BGC0001358: leucinostatin A biosynthetic gene cluster from Purpureocillium lilacinum
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Location: 1,034,990 - 1,134,564 nt. (total: 99,575 nt).
This entry is originally from NCBI GenBank LSBH01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001358
Short description leucinostatin A biosynthetic gene cluster from Purpureocillium lilacinum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: LSBH01000002.1
Compounds
  • leucinostatin A
  • leucinostatin B
Species Purpureocillium lilacinum [taxonomy]
References
Chemical products information
leucinostatin A
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C62H111N11O13
Chemical database entries
PubCHEM
leucinostatin B
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C61H109N11O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • VFPBJ_02521
  • OAQ83753.1
 1034990 - 1036504 (+) sterigmatocystin 8-O-methyltransferase
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  • VFPBJ_02522
  • OAQ83754.1
 1036873 - 1042287 (-) ABC multidrug transporter
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  • VFPBJ_02523
  • OAQ83755.1
 1044084 - 1045854 (+) isotrichodermin C-15 hydroxylase
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  • VFPBJ_02524
  • OAQ83756.1
 1046050 - 1046979 (-) thioesterase-like superfamily domain-containing protein
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  • VFPBJ_02525
  • OAQ83757.1
 1048341 - 1050041 (+) cytochrome P450
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  • VFPBJ_11780
  • OAQ83758.1
 1051221 - 1051962 (-) bZIP transcription factor domain-containing protein
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  • VFPBJ_02526
  • OAQ83759.1
 1054377 - 1054625 (-) hypothetical protein
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  • VFPBJ_02527
  • OAQ83760.1
 1055948 - 1064232 (-) polyketide synthase
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  • VFPBJ_02528
  • OAQ83761.1
 1065257 - 1066391 (-) cytochrome P450
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  • VFPBJ_02529
  • OAQ83762.1
 1066860 - 1070185 (+) abc1 domain-containingprotein
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  • VFPBJ_02530
  • OAQ83763.1
 1070389 - 1071750 (-) branched-chain amino acid aminotransferase
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  • VFPBJ_02531
  • OAQ83764.1
 1072576 - 1074342 (+) basic-leucine zipper (bZIP) transcription factor
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  • VFPBJ_02532
  • OAQ83765.1
 1075701 - 1083956 (+) KR domain-containing protein
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  • VFPBJ_02533
  • OAQ83766.1
 1084230 - 1085491 (-) phenylacetyl- ligase protein
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  • VFPBJ_11781
  • OAQ83767.1
 1088115 - 1089327 (+) hypothetical protein
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  • VFPBJ_02534
  • OAQ83768.1
 1089695 - 1091155 (+) zn-dependent hydrolase oxidoreductase family protein
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  • VFPBJ_02535
  • OAQ83769.1
 1092705 - 1093707 (+) Amt4
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  • VFPBJ_02536
  • OAQ83770.1
 1093942 - 1094789 (-) signal transduction protein
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  • VFPBJ_02538
  • OAQ83771.1
 1096300 - 1097240 (+) nucleoside-diphosphate-sugar epimerase protein
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  • VFPBJ_02539
  • OAQ83772.1
 1098659 - 1134564 (+) nonribosomal peptide synthase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
VFPBJ_02533
Module ?
Specificity: (E)-4-methylhex-2-enoic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
VFPBJ_02539
Module ?
Specificity: 4-methylproline
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 3-hydroxyleucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 2-aminoisobutyric acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 2-aminoisobutyric acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 2-aminoisobutyric acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: beta-alanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
  • Fixed biosynthetic classes
Detailed domain annotation
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