BGC0001169: piericidin A1 biosynthetic gene cluster from Streptomyces sp. SCSIO 03032
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Location: 1 - 49,160 nt. (total: 49,160 nt).
This entry is originally from NCBI GenBank KF874660.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0001169
Short description piericidin A1 biosynthetic gene cluster from Streptomyces sp. SCSIO 03032
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: KF874660.1
Compounds
  • piericidin A1
Species Streptomyces sp. SCSIO 03032 [taxonomy]
References
Chemical products information
piericidin A1
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C25H37N1O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHE80990.1
 1 - 801 (-) PieR
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  • AHE80991.1
 1190 - 8497 (+) PieA1
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  • AHE80992.1
 8530 - 18633 (+) PieA2
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  • AHE80993.1
 18700 - 23964 (+) PieA3
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  • AHE80994.1
 23977 - 30507 (+) PieA4
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  • AHE80995.1
 30534 - 36179 (+) PieA5
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  • AHE80996.1
 36194 - 43381 (+) PieA6
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  • AHE80997.1
 43378 - 44067 (+) PieB1
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  • AHE80998.1
 44183 - 44725 (+) PieC
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  • AHE80999.1
 44727 - 46568 (+) PieD
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  • AHE81000.1
 46582 - 47367 (+) PieB2
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  • AHE81001.1
 47364 - 49160 (+) PieE
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Polyketide-specific information
Subclass Polyene
Starter unit Malonyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
AHE80993.1
+
AHE80996.1
+
AHE80994.1
+
AHE80995.1
+
AHE80992.1
+
AHE80991.1 		Synthase subclass: Modular type I
Module 0
Specificity: Malonyl-CoA
Genes: AHE80991.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Genes: AHE80991.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Methylmalonyl-CoA
Genes: AHE80992.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Genes: AHE80992.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Genes: AHE80993.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Genes: AHE80994.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Genes: AHE80995.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Methylmalonyl-CoA
Genes: AHE80996.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 8
Specificity: Methylmalonyl-CoA
Genes: AHE80996.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: YU43TGF6RSKW2WJOQIFYBQO4, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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