19. Score:
                     61.2. Matches aSDomain: nrpspksdomains_Caci_2723_PCP.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR010071"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     380.2; E-value: 2e-115)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:TFAM:TIGR01733"
                     /locus_tag="Caci_2723"
                     /note="TIGRFAM: amino acid adenylation domain protein;
                     PFAM: AMP-dependent synthetase and ligase;
                     phosphopantetheine-binding; KEGG: bbt:BBta_4110 putative
                     non-ribosomal peptide synthase"
                     /product="peptide synthetase-like protein"
                     /protein_id="ACU71638.1"
                     /sec_met_domain="novH (E-value: 0.0, bitscore: 1018.9,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRHLSQIWDDAALRHSRDTALIAGEETLSYGAVNERANRLARVL
                     IAGGAGPGRLVALALGRTVDMAVAVLAVAKTGAAFLPVDPEYPAERVAHMLRDAAPVLV
                     CATAATLGRLPADVPVPSLVLDSAPQLSALRAQAATDVTDEERRQPVSVTDLAYVIYTS
                     GSTGLPKGVAVTHTGLAGLAAAKIDTMRVGGDSRVLQFASPSFDAYLTEILAALTSGAA
                     LVIPPAGVLAGDVLRAVLRDHAVTHAVLPPTAAGTIAPEDVPDLRTLVVAGEALPAALV
                     ERWAPHVRMINAYGPTEGTVCATMTGPLAAGEPITIGTPMPGVSVYVLDDTLRPVPPGE
                     IGEVFIAGDGLARGYLGRPELTAQRFLADPFSSAGTRMYRTGDLASWPAGGGIVFHGRV
                     DEQVKLRGFRIELGEVESVLGRHPEVARAVAVVRSSSVAGAYGLAHHTAAQLLAYVVPA
                     DGGRPSSAALREHAARFLPEYMVPALFTTVDALPLTPNGKVDRAALPEPAAAPHMVGGG
                     PRTPAEKALCLIFGELLGFDEVGVGADFFALGGTSIVAIDVILRAQDFGLELTPRALID
                     NPTIEMLAAAAADGS"
     aSDomain        complement(9111..9311)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2723_PCP.1"
                     /evalue="2.30E-19"
                     /label="Caci_2723_PCP.1"
                     /locus_tag="Caci_2723"
                     /protein_end="589"
                     /protein_start="522"
                     /score="61.2"
                     /tool="antismash"
                     /translation="EKALCLIFGELLGFDEVGVGADFFALGGTSIVAIDVILRAQDFGL
                     ELTPRALIDNPTIEMLAAAAAD"
     aSModule        9111..10850
                     /complete
                     /domains="nrpspksdomains_Caci_2723_AMP-binding.1"
                     /domains="nrpspksdomains_Caci_2723_PCP.1"
                     /locus_tags="Caci_2723"
                     /monomer_pairings="tyr -> tyr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(9630..9695)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0006"
                     /evalue="2.20E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="Caci_2723"
                     /protein_end="416"
                     /protein_start="394"
                     /score="35.7"
                     /tool="antismash"
                     /translation="FHGRVDEQVKLRGFRIELGEVE"
     aSDomain        complement(9660..10850)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2723_AMP-binding.1"
                     /evalue="5.90E-104"
                     /label="Caci_2723_AMP-binding.1"
                     /locus_tag="Caci_2723"
                     /protein_end="406"
                     /protein_start="9"
                     /score="339.7"
                     /specificity="consensus: tyr"
                     /tool="antismash"
                     /translation="DDAALRHSRDTALIAGEETLSYGAVNERANRLARVLIAGGAGPGR
                     LVALALGRTVDMAVAVLAVAKTGAAFLPVDPEYPAERVAHMLRDAAPVLVCATAATLGR
                     LPADVPVPSLVLDSAPQLSALRAQAATDVTDEERRQPVSVTDLAYVIYTSGSTGLPKGV
                     AVTHTGLAGLAAAKIDTMRVGGDSRVLQFASPSFDAYLTEILAALTSGAALVIPPAGVL
                     AGDVLRAVLRDHAVTHAVLPPTAAGTIAPEDVPDLRTLVVAGEALPAALVERWAPHVRM
                     INAYGPTEGTVCATMTGPLAAGEPITIGTPMPGVSVYVLDDTLRPVPPGEIGEVFIAGD
                     GLARGYLGRPELTAQRFLADPFSSAGTRMYRTGDLASWPAGGGIVFHGRVDEQVKLR"
     CDS_motif       complement(9696..9728)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0005"
                     /evalue="5.20E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="Caci_2723"
