LOCUS       BGC0001458             11295 bp    DNA     linear   CON 13-FEB-2022
DEFINITION  Salinispora tropica CNB-440, complete sequence.
ACCESSION   BGC0001458
VERSION     BGC0001458
KEYWORDS    .
SOURCE      Salinispora tropica CNB-440
  ORGANISM  Salinispora tropica CNB-440
            Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
            Salinispora.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP000667.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4001585
            Source DNA and bacteria available from Paul Jensen
            (pjensen@ucsd.edu)
            Contacts: Paul Jensen (pjensen@ucsd.edu)
            Paul Richardson (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-PGF
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 01:47:42
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..11295
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001458"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11295
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="AfsA"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            101..2758
                     /locus_tag="STROP_RS20900"
                     /old_locus_tag="Strop_4143"
     CDS             101..2758
                     /EC_number="2.7.9.2"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018797027.1"
                     /locus_tag="STROP_RS20900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4143"
                     /product="phosphoenolpyruvate synthase"
                     /protein_id="WP_012015337.1"
                     /transl_table=11
                     /translation="MSTVAIETDVTKWRAMGAKASNLAAMRNLGVHVPRWSAVSSDVFT
                     AFLERVEGIDVLLTQGTEEPERVAAEVTRRMRATVLPDHLADPIQAAYQAAGGGRVAVR
                     SSGLEEDGDRYSFAGQFDTFLNVSEADEVLDRVKDCWASAFSARSLTYRLRNGLPLRAT
                     GMGVLIQQMVRSEVSGVLFTADPATGAGDRYVVSAVYGLGEGIVSGAVDADTATLEAAT
                     GTVLATELGDKSERYEPAAGGGVEAVEVPDADRAQLSLDRVDLGTLWEAGRAISDAFGA
                     PQDIEWAVADGQLWILQSRPITTVPTASRPVGELRIWDNSNIVESFRGITSPLTFTFAS
                     TVYGAVYESYARSLHVPEKQLAQMHEWLPALLGSFHGRVYYNLINWYRLQRIAPFYDVN
                     RKLLEVAMGVDEALPDEIAEGLYPYEFDSAWQRRRARVVTYTTFFWKYLRMDRDVTRFV
                     AYFYEQYAIFDKRDYAAMPADEVYRAFQDLIRSLNRRWGPMQMLDSTILLSMGILTMLG
                     RRWLPHAPEWLTWAAARPGADVESAEPARELAALAATVKADDELRHLVTETDPAAIPGA
                     LAAAGHTTLLAAVDAYVEAHGYRSPDELKLEVPDLHEDPSSLYLMLRDALQAPPETTSG
                     DSAQEYLDQHLRGPRRWIYELTRRKVSRSLAARERLRFCRTKAFGSAKRMLRALGRHLQ
                     QVGAIERFEDVFLLRLDELAGAYEGKIAHDELRDIVAARRRTQDRQATMSAPPRFRTYG
                     APYWEGNLEAAGWSVGRATRTGVGELRGTPSSPGVTTGRVVVTTRPQDVNGGIIVAYST
                     DPGWVAALPSATGLIIERGSPLTHVAIVARELGVPTIVKAKGATQELETGMTVRMDGGT
                     GTITILNDTEGTSA"
     gene            2755..4440
                     /locus_tag="STROP_RS20905"
                     /old_locus_tag="Strop_4144"
     CDS             2755..4440
                     /NRPS_PKS="Domain: CAL_domain (35-466). E-value: 4.3e-72.
