LOCUS       BGC0001226              6018 bp    DNA     linear   BCT 06-NOV-2018
DEFINITION  Streptomyces collinus Tu 365 chromosome, complete genome.
ACCESSION   BGC0001226
VERSION     BGC0001226
KEYWORDS    .
SOURCE      Streptomyces collinus Tu 365
  ORGANISM  Streptomyces collinus Tu 365
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     Genome was manually curated based on annotation generated by the
            NCBI Prokaryotic Genomes Automatic Annotation Pipeline Group.
            Information about the Pipeline can be found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html.
            Bacteria available from Dr. Wolfgang Wohlleben
            (wolfgang.wohlleben@biotech.uni-tuebingen.de).
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 00:07:05
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 182317
            Orig. end    :: 188335
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..780)
                     /gene="stcH"
                     /locus_tag="B446_00775"
     CDS             complement(1..780)
                     /codon_start=1
                     /gene="stcH"
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 129.2; E-value: 2.5e-39)"
                     /gene_kind="transport"
                     /locus_tag="B446_00775"
                     /note="COG0842 ABC-type multidrug transport system,
                     permease component"
                     /product="ABC transporter"
                     /protein_id="AGS66993.1"
                     /transl_table=11
                     /translation="MHALVHRDLLRMAAQPTHTALMLLQPVLYLFALGGGLAALIPDSS
                     LGVGYQAYLFPGMLMMTVQAPAIIVGVRLITDRQSGYLRELLMAPVARPTLLIGSCAGG
                     TLVSTVQGTVLLTLAGAVGLPYDPLLLALLLAGMILASFTVTALSLLLAVSIDRPEAFH
                     MLLGLVMMPLLFLSGGFFPLHNLPGWAHTLAAVNPLAYGVDLLRRCIALRAGHQAATTA
                     GITWSGWQPPLLLEGALLLAGGATALLWAAHRFSRPE"
     subregion       1..6018
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6018
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(954..1952)
                     /gene="stcT"
                     /locus_tag="B446_00780"
     CDS             complement(954..1952)
                     /codon_start=1
                     /gene="stcT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 193.4; E-value:
                     7.9e-59)"
                     /gene_kind="transport"
                     /locus_tag="B446_00780"
                     /note="COG1131 ABC-type multidrug transport system, ATPase
                     component"
                     /product="daunorubicin resistance ABC transporter ATPase
                     subunit"
                     /protein_id="AGS66994.1"
                     /transl_table=11
                     /translation="MFQGETYAFLGPNGAGKSTTLALLCALARPTAGQAMVAGADVLER
                     PEQVRRRVGMLFQHSALDPDLTAEQNLHIHARLYGLRRRQARLRVTEMLEAVALADRRR
                     SPVRTLSGGMRRRLELARGLLHAPQVLFLDEPTTGLDPHARAQVWQHLRALREQHGSTL
                     FITTHYLEEAENCDRLGILDHGRLVAEGTPHALKAEIGEDRLVLHTGDDTAACHVVNRA
                     VDQAVRRAVDRAEDRAEDRAEDRTVSGAVSAGSAVTLDAGGLSLRLPDGSAWIPRLCAA
                     LADHGIAVHAASATPPTLDDVFFHHTGRSIHTPRSHPAASATAPAAAQEAP"
     gene            complement(2750..2905)
                     /gene="stcA"
                     /locus_tag="B446_00784"
     CDS             complement(2750..2905)
                     /codon_start=1
