LOCUS       BGC0001206             11720 bp    DNA     linear   BCT 15-MAR-2015
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 12648 indolmycin
            biosynthetic gene cluster, complete sequence; and Ind0 (ind0) gene,
            complete cds.
ACCESSION   BGC0001206
VERSION     BGC0001206
KEYWORDS    .
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 23:58:41
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11720
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..11720
                     /culture_collection="ATCC:12648"
                     /db_xref="taxon:67263"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces griseus subsp. griseus"
                     /strain="ATCC 12648"
                     /sub_species="griseus"
     subregion       1..11720
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11720
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(862..1827)
                     /gene="ind0"
     CDS             complement(862..1827)
                     /codon_start=1
                     /gene="ind0"
                     /note="putative tryptophanyl-tRNA synthetase"
                     /product="Ind0"
                     /protein_id="AJT38681.1"
                     /transl_table=11
                     /translation="MIKLSGITPSGEAHLGNYLGAVRRWAREPGEGDLYFVSNLHAMTT
                     PHEPDRLRKLTEHQLAILIASGVPAESMFVQSDLIQEHMALSWLLECTCTFGEARRMVQ
                     FKEKSDGNSSVRLGLLTYPVLMAADILLHGTTEVPVGNDQNQHVELARTLARRFNSTYG
                     EVFVVPEAVLPTTGARVRDLANPAKKMSKSSSEPDSIVYVLDDPDVVRRKFRRAVTDGL
                     GKVAYDPQEQPGVANLLEIMAACTDMTPVAVASGMTTYRELKESVADVVVKELAPVRER
                     ALDLLRSGSELREIRAAGADRARDRSGSRLNRALELAGVG"
     misc_feature    862..11207
                     /note="indolmycin biosynthetic gene cluster"
     gene            2494..3483
                     /gene="ind1"
     CDS             2494..3483
                     /codon_start=1
                     /gene="ind1"
                     /note="putative methyltransferase"
                     /product="Ind1"
                     /protein_id="AJT38682.1"
                     /transl_table=11
                     /translation="MTRTDFAQSAVASIFTGAIASHAAVLADDLGLFDALAKGKLRNRD
                     LDRSPWLRNRIRISGALEALCRVGAVQRCTDGYELTDVGTELAGQVPVFRLWLGGYASV
                     LAGQISIGADPATGVHGGIVAESSGAIGARYLDETIVNLLESLRPEGRICDIGCGTGAR
                     LLRVCRRVNQPGIGYDLSAKAVEAARETVDEARRIGVDIDVRQGDATALTQDHPDVDIV
                     TQAFMTHHIAPDEYCAAVLRSYRSRFPRARYLVIFDTVPSQDSEEPEIFAPGFDYIHAL
                     QNMEPRSRGAARRMFTEAGYICREEVELAVPNSYAWVLEMRDREGPAS"
     gene            3480..5192
                     /gene="ind2"
     CDS             3480..5192
                     /codon_start=1
                     /gene="ind2"
                     /note="putative dehydrogenase"
                     /product="Ind2"
                     /protein_id="AJT38683.1"
                     /transl_table=11
                     /translation="MKLDDKRILIIGAGEVGTAVAEDLVNRSDPTEIIIHTSRQQTMDM
                     RVGHLKEMAGPRTLLTGSWGDIFAPYELTHRSRSEINDRNVRLALAEFFLQPSGEAQLR
                     RTTIYELISRHRPHIVIDAVNSASVCTYTEDPHQTCGELLDLARGTGGPRTAEAPAELP
                     AVTPDIADVATDALLSLSTPILHRYVDSLRRAMADFQVERFIKVSTTGLGGMGYNCPYT
