BGC0001344: tubulysin A biosynthetic gene cluster from Cystobacter sp. SBCb004
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Location: 1 - 51,513 nt. (total: 51,513 nt).
This entry is originally from NCBI GenBank GU002154.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001344
Short description tubulysin A biosynthetic gene cluster from Cystobacter sp. SBCb004
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: GU002154.1
Compounds
  • tubulysin A
  • tubulysin B
  • tubulysin C
  • tubulysin D
  • tubulysin E
  • tubulysin F
  • tubulysin G
  • tubulysin H
  • tubulysin I
Species Cystobacter sp. SBCb004 [taxonomy]
References
Chemical products information
tubulysin A
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C43H65N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin B
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C42H63N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin C
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C41H61N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin D
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C43H65N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin E
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C42H63N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin F
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C41H61N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin G
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C43H63N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin H
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C40H59N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin I
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C40H59N5O10S1
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADH04671.1
 1 - 2208 (+) hypothetical protein
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  • ADH04672.1
 2283 - 6932 (+) hypothetical protein
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  • ADH04673.1
 7076 - 7897 (+) hypothetical protein
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  • ADH04674.1
  • tubA
 8019 - 9317 (+) TubA
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  • ADH04675.1
 9336 - 9995 (-) hypothetical protein
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  • ADH04676.1
  • tubZ
 9983 - 11143 (-) TubZ
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  • ADH04677.1
 11143 - 12327 (-) hypothetical protein
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  • ADH04678.1
  • tubB
 12483 - 17045 (+) non-ribosomal peptide synthetase
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  • ADH04679.1
  • tubC
 17042 - 24928 (+) non-ribosomal peptide synthetase
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  • ADH04680.1
  • tubD
 24918 - 35453 (+) hybrid polyketide synthase/non-ribosomal peptide synthetase
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  • ADH04681.1
  • tubE
 35446 - 38931 (+) non-ribosomal peptide synthetase
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  • ADH04682.1
  • tubF
 38938 - 47469 (+) polyketide synthase
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  • ADH04683.1
 47387 - 48400 (-) hypothetical protein
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  • ADH04684.1
 48472 - 49578 (-) hypothetical protein
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  • ADH04685.1
 49582 - 49956 (-) hypothetical protein
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  • ADH04686.1
 50228 - 50584 (+) hypothetical protein
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  • ADH04687.1
 50698 - 51513 (-) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
tubB
Module ?
Specificity: pipecolic acid
Evidence for specificity:
  • Structure-based inference
  • Feeding study
  • Mass spectrometry
tubC
Module ?
Specificity: isoleucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
tubD
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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