BGC0001327: rakicidin A biosynthetic gene cluster from Micromonospora purpureochromogenes
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Location: 164,252 - 202,669 nt. (total: 38,418 nt).
This entry is originally from NCBI GenBank NZ_JOEU01000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001327
Short description rakicidin A biosynthetic gene cluster from Micromonospora purpureochromogenes
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
NZ_JOEU01000001.1
164252 - 202669
via
Compounds
  • rakicidin A
  • rakicidin B
Species Micromonospora purpureochromogenes [taxonomy]
References
Chemical products information
rakicidin A Evidence:
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C32H54N4O7
Chemical database entries
NPAtlas
rakicidin B Evidence:
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C33H56N4O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IH31_RS0100575
  • WP_036342114.1
 164252 - 172972 (+) type I polyketide synthase
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    • IH31_RS34685
    • WP_052165465.1
    		 172969 - 177789 (+) type I polyketide synthase
    • Scaffold biosynthesis
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    • IH31_RS0100585
    • WP_030498974.1
    		 177791 - 181162 (+) tyrocidine synthase 3
    • Scaffold biosynthesis
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    • IH31_RS0100590
    • WP_030498975.1
    		 181179 - 186842 (+) type I polyketide synthase
    • Scaffold biosynthesis
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    • IH31_RS0100595
    • WP_052165466.1
    		 186946 - 191502 (+) non-ribosomal peptide synthetase
    • Scaffold biosynthesis
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    • IH31_RS0100600
    • WP_030498977.1
    		 191499 - 196208 (+) hypothetical protein
    • Scaffold biosynthesis
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    • IH31_RS0100605
    • WP_030498978.1
    		 196205 - 197917 (+) hypothetical protein
    • Transport
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    • IH31_RS0100610
    • WP_084212913.1
    		 197871 - 198734 (+) alpha/beta fold hydrolase
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      • IH31_RS0100615
      • WP_030498980.1
      		 198731 - 201598 (+) hypothetical protein
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        • IH31_RS0100620
        • WP_030498981.1
        		 201680 - 202669 (+) clavaminate synthase
        • Tailoring
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        Biosynthesis information

        Biosynthetic modules

        Name
        2
        Type
        nrps-type1
        Genes
        IH31_RS0100585
        Substrates
        serine (evidence: Feeding study)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        4
        Type
        nrps-type1
        Genes
        IH31_RS0100595
        Substrates
        glycine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation, methyltransferase
        Name
        5
        Type
        nrps-type1
        Genes
        IH31_RS0100600
        Substrates
        3S-hydroxyasparagine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        1
        Type
        pks-modular
        Genes
        IH31_RS34685
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        3
        Type
        pks-modular
        Genes
        IH31_RS0100590
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Corrected NRP module activity
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Removed gene names of 'No gene ID'
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Removed gene annotation with no reference name or ID
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Updated bioactivity data
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Updated NRP substrate specificities
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated reference publication(s) (MIBiG Annotathon)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated compound(s) information (NPAtlas curation)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2018-08-06
        Submitted
        • (ID: DPAKSDGGIIU3JRGIDNMS7RSG)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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