                     /protein_end="394"
                     /protein_start="383"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="LASWPAGGGIV"
     CDS_motif       complement(9780..9869)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0004"
                     /evalue="7.10E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="Caci_2723"
                     /protein_end="366"
                     /protein_start="336"
                     /score="53.5"
                     /tool="antismash"
                     /translation="PPGEIGEVFIAGDGLARGYLGRPELTAQRF"
     CDS_motif       complement(10206..10238)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0003"
                     /evalue="8.40E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="Caci_2723"
                     /protein_end="224"
                     /protein_start="213"
                     /score="0.9"
                     /tool="antismash"
                     /translation="LAALTSGAALV"
     CDS_motif       complement(10350..10409)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0002"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="Caci_2723"
                     /protein_end="176"
                     /protein_start="156"
                     /score="32.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGLPKGVAVTH"
     CDS_motif       complement(10626..10667)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0001"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="Caci_2723"
                     /protein_end="84"
                     /protein_start="70"
                     /score="13.3"
                     /tool="antismash"
                     /translation="LAVAKTGAAFLPVD"
     gene            11043..12563
                     /locus_tag="Caci_2724"
     CDS             11043..12563
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR003042"
                     /db_xref="InterPro:IPR006076"
                     /db_xref="InterPro:IPR006905"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 397; E-value: 2e-120)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF04820"
                     /locus_tag="Caci_2724"
                     /note="PFAM: tryptophan halogenase; monooxygenase FAD-
                     binding; FAD dependent oxidoreductase; KEGG: fal:FRAAL4634
                     putative halogenase"
                     /product="tryptophan halogenase"
                     /protein_id="ACU71639.1"
                     /sec_met_domain="Trp_halogenase (E-value: 7.4e-29,
                     bitscore: 90.7, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRSDRRILTKRMVFSEMTEVIVVGGGPAGSTAAALLAKNGVSVT
                     LLEREAFPRYHVGESITYSCRGVLDYIGALEKIEARGYTRKTGVLLRWGQELDWAIDWT
                     AQFGPDVRSWQVDREDFDQVLLQHAAECGAQVLEQAQVKRVVFEDGRAVGVEWTPQGHS
                     EPQITRADLVLDASGRAGLISAQHFRDRRATEIFRNVAIWGYWDGGELLPDSPSGSINV
                     ISSPEGWYWVIPLSGNRFSVGYVTHKSVFVERRKDYDTLDDMLAAVVAESPTVSEAMAK
                     GTVRPGARVEQDFSYAADSFCGPGHFLVGDAACFLDPLLSTGVHLAIYSGLLAAASVLS
                     IENGDVTETEAYAFYESRYRNSYERLFTLVAGFYQKHAGKDRYFELAKALTREHKGLEG
                     SADLAFGEITSGITDLREAKDDSGLGDRPIRESVAEAASRRSKVQDLLSATEQAQQRAE
                     AGLPNTGGDRGRSRVQIDADDLYDAATGLHLVMEPRLGIQRAAVPAAG"
     gene            complement(12644..13939)
                     /locus_tag="Caci_2725"
     CDS             complement(12644..13939)
                     /codon_start=1
                     /db_xref="InterPro:IPR000792"
                     /gene_functions="regulatory (smcogs) SMCOG1149:LuxR family
                     transcriptional regulator (Score: 84.2; E-value: 1.1e-25)"
                     /gene_kind="regulatory"
                     /inference="protein motif:PFAM:PF00196"
                     /locus_tag="Caci_2725"
                     /note="PFAM: regulatory protein LuxR; SMART: regulatory
                     protein LuxR; KEGG: saq:Sare_1270 LuxR family
                     transcriptional regulator"
                     /product="transcriptional regulator, LuxR family"
