BGC0001391 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001391 (Bacillus thuringiensis serovar rongseni)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	10,393

BGC0001391 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 10,393 nt. (total: 10,393 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 10,394
Label		BGC0001391

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.1	1.00	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.1	0.34	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.1	0.32	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.1	0.32	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.31	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000539.1	0.29	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000500.1	0.29	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.1	0.28	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000528.1	0.24	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001311.1	0.24	RiPP	flavecins	Ruminococcus flavefaciens FD-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.1	1.00	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.1	0.67	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.1	0.66	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.1	0.65	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.65	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000539.1	0.63	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000500.1	0.62	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.1	0.62	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000528.1	0.58	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001311.1	0.57	RiPP	flavecins	Ruminococcus flavefaciens FD-1

Similar known gene clusters

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for thsM1

thsA1

Leader:

MLDVIKNRKKIEEKLELPEILLEEVEEHSAMGG

Core:

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

Core with dehydrations:

INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

thsA2

Leader:

MLKEEKLEKITGLIPESELEEHLSG

Core:

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSCNK

Core with dehydrations:

EDhaDhaGAGDhbPAIDhbDhbAIDhaAIIAADhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

thsA2_

Leader:

MKEQKLEKITGLIPESELEEHLSGESSGAGTPAITTAISAIIGA

Core:

TAQSPCPTSACSKSCNK

Core with dehydrations:

DhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

Lanthipeptide(s) for thsM2

thsA1

Leader:

MLDVIKNRKKIEEKLELPEILLEEVEEHSAMGG

Core:

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

Core with dehydrations:

INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

thsA2

Leader:

MLKEEKLEKITGLIPESELEEHLSG

Core:

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSCNK

Core with dehydrations:

EDhaDhaGAGDhbPAIDhbDhbAIDhaAIIAADhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

thsA2_

Leader:

MKEQKLEKITGLIPESELEEHLSGESSGAGTPAITTAISAIIGA

Core:

TAQSPCPTSACSKSCNK

Core with dehydrations:

DhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

thsA1 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 3927.0 Da

Molecular weight: 3929.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3947.4 Da N = 1; 3965.4 Da N = 2; 3983.4 Da N = 3; 4001.5 Da N = 4; 4019.5 Da N = 5; 4037.5 Da N = 6; 4055.5 Da N = 7; 4073.5 Da N = 8

thsA2 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3278.7 Da

Molecular weight: 3280.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3298.7 Da N = 1; 3316.7 Da N = 2; 3334.7 Da N = 3; 3352.7 Da N = 4; 3370.8 Da N = 5; 3388.8 Da N = 6; 3406.8 Da N = 7; 3424.8 Da N = 8; 3442.8 Da N = 9

thsA2_ - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 1603.7 Da

Molecular weight: 1604.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 1622.8 Da N = 1; 1640.8 Da N = 2; 1658.9 Da N = 3

thsA1 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 3927.0 Da

Molecular weight: 3929.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3947.4 Da N = 1; 3965.4 Da N = 2; 3983.4 Da N = 3; 4001.5 Da N = 4; 4019.5 Da N = 5; 4037.5 Da N = 6; 4055.5 Da N = 7; 4073.5 Da N = 8

thsA2 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3278.7 Da

Molecular weight: 3280.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3298.7 Da N = 1; 3316.7 Da N = 2; 3334.7 Da N = 3; 3352.7 Da N = 4; 3370.8 Da N = 5; 3388.8 Da N = 6; 3406.8 Da N = 7; 3424.8 Da N = 8; 3442.8 Da N = 9

thsA2_ - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 1603.7 Da

Molecular weight: 1604.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 1622.8 Da N = 1; 1640.8 Da N = 2; 1658.9 Da N = 3