LOCUS       BGC0001437             19561 bp    DNA     linear   BCT 06-JUL-2017
DEFINITION  Pseudomonas fluorescens obafluorin biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0001437
VERSION     BGC0001437
KEYWORDS    .
SOURCE      Pseudomonas fluorescens
  ORGANISM  Pseudomonas fluorescens
            Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
COMMENT     [WARNING] On Jul 16, 2019 this sequence was replaced by KX931446.2.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 01:37:10
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 19561
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..19561
                     /culture_collection="ATCC:39502"
                     /db_xref="taxon:294"
                     /mol_type="genomic DNA"
                     /organism="Pseudomonas fluorescens"
                     /strain="ATCC 39502"
     protocluster    1..19561
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[9377:15110]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9378..15110
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..19561
                     /SMILES="NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="Autoind_synth"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="hserlactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..19561
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001437"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19561
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="hserlactone"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="Autoind_synth"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..11894
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1384:1894]"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1385..1894
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="2"
     cand_cluster    1..11894
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="2"
                     /tool="antismash"
     misc_feature    425..19435
                     /note="obafluorin biosynthesis gene cluster"
     gene            452..1165
                     /gene="obaA"
     CDS             452..1165
                     /codon_start=1
                     /gene="obaA"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1197:autoinducer-binding transcriptional regulator,
                     (Score: 229.3; E-value: 6.9e-70)"
                     /gene_kind="regulatory"
                     /note="transcriptional regulator LuxR family"
                     /product="ObaA"
                     /protein_id="AQZ26579.1"
                     /transl_table=11
                     /translation="MNTWKGDMWNIFEFDICEQSIFKKITATAQQLGFDHCAYGLQLPL
                     PLTAPKVIILDNYPDAWRARYSAAHYVKIDPAVLHGRRTQDPLVWSASSFSLAPELWEE
                     ANAHGIKVGWSQSHIDLVGAGGMLSVSRCAQPLSPSELADIQSKLVWLVSIAHSSLSRA
                     ITHRHRKEQDPNLTFRELEVLKWTADGKSAGEISDILTVSKNTIDFHIKNAILKLKTCN
                     KTAAVVRAAMLGLLV"
     gene            1385..1894
                     /gene="obaB"
     CDS             1385..1894
                     /codon_start=1
                     /gene="obaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /note="ObaB"
                     /product="N-acylhomoserine lactone synthase"
                     /protein_id="AQZ26580.1"
                     /sec_met_domain="Autoind_synth (E-value: 6.8e-29, bitscore:
                     90.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAIGHYRHKVFVEHLGWKLNCTDGLEYDQFDRDDTVYVVARNDD
                     DHIIGTARLLSTTRPYLLSEVFPELLSGETPPNSETVLELSRFAAMDFDVRNKKAASQF
                     SSDIAIDLMRETLASAAGQGANKLITVSPLGVERLLRNVGIHASRAGKVTHSDGKKIFA
                     SWITVA"
     gene            1982..2932
                     /gene="obaC"
     CDS             1982..2932
                     /codon_start=1
                     /gene="obaC"
                     /note="ObaC"
                     /product="N-oxygenase"
                     /protein_id="AQZ26581.1"
                     /transl_table=11
                     /translation="MPESQLLNKITDTWYAKATVRSTPRILVPDYSSEQLIYPVARCSI
                     CEHPLVLELGPQVRSYILTQAAYQFLYGVGLLETKFVIQCCLDMLHNNIKDISDAAKLQ
                     ALTVIVDEGYHAHVALDYIIQMKKKSAIEPLEVPQTNRKLDATARAYASLPESMRMDFQ
                     LLAVTLAENVLTDEVANLGRERELAQSFTTLMMDHVRDEGRHSRFFADLMKERWPQLPR
                     ATQEHFGLMLPAYLDDFLGADLSRGFERKILAHCGLTEAQAEQVIHESDPHFSTDQARM
                     KKSILQRIYRLLNQIGVLELDSVKDAFSDRNYVTT"
     gene            2958..3557
                     /gene="obaD"
     CDS             2958..3557
                     /codon_start=1
                     /gene="obaD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 105.3; E-value: 5.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /note="ObaD"
                     /product="4-Amino-4-deoxychorismate synthase component II"
                     /protein_id="AQZ26582.1"
                     /transl_table=11
                     /translation="MFKTLIIDNFDSFTYNLYQYMGQVTGEEPDVFTNDASPHDIDLGR
                     YDCIIVSPGPGTPKRRQDVGISEDMIRDAHVPLLGVCLGHQCMAHVHGMDVDHAPEPMH
                     GRVRHIRHNNEGVFKGLPVDMPVVRYHSLVVKALKGPFELSAWDENGMIHGIRHTERPL
                     YGIQFHPESICTDSGLDLLRNFRDIAHRHKLERLPR"
     gene            3598..5058
                     /gene="obaE"
     CDS             3598..5058
                     /codon_start=1
                     /gene="obaE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 369.4; E-value:
                     5.6e-112)"
                     /gene_kind="biosynthetic-additional"
                     /note="ObaE"
                     /product="4-Amino-4-deoxychorismate synthase component I"
                     /protein_id="AQZ26583.1"
                     /transl_table=11
                     /translation="MTTFDVEVRALDYNPDPLRVFRSEFLASPRHFFLESSVVKPGFSR
                     FSFMGDSHGRLAETITYDTSSRSVRVERSDGVTREPTSDFLELMAARLNHYHCEQPQWL
                     PFDFNLGYVGLLGYELKCETLGAQAYASHSHDAAFILATRMIAFDHAEQRCYLLYLVEH
                     DEDRQDAAQWFDQVQARLREQPQVAEPVSRQRKLSLPQVEAWIQEHACIRHSKQRYIDK
                     INEAQREIIDGETYEVCLTNLIEFAFADSSFDLYCVMRELTPAPHAGYFSIPDFQIISS
                     SPERFLKIDRHHQVEAKPIKGTRPRGRCAEEDQELIEQMRGDEKDRAENLMIVDLLRND
                     LGQVCTIGSVRVPALFAVETYSHVHQLVSTISGQLKPSLSAVDCVRATFPGGSMTGAPK
                     KRTMEIIDRLEEGPRGAYSGSLGWFGLGGACDLNIMIRSITVDAQVARFGVGGAITSLS
                     DPLGEYIETMVKASGVVEAVTQLRSTSV"
     gene            5055..6317
                     /gene="obaF"
     CDS             5055..6317
                     /codon_start=1
                     /gene="obaF"
                     /note="ObaF"
                     /product="4-Amino-4-deoxychorismate mutase/prephenate
                     dehydrogenase"
                     /protein_id="AQZ26584.1"
                     /transl_table=11
                     /translation="MSLSSPHRHAVVVGILGSIGQLLANQLSIAGYSVTGIDIAVDDQS
                     AQPHTVIQGDVLRPGNEIKQRLGDAQILVLALAQNVLSEALPQLLPSLRSDCLIVDTLS
                     IKSEFADFVATLDVAQPMVGINPMFSGDLDPAGRPVAVVTYRDGDGDAVARLVEWLHSW
                     PANVFQMTASEHDRTMAYLQTLGHALVMGMGLTLAESAAPLENLFELAPPPFKVMLALL
                     ARMTKNHPDVYWEIQSNNPYSQEIRSRMLAQLGKLDDRVNSGSRLDYHVSMAMLRNALK
                     PLNPGLENTSRHLFEQLDQAPKAIEGAPESLADYRQRIDHIDDQLVDLLGQRLSLIREV
                     AQSKKDHQTAVMQPNRVVQVVERCKARGRRHHIRESLIEQLYGLIIDEACQIEYDVIGG
                     PRESLYEASPSAFTSSAEKTQ"
     gene            6314..7636
                     /gene="obaG"
     CDS             6314..7636
                     /codon_start=1
                     /gene="obaG"
                     /note="ObaG"
                     /product="threonine transaldolase PLP-dependent"
                     /protein_id="AQZ26585.1"
                     /transl_table=11
                     /translation="MSNVKQQTAQIVDWLSSTLGKDHQYREDSLSLTANENYPSALVRL
                     TSGSTAGAFYHCSFPFEVPAGEWHFPEPGHMNAIADQVRDLGKTLIGAQAFDWRPNGGS
                     TAEQALMLAACKPGEGFVHFAHRDGGHFALESLAQKMGIEIFHLPVNPTSLLIDVAKLD
                     EMVRRNPHIRIVILDQSFKLRWQPLAEIRSVLPDSCTLTYDMSHDGGLIMGGVFDSPLS
                     CGADIVHGNTHKTIPGPQKGYIGFKSAQHPLLVDTSLWVCPHLQSNCHAEQLPPMWVAF
                     KEMELFGRDYAAQIVSNAKTLARHLHELGLDVTGESFGFTQTHQVHFAVGDLQKALDLC
                     VNSLHAGGIRSTNIEIPGKPGVHGIRLGVQAMTRRGMKEKDFEVVARFIADLYFKKTEP
                     AKVAQQIKEFLQAFPLAPLAYSFDNYLDEELLAAVYQGAQR"
     gene            7633..9336
                     /gene="obaH"
     CDS             7633..9336
                     /codon_start=1
                     /gene="obaH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 319.2;
                     E-value: 9e-97)"
                     /gene_kind="biosynthetic-additional"
                     /note="ObaH"