                     Score: 234.3. Matches aSDomain:
                     nrpspksdomains_STROP_RS20905_CAL_domain.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     289.3; E-value: 7.3e-88)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018824538.1"
                     /locus_tag="STROP_RS20905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4144"
                     /product="AMP-binding protein"
                     /protein_id="WP_012015338.1"
                     /transl_table=11
                     /translation="MTTTLAFSDVRNWLVDPRTDKGIRFLGDGGDWDYHSYADLSLAAR
                     RSAAAMTAAGAQPGEVVCLLMPTSYPTLCAYFGAWAAGLTPCMITPPSLTSSTEYVELV
                     SSILRRAQPVLMITTERYQDIADSALAAADLPGRAFLHREAEEPVEVPKAGPDDLAILQ
                     FTSGSTGVPRGVPVTWQNLAVNVSCTRAWSAWGEDDSVASWLPLYHDMGLVGTLLAAVC
                     SQADLWLMQPAQFLRDPGRWLECMTRATITAAPPFAYEYAVERISAERIASWDLSGWRT
                     AFVGAQTINPAVLDSFVEATAAAGFNRGTLTPAFGMAETTLGVTGTDHGVPPLVVQVRP
                     DTLRFGQRVELTRQFHLGEEPVPTRNGWLTGCGGPRLGTRISIVDQDGVELPPGHLGEI
                     KVSGETVTAGYTNDADSGGTRFTPDGLRTGDAGFLHAGQLFVLGRMGDSLKIRGRNVYV
                     EDLEAAVVGATGLSPSRCVVISAPETERAGVLLLVEGGRRGWEESAYHTLRSRLGVEPR
                     VRFAVGSRGLIQHTTSGKPRRRDMWQRLQEGTLKASIVEPEVPA"
     aSDomain        2860..4152
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STROP_RS20905_CAL_domain.1"
                     /evalue="4.30E-72"
                     /label="STROP_RS20905_CAL_domain.1"
                     /locus_tag="STROP_RS20905"
                     /protein_end="466"
                     /protein_start="35"
                     /score="234.3"
                     /specificity="Minowa: NH2"
                     /tool="antismash"
                     /translation="SYADLSLAARRSAAAMTAAGAQPGEVVCLLMPTSYPTLCAYFGAW
                     AAGLTPCMITPPSLTSSTEYVELVSSILRRAQPVLMITTERYQDIADSALAAADLPGRA
                     FLHREAEEPVEVPKAGPDDLAILQFTSGSTGVPRGVPVTWQNLAVNVSCTRAWSAWGED
                     DSVASWLPLYHDMGLVGTLLAAVCSQADLWLMQPAQFLRDPGRWLECMTRATITAAPPF
                     AYEYAVERISAERIASWDLSGWRTAFVGAQTINPAVLDSFVEATAAAGFNRGTLTPAFG
                     MAETTLGVTGTDHGVPPLVVQVRPDTLRFGQRVELTRQFHLGEEPVPTRNGWLTGCGGP
                     RLGTRISIVDQDGVELPPGHLGEIKVSGETVTAGYTNDADSGGTRFTPDGLRTGDAGFL
                     HAGQLFVLGRMGDSLKIRGRNVYVEDLEAAVV"
     CDS_motif       3232..3288
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STROP_RS20905_0001"
                     /evalue="6.60E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="STROP_RS20905"
                     /protein_end="178"
                     /protein_start="159"
                     /score="18.8"
                     /tool="antismash"
                     /translation="AILQFTSGSTGVPRGVPVT"
     CDS_motif       3928..4017
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STROP_RS20905_0002"
                     /evalue="3.20E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="STROP_RS20905"
                     /protein_end="421"
                     /protein_start="391"
                     /score="13.2"
                     /tool="antismash"
                     /translation="PPGHLGEIKVSGETVTAGYTNDADSGGTRF"
     CDS_motif       4078..4140
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STROP_RS20905_0003"
                     /evalue="4.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="STROP_RS20905"
                     /protein_end="462"
                     /protein_start="441"
                     /score="12.9"
                     /tool="antismash"
                     /translation="LGRMGDSLKIRGRNVYVEDLE"
     gene            4437..6113
                     /locus_tag="STROP_RS20910"
                     /old_locus_tag="Strop_4145"
     CDS             4437..6113
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018792843.1"
                     /locus_tag="STROP_RS20910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4145"
                     /product="hypothetical protein"
                     /protein_id="WP_012015339.1"
                     /transl_table=11
                     /translation="MILDEAEINSLAAETLERIGHPRSVALILEGSIAEGFGNSRSDID
                     FLLIADQEADLPTMPTIFFIAGRRVEIRTRSVGQIVDHLREVNGYVERTPRHVATLDEH
                     LLNRCQRLLRAHVVYRPDLVEKIRDHLAYDDFAVVMTKWWAEHARQSIRYSIALLALDQ
                     VESAAVWARAGLQQAAKSYLARHGETYFEPKWLSLQLDRLAGDPLVERYWQTINAEPGA
                     GGEIEHTRDCIRLVAELGVPGCADDPQRLVVARVPAVTTWQIDDQVHLVRDRRDVFVLG
                     DAATRVWRCIVWGRPLAALRADTERTGVADPGELIAAYLRYGLIRITWQGAPISPRIPM
                     AAPLGPITPAPAASSPILGIAGAEPPHPRAIALLPLPAPRFAAAAMALMWGNFMIENAL
                     EDLQGALDREQWRVAALTTVRAVNGGLRALLSAHGVSPLPPDPELLHRLDLLSDGHSHI
                     RVLAERLYATVATTEEEARLLLTLLHEYVTNIRKASGGEAFPSSFDSADGWQRTLDIGY
                     DLLRLGAYLDQQLPLDEAQDLLSSGGVQPHARAGAAAAQET"
     protocluster    5236..11295
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[10235:11195]"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10236..11195
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    5236..11295
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     gene            6113..6373
                     /locus_tag="STROP_RS20915"
                     /old_locus_tag="Strop_4146"
     CDS             6113..6373
                     /NRPS_PKS="Domain: PP-binding (11-67). E-value: 6.6e-09.