                     HGSVTEFGLSDALVGKIGSAGVLHQLLWNLHHTAGCDVRLVIPAALIGWESVRHGAYTS
                     RGRPVALQDCSRPLPLHLDRPLGEHAAASSVAEPAAEDEPSAEMVHVPAGDNSTYSRAE
                     MSLSTALGQFESVTREEVAAAVLDTLLGSTRFDLFTAMDTASLQSSYLAAQMRTSTLTS
                     MRQLEKAYDRPSIVSGNLGPTISKDLLELHVLCTAAGSLEQARTMSTTVLASSASALVR
                     EDVYLRQQALSIGLAVLLPDDQWLAGPRLSVPSRIDPEAKVTRADIDDWSRQGWVDLRP
                     ARILHWQENLRRIEQDASAGKTAFALDDTAYDVGEVLAYHYKLTGQARRIKGL"
     gene            5189..6547
                     /gene="ind3"
     CDS             5189..6547
                     /codon_start=1
                     /gene="ind3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="F390 synthetase"
                     /product="Ind3"
                     /protein_id="AJT38684.1"
                     /sec_met_domain="AMP-binding (E-value: 6.4e-08, bitscore:
                     20.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGARQEHKVKDFGQEQIRKLMDEAPELRRELRRNQYLDRSELQQ
                     LQDAAFVKMVRHAYVNVPFYRKKYDEAGVDIESIRGASDAFRLPILEKEDLIEAFPHRS
                     IADGYSLDDLTTAVTGGSSGTTVRVAYSDETMRKRVMTAYRIYDMMMGGYHSHHVQTYV
                     YTGKYPLEGLLDGSFPLVHIWTLDPVEDARRKLLDSKPHMLTLYPSRLEDIRRGLTPQD
                     VAELRENLVVINVKSEMSTQAQRDAWAEFFGVPVLDEYGSEEMAGTVAAQCPDKGYHIW
                     EDIAVVEVVDEAGQPLPDGETGELVATCLYNWAMPMIRYRQGDIAALHPADHSCSCGRT
                     LRQLKSFEGRRNSSFTLPSGRFLSSGYLLDVGYTRLMAYADALDSWSLVQREPDLVVFE
                     CIPGPAMNEAVREAIQREVSELLFHETKVQVEFVDALRTTNRGKRNQIISLVP"
     gene            6604..7755
                     /gene="ind4"
     CDS             6604..7755
                     /NRPS_PKS="Domain: Aminotran_1_2 (18-353). E-value:
                     3.5e-17. Score: 54.4. Matches aSDomain:
                     nrpspksdomains_ind4_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="ind4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 108.7; E-value:
                     5.3e-33)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative aminotransferase"
                     /product="Ind4"
                     /protein_id="AJT38685.1"
                     /transl_table=11
                     /translation="MERFNNLTRYEHVGINQAINLADGHAHQGQNSTQQAIVADLPNIF
                     EAAENALQATTEREFQRAFYTLAGQHSAVDHPRTMLCYSASLSTDLVATFLASRNLTVG
                     LLQPCFDNLATILRRRQVKVVPLGEEQFRPESLDRTFAELNTDAVFLTLPNNPTGFHLD
                     QEQFRRVIDLCAEHQKILIVDCTFRFFAPTPFWDQYAQLEESGISYVVVEDTGKTWPTQ
                     DLKCSILAVSTDLHESVLELHNDILLNVSPFILQLLTAYLRDTERNGLQQTIWSVVRAN
                     RISLRKALEGTVLVPAHPESTISVEWVRIDHPSLRSDDLVEMLAKSQVGILPGDHFYWD
                     DHETGSHFIRFALAREERWFATACGSLREALLARPELIEGAGS"
     aSDomain        6658..7662
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ind4_Aminotran_1_2.1"
                     /evalue="3.50E-17"
                     /label="ind4_Aminotran_1_2.1"
                     /locus_tag="ind4"
                     /protein_end="353"
                     /protein_start="18"
                     /score="54.4"
                     /tool="antismash"
                     /translation="INLADGHAHQGQNSTQQAIVADLPNIFEAAENALQATTEREFQRA