                     /product="nitrophenylpyruvate decarboxylase ThDP-dependent"
                     /protein_id="AQZ26586.1"
                     /transl_table=11
                     /translation="MTNLPSTHINLTSEEVSLGDLVGRVLVESGIDDLFCIPGDFTMQL
                     SRELLTTPGLALRTMSHEYGTTLAALGYAVGKGVPGAVCFTYGVGVLNATNAIAQAYVE
                     RVPLLVFSGSPGTRERQAPLFLHHTIVDHQTQYRIMKEITVHQVCVTDPHQVLEQLREA
                     VALAVLHSRPVYIEIPRDLFQARVRYSPARRVPLEPSTRYSQAARQAAELAYALVRKAR
                     DPVFVPGLDLKRRGLTDLAMRVCERLAMPWVATPMSRGGIPVSHPNYRGIYAGPASPSR
                     VTRELLAKCDVLMLIGEPNSDVNMGIASHIAKGRLIHADDGKISVGRQHFNASTAEFLI
                     AFSDVIHNAKTPLAPLTETQKDFIVPTPASLYPSEESPLTPFDIINELNRHFVTQPDTQ
                     LVVDCGDVFFMSLGMFPADVLTSPLYMSMGIAVPGAMGYQLGTGKRPIVLVGDGAFHMT
                     GNELMRAAKFGLSPIVIVLNNQRWASLSSDAADIALTEQMPMSFSAAGQFLQVQAFTAT
                     TGRELRQHLEEALNMDRPVLIDAQVDPSKRSYLCERFFDAVKGQQHLPKA"
     gene            9378..15110
                     /gene="obaI"
     CDS             9378..15110
                     /NRPS_PKS="Domain: Condensation_Starter (6-295). E-value:
                     8e-82. Score: 266.7. Matches aSDomain:
                     nrpspksdomains_obaI_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (460-871). E-value:
                     2.3e-103. Score: 337.7. Matches aSDomain:
                     nrpspksdomains_obaI_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (983-1043). E-value: 2.6e-13. Score:
                     41.8. Matches aSDomain: nrpspksdomains_obaI_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1068-1283). E-value:
                     4.9e-20. Score: 64.7. Matches aSDomain:
                     nrpspksdomains_obaI_Thioesterase.1"
                     /NRPS_PKS="Domain: AMP-binding (1412-1813). E-value:
                     2.2e-86. Score: 281.8. Matches aSDomain:
                     nrpspksdomains_obaI_AMP-binding.2"
                     /codon_start=1
                     /gene="obaI"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     300; E-value: 6e-91)"
                     /gene_kind="biosynthetic"
                     /note="ObaI"
                     /product="obafluorin dimodular nonribosomal peptide
                     synthetase"
                     /protein_id="AQZ26587.1"
                     /sec_met_domain="Condensation (E-value: 4.2e-56, bitscore:
                     180.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-113, bitscore:
                     368.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-11, bitscore:
                     34.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.5e-11, bitscore:
                     35.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASFTTALTSAQQSIWMGHQFDPQSPAYNVASYIEMSGDIDPQR
                     LQHALQRAVDDIEALRARFHEDETQGGALTQTILAQVAVELNVFAVDAEQARSWMESDL
                     ARPTDLTSGPIFSSALLQVAPNVNYWYFKTHHIVMDGVALSMLFKRVADLYGQAPDLCS
                     PSPFGSVRQVLENEQAWRASPAFAQDREFWQQHCQDMAEVASLNSDVAQPSYQAIQHRR
                     VLDESIMASLRERAEAMDSQWVNVLLAAFGAFVGRSTGYRQVTVGVPMMNRFATGAINV
                     PCTLANVLPLRLDIKPGQSVEQLVASVQAQLDRMRPHQRYRAEDIRRDCNLLGDNRRLT
                     GPQINIDFFSAKLSFDGVPGEVNVLSAGPADDLSLLIQTPADDKTLNIIAMANPALYSR
                     AALERHVQRFIDFVERFAAASDTPLGQLDAYDATDPGYAQGNACFSPVNQAHTLAQTLV
                     ERFERAVHATPDAIALTFNGEHLTYQALNQRANRLAHLIQDQTGQTSPQPVALLLARSV
                     QTFVCILGVLKAGAHYVPLDPDAPAERITTILEDTCPTLVICDQSSQALVSGSDVKVMV
                     IDTPSCMDAVQQQSIDNLQSGPRANDLAYIIYTSGSTGKPKGVCITHHNVVRLFENTHH
                     WFDYRSSDVWTACHGYIFDASVWEMWGAFAHGGRLVLVPVDTTRDPEKLLELVVQEQVT
                     VFGQIPSAFYRFMEAQADQPALAARLNLRYQCFGGEALDLSRLKPWFEHYGHSRTRLLN
                     LYGITETTINATYQFVTLEQVQTNQGSLIGTVYDDLDIKVLDDALRPVPVGGYGEMYVR
                     GAGLARGYLNRQDLDATRFVADPFGAPGERMYRSGDVAALQEGGVLEYIGRADQQVKVR
                     GYRIELGEIETQLRGHPLLSDAIALVVTDASGDPKLVAHVVPKATCRCEDIDTAQVRDY
                     LRERLPSYMVPGAIGVQERLPVTLSGKVDRKALPTIALSGARQVEAPRDELDERVLAAW
                     SEQLEIDTLGIDDNFFDIGGDSIKAIRICRDLGLPVTELFDHPTPRANADYLRDHQDND
                     AQGAVNWLHAFDKSAKKERLNLVCVPFAGGNAFAYRNLVNQLSSVFNCVSVNLPGHDIM
                     RPDEGMQALEVVADAATQEILATLSGPIIVYGHCAGNATAIEIARRLEQAGADLKALVI
                     GGMLLDQDPVDVQARVADQSGENIIDFLQQIGGFKEVLDDASMASIARMTKHDATQTAR
                     FFAEEALNRQTLQAPIHVIVGDMDPLTPDYEERYKDWQMYSSDVTLSVIEGGGHYFVTD
                     LAEPLAQVLLANYKHLNPVVPVRAPRALRAFHNPFDDVEGRFSLLANDARQLSLWPEFA
                     PTPAGWTALFGPASHSECLARTQAYDHEALISPPAPTEGLDAPYWPEAFESRYRASGWW
                     TGETLGAILTRHALLAPQRVAVTDGDRNLSYSQLDSNADRIADGFATLGVKAGDRVVVQ
                     LPNSMEFIETIFGLFRLGAIPVFALPSDRLNEITHIFEISGAIAYVIKDQALGFDYRRI
                     ATELTQQIASIKQVIVVGDAEGFVPFANLYGRTAAWPQRSSREPALITLSGGSTALPKL
                     ILRRHDDYLYSFKASARICQLDSDSVYLCVLPAGHNFTLSSPGFLGVLYAGGRVVMTSD
                     PSGSGAFALIERERVTLTSVVPSLAQAWLHSSRDHDLSSLQLLQVGGARLSDDVAERLA
                     TSFDCQLQQVYGMSEGLVCYTAVGDTEEHVLHTQGRPISSGDEILIVDENDEPVANGVA
                     GQLLVRGPYTIRGYLNAPEHNARAFTPDGFYRTGDVVVFRDDGYLVVTGRIKDQVNRGG
                     EKIAAEEIEGYLLAHPGVLEAGIIGLPDEYLGEVSCAVVVLAPGAQLTASALKSFVRQQ
                     GIAAFKVPDQVHLVPSLPKTTLGKIDKKLLRVQLGQ"
     misc_feature    9384..10658
                     /gene="obaI"
                     /note="Region: Condensation domain; Module 2"
     aSDomain        9396..10262
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_obaI_Condensation_Starter.1"
                     /domain_subtype="Condensation_Starter"
                     /evalue="8.00E-82"
                     /label="obaI_Condensation_Starter.1"
                     /locus_tag="obaI"
                     /protein_end="295"
                     /protein_start="6"
                     /score="266.7"
                     /tool="antismash"
                     /translation="TALTSAQQSIWMGHQFDPQSPAYNVASYIEMSGDIDPQRLQHALQ
                     RAVDDIEALRARFHEDETQGGALTQTILAQVAVELNVFAVDAEQARSWMESDLARPTDL
                     TSGPIFSSALLQVAPNVNYWYFKTHHIVMDGVALSMLFKRVADLYGQAPDLCSPSPFGS
                     VRQVLENEQAWRASPAFAQDREFWQQHCQDMAEVASLNSDVAQPSYQAIQHRRVLDESI
                     MASLRERAEAMDSQWVNVLLAAFGAFVGRSTGYRQVTVGVPMMNRFATGAINVPCTLAN
                     VLPLRLDI"
     aSModule        9396..13226
                     /complete
                     /domains="nrpspksdomains_obaI_Condensation_Starter.1"
                     /domains="nrpspksdomains_obaI_AMP-binding.1"
                     /domains="nrpspksdomains_obaI_PCP.1"
                     /domains="nrpspksdomains_obaI_Thioesterase.1"
                     /final_module
                     /locus_tags="obaI"
                     /monomer_pairings="thr -> thr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       9456..9575
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0001"
                     /evalue="5.90E-16"
                     /label="C2_starter_024-063"
                     /locus_tag="obaI"
                     /protein_end="66"
                     /protein_start="26"
                     /score="51.0"
                     /tool="antismash"
                     /translation="PAYNVASYIEMSGDIDPQRLQHALQRAVDDIEALRARFHE"
     CDS_motif       9780..9842
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0002"
                     /evalue="1.80E-08"
                     /label="C3_starter_134-155"
                     /locus_tag="obaI"
                     /protein_end="155"
                     /protein_start="134"
                     /score="27.2"
                     /tool="antismash"
                     /translation="HHIVMDGVALSMLFKRVADLY"
     CDS_motif       10167..10253
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0003"
                     /evalue="2.40E-08"
                     /label="C5_starter_265-294"
                     /locus_tag="obaI"
                     /protein_end="292"
                     /protein_start="263"
                     /score="26.4"
                     /tool="antismash"
                     /translation="VTVGVPMMNRFATGAINVPCTLANVLPLR"
     CDS_motif       10302..10415
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0004"
                     /evalue="3.40E-14"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="obaI"
                     /protein_end="346"
                     /protein_start="308"
                     /score="45.3"
                     /tool="antismash"
                     /translation="QAQLDRMRPHQRYRAEDIRRDCNLLGDNRRLTGPQINI"
     misc_feature    10689..12290
                     /gene="obaI"
                     /note="Region: Adenylation domain; Module 2"
     aSDomain        10758..11990
