BGC0001378: tiancimycin biosynthetic gene cluster from Streptomyces sp. CB03234
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Location: 1 - 49,994 nt. (total: 49,994 nt).
This entry is originally from NCBI GenBank KT716443.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001378
Short description tiancimycin biosynthetic gene cluster from Streptomyces sp. CB03234
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: KT716443.1
Compounds
  • tiancimycin
Species Streptomyces sp. CB03234 [taxonomy]
References
Chemical products information
tiancimycin
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C20H30O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AME17991.1
 3459 - 3887 (-) hypothetical protein
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  • AME17992.1
 4086 - 5783 (+) ATP-dependent DNA helicase RecQ
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  • AME17993.1
  • tnmA
 6637 - 7137 (-) flavin reductase
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  • AME17994.1
  • tnmR7
 7173 - 8087 (-) AraC family transcriptional regulator
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  • AME17995.1
  • tnmB
 8293 - 9204 (-) enediyne self-sacrifice resistance protein
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  • AME17996.1
  • tnmR3
 9411 - 10697 (+) hypothetical protein
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  • AME17997.1
  • tnmC
 10694 - 12067 (+) ketone reductase
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  • AME17998.1
  • tnmD
 12156 - 13478 (+) PBS lyase HEAT-like repeat protein
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  • AME17999.1
  • tnmF
 13506 - 14156 (+) hypothetical protein
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  • AME18000.1
  • tnmG
 14310 - 16523 (+) hypothetical protein
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  • AME18001.1
  • tnmH
 16539 - 17573 (+) O-methyltransferase
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  • AME18002.1
  • tnmE10
 17647 - 18090 (-) type II thioesterase
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  • AME18003.1
  • tnmE
 18087 - 24416 (-) enediyne polyketie synthase
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  • AME18004.1
  • tnmE5
 24413 - 25423 (-) hypothetical protein
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  • AME18005.1
  • tnmE4
 25433 - 27391 (-) hypothetical protein
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  • AME18006.1
  • tnmE3
 27617 - 28585 (-) hypothetical protein
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  • AME18007.1
  • tnmI
 28843 - 29682 (-) oxidoreductase
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  • AME18008.1
  • tnmR1
 29775 - 30518 (-) HxlR family transcriptional regulator
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  • AME18009.1
  • tnmJ
 30684 - 31796 (+) putative methyltransferase
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  • AME18010.1
  • tnmK1
 31827 - 33281 (+) secreted hydrolase
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  • AME18011.1
  • tnmK2
 33278 - 34747 (+) secreted hydrolase
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  • AME18012.1
  • tnmL
 34764 - 36026 (+) cytochrome P450 monooxygenase
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  • AME18013.1
  • tnmM1
 36097 - 37110 (-) rieske (2Fe-2S) iron-sulfur domain protein
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  • AME18014.1
  • tnmM2
 37187 - 38206 (-) rieske (2Fe-2S) iron-sulfur domain protein
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  • AME18015.1
  • tnmN
 38400 - 38840 (+) ester cyclase
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  • AME18016.1
  • tnmO
 38888 - 39376 (+) hypothetical protein
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  • AME18017.1
  • tnmP
 39373 - 40536 (+) epoxidase
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  • AME18018.1
  • tnmR2
 40610 - 41890 (+) putative tegulator
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  • AME18019.1
  • tnmQ
 41943 - 42512 (-) hypothetical protein
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  • AME18020.1
  • tnmS1
 42520 - 42900 (-) glyoxalase/bleomycin resisance protein/dioxygenase
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  • AME18021.1
  • tnmT1
 43014 - 44681 (-) transporter
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  • AME18022.1
  • tnmS2
 44709 - 45116 (-) glyoxalase/bleomycin resisance protein/dioxygenase
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  • AME18023.1
  • tnmR4
 45113 - 45697 (-) AraC family transcriptional regulator
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  • AME18024.1
  • tnmT2
 45786 - 47492 (-) MFS transporter
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  • AME18025.1
  • tnmS3
 47612 - 47986 (-) glyoxalase/bleomycin resisance protein/dioxygenase
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  • AME18026.1
 47998 - 48711 (-) hypothetical protein
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
tnmE Synthase subclass: Enediyne type I
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Merged info from duplicate BGC0001804
  • Added back pks synthase subclass lost in 2.0 conversion
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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