                     FYTLAGQHSAVDHPRTMLCYSASLSTDLVATFLASRNLTVGLLQPCFDNLATILRRRQV
                     KVVPLGEEQFRPESLDRTFAELNTDAVFLTLPNNPTGFHLDQEQFRRVIDLCAEHQKIL
                     IVDCTFRFFAPTPFWDQYAQLEESGISYVVVEDTGKTWPTQDLKCSILAVSTDLHESVL
                     ELHNDILLNVSPFILQLLTAYLRDTERNGLQQTIWSVVRANRISLRKALEGTVLVPAHP
                     ESTISVEWVRIDHPSLRSDDLVEMLAKSQVGILPGDHFYWDDHETGSHFIRFAL"
     gene            7752..8711
                     /gene="ind5"
     CDS             7752..8711
                     /codon_start=1
                     /gene="ind5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 191.6; E-value: 2.3e-58)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative dehydrogenase"
                     /product="Ind5"
                     /protein_id="AJT38686.1"
                     /transl_table=11
                     /translation="MSATRTPRIVCLDEPTYLTGGFLRQLSALGAVRVHYDRPGQREAV
                     RRLATADVALVEWTRLSADLLRAVRDTAGSGGVRHISTLLSATDQIDLGATRELGISVS
                     HCPDYSVSAVAEYVIACVGTLSRQILPASRAGAAGVAHRYPPFLGGDLRGSVLGLVGTG
                     RIGRAVARRADALGMRVLGSNREGRAVPGVEVVGLEELARRSDVLSVQVPSNESTRELL
                     SEELIGLLRPGCVVVSVSRAQTFAMHALADRHRAGELGGIALDDAPAELVPTLSAQPNT
                     LLTPGIAWYSRDSRQDNLTEVLANVSGFLKGEPVNVVR"
     gene            8698..9387
                     /gene="ind6"
     CDS             8698..9387
                     /codon_start=1
                     /gene="ind6"
                     /product="Ind6"
                     /protein_id="AJT38687.1"
                     /transl_table=11
                     /translation="MSFDNQNRDKTPVGAFPWLEDQLSHTGAAAVVRRTPGMPNALEVR
                     VHADRAPEICVLCCWHEPWTAGPLGIESDVSMSALYVLELLDHACRAAGPSLVAHFIAD
                     DNEHSRTSAFAAGRAQLAEAPAPVLAVVAAGCAPGGGLAVPSTAGTRQPLTVPPALPRL
                     TEGLDPDVIEALEVCAEAGITACVVDPAGRDHDLWPATELYRTLAAAARGEEWNPHAHG
                     LGDIGVG"
     gene            9353..10066
                     /gene="ind7"
     CDS             9353..10066
                     /codon_start=1
                     /gene="ind7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 73.1; E-value:
                     4.2e-22)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative methyltransferase"
                     /product="Ind7"
                     /protein_id="AJT38688.1"
                     /transl_table=11
                     /translation="MHTDWETSESAEDYSRNTAAAQWEPMGYPAVFRSLALATTDSDNA
                     PPILDYGCGPGFVDRHVAEKYGRRVIAVDISSSMIDLARSQHSHPLVTYRHVPDSQLDF
                     LGDKEIGGCMSCFVLMQMADSDTQVEICRRIRRTLAPGAMLAVLNTHPDSVGIQFATLR
                     NGEPDRVYQPGDPMTTVLTTDKGVLRLQDYYWRVTDYVHALEAAGFHEVTVEHLPPPPA
                     DPTPHPQFLLVRGTA"
     gene            10122..11207
                     /gene="ind8"
     CDS             10122..11207
                     /NRPS_PKS="Domain: Aminotran_1_2 (36-353). E-value:
                     2.9e-43. Score: 140.2. Matches aSDomain:
                     nrpspksdomains_ind8_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="ind8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 158.5; E-value:
                     4.1e-48)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative aminotransferase"