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_obaI_AMP-binding.1"
                     /evalue="2.30E-103"
                     /label="obaI_AMP-binding.1"
                     /locus_tag="obaI"
                     /protein_end="871"
                     /protein_start="460"
                     /score="337.7"
                     /specificity="consensus: thr"
                     /tool="antismash"
                     /translation="FERAVHATPDAIALTFNGEHLTYQALNQRANRLAHLIQDQTGQTS
                     PQPVALLLARSVQTFVCILGVLKAGAHYVPLDPDAPAERITTILEDTCPTLVICDQSSQ
                     ALVSGSDVKVMVIDTPSCMDAVQQQSIDNLQSGPRANDLAYIIYTSGSTGKPKGVCITH
                     HNVVRLFENTHHWFDYRSSDVWTACHGYIFDASVWEMWGAFAHGGRLVLVPVDTTRDPE
                     KLLELVVQEQVTVFGQIPSAFYRFMEAQADQPALAARLNLRYQCFGGEALDLSRLKPWF
                     EHYGHSRTRLLNLYGITETTINATYQFVTLEQVQTNQGSLIGTVYDDLDIKVLDDALRP
                     VPVGGYGEMYVRGAGLARGYLNRQDLDATRFVADPFGAPGERMYRSGDVAALQEGGVLE
                     YIGRADQQVKVR"
     CDS_motif       10947..10988
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0005"
                     /evalue="7.10E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="obaI"
                     /protein_end="537"
                     /protein_start="523"
                     /score="16.1"
                     /tool="antismash"
                     /translation="LGVLKAGAHYVPLD"
     CDS_motif       11187..11246
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0006"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="obaI"
                     /protein_end="623"
                     /protein_start="603"
                     /score="32.6"
                     /tool="antismash"
                     /translation="AYIIYTSGSTGKPKGVCITH"
     CDS_motif       11781..11870
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0007"
                     /evalue="6.00E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="obaI"
                     /protein_end="831"
                     /protein_start="801"
                     /score="37.8"
                     /tool="antismash"
                     /translation="PVGGYGEMYVRGAGLARGYLNRQDLDATRF"
     CDS_motif       11955..12020
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0008"
                     /evalue="5.00E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="obaI"
                     /protein_end="881"
                     /protein_start="859"
                     /score="37.7"
                     /tool="antismash"
                     /translation="YIGRADQQVKVRGYRIELGEIE"
     CDS_motif       12063..12104
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0009"
                     /evalue="5.70E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="obaI"
                     /protein_end="909"
                     /protein_start="895"
                     /score="-2.2"
                     /tool="antismash"
                     /translation="LVVTDASGDPKLVA"
     misc_feature    12324..12500
                     /gene="obaI"
                     /note="Region: Peptidyl carrier protein domain; Module 2"
     aSDomain        12327..12506
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_obaI_PCP.1"
                     /evalue="2.60E-13"
                     /label="obaI_PCP.1"
                     /locus_tag="obaI"
                     /protein_end="1043"
                     /protein_start="983"
                     /score="41.8"
                     /tool="antismash"
                     /translation="RVLAAWSEQLEIDTLGIDDNFFDIGGDSIKAIRICRDLGLPVTEL
                     FDHPTPRANADYLRD"
     misc_feature    12579..13277
                     /gene="obaI"
                     /note="Region: Thioesterase domain; Module 2"
     aSDomain        12582..13226
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_obaI_Thioesterase.1"
                     /evalue="4.90E-20"
                     /label="obaI_Thioesterase.1"
                     /locus_tag="obaI"
                     /protein_end="1283"
                     /protein_start="1068"
                     /score="64.7"
                     /tool="antismash"
                     /translation="NLVCVPFAGGNAFAYRNLVNQLSSVFNCVSVNLPGHDIMRPDEGM
                     QALEVVADAATQEILATLSGPIIVYGHCAGNATAIEIARRLEQAGADLKALVIGGMLLD
                     QDPVDVQARVADQSGENIIDFLQQIGGFKEVLDDASMASIARMTKHDATQTARFFAEEA
                     LNRQTLQAPIHVIVGDMDPLTPDYEERYKDWQMYSSDVTLSVIEGGGHYFVT"
     CDS_motif       12774..12839
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0010"
                     /evalue="2.70E-04"
                     /label="NRPS-te1"
                     /locus_tag="obaI"
                     /protein_end="1154"
                     /protein_start="1132"
                     /score="13.5"
                     /tool="antismash"
                     /translation="GPIIVYGHCAGNATAIEIARRL"
     misc_feature    13323..13466
                     /gene="obaI"
                     /note="Region: MbtH-like domain; Module 1"
     aSDomain        13614..14816
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_obaI_AMP-binding.2"
                     /evalue="2.20E-86"
                     /label="obaI_AMP-binding.2"
                     /locus_tag="obaI"
                     /protein_end="1813"
                     /protein_start="1412"
                     /score="281.8"
                     /specificity="consensus: dhb"
                     /tool="antismash"
                     /translation="RHALLAPQRVAVTDGDRNLSYSQLDSNADRIADGFATLGVKAGDR
                     VVVQLPNSMEFIETIFGLFRLGAIPVFALPSDRLNEITHIFEISGAIAYVIKDQALGFD
                     YRRIATELTQQIASIKQVIVVGDAEGFVPFANLYGRTAAWPQRSSREPALITLSGGSTA
                     LPKLILRRHDDYLYSFKASARICQLDSDSVYLCVLPAGHNFTLSSPGFLGVLYAGGRVV
                     MTSDPSGSGAFALIERERVTLTSVVPSLAQAWLHSSRDHDLSSLQLLQVGGARLSDDVA
                     ERLATSFDCQLQQVYGMSEGLVCYTAVGDTEEHVLHTQGRPISSGDEILIVDENDEPVA
                     NGVAGQLLVRGPYTIRGYLNAPEHNARAFTPDGFYRTGDVVVFRDDGYLVVTGRIKDQV
                     NR"
     misc_feature    13620..15071
                     /gene="obaI"
                     /note="Region: Adenylation domain; Module 1"
     CDS_motif       14073..14129
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0011"
                     /evalue="8.60E+00"
                     /label="NRPS-A_a3"
                     /locus_tag="obaI"
                     /protein_end="1584"
                     /protein_start="1565"
                     /score="0.3"
                     /tool="antismash"
                     /translation="LITLSGGSTALPKLILRRH"
     CDS_motif       14247..14279
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0012"
                     /evalue="1.10E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="obaI"
                     /protein_end="1634"
                     /protein_start="1623"
                     /score="0.6"
                     /tool="antismash"
                     /translation="LGVLYAGGRVV"
     CDS_motif       14637..14720
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0013"
                     /evalue="1.50E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="obaI"
                     /protein_end="1781"
                     /protein_start="1753"
                     /score="20.5"
                     /tool="antismash"
                     /translation="GVAGQLLVRGPYTIRGYLNAPEHNARAF"
     CDS_motif       14787..14849
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaI_0014"
                     /evalue="6.80E-02"
                     /label="NRPS-A_a8"
                     /locus_tag="obaI"
                     /protein_end="1824"
                     /protein_start="1803"
                     /score="6.3"
                     /tool="antismash"
                     /translation="TGRIKDQVNRGGEKIAAEEIE"
     gene            15153..15797
                     /gene="obaJ"
     CDS             15153..15797
                     /codon_start=1
                     /gene="obaJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 258.5; E-value: 9.1e-79)"
                     /gene_kind="biosynthetic-additional"
                     /note="ObaJ"
                     /product="isochorismatase"
                     /protein_id="AQZ26588.1"
                     /transl_table=11
                     /translation="MAIPKIMEYRAPSEVALQRKPLDWTVEPSRAALLIHDMQNYFLAP
                     YASKAFIDGVIHRIAAIKECCHALNIPVYYTAQPGNQSSDDRGLLTDFWGPGMPEEGNA
                     KDIVAGLEPTAERDEVLVKHRYSAFAKSPLLKSLQEGRRDQLIICGVYAHIGCLVTATE
                     AFMCDIQPFVVADAMGDFSLDLHEMAIRHMASCSSKIMSCDDMLAELGKAR"
     gene            15794..16060
                     /gene="obaK"
     CDS             15794..16060
                     /NRPS_PKS="Domain: PP-binding (14-67). E-value: 1.8e-07.