                     /protein_id="ACU71640.1"
                     /transl_table=11
                     /translation="MRGIIIRNDDLRSVRAPVCGVTDRLTRSRRSWLAGRLESGIGHAD
                     AAFRTDCTECAEPCSQYAGLWLAMLLSQIRRVDRAVRALDAVDISAAARGDRPLATAAT
                     LVRAKVEAAAGRFDTATALAAAGLREAEEVGLKSWTPLGNFVIALTAVRQGDLATALRY
                     AQRMEEDAVFGRKMLPPGQAAWAILQIAEAEQGWEKVAARAAELLDSGHVIRQLLISEP
                     AAAPWLVRLMLKSGERALAQEGVWASRRLAAVNPGVRSTAAAALHAVALYEADMEKLAS
                     AAELHVDQWARASAVEDVGAVLTDRKGDRGRAALILEDARGAYAQIGALRDAARVKSRL
                     RGINTIVPAQDQGLPASGVAGLTRTEYAIAKLVAGGLTNGQAAEQLYLSRHTVAFHLRK
                     IFRKLGVASRVQLARLWAELDSGGGLEPGAAG"
     misc_feature    complement(13493..13495)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14208..15710)
                     /locus_tag="Caci_2726"
     CDS             complement(14208..15710)
                     /codon_start=1
                     /db_xref="InterPro:IPR001411"
                     /db_xref="InterPro:IPR004638"
                     /db_xref="InterPro:IPR007114"
                     /db_xref="InterPro:IPR011701"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 362.3; E-value:
                     4.8e-110)"
                     /gene_kind="transport"
                     /inference="protein motif:TFAM:TIGR00711"
                     /locus_tag="Caci_2726"
                     /note="TIGRFAM: drug resistance transporter, EmrB/QacA
                     subfamily; PFAM: major facilitator superfamily MFS_1; KEGG:
                     sgr:SGR_1339 major facilitator superfamily permease"
                     /product="drug resistance transporter, EmrB/QacA subfamily"
                     /protein_id="ACU71641.1"
                     /transl_table=11
                     /translation="MTQSYERAAPPDDGPADPNRWRALTVCLVAGFMTLLDVSIVNVGL
                     PQMEAGLRASPADVSWVRAGYTLTFGLVLVPSGKLGDALGRKRVFLLGLFLFTGVSLMC
                     ALSPTAQWLVVARLLQGVAGGLLNPQIIAMIQQLFRGSERGKAFGLYGGTVAVATAIGP
                     LAGGLLIEAGGWRWMFLINLPIGVVGLVLGVLLVPKIPPRRRGRGMDLVGVALLGGGIT
                     SIMLPLIEQEQGGAAVHWWLLGLAAVLLVAFVFWERWWKGRGLDPLVNLSLLRTPSFGA
                     SSLVGLAYFAGYPGVLFILSLYLQQGRAYSALAAGATSMPFAVGSAISAAVSGRAVYRI
                     GRVLVVAGLVAVLAGLIPAAVIIQHDTGGAVWARLFLPLLVAGLGSGLVIGPNQTLALQ
                     FVPPASSGTAAAMVQTGQRIGMSVGTAMAATMFFGHLKVLRHDYSGAASRSLYGAAALV
                     TVALAAASVDLAAARRLRRRPATGQAAEVPGSRTGSAVVKRS"
     gene            15767..16561
                     /locus_tag="Caci_2727"
     CDS             15767..16561
                     /codon_start=1
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR004111"
                     /gene_functions="regulatory (smcogs) SMCOG1239:TetR family
                     transcriptional regulator (Score: 238.9; E-value: 9.3e-73)"
                     /gene_kind="regulatory"
                     /inference="protein motif:PFAM:PF02909"
                     /locus_tag="Caci_2727"
                     /note="PFAM: Tetracyclin repressor domain protein;
                     regulatory protein TetR; KEGG: sco:SCO7624 TetR family
                     transcriptional regulator"
                     /product="transcriptional regulator, TetR family"
                     /protein_id="ACU71642.1"
                     /transl_table=11
                     /translation="MSTENVDETAATRSIWERMALSPPVHRPVLTHALIAEAALRIADA
                     DGLEAVSMRRLATELGVSSMTCYRYVSGKDDVIELMLDTVRGGMLLDEDELAEPGEPGE
                     SAGRAEPAGSSHWRRVLRASAMRFRGVILMHPWMTDLPGRILFAPTPAFLAVAEQNLAA
                     FDGLGLTAAQITDITGAVTAYTRAGTHDEVTRERLRAPEGWTSPRDAKDANTDRLAWLL
                     ANGDYPRYERSLHEGAPRHDEQARFEFGLDCLLDGIAARLSR"
ORIGIN
        1 ctacgccgtt cgagccggac cggagggcga gggcgcgtct cggtcaggcc gtgaacccgg
       61 gcgccacggc gcgggggtcg ccggggacgc ggccgaggtc aggcggtgca ggaccggggt
      121 ggtgacggcg gtcgtcgcca ccgccatcaa cagcagcgcg gtgaacaggt gggcgtcgat
      181 gatgccgatc gacaggccga tgtcgagaac gacgatctcg gtcagtccgc gcgtgttcat
      241 caggactccg aggatcagcg cctcgcgccg gtccgtgccg cagatgcggg ccgcggccgc