                     /product="Ind8"
                     /protein_id="AJT38689.1"
                     /transl_table=11
                     /translation="MSSTPAPGFGRIAEIDRLSAYRQEDAAAEGEDRFVWDLSNNESAL
                     PPLPAVAEAVRQGGLHTARYPDPTAGSLVRALSRHFGIDTRKVLVGPGSAGVLQQLLLS
                     LCGDGDEVIHASPCFDAYPLLIAVAGARCLPVPLTELGDHDLPEILARVTPRTRVVILC
                     SPHNPTGSRLPDTDLRGFLADLPRHVTVVLDEAYIEFDEAKEPRDLNVLRRDPRVVLLR
                     TFSKAYGLAGLRVGYALAAPDILERARKTAIPFSVTRTAELAAIVSLEQQEALAERMAH
                     TRKLRTDLHAALDAEGLSPLPSCGNFIWIPLGSSSESFAAMVQGAGIKVRACPGQGVRI
                     SVGSEPAHRHLLEVVRHRAKS"
     aSDomain        10230..11180
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ind8_Aminotran_1_2.1"
                     /evalue="2.90E-43"
                     /label="ind8_Aminotran_1_2.1"
                     /locus_tag="ind8"
                     /protein_end="353"
                     /protein_start="36"
                     /score="140.2"
                     /tool="antismash"
                     /translation="DLSNNESALPPLPAVAEAVRQGGLHTARYPDPTAGSLVRALSRHF
                     GIDTRKVLVGPGSAGVLQQLLLSLCGDGDEVIHASPCFDAYPLLIAVAGARCLPVPLTE
                     LGDHDLPEILARVTPRTRVVILCSPHNPTGSRLPDTDLRGFLADLPRHVTVVLDEAYIE
                     FDEAKEPRDLNVLRRDPRVVLLRTFSKAYGLAGLRVGYALAAPDILERARKTAIPFSVT
                     RTAELAAIVSLEQQEALAERMAHTRKLRTDLHAALDAEGLSPLPSCGNFIWIPLGSSSE
                     SFAAMVQGAGIKVRACPGQGVRISVGSEPAHRHLLE"
ORIGIN
        1 tttcgggacc cgcggccggg ccttgcgggc gccggccgcg tgctgatggg cccggcagga
       61 ggtcgagtcg acgccgacca tcgaccagtc gattcggccc gcgaggttgg cgtcggcctg
      121 gaccgactgc aagatccggt cccaggtgcc gtccgccgac cagcggcgat gccgttcata
      181 gacggtcttc cacgagccgt agcgttccgg caggtcacgc cacggaaccc cggtccgaat
      241 ccgaaacatg atcccgtcga tgacgatgcg gtgatcgttc caccggccgc cctgaccacc
      301 cggcggaggc agatgcggct ccagtagcga ccactctcga ttagtcagat ccccccgacc
      361 catgactgga ccaacgagcg accggtcaga aagtcacatg atccgccgga caggacctag
      421 tggccgccga cccgagctgc gtgcggtcgt cctcaggcac ctggctgccg cgcgctcgct
      481 gctggcgccc gggaatgagg tgttcgtccg cgatctcgtc cgccaagcgg aggacctggc
      541 cgcgctggag tgggtggaga accacggtga ctttcacgtg gttcattagg caagtcgact
      601 gtcgggttcg aagttgtcgg gattttggcc cagggatctc agctgtcgca ggtgtgggtg
      661 gcttcgccgg gaggcgcggt aaagaatggt tctgcgcaca cgtcacgatc tggcagccgt
      721 agtgtcggcc ggcggcgacc atctgcgggt gatgcaccgg gatcccggca gtgtgctcga
      781 cggtcaccgg cgacatcaca cgatcaagtt cagtagcggc cccggagcgg gagctcgacc
      841 cgctcccgct ccggtcaacg ctcagcccac tccggcgagt tcgagtgcgc ggttcaaacg
      901 agatccggac cggtcccggg cgcggtccgc tcctgcggca cggatctccc gcagctcgga
      961 tccgctccgg agaaggtcca gggcacgctc acggacgggc gccaactcct tgacgaccac
     1021 atcggccacg gactccttga gctcgcggta cgtcgtcatg ccactggcga cggcaacagg
     1081 ggtcatgtcg gtgcacgcgg ccatgatctc cagaagattg gcgacgccgg gctgctcctg
     1141 cgggtcgtag gcgaccttgc ccaacccgtc cgtcacggca cgccggaact tgcggcggac
     1201 gacgtccgga tcatccagga cgtaaacgat actgtccggt tccgaggacg acttcgacat
     1261 cttcttggcg ggattcgcca aatctcggac ccgggcaccc gttgtgggca ggaccgcctc
     1321 ggggaccacg aagacctcgc cgtatgtcga gttgaaccga cgagccaggg tgcgagcgag
