BGC0001283: arsono-polyketide biosynthetic gene cluster from Streptomyces lividans 1326
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Location: 1,080,808 - 1,113,162 nt. (total: 32,355 nt).
This entry is originally from NCBI GenBank NZ_CM001889.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001283
Short description arsono-polyketide biosynthetic gene cluster from Streptomyces lividans 1326
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The actual structures of these products are still subject to further investigation and will be discussed in detail in a future publication. "
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: NZ_CM001889.1
Compounds
  • arsono-polyketide
Species Streptomyces lividans 1326 [taxonomy]
References
Chemical products information
arsono-polyketide
(no structure information available)
C15H28As1O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SLI_RS05010
  • WP_016325493.1
 1081206 - 1081619 (+) arsenate reductase ArsC
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  • SLI_RS05015
  • WP_016325494.1
  • trxB
 1081616 - 1082608 (+) thioredoxin-disulfide reductase
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  • SLI_RS05020
  • WP_016325495.1
 1082697 - 1083119 (-) cobalamin B12-binding domain-containing protein
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  • SLI_RS05025
  • WP_016325496.1
 1083162 - 1084757 (-) methylmalonyl-CoA mutase family protein
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  • SLI_RS05030
  • WP_016325497.1
 1084813 - 1085088 (-) DUF5988 family protein
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  • SLI_RS05035
  • WP_042799404.1
 1085582 - 1085935 (-) metalloregulator ArsR/SmtB family transcription factor
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  • SLI_RS05040
  • WP_042799405.1
 1086020 - 1086799 (+) SDR family NAD(P)-dependent oxidoreductase
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  • SLI_RS05045
  • WP_016325500.1
 1086860 - 1088341 (-) NAD(P)-binding domain-containing protein
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  • SLI_RS41050
  • WP_016325501.1
 1088377 - 1088538 (-) hypothetical protein
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  • SLI_RS05050
  • WP_042799407.1
 1089037 - 1096113 (+) SDR family NAD(P)-dependent oxidoreductase
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  • SLI_RS05055
  • WP_007445820.1
 1096140 - 1097180 (+) ketoacyl-ACP synthase III family protein
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  • SLI_RS05060
  • WP_016325503.1
 1097289 - 1097960 (+) VTT domain-containing protein
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  • SLI_RS05065
  • WP_016325504.1
  • aepY
 1097957 - 1099060 (+) phosphonopyruvate decarboxylase
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  • SLI_RS05070
  • WP_016325505.1
 1099136 - 1099537 (-) metalloregulator ArsR/SmtB family transcription factor
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  • SLI_RS05075
  • WP_016325506.1
 1099606 - 1101171 (-) DHA2 family efflux MFS transporter permease subunit
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  • SLI_RS05080
  • WP_042799411.1
 1101916 - 1102638 (+) CTP synthase
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  • SLI_RS05085
  • WP_016325508.1
 1102749 - 1105271 (+) molybdopterin-dependent oxidoreductase
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  • SLI_RS05090
  • WP_016325509.1
  • aroA
 1105327 - 1106649 (+) 3-phosphoshikimate 1-carboxyvinyltransferase
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  • SLI_RS05095
  • WP_016325510.1
  • gpmI
 1106646 - 1108181 (+) 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
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  • SLI_RS05100
  • WP_016325511.1
 1108178 - 1108537 (+) hypothetical protein
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  • SLI_RS05105
  • WP_016325512.1
 1108858 - 1109730 (+) phosphate ABC transporter substrate-binding protein
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  • SLI_RS05110
  • WP_016325513.1
  • pstC
 1109734 - 1111545 (+) phosphate ABC transporter permease subunit PstC
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  • SLI_RS05115
  • WP_042799412.1
 1111533 - 1112222 (+) ATP-binding cassette domain-containing protein
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  • SLI_RS05120
  • WP_042799413.1
 1112344 - 1112685 (-) metalloregulator ArsR/SmtB family transcription factor
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  • SLI_RS05125
  • WP_007445854.1
 1112803 - 1113162 (-) metalloregulator ArsR/SmtB family transcription factor
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
SLI_RS05050 Synthase subclass:
Module 1
Genes: SLI_RS05050
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.2
  • Hidden contributor (ID: YFQE6LBJ4VCTUO2RYKJB5QD7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
Detailed domain annotation
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