      301 cactgctccg atcttcgccg tcgaggccag ggccacgacg ccgaagccga gctcgaagcc
      361 ggcccagccc agggtgtgga agtccgcgct caggccggtg gcgacgaagt acaccggcat
      421 caggatcgcg ccggtgcgct ccagcggctc ggcgatgtcg agcatgagga cggcgcggga
      481 gtcccgcggc atcaccaggc cgagcaggaa cgccccgaag gcggcgtgca atcccgccgc
      541 cgaggacacg tacgacgatg ccagcaccgc ggccacgacc agcggcagcg tcccgcccga
      601 gccgaccgcg cggacgtgcg ccagcgccgt gcgaagcagc ggccggacga tcaggaacat
      661 cgccgccagg tagacaacga ccagcgggag cgtcgtccat gatgccgccg agccggtcgc
      721 cgacgccgcg atgaccacga gcgccagccc gagccagccg cacaggtccg tgccggccgc
      781 catcgccatc gcggtctgcc cgaccggcgt gttccgcagc ggactgtcac cgaggatccg
      841 ggccaggacc gggaaggcgg tgatcgccaa cgcgacgccg atgtagacca cgaacaccgc
      901 ttccgtgacg cggtggcccg accgggttcc ggcataggcc ggatacagcg cgaaggcgag
      961 cgcggcgccg accgcgaacg gcacgacgaa gttcgcggcc gtcatcgcga tcgtcgccgt
     1021 gcgccgcgcc cgcacgaccg agacgtccag ctcccacccg atggcgaaca tgaacagcag
     1081 caggcccagc tcggccacgg aggtcagggt gccgcggccg gacgccggga acagccggcc
     1141 ggtggggtcg cccggcagca ggccgagcag gctcggcccg agggcgactc cggccaggat
     1201 ctccacgacg accgccgact ggcgcagcgg ccgggcggcc gtgcgcgccg cccaggccgc
     1261 gacgatcgcc accgcgacct ctccggcaag aaccgcgtcc ggcgcgaccg cgaacgccat
     1321 gggtcatcac ccccgcttcc ggtcgccgac gagcccttct tcgactggcg ccttctctgc
     1381 tgaccccttc tccgctgagc ccttgtcggc cggcgccacg tcctcgagcc gtgccgcggc
     1441 gaagcggccg ggccggaagt ccgcgagcgc cgcagcctcc ttcgacccca gcacctcgcc
     1501 ggcgaccagc cgcgcgagat actgcgcgag cgtgatcccg ctgtgcgtca cgacgacata
     1561 cagtcccggc acgctctcgg tgaagcccgc caccgtgagc ccgtcggccg gcatcggccg
     1621 gacgccgacg cgcaccgcgt cgagcgtcac ctccgccatc gccgggaaca gcctccgggc
     1681 ccgctccagc agccgcggcc cgttctcgaa caccgcgggg tcgtttcgcg ggacgcgcga
     1741 cccggcgccg tcgccgccga ggaccgcccg gccgtaggcc gaggggcgca ggcccatgtc
     1801 cggggtgtgc acgatgcggc gcagcgggct gcgcagcggg gcggtgaacg cgaggccgcc
     1861 gacggcggtg tagcgctcgt cgggggaccc ctcacggccc tcgccgccgg acgcgcgcgg
     1921 cttgcgcgcc gtctcggaga tcatcggcac cgcgatgccg gagcccgcga gcagcgcttc
     1981 ggtggccgtg ccggtcgcgc acaccacata gtcggcgagc agttcctcgc cgtcggccag
     2041 cagcaccttc gtcccggcgc cggccggctc gaacccgacg acggcgtggt gcgtccggat
     2101 cacgccggta ccggcccgga cgtcggccag cgcgtcggag accatctcct cggcgtcgac
     2161 ccagccctcg tccgggaaat aggcggcggc cgcgatccgg tcggggtcga tgagcggttc
     2221 gaggtcggcc gcccgccgcg cggacacgtt ctcggccgcg tagccgcgcg cggcgaggtc
     2281 cgcgacgttg gcctccagcg cctccgccga ggccgcgtcc acggcgacct ccacattgcc
     2341 gaccgcgtgg aaccagccgc tcccgacccc cgcccgggcc agccggtggt actcggccag
     2401 gccctcggcg ttgagccgga agtaggactc gggccgcttc ttctgcgcgt tcgcccaggc
     2461 gaagctggtc gagctggtgc cggagccggg caccgcggcg tccagcaggg tgacgcgggc
     2521 cgagcgggcc gcgcacgctc cggcgatgca ggtgccgagg acgccgccgc cgacgaccac
     2581 cacacggggc cggttcctca tgcgtgggtc ctcccgatcg tcgcgacctg cgcggccggg
     2641 cggtccgcgc cggtcaggtt caccagcacc acggagtccg gcgccagcag cccggcctct
     2701 gccgcctcca gcactccggc gaacgccgtc gagctggcga agcagacgtc gacgccgacg
     2761 gtctcggcga gcacgcgccg cgcgtgccgg atccgctcct cgccggcggc caggatccgg
     2821 ccgccgctgg tcagacacag gtccctgatg tacgggtagg tcccggtcgg gtcgccgcgc
     2881 aggatcgcgt aggccaggcc cttggggtcg cgcacgacgt ggcgcggcgc gatctggtcg
     2941 gcgtcctcgg cgaaggcctg cgccatcggc gagcagctgg cttgctggac ggccatgaac
     3001 gagggcacct tgcccagccg cccgagctcg cggtactcca ccgcgccctt gtaggcgccg
     3061 accaggccca tgccgctgct gacggcctgg aacacgtagt ccggctcggc ctgcatctcg
     3121 tcgtaggcct ccaggtaggc cagtttgagg ccctcgcggc ggccgaggtt gaagaacccg
     3181 ccctcccaga agaagccgtt gtcctgggcg aagcgctcgc cgacgcggcc ggcggtgacg
     3241 aactcgccgt ccacgacgtg ggtcacgatg cgcggatggt cggcgtagtt gaggcggctg
     3301 acgaactcgc ggccgacgaa gatgtgcagg gtgaagccgg ggaccagcga gacggcgcgc
     3361 gcgtaggcgg tggagctgtt gccggtggag gacagcacga ggtcgcggac gcccagctcg
     3421 ccgaagcggg acaggcacac cgaggcgacg cggtccttcg tcgaggacgt cgggttcacg
     3481 gcctcgttct tgaagtagag ctgggctatg cccagcgccg aggccagctc cgggacctgg