     1381 ttccacgtgc tggttctggt cgttgccgac cgggacttcg gtcgtaccat gcagcaggat
     1441 gtccgccgcc atgagcaccg gataggtgag cagacccagg cgcactgagc tgttgccgtc
     1501 ggacttctcc ttgaactgca ccatgcgcct ggcctctccg aaggtgcagg tgcactccag
     1561 cagccaggac agcgccatgt gctcctggat gaggtcggac tgcacgaaca tgctctcggc
     1621 cgggactccg gacgcgatga ggatcgcgag ctggtgctcg gtcaacttcc gcagtcggtc
     1681 cggctcatgg ggggtcgtca tggcatgcag attgctgacg aagtagaggt ccccctcgcc
     1741 cggttccctg gcccaacgcc gaacggctcc aaggtagttg cccagatgcg cttcacctga
     1801 gggggtgatt cccgacagct tgatcatcac tgctccctta cgaggtcttc gccagggccc
     1861 gtgcaatggt cgaccgccat ggccagccac cgtgcggggc gtctggcctg taggaggagg
     1921 gcacagcagt cagacccgct ggaaagcggg ccaccacgat cgacttctgt tccacatggc
     1981 accagagggt agcagcaaga gatcatgagg gcggtacctt cgggccacca gttcaccatt
     2041 gcgtcagagc tagcgaattt gcgccactcg gcttgatttc gcgctagaac tggtgaccga
     2101 tgcctgggat cacggcagcg cttactcgag aaagtcagat acttccgttc atccggcgca
     2161 tcgccgcagg ttagtggctt gatgaaacaa accgcatgag tttccccgct caggcgcgat
     2221 ctcgcgagcc ggaccggacg ggggccgcgg tagaaccggc tttacatcgg acactatcgc
     2281 tatcattcgg agcagctcgt ggccgaaagg ggcccgggtg gccaatttaa gcggcatgct
     2341 ttccggtcaa gacgcagcct gaagcgatga ttatgcacgg cgatcttgac ggttgagagg
     2401 ctaggtggct acggtcacta tcgttgccgt tgttgctgct ttcgctctga tctgcacttg
     2461 acccattcgc actcaatccg gtgggagaag tacttgacca ggaccgattt cgcccaatcc
     2521 gcggtcgcat ccatattcac aggagccatt gcctctcacg ctgccgtact tgccgacgac
     2581 cttggcttgt ttgatgcgct ggcaaaaggt aagctgcgca atcgagacct tgatcgttcc
     2641 ccgtggctgc gtaatcgaat acgaatatcg ggcgcgcttg aggctttgtg tcgagtggga
     2701 gccgtacagc gctgcactga cggctatgaa ctcaccgatg ttggtacgga gcttgcaggg
     2761 caggttcctg tcttccgcct gtggctgggc ggttacgcat ccgtcttggc cggtcaaatc
     2821 tccatcggcg ctgaccctgc gactggtgtg cacggcggaa tcgtggccga gtcctccggt
     2881 gcgatcgggg ctcgctatct cgacgagacc atcgtcaatc tgctggagtc gctgcgcccc
     2941 gagggtcgca tctgcgacat cggctgtggt accggtgcca gactcctgcg cgtctgtcgc
     3001 cgggtgaacc agcccggaat cggatacgac ctatccgcca aagcggttga agcggcccgg
     3061 gaaaccgtcg acgaggcacg tcggatcggt gtcgacattg acgtccggca aggggatgcg
     3121 accgctctca ctcaggacca ccccgacgtt gacatcgtca ctcaggcatt catgacgcat
     3181 cacatcgccc ccgatgagta ctgcgcggct gtgctgcgtt cctatcgatc gcgttttcct
     3241 cgggctcgct atctcgtcat cttcgacacg gtgccgtcac aggacagcga agaaccggaa
     3301 atattcgccc caggattcga ctacatacat gccctccaga acatggaacc gcggagcaga
     3361 ggtgcggctc ggagaatgtt taccgaagcc ggatatatct gccgggagga ggttgagctg
     3421 gctgttccca acagctatgc atgggttctt gaaatgcgtg accgcgaggg gccggcttca
     3481 tgaagctgga cgacaagaga attctcatca tcggcgccgg cgaagtggga actgctgttg
     3541 ccgaggatct ggtgaacaga tccgatccga ccgagatcat tattcacacg tcacgtcagc
     3601 agacaatgga catgagagtc ggccacctaa aggagatggc tggccctcga acgctgctga
     3661 ccgggtcgtg gggagacatt ttcgcgccgt acgagctcac ccacaggtct cgttcggaga
     3721 tcaatgaccg gaacgtaaga ctggcgctgg cggaattctt tctgcagccg tccggagagg
     3781 ctcagttgcg gcggacaacc atctacgagc tgatcagtcg ccatcgcccg cacatcgtca
     3841 tcgacgccgt caactccgcc tccgtatgca cctacaccga ggacccgcac cagacatgcg
     3901 gggaactgct cgatctcgcc cgaggaacgg gcggccctcg gactgccgaa gcgccggcgg