                     Score: 23.5. Matches aSDomain:
                     nrpspksdomains_obaK_PP-binding.1"
                     /codon_start=1
                     /gene="obaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="ObaK"
                     /product="obafluorin aryl carrier protein"
                     /protein_id="AQZ26589.1"
                     /sec_met_domain="PP-binding (E-value: 4.6e-08, bitscore:
                     23.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQGKLIYDKADFYAEIAAILRIPTEELAELESPQEAGVDSVRLL
                     TLSEKWRKRGIDVSFMELAERPGFTAWWELLSARMPVTECEQP"
     aSDomain        15836..15994
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_obaK_PP-binding.1"
                     /evalue="1.80E-07"
                     /label="obaK_PP-binding.1"
                     /locus_tag="obaK"
                     /protein_end="67"
                     /protein_start="14"
                     /score="23.5"
                     /tool="antismash"
                     /translation="AEIAAILRIPTEELAELESPQEAGVDSVRLLTLSEKWRKRGIDVS
                     FMELAERP"
     gene            16057..16827
                     /gene="obaL"
     CDS             16057..16827
                     /NRPS_PKS="Domain: PKS_KR (7-161). E-value: 8.5e-14. Score:
                     43.7. Matches aSDomain: nrpspksdomains_obaL_PKS_KR.1"
                     /codon_start=1
                     /gene="obaL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     222.1; E-value: 1.4e-67)"
                     /gene_kind="biosynthetic-additional"
                     /note="ObaL"
                     /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"
                     /protein_id="AQZ26590.1"
                     /sec_met_domain="adh_short (E-value: 1.9e-34, bitscore:
                     109.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRFEHQSIVVTGAAQGIGAAITRLLLQEGADVFALDNNAQALAA
                     LADEQRSPRLHPKVVDITRPHEVEVAIAAIDNQYPLTGLVNNAGVLVAKSIATTSAEEW
                     QTTFEVNVHGTFFVSRAVATRMAERGQGAIVTVASNAGSTPRINMGAYCSSKAAAAMLT
                     RCIGLEFAAQGVRCNVVSPGSTRTSMLATIAGEGPQTEQRIIAGDPGQYRLGIPLQKIA
                     EPQDIAAVVAFLLSGDANHITLQNLVVDGGATFE"
     aSDomain        16078..16539
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_obaL_PKS_KR.1"
                     /evalue="8.50E-14"
                     /label="obaL_PKS_KR.1"
                     /locus_tag="obaL"
                     /protein_end="161"
                     /protein_start="7"
                     /score="43.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="SIVVTGAAQGIGAAITRLLLQEGADVFALDNNAQALAALADEQRS
                     PRLHPKVVDITRPHEVEVAIAAIDNQYPLTGLVNNAGVLVAKSIATTSAEEWQTTFEVN
                     VHGTFFVSRAVATRMAERGQGAIVTVASNAGSTPRINMGAYCSSKAAAAM"
     CDS_motif       16081..16149
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_obaL_0001"
                     /evalue="1.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="obaL"
                     /protein_end="31"
                     /protein_start="8"
                     /score="14.2"
                     /tool="antismash"
                     /translation="IVVTGAAQGIGAAITRLLLQEGA"
     gene            16947..18020
                     /gene="obaM"
     CDS             16947..18020
                     /codon_start=1
                     /gene="obaM"
                     /note="ObaM"
                     /product="DAHP synthase"
                     /protein_id="AQZ26591.1"
                     /transl_table=11
                     /translation="MPNYQGKQLPAVLKQLSRLPGLVSEDDIVRLRRALVHAAQGHTFV
                     QLMGQREQSLNDVTHATFDQRFKTVESLSRYLALMLGLPVLAIGSVAGSYAHTQPDATE
                     LVDGITLDRYFGDMVNCQAPTPWARRPDANRLLWAYEATEAAMQRLRAKASAIHTSHEC
                     AHLDYEEALVRRTRHSGFYASSASLLWIEACNLFSDSCYVEFARGLDNPIALRLGGPLD
                     THTLVNIVERLNPERQTGKILLIANTADGTQAVGEAIRALQTQRSPVIWLCDPLNRHTA
                     HPATCSLTQSVAQQWDQTLNLHRTLDSRLSGIALEVRSHASSLAAPERHEDAVPFFDFQ
                     KTLQLCSHLAHAYRESR"
     gene            18017..19435
                     /gene="obaN"
     CDS             18017..19435
                     /codon_start=1
                     /gene="obaN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 207.1; E-value:
                     1e-62)"
                     /gene_kind="biosynthetic-additional"
                     /note="ObaN"
                     /product="isochorismate synthase"
                     /protein_id="AQZ26592.1"
                     /transl_table=11
                     /translation="MNTPKQSSYANPYPNLNAHELGAALLPVLERRFPKLAGEFMGLFS
                     QHTDGVRTSMVGLGSEFRVVVTHDGAHLNLQLQHEQAVCLAQTLALDASRLFHEQLFDA
                     VARFVEQLCPWLMQKHGLPASATFLGGWRCATHPEHLSEPLVFTLPRLFCRISDEQLTF
                     SCLHDDIWYAIDERLIASAADFTPTANPRITQREDIPACADYVNDLVGLLNELACTDAD
                     KVVIGREVKLTLERPISPALLLRLVAPRPNPHYEFVFRWADQVAWVGISPETLLRKDND
                     LLVVEPLAGTRKGSSEGEKNARYRHELTSDLKELEEHETAAGLFLEQLATVCENGSLDL
                     RESRSVIDLGYVQHLKSLISGTVKAGLNVFDALAAVYPPATIWGKPLAVCGERIRRYEQ
                     IDRGFFTGGLGYFTLGDDANFALAIRTVKLTESHIHVYAGSGIVKASDPYREWLETTNK
                     MKPYLANEYVWNIS"
ORIGIN
        1 gttcgcaaga cctgcaggcg cagtagcgcg aaagtcgagt gtaccaccgg ctctggagcc
       61 cttcgggcgc cgccggacga agtgtgtgtt catcaagcac gggtaaagct gaagctgcgc
      121 aaggctacag aatatcgaat ggattcaaaa gcctaatctg gcgcacgcag gcctgcccgt
      181 cggccacaaa cacacgtgag cctacgccgg ccgcgtcact tgcctgactc tatagtttca
      241 ctagtgccca cagcccgttg atagtatctt cgccgcgatg tttctaaaca tttcaaggct
      301 gcatgaatgc caggtcagat ctgcttcatt caggcgctgc tgaaaaaata aggatgggac
      361 gccgctcccg gcaccttcat caggtaacgc ggagccgggc acagtccctg aaacgtgacg
      421 tgccgttgag gcagagagac aaggaggtct gatgaataca tggaaaggcg atatgtggaa
      481 cattttcgag ttcgacatat gtgaacaaag tattttcaaa aaaattaccg ccactgcgca
      541 gcaactcggc tttgaccact gcgcttatgg cctgcaactg cctttgccac tgaccgcccc
