BGC0001233: feglymycin biosynthetic gene cluster from Streptomyces sp. DSM 11171
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Location: 1 - 72,176 nt. (total: 72,176 nt).
This entry is originally from NCBI GenBank KT809366.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001233
Short description feglymycin biosynthetic gene cluster from Streptomyces sp. DSM 11171
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KT809366.1
Compounds
  • feglymycin
Species Streptomyces sp. DSM 11171 [taxonomy]
References
Chemical products information
feglymycin
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C95H97N13O30
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALK27898.1
  • fegA
 1 - 1068 (+) putative 3-deoxy-D-arabinoseheptulosonate 7-phosphate synthase
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  • ALK27899.1
  • fegB
 1431 - 2438 (+) putative transcriptional regulator
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  • ALK27900.1
  • fegC
 2638 - 3777 (-) hydroxymandelate oxidase
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  • ALK27901.1
  • fegD
 3761 - 4861 (-) putative hydroxymandelate synthase
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  • ALK27902.1
  • fegE
 5029 - 6225 (+) putative prephenate dehydrogenase
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  • ALK27903.1
  • fegF
 6554 - 9463 (+) putative LuxR regulatory protein
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  • ALK27904.1
  • fegG
 9603 - 11930 (+) putative hydroxyphenylglycine aminotransferase/hydroxymandelate oxidase fusion protein
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  • ALK27905.1
  • fegH
 12002 - 13168 (+) putative 3,5-dihydroxyphenylacetyl-CoA Synthetase
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  • ALK27906.1
  • fegI
 13192 - 13845 (+) putative enoyl-CoA hydratase
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  • ALK27907.1
  • fegJ
 13842 - 15149 (+) putative 3,5-dihydroxyphenylacetyl-CoA oxygenase
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  • ALK27908.1
  • fegK
 15146 - 15958 (+) putative enoyl-CoA hydratase
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  • ALK27909.1
  • fegL
 16221 - 17030 (+) putative alpha/beta hydrolase
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  • ALK27910.1
  • fegM
 17050 - 18306 (-) putative histidine kinase
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  • ALK27911.1
  • fegN
 18314 - 18967 (-) putative two component transcription regulator
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  • ALK27912.1
  • fegO
 19297 - 19521 (+) putative antibiotic synthesis protein MbtH
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  • ALK27913.1
  • fegP
 19602 - 21659 (+) putative ABC transporter
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  • ALK27914.1
  • fegQ
 21744 - 38087 (+) non-ribosomal peptide synthase
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  • ALK27915.1
  • fegR
 38216 - 61951 (+) non-ribosomal peptide synthase
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  • ALK27916.1
  • fegS
 61953 - 72176 (+) non-ribosomal peptide synthase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
fegQ
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
fegR
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
fegS
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.2
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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