     3961 aactacccgc ggtgacgccc gacatcgccg atgtggcgac cgatgcgttg ttgtccctct
     4021 ccaccccgat ccttcaccgc tacgtcgact cgctgcgccg ggccatggcg gactttcagg
     4081 tggaacgatt catcaaggtg tcgacgaccg ggctgggcgg catgggctac aactgcccct
     4141 acacccacgg ctctgtcacc gagttcggac tgtccgacgc tctggtgggg aagatcggct
     4201 ccgccggcgt gctccaccag ctgctgtgga acctgcatca tactgcgggg tgcgatgtcc
     4261 gcctggtgat ccccgctgcg ctgatcggct gggagtccgt gcgtcacggc gcgtacacct
     4321 cacgcggacg gccggtggca ctgcaggact gttcccgtcc cctgccgctg cacctggacc
     4381 ggccgctggg cgaacacgca gcggcgtcat cggtggcgga gcccgccgcc gaggacgagc
     4441 cgtcggcgga gatggtccat gtgccggccg gtgacaattc cacctacagc cgggcggaga
     4501 tgagtctgag cacggcgctt ggccagttcg aaagcgtgac acgtgaagaa gtcgccgcgg
     4561 cagtgctgga cacactcctc ggctccaccc gcttcgatct cttcacggcc atggacaccg
     4621 cgtcattgca gtcctcctat ctggcagccc agatgcgcac ctccacactc acgtccatga
     4681 ggcagctgga gaaggcgtac gaccgaccga gcatcgtcag cgggaacctc gggcccacga
     4741 tctccaagga cctgctggaa ctgcatgtcc tgtgcacggc ggctggttcc ttggagcagg
     4801 cgcgcaccat gagcaccacc gtcctcgcct caagcgcctc ggctctcgtc cgcgaggacg
     4861 tgtatctgcg gcagcaggca ctctccatcg gcctggccgt gctactgccc gacgatcagt
     4921 ggctggccgg accacgcctt tcggtgccga gccggatcga ccccgaggcc aaggttaccc
     4981 gcgccgacat cgacgactgg tcacgccagg gatgggtgga tctgcgaccg gccaggatcc
     5041 tgcactggca ggagaacctc cggcggatcg aacaggacgc atctgccggg aagaccgcgt
     5101 tcgcgctcga cgacacggcg tacgacgtcg gagaagtact cgcctaccac tacaagctca
     5161 ccggacaggc ccgtcgcatc aagggcctgt gaagggtgcg agacaggagc acaaagtgaa
     5221 ggacttcggc caggaacaga ttcgcaagct gatggacgag gcgccggaac tgcggcggga
     5281 gctgcggcgc aaccagtatc tggaccgctc cgagctgcag cagttgcagg acgccgcctt
     5341 cgtgaagatg gtcaggcacg cctatgtcaa cgtcccgttc taccgcaaga agtacgacga
     5401 ggccggggtc gacatcgagt ccatccgcgg ggcgtcggac gccttccggc tgcccattct
     5461 ggagaaggaa gacctgatcg aggcgtttcc gcaccggtcc atcgcggacg gctacagtct
     5521 cgacgacctc acgacagcgg tgaccggcgg ctccagcggg acgacggtgc gtgtggcgta
     5581 ctccgacgag accatgcgca agcgcgtcat gacggcctac cgcatctacg acatgatgat
     5641 gggcggctat cactcgcacc acgtccagac ctacgtctac acggggaagt acccgctgga
     5701 ggggctgctc gacggcagct tccccctggt ccacatctgg acgctggatc cggtggagga
     5761 cgcccggcgc aagctgttgg acagcaagcc gcacatgctc actctctacc cctcccgtct
     5821 ggaggacatc cgcaggggac tcaccccgca ggacgtggcc gagctccgcg agaacctcgt
     5881 cgtcatcaac gtcaagtccg agatgtccac ccaggctcag cgcgacgcct gggcggagtt
     5941 cttcggggtt cccgtgctgg acgagtacgg ctccgaggag atggcgggga ccgtcgcggc
     6001 ccagtgcccg gacaagggct accacatctg ggaggacatc gccgtcgtgg aggtggtgga
     6061 cgaggcgggg cagccgttgc ctgacggaga gactggagag ctggtggcca cctgtctcta
     6121 caactgggcg atgccgatga tccgctaccg ccagggcgac atcgcggcgc tccacccggc
     6181 ggaccactcc tgttcgtgcg gccgtaccct ccggcagctg aagtccttcg agggccggcg
     6241 caattcgtcg ttcaccctgc cgagcggacg gttcctctcc tccggctatc tgctcgacgt
     6301 cggctacacc cggctcatgg cgtacgcgga cgcgctggac tcctggagcc tggtgcagcg
     6361 ggaaccagat ctcgtggtct tcgagtgcat tccgggcccg gccatgaacg aagcggtccg
     6421 ggaggccatc cagcgtgagg tcagcgaact gctcttccac gagaccaagg tccaggtgga
     6481 gtttgtggac gcgctgcgca ccactaatcg gggcaagcgc aaccagatca tcagcctggt