     3541 aagcacgggg tgtttccctc cccgccccag tgcagcgacg agcgctcgcg gaccgggagc
     3601 agcgagaagt agtgctgaag ggggtcaggg ccctgcttct cggccgggat ctgtacctgg
     3661 tcgaggtcgt agatggcgtc gatggcgccg ccgcactcgg tgcatttgtt gaaggccggt
     3721 tcgatgaact cgtgctcaca gcgcacgcag aagtatctga tgaccttggc gctgccggct
     3781 tctccggcgc tgttggtgtc gccggcgccg ctggtgccgt ccccggccga gccgcggacc
     3841 ttccggatca ggctttcgta gtttccgatg aattcggcca cgccggttca tcccttcccg
     3901 cctcggggtg cgagctctgc tcgcggacca ggacccgatc gaccttgccg ttgacgttga
     3961 tcgggaatgc gcgccaccgc gtgagggtgg ccggaacgtg ggtgggggtc atcagggccg
     4021 cgacgtgccc gcgcagcgcc tcgcgcgccg gcgggtcgtc ctcgcgcagc acgacggcgg
     4081 cgtgcagctc gccgagcagg tccggaccct gccgtcccca gacacaggcg tcggcgacgc
     4141 cggggtgccc ggccaggacc ttctcgacct cgatcgggtg gacgcgggtg tcgtgcacct
     4201 tgacgacgtc gtccatccgg ccgaacagcc gcaggtagcc gttgtcgccg atccgcccga
     4261 ggtcgccggt gtgcacccag ccgtcgcgga gcacccgggc ggtcaggtcg ggatcggcgg
     4321 cgtagccgag catgttgttg gcaccgcgca ccacgacctc gccgagctgc ccggccggca
     4381 ggccgcggcc ggtccgcgga tcgcggacgg ccaccgtcag gtcggtccgc gggcgtccga
     4441 cggtgtcgag cagctcggcg acgtcgtggt cggcggcggt gagcatggcg atctggccgg
     4501 tctcggtggt gccgtaggag tggtgcagga cgccggggaa gaccttgacg gcttcgcgga
     4561 cacgctccgg cgaggccgcg cagccgatgt agagcaggcg gcgcagcgag gacaggtcgg
     4621 tggtcggagc gtccgggtgg ttcgtgagct gatacaggag cgggacgccg atcagggtgt
     4681 cggtgacgcg gtattcggcg atgtcgcgca ggaaggcggc gggttcgaag gctgtgcgga
     4741 gcagtgcgct gccgccggag gcgatcgcca tgtcggtgag caggccgccg gtgtggctga
     4801 cggcgctgac cgcgaggaag gtcttcgcgg acgtgaaggt ggcctcgttg aggacgacgt
     4861 tgttccaggc gacgaagggt ttgaccacgc ctttggggct gccggtgctg ccgctggtgt
     4921 agatgaccat ggcgcgggtg ggggtgtggg gggtcaggtc gatggtgctg gcggcgctgc
     4981 cggtggcggt ggtggtggtc ggctcggcga ccgggctgcc gtcgatggat acgggccctg
     5041 acaggggtgt cccgagcgcg cagaggcgga cttcggatcg ggaggcgagg agcgcgcgga
     5101 tgccgtcggc ctcggcggcg ttgtcctcgt cgaacagcag gaccgacgcg ccggtctcgt
     5161 gcaccatgcg ggcgcgggtc tggcgggtga ggccgtgggt ggtcgtcccg tggttcgagc
     5221 cgctgacgta gacgacggtc gcgccgacga ggtggacggc gtagcgggtg gccagcatcc
     5281 aagggctgtt cacggaggtc aggacggcga cggtgtcgtc gctgccgacg tccagccggc
     5341 gcagcgcggt ggccacccgt atcagggcgc tgcgcagctc ggcggccggg acgacggtgt
     5401 cctgccagcg gatcaccggc cggtcgtcgt cgagcgcgag ctggtcgagg atgcgggcga
     5461 cgtagtggcc cgggtctttc atggtctact cccatctggc ggacggcgcc gccgggcggc
     5521 cggcgaggta gccgccctgc ccggtgatcg ccgaggcctg atcgctgatc aggaatccgg
     5581 tcagggccgc cacgccggcg gcatagctcg ggccggtgcc gccgccgccg gcggccgcgg
     5641 cgggcggcgg cgcgggcgcg tgggccggac cggcgggata gcagctgctc ggcgcgatgt
     5701 agttcgcggt gacgccgtac gcggccaact ccagcgccgc ggagcgggtg aaaccgacga
     5761 gcccgccgag cacggtctgc ccgtcgcgcc actcgcggtc cgccgccccg tcggccaccg
     5821 ccggctgcgc gatattgacg atccggcccc accggttgcg caccatgtgc gcgcagacgg
     5881 cacggcagca ggcgaacagc gcccgcaggc tgcgccgcgc atcggcgtag cgctcctcgg
     5941 cggacagcgg ctcgggaccg ccgagcggaa cgcagttcac cagaacactg ggactgccca
     6001 ggaccgagcg cgccccgccg agcgcagcgg cgaacgaccg gccgtcggcg aggtcggccc
     6061 ggatggcgag gcagtgccgc ccgccggcga agaaccgctc cgtgacctcg acgggcacgg
     6121 ccacgtcggc gccgatcaga gcgacatcga ggccgagctc cgcgagctgg agcgcggcag
     6181 ccaggccggt atcgcacgcc ccgccggcca cgacggccat ccgggacagc gcgccggtct
     6241 gcccggcagc cgcggtcagc ccggtcaccg cgagccgcct tcgccgcacg ccgccggcag
     6301 tctgcgccgc gcgccggaga tgctcgcttt gccgaccgtg ctcgcgccgc cgaacaggga
     6361 ctcgccggag aagctcgcgc cgccgaccgt gctcgcgccg ccgatcaggg acttgccgaa
     6421 gaggctcgct tcagtggccg aattcgcgcc gccgaacagg gacccgccgg aaacgctcgc
     6481 ttcgccagcc gtgctcgcac cgccgaccag gcgcccgccg aacaagctca cttcgccgaa
     6541 ctcgctcgcg ccgctgaacc tgctcgcgcc gccgaacctg ctcgcgccgc cgaacctgct
     6601 cgcgccgccg aacctgctcg cgccgccgga gaagctcgcg ccgccgaact cgctcgcgcc
     6661 gctgaacctg ctcgcgccgc cgaacctgct cgcttcgccg aacctgctcg cgctgccgaa
     6721 cctgctcgcg ccaccgcaca gcacgctccg ccgactcatc gccggcctcc gtcgacggac