      601 caaggtcatt attctcgaca actaccctga tgcctggaga gcccgctaca gcgcggctca
      661 ctacgtcaag attgatcctg cggtcctgca tgggcgtcgc acgcaggatc cactggtctg
      721 gagtgcgtca agtttcagtc tcgcccctga actgtgggag gaggcaaatg ctcatggcat
      781 taaagtaggc tggtcgcagt cgcacatcga tctggttggc gccggcggta tgctcagcgt
      841 gtccaggtgc gcacagccac tgagcccatc agaactggcg gatattcaaa gcaaacttgt
      901 ctggctggtg tccattgctc attcttcgct gtcgagagcc atcacccatc gtcatcgaaa
      961 agaacaagac cccaacctga cgtttcgtga attggaagta ctcaaatgga ccgccgatgg
     1021 aaaatcagca ggcgagattt cagacattct taccgtgtct aaaaacacca tagactttca
     1081 tattaaaaat gccattctca agctaaaaac ctgcaataaa accgctgccg tcgtgcgtgc
     1141 ggccatgctc ggtttacttg tgtgaatgag tgatcgaata ctcagcgcgt caataatata
     1201 gcgctgtcga gtgccagaat catggcatgt acgaaactag cacgcggtgc ccagtcgggc
     1261 aacctacgat ttatggtagg tggcccgcga cccattttta tatctaattg cccggcagac
     1321 tctcgccagg tgataaaaag tgcacttcat taccggaaca tcatccacat tgccgcccgc
     1381 tgtaatgacc gcgataggac actatcgtca caaagtgttc gttgaacacc tgggttggaa
     1441 gctgaattgc accgacggtc tcgaatacga tcaattcgat cgtgacgaca ccgtctatgt
     1501 ggttgctcgg aatgacgatg atcacatcat cggcactgcc cggttactca gcaccacccg
     1561 cccctattta ttgagcgaag tgtttcccga gttgttaagc ggcgaaacac cgccgaattc
     1621 ggaaactgtc ctggaattgt cgcgcttcgc cgcaatggat ttcgacgtgc gaaataaaaa
     1681 agcggcgtct cagttttctt ccgatatcgc catcgacttg atgcgcgaaa ccctggcgag
     1741 cgccgccggc cagggcgcaa acaagttaat tacggtgtcg cccctgggcg ttgaacggtt
     1801 gctgcgcaat gtcggcattc atgccagccg tgccggaaaa gtcacgcact ccgacggaaa
     1861 gaagattttc gcatcgtgga taacagtcgc gtgattcacc ccttttttat tagctgacag
     1921 acacaccacc gtcgaccgcg acgctgttcg cgcctcgtgt ctcaacccct ggagggccgt
     1981 catgcctgaa tctcaattgc tcaataaaat taccgacacc tggtacgcca aggcgaccgt
     2041 acgctcaacc ccacgcattc tcgtgcccga ctacagcagc gaacagctta tttatccagt
     2101 ggcgcgctgc tctatctgcg agcacccctt ggtgctggag ctgggcccgc aggtacgctc
     2161 gtatatcttg acccaggcgg cttatcagtt tctgtacggc gtcggcttac tcgaaacaaa
     2221 attcgtcatc cagtgctgtc tggacatgct tcataacaat attaaagaca tcagtgatgc
     2281 agccaaactg caggcgctga cggtgatcgt tgacgagggc taccatgctc atgttgcgct
     2341 tgactacatc attcagatga agaaaaagag cgccattgaa cccctggaag tgccgcaaac
     2401 caatcgcaaa cttgatgcca ccgcgcgcgc ctatgccagc ctgccggaaa gtatgcgcat
     2461 ggacttccaa ctgttggccg tgacactcgc cgagaacgtc ttgaccgatg aagttgccaa
     2521 cttgggccgt gagcgggaac tggcccagtc gtttaccaca ttgatgatgg accatgtacg
     2581 cgatgaaggc cgccattctc gatttttcgc ggacttgatg aaagagcgct ggccacaact
     2641 gcctcgcgca acacaagaac acttcggttt aatgctaccg gcctacctgg atgattttct
     2701 cggggccgat ctcagccgcg gtttcgaacg caagatactc gctcattgcg gtttgaccga
     2761 ggcgcaggca gaacaagtga ttcatgaatc cgatccgcac ttctcaacgg atcaggcccg
     2821 catgaaaaaa tcgatattgc aacgtatcta ccgactgctc aaccagatcg gcgtattaga
     2881 actggacagc gttaaagatg ctttttcaga tcgcaactat gtcacgactt gagcgttaag
     2941 aaacgagagc cggccccatg ttcaagactt tgatcatcga taacttcgat tctttcacct
     3001 acaacctcta tcaatatatg gggcaagtaa cgggggaaga acctgatgtc tttaccaatg
     3061 atgcgtcgcc ccacgatatc gacttgggcc gctacgactg catcatcgta tctccaggcc
     3121 cgggcacacc caagcgccgg caagacgtgg ggatcagtga agacatgatc cgcgacgcgc
     3181 atgtgcctct gctgggggtt tgcctcgggc atcagtgcat ggcgcacgtg catggcatgg
     3241 atgtggacca tgcgccggaa cccatgcacg gcagggtcag gcatatacgc cacaacaatg
     3301 aaggcgtgtt caaaggcctg cccgtggata tgccggtggt tcgttatcac tccctcgtgg
     3361 tgaaggcgct caaggggccc ttcgaactca gcgcctggga tgaaaacggc atgatccacg
     3421 gtatccgcca taccgaacga ccgctctacg gcatccagtt ccatcccgaa tccatctgta
     3481 ccgactccgg gcttgacctg ctgcgcaact ttcgagacat cgcgcatcgg cacaagctcg
     3541 agcgtctacc ccgctaaacc tgccggatgc cggcatcaca actatcagga gtgggcaatg
     3601 acgacctttg atgtcgaagt cagagcgctt gattacaacc ccgatccatt gcgtgtattt
     3661 cgcagcgagt ttcttgcttc gccgcgtcat ttctttctcg aaagcagcgt ggtgaaacca
     3721 ggtttttcgc gtttctcctt tatgggcgat tcccatggcc gccttgctga aacgatcacc
     3781 tacgacacct cctcccgcag cgtgcgcgtt gagcgcagcg acggcgttac ccgggagccg
     3841 acgtcggact ttcttgagtt gatggccgcg cgcctcaacc attaccactg cgagcagccg
     3901 cagtggctgc catttgactt caacctcggg tacgtcggcc tgctgggcta cgaactcaag
     3961 tgcgaaaccc tcggcgctca ggcttacgca tcccactcac acgatgcagc attcatcctg
     4021 gcaacccgga tgattgcttt cgaccacgcc gagcagcgct gttacctgct gtacctggtt
     4081 gaacatgacg aagaccggca ggatgcggcg cagtggttcg atcaggtcca ggcgcgactg
     4141 cgcgagcaac cccaggtggc ggagcctgtc agccgtcaac gcaagctgtc actgcctcag
     4201 gttgaggcgt ggatacaaga gcacgcctgt atacggcact ccaagcagcg ctatatcgac
     4261 aagatcaacg aggcccagcg cgagatcatt gacggtgaga cctatgaggt ctgcctgacc
     4321 aacttgatcg agtttgcgtt cgccgactca tccttcgacc tttattgcgt aatgcgcgag
     4381 ctgacgcccg ctcctcacgc cggttatttt tcgatccccg actttcagat catcagttcg
     4441 tcaccggaac gctttctgaa aatcgaccgt caccaccaag tggaagccaa gccgatcaaa
     4501 ggcacccggc cgcgcgggcg gtgcgccgag gaagatcagg aactgatcga acagatgcgc
     4561 ggtgacgaaa aagaccgggc agaaaacctg atgatcgtcg acctgttgcg caacgacctg
     4621 gggcaggtct gcaccattgg ttcggtaagg gtgccagcgc tgtttgcggt cgaaacctac
     4681 tcccacgtgc accaactggt ctcgaccatc agcgggcagc tcaaaccatc actcagcgcg
     4741 gttgactgtg tacgggcgac gtttccgggt ggctcgatga ccggcgcgcc gaagaaacgc
     4801 acgatggaaa tcatcgaccg cctcgaagag ggcccacgtg gcgcctattc cggctcgctc
     4861 ggctggtttg gcctgggcgg cgcctgcgat ctcaacatca tgattcgctc catcaccgtc
     4921 gacgcccagg tcgcccgctt cggcgtcggc ggcgcaatta cctcgctctc tgacccgctg
     4981 ggcgaataca tcgagaccat ggtcaaggcc agcggtgttg tcgaggccgt cacacaattg
     5041 aggagcacat cggtatgagc ctttcctccc cgcatcgcca tgccgttgtc gtcggcatac
     5101 tcggctcaat cggccagcta ctggccaatc aactgagcat tgccgggtac agcgtcaccg
     5161 gtattgatat tgccgtcgat gatcaatcgg cgcagcccca cacggttatc cagggcgatg
     5221 tcttgcgtcc cggcaatgaa ataaagcagc gactgggtga tgctcaaatc ctcgtgttgg
     5281 cgttggccca gaacgtcctg agcgaagcgc tgccgcagct gttgccctct ttacgctccg
