BGC0001157: bottromycin A2 biosynthetic gene cluster from Streptomyces scabiei 87.22
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 6,304,534 - 6,321,700 nt. (total: 17,167 nt).
This entry is originally from NCBI GenBank FN554889.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001157
Short description bottromycin A2 biosynthetic gene cluster from Streptomyces scabiei 87.22
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • RiPP (Bottromycin)
Loci NCBI GenBank: FN554889.1
Compounds
  • bottromycin A2
Species Streptomyces scabiei 87.22 [taxonomy]
References
Chemical products information
bottromycin A2
Copy SMILES
C42H62N8O7S1
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCAB_56591
  • CBG72685.1
6304534 - 6305976 (-) putative cytosolic aminopeptidase
  • Tailoring (Hydrolysis)
Sequence-based prediction
copy AA seq
copy Nt seq
  • SCAB_56601
  • CBG72686.1
6305981 - 6306553 (-) hypothetical protein
  • Regulation
Knock-out
copy AA seq
copy Nt seq
  • SCAB_56611
  • CBG72687.1
6306673 - 6308631 (-) Radical SAM methyltransferase
  • Tailoring (Methylation)
Knock-out
copy AA seq
copy Nt seq
  • SCAB_56621
  • CBG72688.1
6308639 - 6309775 (-) P450
  • Tailoring (Oxidation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • SCAB_56631
  • CBG72689.1
6309855 - 6311276 (-) Putative hydrolase
copy AA seq
copy Nt seq
  • SCAB_56641
  • CBG72690.1
6311273 - 6312088 (-) Putative hydrolase
copy AA seq
copy Nt seq
  • SCAB_56651
  • CBG72691.1
6312123 - 6314138 (-) Radical SAM methyltransferase
  • Tailoring (Methylation)
Knock-out
copy AA seq
copy Nt seq
  • SCAB_56661
  • CBG72692.1
6314135 - 6315574 (-) YcaO domain protein
  • Tailoring (Heterocyclization)
Sequence-based prediction
copy AA seq
copy Nt seq
  • SCAB_56671
  • CBG72693.1
6315426 - 6316682 (-) YcaO domain protein
  • Tailoring (Heterocyclization)
Sequence-based prediction
copy AA seq
copy Nt seq
  • SCAB_56681
  • CBG72694.1
6316746 - 6316880 (-) Precursor peptide
  • Scaffold biosynthesis
Knock-out
copy AA seq
copy Nt seq
  • SCAB_56691
  • CBG72695.1
6317014 - 6318951 (-) Radical SAM methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • SCAB_56701
  • CBG72696.1
6319368 - 6320207 (+) Methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • SCAB_56711
  • CBG72697.1
6320390 - 6321700 (+) Major facilitator superfamily protein
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
RiPP-specific information
Subclass Bottromycin
Cyclic? yes
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: YDLZYFWUWQQQNGTRZENZCBP5, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.