     6781 acggtctgcc cggtcaggta gccggagtcg cggccggtga ggaaggccac cacggcggcg
     6841 atgtcgtcga ccgttccgac gcggccgacc gccgcgtggg atgccgcctc cttcaggaac
     6901 gcctcgcggt ccacgccgag gcgatcggcc agttcggcga ccatcggggt cgcgacgaag
     6961 ccgggcgcca ccgcgttcac ggtgatgccg tgcgggccga gttcggaggc cagggcgcgg
     7021 gtgaagccgg cgagggcggc tttcgcggtc gcgtagttgc tctggcccgg gttgccgtcc
     7081 gccgcgaccg agctgaaggt cacgatgcgg cccgtgccgc ggtgcttcat gagctcggcg
     7141 gccgccaggg accagcgcat cgtgccgccc aggctgacgt ccagcactgt gtcccactcc
     7201 gggtcgtcca tggccaggag caggcggtcg cgggtgacgc cagcgcagtt caccaggatg
     7261 tcgaggcgcc cgtaggccgc cgcgatccgc agcatcgccg tccgcacctc ggccgcgacc
     7321 gccacatcgc agccgatgcc gagcgcccgg ccgcccgccc ggcgcacggc cgcgacggtc
     7381 ccggccgtgt cccgctcctc gcggtccacc acgacgacgg tcgccccgcc cgccgcgagc
     7441 cgcagcgcca cggccgcgcc gatgccccgg gccgccccgg tgacgaccgc gacggttccg
     7501 gtgccgtccg gcgtcctgct catcgcgggc cgccggagcc ggtcgcggca gtcgactgtg
     7561 cgcgggctga ctctgtgccc gtcgactccg tgccagccga ctctccgcca gccgaccctg
     7621 tgccagacga ctctccgccg gcagactccg cgcctgcccg gtccacccag acccgcccga
     7681 tctccgccaa gcacgcgtgc cgctcggccg gtccgaacac cgcccgccag ccgcccggca
     7741 ccggcacgtc gccggccgcc ggccacagcg agtactcctg cgccgcgttc cccagcacca
     7801 agaacggcgc cgcctcatcg tccaaaacgt tcatgtccca ctcactccga tccgctggtc
     7861 gaggcgatcc gccgcgtcac gccgtcatcc gcaccggcat cgagtgcatg ccgtgcagga
     7921 tgctggagta gatccacttc tcctcgccga tctgctcgac gttcccgacc aggcgccgca
     7981 gtccgtccag caccgcgtgc acctccatgc ggccgaggta gtggccgagg cagtagtgca
     8041 tgccgtaggc gaacgtgaag tggttgttgg gggtgcgccc gagcaggaac cggtccggct
     8101 cgtcgaagac ctcttcgtcg cggttcgccg agtagatcca gacgctcgcc acgtcgccgg
     8161 ccttgatcag cttcccgccc agctcgacgt cgccggtcgc ggtgcgcccg ccgtgcaggg
     8221 agggcaccgt ccagcgcagc gcttcctcgg tcgcggtctt gatgtcgacg tcgccgttct
     8281 tcagcgcgcg ccactggtcg gggttctcgg tcagggccag gatggtgccg gtgatcgcgt
     8341 ggcggccggt ctcgtcgccg ccgatcatca ggccgtagca gttcgccatc agctcggtcg
     8401 cgctgagcgg ctcgcccttg atgcggcagt tcgccagcag cgtcaccatg tcgtcgtact
     8461 cggcgccgcg gcgctccttg gccagcctgc tgaaatacag caggatctcg ctcttggcga
     8521 cccaggcctc ctgcggcggc tcgtccgcgt ggtcggtgct ccacgcgtgc gaggtcaggc
     8581 cgagcaggtg gtggcggtcg gattcgggga tctccagcag gtcgcagatc gccccgagcg
     8641 ggacgttcgc cgccacgtcg tgggccgcgt cgcactcgcc catgtcgagc gcgttcttca
     8701 gcaggcggtc cacggtctgc tggagcgagt gccggacggc ctccagcgtg cgggggttca
     8761 gaccgcgggt catgacgttg cggatctgct ggtggcgcgg gccgtcggtg accgccagca
     8821 tcgtgccgga cgccgagtcg cccccggtga gcagggtcgc cagcgcgttg ccgccggcgg
     8881 tcgtgaagtg gcccttgtcc tggtagacct tgtggacgtc ggcgtgccgg gtgatcaccc
     8941 agaacccggg gcggccgtcc accggccggt gccagtgcac ggggtcgttc gcgcgcaggt
     9001 ggcgccagac ctcgtccagg ttgttctccg cgtgcaggac cggcgaggcc aggtccacgc
     9061 ggtcgaggtc gtccggttgg acgacgggcc ggggtgtcat gtcagctccc gtccgccgcg
     9121 gccgcggcga gcatctcgat ggtggggttg tcgatcaggg cgcgcggggt gagttcgagc
     9181 ccgaagtcct gggcccgcag gatcacgtcg atcgccacga tgctggtccc gccgagcgcg
     9241 aagaagtcgg cgccgacgcc gacctcgtcg aacccgagca gctcgccgaa gatcaggcac
     9301 agcgccttct ccgccggcgt ccggggcccg ccgccgacca tgtgcggcgc cgcggccggc
     9361 tccggaagcg ccgcgcggtc gaccttgccg ttcggcgtca gcggcagggc gtccacggtg
     9421 gtgaacagcg cgggcaccat gtactcgggc aggaagcgcg ccgcgtgttc gcgcagcgcc
     9481 gcggacgagg gccggccgcc gtcggccggg accacgtagg cgaggagctg cgccgcggtg
     9541 tggtgcgcga ggccgtaagc gcccgcgacc gacgaggagc gcacgaccgc gaccgcgcgt
     9601 gccacctccg gatgccggcc gaggacggac tccacctctc ccagctcgat ccggaagccg
     9661 cgcagcttga cctgctcgtc gacccggccg tggaagacga tgccgccgcc cgcgggccag
     9721 gaggcgaggt cgcccgtccg gtacatgcgc gtgccggccg aggagaacgg gtcggccagg
     9781 aaccgctgcg cggtcagctc cggacggccc agatagccgc gggccagccc gtcgccggcg
     9841 atgaacacct cgccgatctc gccgggcggg accggccgca gggtgtcgtc gagcacgtac
     9901 accgacaccc cgggcatcgg cgtgccgatg gtgatcggct cgccggcggc cagcggtccg
     9961 gtcatcgtgg cgcagaccgt gccctcggtc gggccgtagg cgttgatcat gcggacgtgc
    10021 ggagcccagc gctcgaccag cgcggccggc agcgcctcgc cggcgacgac cagggtgcgc
