BGC0001214: marformycin A biosynthetic gene cluster from Streptomyces drozdowiczii
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Location: 1 - 47,529 nt. (total: 47,529 nt).
This entry is originally from NCBI GenBank KP715145.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001214
Short description marformycin A biosynthetic gene cluster from Streptomyces drozdowiczii
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KP715145.1
Compounds
  • marformycin A
  • marformycin B
  • marformycin C
  • marformycin D
  • marformycin E
  • marformycin F
Species Streptomyces drozdowiczii [taxonomy]
References
Chemical products information
marformycin A
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C43H68N8O10
Chemical database entries
NPAtlas
marformycin B
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C44H70N8O10
Chemical database entries
NPAtlas
marformycin C
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C43H68N8O11
Chemical database entries
NPAtlas
marformycin D
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C44H70N8O11
Chemical database entries
NPAtlas
marformycin E
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C42H66N8O11
Chemical database entries
NPAtlas
marformycin F
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C42H66N8O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJV88371.1
 1 - 1512 (+) hypothetical protein
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  • AJV88372.1
 1634 - 2599 (+) nucleotide-binding protein
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  • AJV88373.1
 3153 - 3746 (-) MfnA
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  • AJV88374.1
 3875 - 4597 (-) MfnB
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  • AJV88375.1
 5165 - 16174 (+) MfnC
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  • AJV88376.1
 16156 - 20772 (+) MfnD
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  • AJV88377.1
 20790 - 31691 (+) MfnE
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  • AJV88378.1
 31743 - 31970 (+) MfnF
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  • AJV88379.1
 31967 - 33094 (+) MfnG
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  • AJV88380.1
 33094 - 33444 (+) MfnH
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  • AJV88381.1
 33479 - 34774 (+) MfnI
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  • AJV88382.1
 34780 - 35436 (+) MfnJ
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  • AJV88383.1
 35426 - 37030 (+) MfnK
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  • AJV88384.1
 37050 - 37322 (+) MfnL
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  • AJV88385.1
 37400 - 38125 (+) MfnM
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  • AJV88386.1
 38122 - 39396 (+) MfnN
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  • AJV88387.1
 39866 - 40987 (+) MfnO
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  • AJV88388.1
 41632 - 42024 (+) MfnP
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  • AJV88389.1
 42158 - 42538 (-) MfnQ
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  • AJV88390.1
 42512 - 44158 (+) MfnR
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  • AJV88391.1
 44653 - 45135 (-) transposase
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  • AJV88392.1
 46379 - 46894 (+) transposase
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  • AJV88393.1
 47096 - 47266 (+) ATP/GTP-binding protein
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  • AJV88394.1
 47395 - 47529 (+) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AJV88375.1
Module ?
Specificity: valine / allo-isoleucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
AJV88376.1
Module ?
Specificity: valine / allo-isoleucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Knock-out studies
AJV88377.1
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
AJV88383.1
Module ?
Specificity: piperazic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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