BGC0001397: lidamycin biosynthetic gene cluster from Streptomyces globisporus C-1027
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Location: 20,150 - 92,825 nt. (total: 72,676 nt).
This entry is originally from NCBI GenBank CP013739.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001397
Short description lidamycin biosynthetic gene cluster from Streptomyces globisporus C-1027
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: CP013739.1
Compounds
  • lidamycin
Species Streptomyces globisporus C-1027 [taxonomy]
References
Chemical products information
lidamycin
Copy SMILES
C43H42Cl1N3O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • WQO_33745
  • ALU98527.1
 20150 - 21469 (+) hypothetical protein
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  • WQO_33750
  • ALU98419.1
 21575 - 23902 (-) daunorubicin resistance protein DrrC
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  • WQO_33755
  • ALU98420.1
 23983 - 25365 (-) sodium:proton exchanger
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  • WQO_33760
  • ALU98528.1
 25352 - 26830 (-) tryptophan halogenase
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  • WQO_33765
  • ALU98421.1
 27013 - 28080 (+) glucose-1-phosphate thymidylyltransferase
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  • WQO_33770
  • ALU98422.1
 28213 - 28599 (-) hypothetical protein
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  • WQO_33775
  • ALU98423.1
 28691 - 29923 (-) dTDP-4-dehydro-6-deoxyglucose aminotransferase
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  • WQO_33780
  • ALU98424.1
 29920 - 30654 (-) SAM-dependent methyltransferase
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  • WQO_33785
  • ALU98425.1
 30654 - 31925 (-) SAM-dependent methyltransferase
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  • WQO_33790
  • ALU98426.1
 32032 - 33189 (-) epoxide hydrolase
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  • WQO_33795
  • ALU98529.1
 33263 - 33820 (-) anthranilate synthase subunit II
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  • WQO_33800
  • ALU98427.1
 33922 - 35403 (-) aminodeoxychorismate synthase component I
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  • WQO_33805
  • ALU98530.1
 35420 - 36832 (-) CoF synthetase
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  • WQO_33810
  • ALU98428.1
 36871 - 37542 (-) NADPH-dependent FMN reductase
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  • WQO_33815
  • ALU98429.1
 37562 - 38797 (-) hypothetical protein
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  • WQO_33820
  • ALU98430.1
 38983 - 39561 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • WQO_33825
  • ALU98431.1
 39812 - 41167 (+) FAD-binding monooxygenase
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  • WQO_33830
  • ALU98432.1
 41211 - 42590 (+) hypothetical protein
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  • WQO_33835
  • ALU98433.1
 42587 - 43585 (+) dTDP-glucose 4,6-dehydratase
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  • WQO_33840
  • ALU98434.1
 43629 - 45194 (+) MFS transporter
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  • WQO_33845
  • ALU98435.1
 45277 - 46587 (+) phenylacetate--CoA ligase
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  • WQO_33850
  • ALU98436.1
 46556 - 46765 (+) hypothetical protein
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  • WQO_33855
  • ALU98531.1
 46866 - 48389 (+) Pyoverdin chromophore biosynthetic protein pvcC
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  • WQO_33860
  • ALU98437.1
 48463 - 49299 (-) hydrolase
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  • WQO_33865
  • ALU98438.1
 49521 - 49943 (-) DUF4440 domain-containing protein
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  • WQO_33870
  • ALU98439.1
 50224 - 51495 (+) cinnamoyl-CoA reductase
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  • WQO_33875
  • ALU98440.1
 51564 - 52943 (+) hypothetical protein
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  • WQO_33880
  • ALU98441.1
 52988 - 53269 (+) phosphopantetheine-binding protein
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  • WQO_33885
  • ALU98442.1
 53372 - 54985 (-) tyrosine 2,3-aminomutase
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  • WQO_33890
  • ALU98443.1
 55057 - 57672 (-) hypothetical protein
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  • WQO_33895
  • ALU98444.1
 57908 - 60016 (+) hypothetical protein
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  • WQO_33900
  • ALU98445.1
 60170 - 61171 (+) methyltransferase
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  • WQO_33905
  • ALU98532.1
 61243 - 62484 (+) cytochrome
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  • WQO_33910
  • ALU98446.1
 62537 - 63718 (-) acyl-CoA dehydrogenase
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  • WQO_33915
  • ALU98447.1
 64022 - 64357 (+) hypothetical protein
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  • WQO_33920
  • ALU98448.1
 64354 - 65394 (+) alkylhydroperoxidase
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  • WQO_33925
  • ALU98449.1
 65425 - 66345 (-) short-chain dehydrogenase
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  • WQO_33930
  • ALU98450.1
 66370 - 66921 (-) alkylhydroperoxidase
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  • WQO_33935
  • ALU98451.1
 67250 - 67888 (-) hypothetical protein
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  • WQO_33940
  • ALU98533.1
 68148 - 69383 (+) DNA-binding protein
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  • WQO_33945
  • ALU98452.1
 69910 - 70884 (+) hypothetical protein
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  • WQO_33950
  • ALU98453.1
 70931 - 71734 (-) wyosine base formation domain-containing protein
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  • WQO_33955
  • ALU98454.1
 71837 - 72307 (-) 4-hydroxybenzoyl-CoA thioesterase
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  • WQO_33960
  • ALU98455.1
 72444 - 74099 (-) glucose-methanol-choline oxidoreductase
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  • WQO_33965
  • ALU98456.1
 74096 - 74686 (-) regulator
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  • WQO_33970
  • ALU98457.1
 74971 - 76023 (+) transcriptional regulator
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  • WQO_33975
  • ALU98458.1
 76049 - 76903 (+) hypothetical protein
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  • WQO_33980
  • ALU98459.1
 76791 - 78140 (-) cytochrome P450
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  • WQO_33985
  • ALU98460.1
 78137 - 78685 (-) flavin reductase
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  • WQO_33990
  • ALU98461.1
 78811 - 84630 (-) erythronolide synthase
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  • WQO_33995
  • ALU98462.1
 84627 - 85757 (-) enediyne biosynthesis protein
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  • WQO_34000
  • ALU98463.1
 85754 - 87622 (-) RNA-binding protein
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  • WQO_34005
  • ALU98534.1
 87679 - 88584 (-) enediyne biosynthesis protein
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  • WQO_34010
  • ALU98464.1
 88761 - 89789 (-) enediyne biosynthesis protein
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  • WQO_34015
  • ALU98465.1
 89926 - 90369 (-) HxlR family transcriptional regulator
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  • WQO_34020
  • ALU98466.1
 90516 - 91079 (+) hypothetical protein
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  • WQO_34025
  • ALU98467.1
 91084 - 91545 (+) hypothetical protein
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  • WQO_34030
  • ALU98468.1
 91635 - 92822 (-) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
WQO_33890
Module ?
Specificity: S-beta-tyrosine / R-beta-tyrosine
Evidence for specificity:
  • ATP-PPi exchange assay
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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