    10081 aggtccggga cgtcctcggg ggcgatggtc cccgcggcgg tcgggggcag caccgcgtgg
    10141 gtgacggcgt ggtcccgcag caccgcgcgc agcacgtcgc cggccaagac cccggccggc
    10201 gggatgacga gcgcggcgcc ggaggtcaag gccgcgagga tctctgtgag gtacgcgtcg
    10261 aagctcggcg aggcgaactg caggacccgg ctgtcgccgc cgacccgcat cgtgtcgatc
    10321 ttcgccgcgg ccaggcccgc gagcccggtg tgggtgacgg ccacgccctt gggcaggccg
    10381 gtggagccgg aggtgtagat gacgtaggcc aggtcggtca cagagaccgg ctggcggcgc
    10441 tcctcgtccg tgacgtcggt ggcggcttgg gcccgcaggg cactgagctg cggcgccgag
    10501 tccagcacga ggctcgggac cggcacgtcg gccggcagcc ggccgagggt cgcggcggtc
    10561 gcgcagacca gcaccggagc cgcgtcccgc agcatgtgcg cgacgcgttc ggccgggtac
    10621 tcggggtcga cgggcaggaa ggcggctccg gtcttcgcca cggcgagcac cgccaccgcc
    10681 atgtccacgg tgcggcccag cgccagggcg accaggcgcc cgggaccggc gccgccggcg
    10741 atcagcactc tggccaggcg attggcgcgc tcgttcaccg cgccataaga aagtgtttct
    10801 tctcccgcga taagtgcggt gtcgcgggaa tgtctcaggg cagcgtcatc ccatatctgg
    10861 gacagatggc gtcgcacggc attctcctct caccagagtc aggactcgga ttttcgccac
    10921 cgtatgccgc cccggagccc ggccgccatc ccccaccttg gtagagcgaa gagcccggaa
    10981 tagcactacc aacatggggg atagtgcgcg gcgcgcgacg ggcctagcgt tcggaaaaag
    11041 ggatgtcgcg ctctgacaga aggatcctga caaaaaggat ggtgttttcg gagatgaccg
    11101 aggtaatcgt cgtcggcggc ggtccggccg gatcgaccgc agccgcccta ctggccaaga
    11161 acggagtttc ggtcacgctc ctggaacgcg aggcgttccc ccgctaccac gtcggcgagt
    11221 cgatcacgta ctcgtgccgg ggcgtgctgg actacatcgg cgcgctggag aagatcgaag
    11281 cccgcggcta cacccgcaag accggcgtgc tgctgcgctg gggacaggag ctggactggg
    11341 cgatcgactg gaccgcgcag ttcgggccgg acgtgcgctc ctggcaggtg gaccgggagg
    11401 acttcgacca ggtgctgctg cagcacgcgg ccgagtgcgg cgcccaggtc ctggagcagg
    11461 cgcaggtcaa gcgggtggtg ttcgaggacg gccgcgccgt cggcgtcgag tggacgcccc
    11521 agggccacag cgagccgcag atcacccgcg cggacctggt cctcgacgcc tcgggccggg
    11581 ccggtctgat cagcgcccag cacttccgcg accgccgcgc caccgagatc ttccgcaacg
    11641 tcgcgatctg gggctactgg gacggcggcg agctgctgcc ggacagtccg tccgggagca
    11701 tcaacgtcat ctcctcgccc gagggctggt actgggtcat cccgctgagc gggaaccggt
    11761 tcagcgtcgg ctacgtcacg cacaaatcag tgttcgtcga gcggcgcaag gactacgaca
    11821 ccctggacga catgctcgcg gcggtggttg ccgagtcgcc gacggtgagc gaggcgatgg
    11881 ccaagggcac ggtccgcccg ggcgcccggg tcgagcagga cttctcctac gcggccgaca
    11941 gcttctgcgg cccgggccac ttcctggtcg gcgacgcggc ctgcttcctg gacccgctgc
    12001 tgtccaccgg cgtgcacctg gccatctaca gcggactgct cgcggccgcc tcggtgctct
    12061 cgatcgagaa cggcgacgtc accgagaccg aggcctacgc gttctacgag tcccgctacc
    12121 gcaactccta cgagcggctg ttcacgctgg tcgcgggctt ctaccagaag cacgccggca
    12181 aggaccgcta cttcgagctg gccaaggccc tgacccggga gcacaagggg ctggagggca
    12241 gcgccgacct ggcgttcggc gagatcacct ccggcatcac cgacctgcgc gaggccaagg
    12301 acgacagcgg gctcggcgac cggccgatcc gcgagtccgt cgccgaggcg gcctcccggc
    12361 gctcgaaggt ccaggacctg ctcagcgcga ccgagcaggc gcagcagcgg gccgaggccg
    12421 ggctgcccaa caccggcggc gaccgcggcc gctcgcgggt gcagatcgac gccgacgacc
    12481 tctacgacgc cgcgaccggg ctgcacctgg tcatggaacc gcggctgggg atccagcggg
    12541 cggcggtgcc ggcggccggc tgacggctga cggctgacgg cgtgagagcg ccgcaccggc
    12601 ccggcggaag ccggccggtg cggcgtcgat ccgtgcgccg ggctcagccg gccgccccgg
    12661 gctccaggcc gccgccggag tccagctcgg cccacagcct cgcgagctgg acgcgggagg
    12721 ccacgccgag cttgcggaag atcttccgca ggtggaaggc gacggtgtgc cgggacagat
    12781 acaactgttc ggcggcctga ccgttggtca ggccgccggc gacgagcttg gcgatggcgt
    12841 actcggtcct ggtcagtccg gcgacaccgc tcgccggcag tccctggtcc tgggccggga
    12901 cgatggtgtt gatccccctg agcctgctct tgacgcgggc cgcgtcccgc agggcgccga
    12961 tctgcgcgta ggcgccgcgg gcgtcctcca ggatcagcgc cgcccgcccc cggtctcctt
    13021 tccggtcggt cagcaccgcg ccgacgtctt cgaccgctga ggcccgcgcc cactggtcga
    13081 cgtgcagctc cgcggcggag gcgagcttct ccatgtccgc ctcgtacagc gccacggcgt
    13141 gcagggcggc ggcggccgtg gagcggacgc cggggttcac cgcggccagg cggcgcgagg
    13201 cccacacgcc ctcctgggcc agagcgcgct cgccggactt gagcatcagc cgcaccagcc
    13261 agggcgccgc cgccggttcg gagatcagca gctgccggat gacgtggccg gagtccagca