     5341 attgcctgat cgtcgacacc ctgtcgatca agagcgaatt cgccgacttc gtcgcgacgc
     5401 tggatgtagc gcaacccatg gtcggcatca acccgatgtt ttccggcgac ctggatcctg
     5461 ccggcaggcc tgtggccgtg gtgacctacc gcgacggcga cggcgacgca gtggcccggc
     5521 ttgtcgagtg gttgcacagc tggccagcga atgttttcca gatgaccgcc agcgagcacg
     5581 atcggacgat ggcatacctg cagacccttg gccacgcgtt ggtcatggga atgggtttga
     5641 cgctggcgga gtccgccgcc cctctggaga acttgttcga actggccccg ccccccttca
     5701 aggtcatgct cgcgctgctg gcgcgcatga ctaaaaacca tcccgatgtg tactgggaaa
     5761 tccagtcgaa caacccctac tcccaggaaa tacgcagtcg catgctggcg cagctgggca
     5821 agcttgatga cagggtcaat agcggctcac gcctggatta ccacgtgtcg atggcgatgc
     5881 tgaggaacgc gctgaagcca ctgaatccgg ggctcgaaaa taccagtcgc cacctgtttg
     5941 agcagcttga ccaggcgccc aaagcgattg aaggggcacc tgaaagcctg gccgactacc
     6001 gccaacgtat cgaccacatc gacgatcaac tggtggactt gctcggccag cgcctgagcc
     6061 tcattcgaga ggtagcgcaa agcaaaaaag atcaccagac cgccgtcatg cagcccaacc
     6121 gcgtggtcca ggtcgtcgag cgttgcaagg ccaggggtcg ccggcaccac atccgcgaat
     6181 ccctgatcga gcaactctac gggctgatca tcgatgaagc ctgccagatc gaatacgacg
     6241 tgattggcgg cccccgcgag tcgctttacg aagccagccc atccgccttc acctcaagcg
     6301 cagagaaaac ccaatgagca atgtcaaaca acaaaccgcc cagatcgtcg attggttgag
     6361 ctcaaccctg ggcaaggacc accagtaccg tgaggacagc ctgagcctca cggcgaacga
     6421 aaactatccc agcgccctgg tgcgcctgac atccggctct acagccggtg cgttctacca
     6481 ttgctcgttt ccctttgaag tacccgcagg cgagtggcat ttcccggaac cgggtcacat
     6541 gaatgccatc gccgatcaag tgcgtgacct gggtaaaaca ctgattggcg cgcaggcctt
     6601 cgactggcgc ccgaacggcg gctcgacagc cgagcaggct ctgatgctcg cggcgtgcaa
     6661 accgggtgaa ggctttgtcc attttgctca ccgcgacggc ggccactttg cgctggagag
     6721 cctggcgcag aaaatgggga tcgagatttt ccacctgccg gtgaacccga ccagcctgct
     6781 gattgacgtc gccaaactcg atgagatggt ccggcgcaac ccgcatatcc gtatcgtcat
     6841 tctcgatcaa tcattcaagc tgcgctggca gccgctggcc gagatccgca gcgtgctgcc
     6901 cgactcctgc accctgacgt atgacatgag ccacgacggc ggcctgatca tggggggcgt
     6961 gttcgattct cccctcagtt gtggcgccga catcgtccat ggcaacacgc acaagacgat
     7021 ccccggcccg caaaaaggct atatcggctt caagtcggct cagcatcccc tgctggtaga
     7081 cacctcgcta tgggtctgcc cgcatttgca gagcaactgc cacgccgaac aactgccgcc
     7141 aatgtgggtg gcattcaagg agatggaact cttcggtcgg gactatgccg cgcagatcgt
     7201 cagtaatgcc aagactctgg cccgtcacct gcatgagttg gggctggatg tgaccggtga
     7261 gtcgttcggt ttcacccaga cccaccaagt gcactttgcc gtgggtgatc tgcaaaaagc
     7321 cctggacctg tgcgtcaaca gcctgcatgc cggcggcatt cgttccacca atatcgaaat
     7381 tcccggcaaa ccgggcgtgc atggcatccg cctgggtgtt caggcgatga cacgccgtgg
     7441 catgaaagaa aaagatttcg aagtggtcgc acgcttcatc gccgacctgt acttcaagaa
     7501 aaccgaaccg gccaaggtcg cgcaacagat caaggaattc ctccaggcct tccccctcgc
     7561 gccattggcc tactccttcg ataactacct ggacgaggag ttactggcgg cggtgtatca
     7621 gggagcccaa cgatgaccaa cctcccctcc acgcacatca acctgacctc cgaggaggtc
     7681 agtctgggcg acctggtggg tcgcgtgttg gtagaaagcg ggatcgatga cctgttttgc
     7741 attcccggtg acttcaccat gcagctgtcg cgtgagctgt tgaccacgcc ggggctcgca
     7801 ctcaggacga tgtcccatga gtacggcacc acactggcgg cgttgggtta tgccgtcggc
     7861 aaaggggtgc ctggcgccgt ttgcttcacc tacggcgtcg gcgtgctgaa cgccaccaac
     7921 gccattgccc aagcctatgt agagcgcgtg ccgttgctgg tgttttccgg ctctccaggt
     7981 acccgtgagc gccaggcgcc gttattcctg caccacacga tcgtggatca ccagacccaa
     8041 tatcgcatca tgaaggagat tacggtgcac caggtctgtg tgacggaccc gcaccaggtg
     8101 ctggagcaac tgcgcgaagc cgtggccttg gcggtgcttc actccaggcc ggtgtatatc
     8161 gaaattcccc gagacctgtt ccaggcgcgg gtgcgctaca gccctgcccg tcgagtgccg
     8221 ttggaaccct cgacacgcta tagccaggcc gctcgccagg ccgcggagct ggcttacgcg
     8281 ctggtgcgca aagcccggga tccggtgttc gtgcccggcc ttgatctcaa gcggcgcggg
     8341 ctgacggacc tggccatgcg cgtctgcgag cgcctggcca tgccgtgggt ggccacgccg
     8401 atgtcccgag gcggcatccc cgtttcgcac cccaactacc gcggcatcta tgccgggcct
     8461 gcgtcaccct ctcgggttac ccgtgagctg ttggccaaat gcgatgtact gatgctcatc
     8521 ggcgaaccca actctgacgt caacatgggc atcgccagtc atatcgccaa aggccgcttg
     8581 atccacgccg atgacggcaa gatcagcgtc gggcgtcagc acttcaacgc ctccaccgcc
     8641 gagttcctga ttgccttcag cgatgtgatc cacaacgcca agacaccgct ggcaccactg
     8701 accgagacgc aaaaggactt catcgtaccg acgccggcca gcctctaccc ctcagaagaa
     8761 agcccgttga cgcccttcga catcatcaac gagctcaacc gtcatttcgt cacccaaccg
     8821 gatacccaac tggtggtcga ctgcggcgac gtgttcttca tgtccctggg catgttccct
     8881 gccgacgttc tgacctcacc gctgtacatg agcatgggga tcgccgtgcc gggcgccatg
     8941 ggctaccaat tgggtacagg caagcggcct atcgtgctgg tgggcgatgg tgcgtttcat
     9001 atgaccggca acgagctgat gcgagccgcc aaattcggcc tgagtcctat cgtgattgtg
     9061 ctcaacaacc aacgctgggc ctcgctttcc tcggatgcgg cagatatcgc gctgaccgaa
     9121 cagatgccca tgagcttctc ggcagccggg caattcctgc aagtccaggc gttcaccgcc
     9181 accacgggcc gcgaactgcg ccagcacctg gaagaagcct tgaacatgga cagaccggtg
     9241 ctgatcgacg ctcaagtcga cccgtccaag cgcagctatt tgtgcgagcg ttttttcgac
     9301 gcggtgaaag gccagcagca cttgcccaag gcatgacctc tcttgcattt accatttccg
     9361 accggagtta aactggcatg tcagcctcat tcaccactgc tttgacatct gcccaacagt
     9421 cgatctggat ggggcatcaa ttcgatccgc aaagccctgc ctacaacgtt gccagctata
     9481 tcgaaatgag cggcgatatc gatccccagc gacttcagca cgccctgcag cgggcggtgg
     9541 acgacatcga agcactacgt gcgcgctttc atgaagacga gactcagggc ggcgcgctga
     9601 cccagaccat cctcgcccaa gtggccgtcg agctcaacgt gtttgcagtg gatgccgagc
     9661 aagcgcgcag ctggatggag agcgacctgg cccgtcccac tgacctgacg agcggcccga
     9721 tcttctccag cgcgctgcta caggtggcgc ccaacgtcaa ctattggtac ttcaaaaccc
     9781 accatatcgt catggatggc gttgcgctct ccatgctgtt caaacgcgtt gccgacctct
     9841 acgggcaagc cccggacctc tgctcgccat cgcctttcgg cagtgttcgg caggtgctgg
     9901 agaacgagca ggcctggcgc gcatcgccgg cctttgcaca ggaccgtgaa ttctggcagc
     9961 agcactgcca ggacatggcc gaagtggcca gcctcaacag tgatgtcgct cagccgtcct
    10021 accaggccat ccaacatcgc cgggtgctgg acgaatccat catggccagc ttgcgcgaac
