BGC0001417: myxochromide D biosynthetic gene cluster from Cystobacterineae bacterium
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Location: 1 - 34,448 nt. (total: 34,448 nt).
This entry is originally from NCBI GenBank KX622587.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001417
Short description myxochromide D biosynthetic gene cluster from Cystobacterineae bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Polyene)
Loci NCBI GenBank: KX622587.1
Compounds
  • myxochromide D
Species Cystobacterineae bacterium [taxonomy]
References
Chemical products information
myxochromide D
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C39H56N6O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78674.1
 1 - 1521 (+) two-component sensor histidine kinase
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  • APZ78675.1
 1576 - 2064 (-) membrane protein
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  • APZ78676.1
 2489 - 3118 (+) uncharacterized protein
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  • APZ78677.1
 3078 - 3563 (+) uncharacterized protein
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  • APZ78678.1
  • mchA
 4086 - 10586 (+) polyketide synthase
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  • APZ78679.1
  • mchB
 10583 - 19729 (+) nonribosomal peptide synthetase
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  • APZ78680.1
  • mchC
 19762 - 31347 (+) nonribosomal peptide synthetase
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  • APZ78681.1
  • mchD
 31344 - 31826 (+) membrane protein
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  • APZ78682.1
 31848 - 32108 (+) uncharacterized protein
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  • APZ78683.1
 32129 - 32938 (-) aldo/keto reductase
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  • APZ78684.1
 33347 - 34105 (-) uncharacterized protein
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  • APZ78685.1
 34107 - 34448 (-) uncharacterized protein
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
mchA Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 9
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: mchA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • mchC (Type I)
NRP-synthases
Gene Modules
mchB
Module 2
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: Methylation
Module 3
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
mchC
Module 4
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 5 [inactive]
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 6
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 7
Specificity: glutamine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: W3AST4BMPVTIWZ3NNIXB2T6Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
  • Changed gene identifiers used to consistently be 'gene' names
  • Changed amino acid substrates to lower case
Detailed domain annotation
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