    13321 gctcggcggc ccgcgccgcg accttctccc agccctgttc ggcctcggcg atctgcagga
    13381 ttgcccaggc cgcctgcccc gggggcagca tcttgcggcc gaagacggcg tcctcctcca
    13441 tccgctgcgc gtagcggagc gccgtggcca ggtcgccctg ccgcacggcg gttaacgcga
    13501 tcacgaagtt cccgagcgga gtccaggact tcaggccgac ctcctccgcc tcccgcaggc
    13561 cggcggcggc cagcgcggtc gcggtgtcga aacggcccgc cgccgcctcg accttggcgc
    13621 ggaccagcgt cgcggcggtg gccagcggcc ggtcgccgcg cgcggccgcg gatatgtcga
    13681 ccgcgtcgag ggcccggacg gcccggtcga cgcggcggat ctgagacagc agcatggcca
    13741 gccagagccc tgcgtactgg ctgcatggtt cggcgcactc cgtgcagtcc gtgcggaacg
    13801 ccgcgtcggc gtggccgatc ccactctcca gccggccggc cagccaggac ctgcgcgacc
    13861 gcgtcaagcg gtcggtcacc ccgcagaccg gcgcccggac ggaccgcaga tcgtcgttcc
    13921 tgatgatgat gccgcgcatt ccgacactcg tactcatcga agcccccatg atctcatcgc
    13981 ggctccccct gccgaaaaac cggcgtccgc cgtgccttcg ggtcggaagg gcggcggacg
    14041 cgcggtgcct cgggacgggg agagagtaat tgcactcgga aagtcgttga aaacgtcacc
    14101 atcccccatt gaatggcgtt tccatctatg ccctactata taaggaccct caaatataat
    14161 caagttgtta ttcgtgcaag ctcctcccaa tcaggcatcc gggccggtca ggatcttttc
    14221 accacagccg aacccgtccg gctgcccggc acctccgcgg cctgccccgt ggccggacgc
    14281 cgccggagcc gccgcgcggc ggccaggtcg acggacgcgg cggccagggc gaccgtgaca
    14341 agcgccgcgg cgccgtacag acttcgggac gcggcgccgc tgtagtcgtg acgcaggacc
    14401 ttcagatgcc cgaagaacat cgtggcggcc atggcggtgc ccaccgacat gccgatgcgc
    14461 tgcccggtct gcaccatcgc ggccgcggtc ccgctgctgg ccggcggcac gaactggagc
    14521 gccagcgtct ggttcgggcc gatgaccagg ccgctgccga gcccggccac cagcagcggg
    14581 aggaacaacc gcgcccagac cgcgccgccg gtgtcgtgct ggatgatcac ggccgccggg
    14641 atcaggccgg ccaggacggc caccaggccg gccaccacga gcacccgtcc gatgcggtag
    14701 acggcccgcc cgctgacggc cgcgctgatc gccgatccca ccgcgaacgg catgctcgtc
    14761 gcgccggccg ccagcgccga ataggcgcgc ccctgttgca ggtacaggga caagatgaac
    14821 agcacaccgg gatacccggc gaagtaggcc agcccgacca ggctgctcgc gccgaacgac
    14881 ggcgttcgca gcagactgag attgaccagc gggtccagac cgcgcccctt ccaccagcgt
    14941 tcccagaaca cgaaggcgac cagcagcacc gccgccaggc ccagcagcca ccagtgcacc
    15001 gccgcgccgc cctgctcctg ctcgatgagc ggcagcatga tcgaggtgat gccgccgccg
    15061 agcagcgcca cgccgaccag gtccatcccc cggccgcgcc gccggggcgg gatcttgggc
    15121 accagcagca cgccgagcac caggccgacc acgccgatcg gcaggttgat caggaacatc
    15181 cagcgccagc cgccggcctc gatgagcagc ccgccggcca gcgggccgat cgccgtggcc
    15241 acggcgacgg tgccgccgta caggccgaag gccttgccgc gctcgctgcc ccggaacagc
    15301 tgctggatca tcgcgatgat ctgcgggttc agcaggccgc cggccacccc ctggagcagg
    15361 cgggcgacga cgagccactg ggcggtgggc gagagcgcgc acatcaggct gaccccggtg
    15421 aacaggaaga gcccgagcag gaacacgcgt ttgcggccga gggcgtcgcc gagcttcccg
    15481 gagggcacca ggaccaggcc gaacgtcagg gtgtagccgg cgcgcaccca ggagacgtcc
    15541 gccggggagg cgcgcagccc ggcctccatc tgcgggaggc cgacgttcac gatgctgacg
    15601 tcgagcaggg tcatgaagcc ggcgaccagg cacacggtca gggcgcgcca acggttcgga
    15661 tctgcgggcc cgtcatcggg cggcgcggcg cgttcgtagc tctgcgtcat gatttacact
    15721 gtaaacgctc tcgcttacgt tgtaaatccg cgataacgtt gtacacatga gcaccgagaa
    15781 cgtcgacgag acagcggcca cccgctcgat ctgggagcgg atggccctgt ccccgccggt
    15841 ccaccgcccg gtgctgaccc acgccctgat cgccgaggcg gcgctgcgga tcgccgacgc
    15901 cgacggcctc gaggcggtgt cgatgcgaag gctcgccacc gagctcgggg tgtcgtcgat
    15961 gacctgctac cgctacgtct caggcaagga cgacgtcata gagctgatgc tcgacacggt
    16021 ccgcggcggc atgctcctcg atgaggacga actcgccgaa ccgggcgaac ccggcgagtc
    16081 ggccgggcgg gctgagcctg ccggctccag ccactggcgg cgcgtcctgc gggcctcggc
    16141 gatgcgcttc cgcggcgtca tcctgatgca cccttggatg accgacctgc ccggccgcat
    16201 cctgttcgcc ccgaccccgg ccttcctcgc cgtcgccgaa cagaacctcg ccgccttcga
    16261 cggcctcggc ctgaccgcgg cccagatcac cgacatcacc ggcgcggtca ccgcctacac
    16321 ccgcgccggc acccacgacg aggtcacccg cgaacggctg cgcgcccccg agggctggac
    16381 ctcaccgcgg gacgccaagg acgcgaacac cgaccgcctg gcctggctgc tcgcgaacgg
    16441 cgactacccc cgctacgagc gctccctgca cgagggcgcc ccccgccacg acgagcaggc
    16501 ccgcttcgaa ttcggcctcg actgcctcct cgacggcatc gcagcgcgcc tctcgcgctg
    16561 a
//