     6541 cccgtaatcc cgccccatcg agaccgcgcc cgcagccagc gaacagggag agccatgcag
     6601 aaaatggaac ggttcaacaa tctgacgcgc tacgagcatg tcggaatcaa tcaggccatc
     6661 aatctcgccg atggccacgc ccatcagggc cagaacagca cacaacaggc catcgtcgcc
     6721 gacctgccga acatcttcga ggcggccgag aacgctctgc aggccaccac ggagcgggag
     6781 ttccagcggg ccttctacac cctggcagga cagcactccg cggtcgacca cccgcgcacc
     6841 atgctgtgct actcggcgtc cctctccacc gacctcgtgg ccaccttcct ggcgagccga
     6901 aacctgacgg tgggtctgct gcagccgtgt ttcgataatc tggcgaccat cctgcgccgg
     6961 aggcaggtga aggtcgtacc tctgggcgag gaacagttcc gtcccgaatc acttgaccgg
     7021 acgttcgccg agttgaacac ggacgcggtg tttctcaccc tgcccaacaa cccgaccggc
     7081 ttccacctgg accaggagca gttccgccgt gtcatcgacc tctgcgccga gcaccagaag
     7141 atactcatcg tcgactgcac cttccgattc ttcgcgccga caccgttctg ggaccagtac
     7201 gcgcagctgg aggagtccgg catcagctac gtcgtggtcg aggacaccgg gaagacctgg
     7261 ccgacccagg acctgaagtg cagcatcctc gccgtcagca ccgacctgca cgagtcggtc
     7321 cttgaactgc acaacgacat tctgctcaac gtcagtccgt tcatcctgca gttgctcacg
     7381 gcttatctcc gtgacacgga gcgaaatggt ctgcagcaga ccatctggag tgtcgtacgg
     7441 gccaaccgca ttagcctgcg caaggccctg gaagggaccg tcctcgttcc cgcgcacccg
     7501 gagagcacca tcagcgtcga atgggtgcgc atcgaccatc cgtcgctgcg cagcgacgac
     7561 ctggtggaga tgctggcgaa gtcccaggtg ggcatccttc ccggcgacca cttctattgg
     7621 gacgaccacg agacggggtc acacttcatc cgcttcgccc tggcccgcga ggaacgctgg
     7681 ttcgcgacgg cctgcggtag cctgcgggag gccctgctgg cccggcccga gctcatcgag
     7741 ggcgccggtt catgagcgcc acaagaactc cgcgcatagt atgtctcgac gaaccgacct
     7801 atctgaccgg gggtttcctg cgacagctgt ccgccctggg cgcggtacgg gtgcactacg
     7861 accgccccgg ccagcgggag gccgtgcgca ggctcgcgac agccgatgtg gcactcgtcg
     7921 agtggacccg gctgtccgcg gacctgctgc gagcggtacg ggacacggcc ggatcaggag
     7981 gcgttcggca catctccacc ctgctctcgg ccacggacca gatcgatctg ggcgccaccc
     8041 gtgaactcgg tatcagcgtg tcgcactgcc cggactactc ggtgtccgcc gtggccgagt
     8101 acgtcatcgc gtgcgtcgga acactgagcc gccagatcct tccggcgagc cgggccggcg
     8161 ccgccggggt ggctcaccgc tatccgccct tcctgggcgg ggacctccgc ggttcggtgc
     8221 tcggcctcgt cggtacgggc aggatcggca gggcggtcgc gcgccgggcc gatgccctgg
     8281 gcatgcgcgt gctgggaagc aaccgggaag gacgcgcggt acccggtgtc gaggtcgtgg
     8341 gcctggagga actggcgcga cgcagcgatg tgctgtccgt gcaagtgccg tccaacgaga
     8401 gcacccgtga gctgctcagc gaggaactca tcggtctgct caggccgggc tgcgtggtcg
     8461 tgagcgtctc ccgtgcgcag accttcgcca tgcacgccct ggcggaccgg caccgggcgg
     8521 gcgaactcgg cggcatcgct ctggatgatg ccccggcgga gctcgtaccc acgctctcgg
     8581 ctcagcccaa caccctgctc acgcctggga tcgcgtggta cagccgggat tcgcgccagg
     8641 acaacctaac cgaagtcctg gcgaatgtga gcggcttcct gaagggggaa ccggtcaatg
     8701 tcgttcgata accagaacag ggacaagacc ccggtcggcg ccttcccctg gctggaggac
     8761 cagctcagcc acaccggcgc tgccgccgtg gtgagacgga caccggggat gccgaatgcc
     8821 cttgaggtcc gggtgcacgc cgatcgggct ccggagatct gcgtgctgtg ctgctggcac
     8881 gagccgtgga ccgccggacc tcttgggatc gagtccgacg tctccatgtc cgcgctgtac
     8941 gtgctggaac tgctcgacca cgcctgccgc gccgccggac cgtccctcgt ggcgcacttc
     9001 atcgccgacg acaacgagca ctcgcgcacc tctgccttcg cggccggccg cgctcagctg
     9061 gcggaagcgc ccgcacccgt acttgccgtc gtcgcggcgg gttgtgcgcc ggggggcggg