                     Score: 28.1. Matches aSDomain:
                     nrpspksdomains_STROP_RS20915_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020217467.1"
                     /locus_tag="STROP_RS20915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4146"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_012015340.1"
                     /sec_met_domain="PP-binding (E-value: 1.1e-09, bitscore:
                     28.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNAFDESTGYAIIAAMAPHPLPRIGAETHLRDDLMFDSIRLIEL
                     AIALERQFLLPSLDLNESTDLTTAGDVLNLVRQQLKTGGGA"
     aSDomain        6146..6313
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STROP_RS20915_PP-binding.1"
                     /evalue="6.60E-09"
                     /label="STROP_RS20915_PP-binding.1"
                     /locus_tag="STROP_RS20915"
                     /protein_end="67"
                     /protein_start="11"
                     /score="28.1"
                     /tool="antismash"
                     /translation="AIIAAMAPHPLPRIGAETHLRDDLMFDSIRLIELAIALERQFLLP
                     SLDLNESTDLT"
     gene            6370..7470
                     /locus_tag="STROP_RS20920"
                     /old_locus_tag="Strop_4147"
     CDS             6370..7470
                     /NRPS_PKS="Domain: NAD_binding_4 (8-236). E-value: 3.2e-52.
                     Score: 168.9. Matches aSDomain:
                     nrpspksdomains_STROP_RS20920_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     105.9; E-value: 4.6e-32)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018584005.1"
                     /locus_tag="STROP_RS20920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4147"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_012015341.1"
                     /sec_met_domain="NAD_binding_4 (E-value: 5.2e-53, bitscore:
                     168.9, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.1e-17, bitscore:
                     51.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPKRILVTGAAGLVGAEVCARLLKAGHRVSGLVHHTRVLIANN
                     GRAVASATDDRAGTVRLVTGDVTVPRLGLDDDTWTDLANGLDLIVHSAAITDFGHPREV
                     YQAINTTGTAHVLELARERSTPLVHVSTAYVCGERDGMILESQLDVGQRFGNPYEESKL
                     AAEQLVRKAAAESLPTVVIRPSVVVGAARTGAVRDFKNLYVVLKLLSEGRIGSIPGYFD
                     ACVDLVPVDHVAALITAVVDDFDRARDRTLHAVGSSVRMRHISDVLAEYPSFHVPRYIA
                     PANFDPAMLSDLERAYWHRVMSLYESYFRRQQHFDDTVAAGFRGHKRLPSGPNHLRRII
                     DYAVRADYLGAPLPGVAEALSRVNQR"
     CDS_motif       6391..6459
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STROP_RS20920_0001"
                     /evalue="9.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="STROP_RS20920"
                     /protein_end="30"
                     /protein_start="7"
                     /score="8.7"
                     /tool="antismash"
                     /translation="LVTGAAGLVGAEVCARLLKAGHR"
     aSDomain        6394..7077
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STROP_RS20920_NAD_binding_4.1"
                     /evalue="3.20E-52"
                     /label="STROP_RS20920_NAD_binding_4.1"
                     /locus_tag="STROP_RS20920"
                     /protein_end="236"
                     /protein_start="8"
                     /score="168.9"
                     /tool="antismash"
                     /translation="VTGAAGLVGAEVCARLLKAGHRVSGLVHHTRVLIANNGRAVASAT
                     DDRAGTVRLVTGDVTVPRLGLDDDTWTDLANGLDLIVHSAAITDFGHPREVYQAINTTG