                     /gene="stcA"
                     /locus_tag="B446_00784"
                     /note="lanthipeptide prepeptide"
                     /product="streptocollin prepeptide"
                     /protein_id="ALA50776.1"
                     /transl_table=11
                     /translation="MENQTLELLAHLHALPETDPVDFDGASYSGTCACVGLLTLLNTVC
                     VGISCA"
     gene            complement(2950..6018)
                     /gene="stcL"
                     /locus_tag="B446_00785"
     CDS             complement(2950..6018)
                     /codon_start=1
                     /gene="stcL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 123.4;
                     E-value: 2e-37)"
                     /gene_kind="biosynthetic"
                     /locus_tag="B446_00785"
                     /note="involved in the biosynthesis of the lanthipeptide
                     streptocollin; COG0515 Serine/threonine protein kinase"
                     /product="type IV lanthipeptide synthetase"
                     /protein_id="AGS66995.1"
                     /sec_met_domain="LANC_like (E-value: 9.3e-48, bitscore:
                     150.8, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.6e-21, bitscore: 63.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSHATGVDLESLCRRALEATGTGARWTVDAGEVWCRLTPACGMR
                     LRQGWKLHVSATSVSAPQVLVRALDVLLGEESGFKFVRSLEQVSALNSRATPRGSAGKF
                     ITVYPPSDEAAARVALALHRATAGLAGPRILSDQPYAPQSLVHYRYGAFVGRRRVSEQG
                     LLVWFIEDPDGNPVEDKRTGQYCPPPWAVSPFPASVPAPPRRTEPPSGPVLLGGRFAVR
                     EAIRHTNKGGVYRGTDVTTSAPVVIKEARPHVEGDMAGSDVRDWLRAEARILEKLKHTG
                     LAPEPLAVFEIGGHVFLAQEEVPGVPLRTWVAERFRDVGAARYRVEALAQVERLVDLVA
                     AAHACGCVLRDFTPGNVMVRPDGELRLIDLELAVLTDEVMLPTRVGTPGFSAPERLKDA
                     AVCPTADYYSLGATVCFVLAGKVPQLLPEEPDTTAAEERLEQWLAACAPRLRLPGGLQD
                     MILNLMKDDPGARWDPDRAREALHRALPPAGAILPPLGTETLPRDGEGGTGLPGHESGQ
                     PGQRTTLPSPGTETLHGGGTGLPGFGTKALPQDGVDLPSPGTRTPPEDGADPARRGSGL
                     PGGVVALPVDSAEGKPGGTGLSRQGGSLSHPRYPASAPVPVSASAAVPVGGVASVAGSD
                     TVVEAAAAGMVEHLLDTMAPEGGVRLWPVSTLAGETGPCTVQQGAAGVLAVLTRCFELT
                     GDPRLPEVISTAGRWIAARTDTRAIRPGLHFGGRGTAWALYEAGRAVAERRLTDHALAL
                     ALAAVEPTASHDITHGTAGSGLAAAHLWQRTGDERLAELVTAAADRLAAAAQAEPSGVS
                     WPVPAEAVSQEAGKRYLGFAHGSAGIGSFLLAAADVSERPEHLELAVAAGEHLVAHAVR
                     VGEAVQWPAQATDPPTAPYWCHGSAGIGSFLIRLWQRTGDGRYADLARGAAHAVMERAS
                     RAAVAQCHGLAGNGDFLLDMAEATGESAYHAMAEELARLLVCERARRTTHVVFPNEYGE
                     ISTSWSDGAAGILAFLLRTRHHDSRHWMVQQPG"
ORIGIN
        1 ttattcgggg cggctgaagc ggtgggcggc ccagagcagc gcggtggcgc cgccggccag
       61 caggagcgcg ccctccagga gcagtggggg ctgccagccg gaccatgtga tgcccgcggt
      121 ggtggccgcc tggtgccctg cgcgcagcgc gatgcagcgg cgcagcaggt ccacgccgta
      181 ggcgagcggg ttgacggcgg ccagggtgtg ggcccatccg ggcaggttgt gcaacgggaa
      241 gaagccgccg gacaggaaca gcagcggcat catcaccagg ccgagcagca tgtggaaggc
      301 ctcgggccgg tcgatgctca cggccagcag cagggacagg gccgtgacgg tgaaggaggc
      361 caggatcatg ccggccagga gcagcgccag caggagtggg tcgtagggca gaccgacggc
      421 gccggccagg gtgagcagga cggttccctg gacggtggag accagggtgc ctccggcgca
      481 gctgccgatc aggagggtgg gccgcgcgac cggggccatc agcagttccc gcaggtagcc
      541 gctctgccgg tcggtgatca ggcggacacc gacgatgatg gccggtgcct gcaccgtcat