     9121 ctcgccgttc cctcgaccgc ggggacaagg cagccgctga ccgtaccgcc ggccctgccc
     9181 cggctgaccg aaggcctcga ccccgatgtg atcgaggcac tggaagtctg tgccgaggcc
     9241 gggatcacgg cctgtgtcgt ggatcccgcc ggccgcgatc acgatctgtg gccggccacc
     9301 gaactgtacc ggacgctggc cgccgcggcc cgcggagagg agtggaaccc gcatgcacac
     9361 ggactgggag acatcggagt cggctgagga ctactccaga aacaccgcgg cggcacagtg
     9421 ggaacccatg ggatatcccg cggtgttccg cagcctcgcg ctcgccacga cggactcgga
     9481 caacgccccg cccatcctgg actacggatg cggaccgggc ttcgtggacc ggcatgtcgc
     9541 ggagaagtac ggccgcaggg tcattgccgt cgacatctcg tcgtcgatga tcgatctcgc
     9601 ccggtcccag cactctcacc cgctcgtcac ctatcggcat gtgcccgact cgcagctgga
     9661 cttcctgggc gacaaggaaa tcggcggctg catgagctgc ttcgtactca tgcagatggc
     9721 ggacagcgac acccaggtcg agatctgccg ccggatcagg agaaccctcg cccccggagc
     9781 gatgctcgcg gtactcaaca cacacccgga cagcgtgggc atccagttcg ccaccctccg
     9841 caacggggag ccggatcggg tctatcaacc cggcgacccg atgaccaccg tcctcaccac
     9901 ggacaagggc gtactgcgcc tacaggacta ctactggcgc gtcacggact acgttcatgc
     9961 cctggaagcc gcgggcttcc acgaggtcac ggtcgagcac ctgccaccgc caccggcaga
    10021 cccgacgccc cacccgcagt tcctcctggt gcgcggaaca gcctgagatg cccaataacg
    10081 cctggcgccc gccctcgacc atcgacggag aggaggccgt tatgtcatcg acacccgccc
    10141 ccggcttcgg gagaattgcc gaaattgacc gcctctccgc ctatcgacaa gaggacgcgg
    10201 cggcagaggg cgaggaccgg ttcgtatggg acctgtcgaa caacgaatcc gccctgcccc
    10261 cgttgcccgc agtggcggag gcggtgcgac agggaggctt gcacaccgct cggtacccgg
    10321 accccaccgc cggctcattg gtacgggcgc tctcccggca cttcggcatc gacacgcgga
    10381 aggtgctggt cggccccggt agtgccggtg tgctccagca gctcctgctc tccctgtgcg
    10441 gtgatggtga cgaggtaatc cacgcctcgc cgtgtttcga cgcctacccc ctgctgatcg
    10501 ccgttgcggg ggcgaggtgc ctgccggtgc ctctcactga actcggagac catgatctgc
    10561 cggagatttt ggccagagtg accccccgca cgcgagtcgt catactgtgc tccccgcaca
    10621 accccacggg gagccgcctg ccggacaccg atctgcgcgg attcctcgca gatcttcccc
    10681 ggcacgtgac cgtcgttctc gacgaggcct acatcgaatt cgacgaggcg aaggagccac
    10741 gtgacctcaa tgttctccgc cgggacccca gggtcgtact cctgagaacc ttctccaagg
    10801 cgtacgggct ggcgggactg cgagtcggct acgcgctcgc tgcgccagac atcctggaac
    10861 gtgctcgcaa gaccgccatt cccttctctg tcactcgcac cgccgagctc gctgcgatcg
    10921 tctcgctgga gcaacaggag gcactcgccg aacggatggc gcacacgagg aaactgcgca
    10981 ccgatctgca cgcggccctc gacgccgaag ggctctcgcc cctgccctcg tgcggaaact
    11041 tcatctggat cccgctcggg agttcctcgg agagcttcgc cgccatggtg cagggcgcgg
    11101 ggatcaaggt gagggcctgt ccggggcagg gcgtgcggat ttcggtggga agcgagcctg
    11161 cccaccggca cctgcttgaa gtggtacggc accgggccaa gagctgagcc cgggtcaagt
    11221 cgcccaccgc ctcatgcagg gggcacggga tagtgttggg tgctttagac cgtgtcctat
    11281 gtggtgaggc ggaggagtcg cttgtagcag cagatggcgg cggccagtcc gaggaaggcc
    11341 aggtagttgc gggggtgtcg ttcgtagcgg tggttgagcc ggcggtagcc ggtgagccag
    11401 gacatggtcc gctcgatcac ccaacgacgg cgtccgaggc gttctgacga ctcgatgccc
    11461 ttgcgggcga tgcggacgcc gatgcgtttc ccgcggagcc atttccgcag ttcagggatg
    11521 tcgtaggcct tgtcggcgtg caggcgctgg ggcttgaagt ggcggccgcg ttgggggtcg
    11581 tgtctcgttt ggtgaccgag caccatgggc ttcagggctt ggctgtcgtg ggtgttggcg
    11641 gccgagacgc cgacgaccag gggcagtccg ttcgcgtccg acaggacgtg catcttggag
    11701 cccggcttgc cccggtccac
//