                     TAHVLELARERSTPLVHVSTAYVCGERDGMILESQLDVGQRFGNPYEESKLAAEQLVRK
                     AAAESLPTVVIRPSVVVGAARTGAVRDFKNLYVVLKLLSEGRIGSIPGYFDACVDLVPV
                     DHVAAL"
     gene            7467..8447
                     /locus_tag="STROP_RS20925"
                     /old_locus_tag="Strop_4148"
     CDS             7467..8447
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019032637.1"
                     /locus_tag="STROP_RS20925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4148"
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="WP_012015342.1"
                     /transl_table=11
                     /translation="MSSIAAYGPPFPEGLTHDPDKQRYHGTDSYFLEAYEQLSTLTPDP
                     VRFAYEHAMLLMKPDAVASRSIERVIEWLREAHFRIVAVRRLRMRRESVRAIWHYQLNR
                     ATPQRCLLADALCEQSDSLVILARPADPVDVPATVALSVNKGPADPARRRPGQLRARLG
                     DFGFLLNLVHASDEPADLVRELGILLEHRERRALIGQALANTDQHDQTTAIARKLYAAH
                     PPHDLDFVASTRRLTRAVQDLLATTALPDEVRRALCRTLASTSSEPASWAPLVNVIWSA
                     DLPLNGWDFIVVGCHAVSLSRPGYGQLLAGADPGRWRSLATVAAS"
     gene            8414..9352
                     /locus_tag="STROP_RS20930"
                     /old_locus_tag="Strop_4149"
     CDS             8414..9352
                     /GO_component="GO:0016021 - integral component of membrane
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018790813.1"
                     /locus_tag="STROP_RS20930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4149"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_043535521.1"
                     /transl_table=11
                     /translation="MAVPGHRGSVMSSAVGQAPALLRYRAFLGAVFAPGVHVTYAVLWA
                     CAYEAAAVMTAGGVWRPSVGSLVRAMTIIVVLLHLRLADERMDESYDRIHNPDRPLITG
                     LVSVRELRRAGWATAALAIVVNVPLAPWSAVTVALLVGYTELITRLTLHSPRLRDRALL
                     YIVVAYPVQLLIGVYLYTSVTGAKVVQPGIRPALLIIVFAAAFLHFEFARKTVRDPRSG
                     GRTYSATALGITGSGVLTLGWALLACTLLAAITEPWHMSDAALLPYVALVFPVAGAFSY
                     LSGREQRWPTSLAMLYLIVLDAALVTSGWLG"
     gene            9352..10239
                     /locus_tag="STROP_RS20935"
                     /old_locus_tag="Strop_4150"
     CDS             9352..10239
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083:oxidoreductase (Score: 185.8; E-value: 2e-56)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020609208.1"
                     /locus_tag="STROP_RS20935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4150"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_026275164.1"
                     /transl_table=11
                     /translation="MEIGVVLPQGELHGGPRALREYASVAQELGFRHLLAYDHVLGADP
                     AGHPNWQGVYDADDPFHEPLVLFGYLAAVCDLDLVTSVLVLPQRQTALVAKQAAEIDLL
                     SDGRLRLGVGIGWNTVEYEALGRPMQSRGERLDQQITLLRSLWTHRSVSFEHSGERIVA
                     AGINPRPKRPIPIWIGGASPAAYRRAGRTGDGWMPRLQPGPELTAARMIVTKAAEAAGR
                     PPEAIGMHGRVRYLDGGAVGVAAAARRWREAHATHLAVSTLGAGFTSLSEHLEALTAIA
                     RTGLLDENMEGPNR"
     gene            10236..11195
                     /locus_tag="STROP_RS20940"
                     /old_locus_tag="Strop_4151"
     CDS             10236..11195
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020217462.1"
                     /locus_tag="STROP_RS20940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Strop_4151"
                     /product="gamma-butyrolactone synthase"
                     /protein_id="WP_012015345.1"