      601 catcagcatg cccgggaaga ggtaggcctg gtaaccgacg ccgagcgagg agtcggggat
      661 cagcgcggcc agaccaccgc ccagggcgaa gaggtagagc accggctgga gcagcatcag
      721 cgcggtgtgg gtgggctggg ccgccatgcg cagcagatca cgatggacca gagcgtgcac
      781 cgcgcgcagt tcatgagaca gcagtgaccc ggacccgcga ccggcccgac cggacccacc
      841 ggaaggacca gaggttccgg aagacccaga cccaccggga gcaccggagg ccttgggggg
      901 gtgaggggtg tgaggggtgt tggaggcttc cggggccggg agggcgggcg cggtcatggg
      961 gcctcctggg cggccgccgg cgcggtcgcg gacgctgccg ggtgggagcg gggggtgtgg
     1021 atgctgcggc cggtgtggtg gaagaagacg tcgtcgagcg tgggcggggt cgcggacgcg
     1081 gcatgcaccg cgatgccgtg gtccgccaaa gccgcgcaca accgggggat ccaggcactg
     1141 ccgtcgggca gacgcaggga caaccccccg gcgtccagag tgacggcaga ccccgcggac
     1201 acagccccgc tcacggtccg gtcctcagcc cggtcctcag cccggtcctc agcccggtcc
     1261 acggcccggc gcacggcctg gtccacagcc cggttcacga cgtggcaggc cgcggtgtcg
     1321 tcgccggtgt gcagcaccag ccggtcctcg ccgatctcgg ccttcagcgc gtggggggtg
     1381 ccctcggcca cgagccggcc gtggtcgagg atgcccaggc ggtcgcagtt ctccgcctcc
     1441 tccaggtagt gggtggtgat gaacaaggtg ctgccgtgct gctcgcgcag ggcgcgcagg
     1501 tgctgccaga cctgggcgcg ggcgtgcggg tcgagaccgg tggtcggctc gtcgaggaac
     1561 agcacctggg gtgcgtgcag cagaccgcgg gccagttcca gacggcggcg catccccccg
     1621 gaaagggtgc gcaccgggga gcggcggcgg tcggccagag cgacggcctc gagcatctcg
     1681 gtcacgcgca ggcgggcctg gcggcgacgc agcccgtaca ggcgggcgtg gatgtgcagg
     1741 ttctgctcgg ccgtcaggtc ggggtccagg gcgctgtgct ggaagagcat gccgacccgc
     1801 cgccgtacct gctccggccg ctcgaggacg tccgcgcccg ccaccatggc ctgtccggcg
     1861 gtgggacggg ccagggcaca cagcagggcg agggtggtgg acttgcctgc accgttgggg
     1921 ccgaggaagg cgtaggtctc gccctggaac acctccagat ccaggccatc aacagcgcgc
     1981 gtgacactcc cctccggacc cgcgtagctc ttgaccagac cacgggtacg gatggcgggc
     2041 gccggccgga cggcacgccc cccgtcctcc acaaccatgc ccacacccat acccggagca
     2101 gcacccgcac ccggagcagt acccgaggcg gcatccggca cggtgggccg cccggcgtcc
     2161 gggccggtgc ccgggccagg gtccaggtcg gtgagcgcgg tggtgcccgg ggcggtgagc
     2221 gcggtggcgc ctggcccggt acccgggcca gggtcggggg gccggtcccg ggcaacgagc
     2281 ggcacggcgc ccggagcggt gcctgggccg acgtccggag cggtgcccga ggcggtgccc
     2341 ggggcggtgc tcggcttggc gtcgaaagcg gcgctcaagg cagggtccgg tgtggcggaa
     2401 tgcccggcat ccggcgcggt gcccgggcca gcgcctgggt cgatggtcag cgcggcgccc
     2461 gccgcggtac ccgggccggg gtccggggcg gtgggcgggt cggggtcggt gggcggggtg
     2521 gtggtgagtg gggcggtacc gggtgtggtg gtcggggggg ttggtcgggt gcgggcggtg
     2581 tcaccggcag gtgcctgcat ggtcggctcc tcgtccacgg gggtgtcgtg cgcgggcctg
     2641 cgggccgcag cgtgccggct gtggcggtac ggggtgcgga gtgcgggcgg cctgcgctcc
     2701 ggccggcggc tccccctgtc gggggctgcc gccggccgga ggttctcggc taggcgcagc
     2761 tgatgcccac gcagacggtg ttgagcagcg tcagcaggcc gacgcaggcg cacgtcccgg
     2821 agtacgaggc tccgtcgaag tcgaccgggt cggtctccgg aagggcgtgc aggtgggcca
     2881 gcagctcgag ggtctggttc tccatgacat tctccttctt cgtgcgatgg cgacaggggg
     2941 ccctgtcgct cagcccggct gctggaccat ccagtgccgg gagtcgtggt ggcgggtcct
     3001 gagcaggaac gccaggattc ccgcggcgcc gtcgctccag ctcgtggaga tctccccgta
     3061 ctcgttgggg aagacgacgt gggtggtgcg gcgggcccgt tcacagacca ggagacgggc
     3121 cagttcctcg gccatcgcgt ggtaggcgga ctcgccggtg gcctcggcca tatcgaggag
     3181 gaagtcaccg ttgcccgcca gtccgtggca ctgggcgacg gcggcgcgtg aggcgcgttc
     3241 catgacggcg tgtgcggcgc cgcgggccag atcggcgtac cggccgtcgc cggtgcgctg