    10081 gcgccgaggc catggattcg caatgggtca acgtgctgtt ggcggccttt ggcgcgtttg
    10141 tcgggcgtag cacgggttac cgacaggtga ccgttggcgt ccccatgatg aaccgcttcg
    10201 ccacgggcgc aatcaacgtg ccctgcaccc tggccaatgt gctgccgctg cgcctggaca
    10261 tcaaacccgg ccaaagcgtt gagcaactgg tcgccagcgt gcaggcacag ttggaccgca
    10321 tgcgccctca tcagcgctat cgggccgaag acatccgccg cgattgcaac ctgctggggg
    10381 acaaccgacg cctgaccgga ccgcaaatca acatcgattt cttctccgca aagctgtcgt
    10441 tcgatggcgt tcccggcgag gtcaatgtgc tcagcgcagg cccggccgat gatctctcgc
    10501 tgctgatcca aaccccggcc gacgataaaa cgctgaacat cattgccatg gccaacccgg
    10561 cgctgtacag ccgcgctgcc cttgaacggc acgtgcaacg gttcatcgac tttgtcgaac
    10621 gtttcgccgc ggccagcgac acgccattgg ggcagttgga cgcctacgat gcaacagacc
    10681 cgggctacgc ccaaggcaat gcctgcttca gcccggtcaa ccaggcgcat acgctggcgc
    10741 agaccctggt cgaacgcttt gagcgcgccg tgcacgcgac tccggacgcc atcgccctga
    10801 ccttcaacgg cgaacacctc acctatcagg cgctgaacca acgcgccaac cgtcttgccc
    10861 atttgatcca ggaccagacc gggcaaacca gcccccaacc ggtcgcgctg ctattggcgc
    10921 gctcggtcca aacctttgtg tgcatccttg gcgtgttgaa ggccggcgcg cattacgtgc
    10981 cactggaccc ggatgcaccc gccgaacgca tcaccaccat ccttgaggac acctgcccga
    11041 cactggtgat ctgcgaccag tccagccagg cgctggtctc gggcagcgac gtgaaggtca
    11101 tggtgatcga caccccatcg tgcatggatg cggtgcaaca gcaatcgatc gacaacctgc
    11161 aatcgggccc tcgcgccaac gacctggcct acatcatcta cacctcaggt tcgacgggca
    11221 aacccaaagg cgtgtgcatc acccaccaca acgtcgtgcg tctgttcgaa aacacccatc
    11281 actggtttga ttaccgcagc agcgacgtgt ggacggcctg tcacggctac atcttcgacg
    11341 cttccgtgtg ggaaatgtgg ggcgcattcg cgcatggcgg ccgcctggtg ctggtaccgg
    11401 tggacacgac ccgcgacccg gaaaaactgc tggaactggt ggtgcaggag caggtgacgg
    11461 tattcggcca gatcccctct gcgttctacc gtttcatgga ggcccaggcc gatcagccag
    11521 cgctggccgc tcgactgaat ctgcgctacc agtgctttgg cggcgaagcg ctggacttga
    11581 gccggctcaa accctggttc gaacactacg gtcacagccg gacgcgcttg cttaacctgt
    11641 acggcatcac cgaaacgacc atcaacgcga cgtaccagtt cgtcacgctg gaacaggtgc
    11701 agaccaacca gggcagcctg atcggtacgg tctacgatga cctggacatc aaggttctgg
    11761 atgacgcgct gcgtccggta cccgtgggcg gttatggcga gatgtacgta cggggcgcag
    11821 gcctcgcccg tggttacctc aatcgccagg acctggatgc cacgcgcttt gtggccgacc
    11881 ctttcggtgc ccccggtgag cgcatgtacc gcagcggtga cgtggcggca ttgcaggagg
    11941 gtggcgtact ggaatacatc gggcgggccg accagcaggt caaggtccgc ggttatcgca
    12001 ttgaattggg cgaaatcgaa acccaactgc gtggccaccc gctgttgtcc gacgccattg
    12061 cattggtggt gaccgacgcc tcgggcgatc ccaagctggt ggcgcacgtc gtccccaaag
    12121 ccacctgccg ttgcgaggat atcgacaccg cacaggtgcg cgactacctg cgcgagcggt
    12181 taccgtccta catggtgccc ggcgccatcg gcgtgcaaga gcgcctgccc gtcaccttga
    12241 gcggcaaggt tgatcgcaag gccctgccga ccattgccct gtcgggtgca cgccaggtcg
    12301 aagcgccacg cgatgagttg gacgagcgag tgctggccgc ctggagtgag caactggaga
    12361 tagacaccct cggcatcgat gacaacttct tcgatatcgg cggcgattca atcaaagcca
    12421 ttcggatctg ccgggacctg ggactgccgg tcaccgaact gttcgaccac cccacccccc
    12481 gggccaacgc tgactacctg cgcgatcatc aagacaacga cgcgcaaggc gcggtcaact
    12541 ggctgcatgc gttcgacaag agcgcaaaga aagagcgctt gaacctggtc tgcgttccat
    12601 ttgccggcgg caatgcgttt gcctaccgta acctggtcaa ccagctgtcg agtgtcttca
    12661 actgtgtctc ggtgaacttg ccggggcacg acatcatgcg cccggacgaa ggcatgcaag
    12721 cgctggaagt cgtcgctgat gccgcgaccc aggaaatcct cgccacgttg agcgggccga
    12781 ttatcgtcta cgggcactgc gccggtaacg ccaccgccat cgaaatcgca cgccgcctcg
    12841 aacaggccgg cgccgacctc aaggccctgg tgattggcgg tatgctgctg gatcaggacc
    12901 cggtcgacgt gcaggccagg gttgccgacc agagcggcga aaacattatt gatttcctgc
    12961 agcagatcgg cggattcaag gaagtcctcg acgatgccag catggcaagc atcgcgcgca
    13021 tgaccaagca tgacgctacc cagacggcgc gcttcttcgc cgaggaagcg ctgaaccggc
    13081 aaacgctgca agcccccatt catgtaatcg tcggcgacat ggacccgctc acgcccgact
    13141 atgaggagcg ctacaaggat tggcagatgt actcctcgga cgtgacgctg tcagtgatcg
    13201 aaggcggcgg gcattatttc gtcaccgatc ttgccgaacc gttggcgcag gtcttgctgg
    13261 cgaactataa gcacctcaac ccggttgtac ccgtgcgtgc gccccgtgcc ctgcgcgcgt
    13321 ttcataaccc gttcgatgat gtcgagggcc gtttcagcct gctcgccaac gatgcccgcc
    13381 agctttcctt gtggcctgag tttgcgccca cgccggcagg ctggacggcc ctgttcggcc
    13441 cggccagtca cagcgaatgc ctggcccgca cacaagccta cgaccacgag gcgctcatca
    13501 gtcctcctgc accgaccgaa gggctcgatg caccttactg gcccgaagcg ttcgagtctc
    13561 gctaccgcgc cagtggctgg tggaccgggg aaaccctcgg cgccatcctc acccgccacg
    13621 cactgctcgc cccgcagcgg gtagccgtta ccgacggcga tcggaacctg agctattcgc
    13681 aactggacag caatgccgac cgcattgccg acggcttcgc caccctcggt gtgaaggccg
    13741 gtgaccgagt ggttgtgcaa ttgccgaact ccatggagtt catcgaaacc atcttcggcc
    13801 tgtttcgcct tggcgcgatt ccggtgtttg cgttgccctc ggatcgcctg aacgaaatca
    13861 cgcacatctt tgagatttca ggtgcgatcg cctacgtgat caaggaccag gcgctgggtt
    13921 tcgattaccg gcgtatcgca accgagctca cgcagcagat tgcgtcgatc aagcaggtca
    13981 tcgtggtcgg tgatgccgaa gggttcgtcc cgttcgccaa cctgtacgga cgcaccgccg
    14041 cctggccgca gcgcagttcg cgcgagcctg cgcttatcac cttgtccggc ggcagcacgg
    14101 cactgcccaa actcatcctg cgccgccatg acgactacct ttacagcttc aaggccagcg
    14161 cccggatctg ccaactggac agcgacagcg tgtacctgtg cgtgctgcct gccgggcaca
    14221 acttcacgct cagttcgccg ggcttcctcg gcgtgctgta cgccggcggg cgcgtcgtca
    14281 tgacctcgga ccccagcggt tcaggcgcct ttgccctgat agagcgcgag cgcgtgacac
    14341 tgacgtcggt ggttccaagc ctggcccagg cctggctgca ttcctcccgc gaccatgacc
    14401 tgtccagcct gcagttgctg caggtcggag gcgcgcgcct gagcgatgac gttgccgagc
    14461 ggcttgccac ctcgttcgac tgccagctgc agcaggtcta tggcatgtcc gaaggcctgg
    14521 tttgctacac ggcagtgggt gacaccgagg agcacgtgtt gcatacccag ggacgcccta
    14581 tcagcagtgg cgatgaaatc ctgatcgtcg acgaaaacga tgagcccgtg gccaatgggg
    14641 tcgccgggca attgctggta cgcggcccct acaccatccg cggctacctg aatgcgccgg
    14701 aacacaatgc cagggccttc acgccagatg gtttctaccg cacgggggat gtcgtggtgt
    14761 tccgcgatga cggctacctg gtggtcaccg gccgtatcaa ggaccaagtg aaccgcggcg