     3301 ccacagccgg atcaggaacg agccgatacc ggccgagccg tgacaccagt acggcgcggt
     3361 gggcgggtcc gtggcctggg ccggccactg cactgcttca ccgaccctca ccgcgtgagc
     3421 caccaggtgc tcccccgcgg caacagccag ctccagatgc tccggccgct ctgagacgtc
     3481 cgcggccgcc aggaggaagc tgccgatgcc ggccgagccg tgcgcgaaac ccaggtagcg
     3541 tttgccggcc tcctgcgaca ccgcctccgc cggaaccggc cagctcaccc ccgacggctc
     3601 ggcctgagcc gcggcggcca gccggtccgc ggcggcggtg accagttcgg ccagccgctc
     3661 atcaccggtg cgctgccaca ggtgggcggc ggccagacca ctgcccgcgg tgccatgggt
     3721 gatgtcatga ctggcagtcg gctccaccgc agccagagcc aacgccagcg catggtccgt
     3781 caaccgccgc tcggccaccg cacggcccgc ctcgtacaac gcccacgcgg tcccccggcc
     3841 gccgaaatgc agacccggac gaatggcgcg ggtgtccgta cgggcggcga tccaacgacc
     3901 cgcggtcgag atcacctccg gcagacgcgg gtcgccggtg agctcgaaac accgggtcaa
     3961 aaccgccagt acacctgccg cgccctgctg caccgtgcac ggacccgtct cccccgccaa
     4021 cgtcgacacc ggccacaacc gcaccccgcc ctccggggcc atcgtgtcga ggagatgctc
     4081 caccatcccg gcggccgcgg cctcgaccac cgtgtccgac ccggccaccg acgccacccc
     4141 accaacggga acagcagcag aagcggatac gggcacgggg gcggaggcgg gatacctcgg
     4201 atgcgacagg ctcccgccct gccgggacaa gcccgtaccg cctggcttcc cctccgcgct
     4261 gtccacgggc agggcgacca cgcccccggg caggccgctc ccgcgccgcg ccggatccgc
     4321 gccgtcctct ggcggggttc tcgtcccggg tgagggcagg tccacgccgt cttggggcag
     4381 ggctttggtc ccgaatccag gcagtcccgt gccgcccccg tgcagggttt ccgtcccggg
     4441 tgagggcagg gtggtccttt gcccgggctg gccgctctcg tgtcccggca ggcccgtgcc
     4501 gccctcgccg tccctgggca gagtttcggt cccgagtggg ggcaggatgg ccccggccgg
     4561 gggcagggcg cggtggagtg cttcgcgtgc tcggtcgggg tcccagcgtg cgccgggatc
     4621 gtccttcatc aggttgagga tcatgtcctg caggccgccg ggcaggcgga gcctgggggc
     4681 gcaggcggcc agccactgct ccaaccgctc ctcggccgca gtggtgtcgg gctcctcggg
     4741 cagcagctgg ggcaccttgc cggcgagaac gaaacacacg gtggcgccga gactgtagta
     4801 gtcggccgtc ggacagaccg cggcgtcctt gaggcgttcg ggggcgctga acccgggggt
     4861 gccgacacgg gtcgggagca tgacctcgtc ggtcagcacg gcgagttcca ggtcgatcag
     4921 gcgcagttcg ccgtcggggc ggaccatgac gttgccgggg gtgaagtccc tgagcacgca
     4981 gccgcaggca tgcgccgccg caaccaggtc caccagccgt tcgacctggg cgagcgcctc
     5041 cacccggtaa cgtgcggcgc cgacgtcccg gaaccgctcc gcgacccagg tccgcaaagg
     5101 cacacccggc acctcctcct gggcgaggaa cacatgcccg ccgatctcga acaccgcgag
     5161 cggctcgggc gccagcccgg tgtgcttgag tttctccagg atccgggcct cggcccgcag
     5221 ccagtcacgc acatcggagc cggccatatc gccctcgacg tgcggccgcg cctccttgat
     5281 caccaccggg gcggacgtgg tgacgtccgt accgcggtag acaccgccct tgttggtgtg
     5341 ccggatcgct tcccgcaccg cgaaccggcc ccccaacaaa accggcccac tcggtggctc
     5401 ggtccggcgg ggcggggccg gcaccgacgc cgggaacgga ctgacggccc acggcggcgg
     5461 acagtactgc ccggtgcgtt tgtcctccac cgggttgccg tcggggtcct cgatgaacca
     5521 caccagcagc ccctgctccg acacccgccg ccggccaacg aacgcgccgt agcggtaatg
     5581 caccagactc tgcggcgcat acggctgatc ggacaggatc cgcggaccgg ccaaacctgc
     5641 cgtcgcccgg tgcagtgcga gcgccacccg cgccgccgcc tcgtccgagg gcggatagac
     5701 ggtgatgaac ttccccgcac tcccccgcgg cgtcgcccgg gaattcagcg cactcacctg
     5761 ctcgagcgag cgcacgaact tgaatcccga ctcctccccc agcagcacgt ccaaagccct
     5821 gacaaggacc tgcggtgcgg acacggacgt cgccgacaca tgcagcttcc agccctgccg
     5881 cagccgcatc ccgcacgcag gggtgagccg gcaccacacc tcacccgcat ccaccgtcca
     5941 ccgcgcgccg gtgccggtcg cctccaacgc ccgccggcaa agactttcga ggtcgactcc
     6001 ggtcgcgtgg ctcgtcat
//