    14821 gcgaaaaaat cgccgcagaa gaaatagaag gttatctgct tgctcatcca ggcgttctgg
    14881 aggccgggat catcgggctg ccggacgagt acctgggtga ggtgtcgtgc gccgtggtcg
    14941 tattggcgcc cggcgcgcag ctgactgcca gcgccctcaa gtcgttcgtt cgccagcaag
    15001 gcatagcggc cttcaaagtg ccggatcagg ttcatctggt cccgtcgttg cccaagacca
    15061 cgctgggcaa gatcgacaag aaattactgc gagtacaact gggccaataa acccaaggct
    15121 taactggcac ctgaacctac aaggactgaa taatggcaat cccgaaaatc atggaatacc
    15181 gcgcaccgag cgaagtggca ctgcaacgca aaccgttgga ctggaccgtc gagccgtccc
    15241 gtgcggcgct gttgatccac gatatgcaga attacttcct ggcgccttac gcctccaagg
    15301 cgttcatcga tggcgtgata caccgtatcg ccgccatcaa ggagtgctgc catgcgctga
    15361 atattccggt gtattacacc gcccagccgg gcaaccaatc cagtgacgac cgcggcttgc
    15421 tgacggactt ctgggggccg ggcatgcccg aggaaggcaa cgccaaggac atcgtcgcag
    15481 ggcttgaacc caccgccgag cgcgacgagg tgctggtcaa gcatcgctac agcgcctttg
    15541 ccaaatcgcc tcttctcaag agtttgcagg agggccgccg cgaccaactg attatctgtg
    15601 gtgtgtatgc ccacatcggt tgcctggtca cggcgaccga agcattcatg tgcgacatcc
    15661 agcccttcgt ggtggcggat gccatgggcg acttctctct ggacttgcat gaaatggcga
    15721 tacgccatat ggccagttgc tccagcaaaa tcatgtcctg cgacgacatg ctggcagaac
    15781 tggggaaggc acgatgaccc agggcaagct gatctacgac aaagcggatt tttatgccga
    15841 gattgccgcg atactgcgca tccccacgga ggagcttgcc gaactcgagt cgcctcaaga
    15901 ggctggagtc gactcggttc gcctgctgac gctcagtgag aaatggcgca agcgcggcat
    15961 tgacgtgagc ttcatggagc ttgccgaacg gcccgggttt accgcctggt gggaactgct
    16021 cagcgcgcgg atgcctgtga cggagtgcga gcagccatga accgtttcga acatcagtcg
    16081 attgtcgtta ccggcgcggc ccagggtatc ggtgccgcca tcacccgcct gctgctccag
    16141 gaaggcgccg atgtgtttgc cctggacaac aacgcccagg cattggcagc gctggcagac
    16201 gaacaacgct cacccaggct gcatccgaag gtggtcgata tcacccggcc ccacgaagtg
    16261 gaagtggcca ttgccgccat tgacaaccag tacccgctga ccgggctggt caacaatgcc
    16321 ggtgtgctgg tggccaagag cattgccact acgtcagccg aagaatggca aacgaccttt
    16381 gaggtgaatg tccacggtac cttcttcgtc tccagggccg tggccactcg tatggccgaa
    16441 cggggtcaag gcgcaatcgt tacggttgcc tccaatgccg gcagcacgcc gcgcatcaac
    16501 atgggcgctt actgttcgtc caaggccgcg gcagccatgc tcacccggtg cataggcctg
    16561 gaattcgccg ctcagggagt tcgttgcaat gtcgtatcgc ccggctcgac ccgcacctcc
    16621 atgctggcaa ccattgccgg tgaaggaccg cagaccgagc agcgcatcat agcgggcgat
    16681 cccgggcaat atcgactcgg gattccgctg caaaaaatcg ccgagccgca ggatattgct
    16741 gcggtagtgg cctttctgct gtctggcgat gcgaaccaca taaccctgca aaacctggtc
    16801 gttgacggtg gggccacctt tgagtgagtc gcctatcgcc attgatgtcg agtactgcct
    16861 ggaggcttga agtgttgaat ctcgattcgg tatacgcgtc gcaatcctgg cgaccgggaa
    16921 gctggcgcga taaagagcgc cggcacatgc ctaactatca aggcaagcag ctgcccgccg
    16981 tgctcaagca actgtcacgg ctgcccgggc tggtcagtga agacgacatt gtccggctgc
    17041 gacgggcact cgtgcacgca gcgcaagggc acacgttcgt gcagctgatg ggccaacgtg
    17101 aacaaagcct gaacgatgtt actcacgcca cgttcgatca acgcttcaag acggttgaat
    17161 cgttgagccg ctacctcgca ttgatgctgg gcctgccagt actggcaatc ggctcggtcg
    17221 ccggcagtta tgcgcacacc caacctgacg ccacagaact cgtcgacggc atcacgctgg
    17281 atcgctactt tggcgacatg gtcaactgcc aggcgccaac gccgtgggcc aggcgcccgg
    17341 acgccaaccg cctgctgtgg gcttacgagg ccactgaagc ggcaatgcag cggttgcgcg
    17401 ccaaggcatc ggcgatccat accagccatg agtgcgcgca tctggactat gaagaagccc
    17461 tggtacgtcg cacccgtcac tcgggtttct atgcctccag tgcatcgtta ctgtggatcg
    17521 aggcgtgcaa cctgttcagc gacagttgct acgtggaatt tgcccgtggc ctggacaacc
    17581 ctatcgccct tcgcctcggg gggccattgg atacgcacac gctggtcaac atcgtggagc
    17641 gcctcaaccc tgagcgtcaa acgggcaaaa tcctcctgat tgccaatacc gcagatggca
    17701 cccaagcagt gggcgaagcg atccgcgccc tgcagacaca acgatcgccc gtaatctggt
    17761 tatgtgaccc actcaatagg cacaccgcgc acccagcgac ctgcagcctg acccaaagcg
    17821 tcgcccagca atgggatcag accctgaatc tgcacaggac cctcgacagc cggttgagtg
    17881 gcatcgccct ggaagttcgc agccacgcct ccagtcttgc ggcccctgag cgccatgaag
    17941 acgcagtgcc cttcttcgat tttcaaaaaa ccttgcagct atgcagtcat ctggcccatg
    18001 cctatcggga gtctcgatga atacccctaa acagtcgagc tacgccaacc cttatccaaa
    18061 cctgaacgca cacgaactgg gcgccgcgtt gttaccggta ttggagcggc gttttccgaa
    18121 gctggccggt gagttcatgg gcttgttcag ccagcatacc gacggcgtac gaacgtcgat
    18181 ggtcggcctg ggcagtgagt ttcgcgtagt ggtcacccat gatggggcac acctgaacct
    18241 gcagttgcag cacgagcagg cggtgtgtct ggcgcagacg ctggcactgg acgcttcgcg
    18301 attgttccat gaacagttgt ttgatgcggt ggcccgcttt gtggagcagc tatgcccatg
    18361 gttgatgcaa aagcatggct tgcccgcttc tgcgactttc ctcggaggct ggcgttgcgc
    18421 aacccatccc gaacacttga gtgaaccact ggtcttcacc ctgccccggc tattctgccg
    18481 gatcagcgac gagcagctga cgttcagctg tctgcacgac gatatctggt acgccatcga
    18541 cgagcgcctc atcgcctctg cggcagactt cacgccaacg gccaacccgc gcatcaccca
    18601 acgcgaagac attcctgcgt gtgccgacta cgtcaacgat ctggtcggtt tgttgaacga
    18661 gcttgcctgc accgatgcag acaaagtggt cattggccgt gaagtcaaac tgaccctcga
    18721 acggccaatt tcacccgcac tgctgctgcg cctggtggca ccgcgcccca acccgcatta
    18781 cgagttcgtc ttccgatggg ccgaccaggt ggcctgggtc ggtatttcac ccgagacgct
    18841 gctgcgcaag gacaacgacc tgctggttgt cgagcctttg gcgggaaccc gcaaaggctc
    18901 gagcgagggt gaaaaaaacg cccgctatcg gcacgaactc accagcgacc tgaaggaact
    18961 cgaggagcat gaaaccgcag ccgggctctt tcttgaacag ctggccacgg tctgcgagaa
    19021 cggctcattg gacttgcgcg agtcgcgcag cgtaatcgac ctgggttatg tgcaacacct
    19081 caaaagtttg atcagtggca cggtaaaagc agggctgaac gtattcgatg ccttggcggc
    19141 ggtctatcca cccgccacga tctgggggaa acccttggcc gtctgcggcg aacgtattcg
    19201 tcgctatgaa caaatcgacc gcggcttttt taccggtggg cttggttact tcaccctggg
    19261 agatgatgcc aacttcgcgc tggccattcg cacggtcaag ctcaccgaat cgcacattca
    19321 tgtctacgcc ggcagcggta tcgtcaaggc cagtgacccc taccgggaat ggttggaaac
    19381 cactaacaaa atgaaaccct atctcgccaa tgaatatgta tggaacatat cgtgatatgg
    19441 ttgcacaccg cagttccaga cgctcaggca gcatacacag gatgtgttgc ttataagctc
    19501 atgtgcctat acacgatgca ttcacccgtt agaaactatt aatattcgag cacccttaca
    19561 t
//