                     /sec_met_domain="AfsA (E-value: 4.9e-27, bitscore: 83.2,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTRLLTQPHTTVEPGAVHRRHADTVFLADVHPDGTDGYVATAL
                     LPESHTYYSAHTAEANRRLDPMLLLEACRQVVIYIGHNSLGLANDTRFLMDSCEISVPA
                     DAYVQRPDGGSTTLTMRVTVAAVRVGSRLRAFTSRYELSLGAVPIGSTVITSSVVSPAA
                     YTRLRRRACGGSPPPWSDQLCPYLDGAVSPSTVGRLVPADVLLAEVRSDSDKTTARVLL
                     PFDHLGLFDHRQDHVPGTLLIEAARQLGAALSPEPDAAVMTGLAGTFDAFVELDAPVHL
                     VARAGTTDDERSVEVVQGGTVLATIKVATSRAHSGPPR"
ORIGIN
        1 attgcttttc gtacggagga tggtcgcaaa aagccgccct ggacgctacg cccagcggga
       61 cgtcgcatgc cgatcaacac gcactatccg aggaggaagg ttgtcaactg tcgccattga
      121 aaccgacgtt acaaaatggc gagctatggg ggccaaggcg tccaatctgg cggcgatgag
      181 gaaccttggt gttcatgttc cgcgctggag cgcagtttcc agcgatgtct tcaccgcctt
      241 cctggaacgc gtcgaaggca tcgacgtgtt gctgacccag ggcaccgagg aaccggagcg
      301 cgtcgcggcc gaggtcaccc gacggatgcg ggcgaccgtg ctccccgacc acctcgccga
      361 cccgatccag gcggcgtacc aggccgccgg cggcggccgg gtcgcggtgc gctcgtccgg
      421 cctggaggag gacggcgaca ggtactcctt cgccggccag ttcgacacct tcctcaacgt
      481 cagcgaggcc gacgaggtcc tggaccgggt caaggactgc tgggcatcgg ccttctcagc
      541 gcgctcgctg acctaccgtc tgcgcaacgg cctgccactg cgcgcgaccg gcatgggggt
      601 actcatccaa cagatggtgc gctcggaggt cagcggcgtg ttgttcaccg ccgatccggc
      661 taccggtgcc ggcgaccggt acgtggtcag cgctgtctac ggcctcggcg agggcatcgt
      721 ctccggcgct gtcgacgcgg acaccgcgac cctcgaagcg gccaccggta cggttctggc
      781 gaccgagctc ggcgacaagt cggagcgcta cgagcccgcg gccggcggcg gcgtcgaagc
      841 cgtcgaggta ccggacgctg accgggcgca gctgtcgctc gaccgggtcg accttggcac
      901 gttgtgggag gcaggccgcg ccatcagcga cgccttcggt gcaccgcagg acatcgagtg
      961 ggcggtcgcg gacggccagc tgtggatcct gcagagccga ccgatcacca ccgtgccgac
     1021 cgcgagcagg ccggtgggtg agctacggat ctgggacaat tcgaacatcg tggagagctt
     1081 ccggggaatc acgtccccgc tgaccttcac gttcgcctcg acggtctacg gcgcggtgta
     1141 cgagagctat gcccgatccc tgcacgtgcc cgagaagcag ctcgcgcaga tgcacgagtg
     1201 gttgcccgcg ctactcggca gcttccacgg tcgcgtctac tacaacctca tcaactggta
     1261 ccgcctacag cggatcgcgc ccttctacga tgtcaaccgc aagctgctcg aggtcgccat
     1321 gggcgtggac gaggcgctgc cggacgagat cgccgaaggg ctgtacccgt acgagttcga
     1381 ctcggcctgg caacgccgac gcgcacgagt tgtcacctac acgaccttct tctggaagta
     1441 cctgcgcatg gaccgtgacg tcacgcggtt cgtcgcctac ttctacgagc agtacgcgat
     1501 cttcgacaag cgcgactacg ccgcgatgcc cgccgacgag gtgtaccggg cgttccagga
     1561 cctgatccgc agcctgaaca ggcggtgggg tccgatgcag atgctcgact ccacgattct
     1621 gctgtcgatg ggcatcctca cgatgctcgg ccggcggtgg ctgccgcacg cccccgagtg
     1681 gctgacgtgg gccgccgctc ggcccggcgc cgacgtggag tccgccgagc cggcccgcga
     1741 gttggccgcg ctggcggcca ccgtcaaggc cgacgacgag ttgcgccacc tggtgacgga
     1801 gaccgacccg gcggcgatac ccggcgcgct cgcggctgcc gggcacacca ccttgctcgc
     1861 ggccgtcgac gcctacgtgg aggcgcacgg ctaccgcagc cccgacgagc tcaagctgga
     1921 ggtgccggac ctacacgagg atccgtcgag tctgtacctg atgctgcgcg acgcgctaca
     1981 ggctccgccg gagacaacga gcggcgacag cgcgcaggaa tatctcgacc agcacctgcg
     2041 ggggccgcga cgctggatct acgaactgac ccgccgcaag gtgtctcggt cactggcggc
     2101 gcgcgagcgg ctgcggttct gccggacgaa ggcgttcggc tcggccaagc ggatgcttcg
     2161 cgcactcggc cggcacctgc agcaggtcgg ggcgatcgag cggttcgagg acgtgttcct
     2221 gctgcgcctc gacgagcttg ccggggcata cgagggcaag atcgctcacg acgagctacg
     2281 cgacatcgtg gcggcgcgtc ggcgcacgca ggaccgacag gcaacgatgt ccgccccacc
     2341 gcgcttccgg acgtacggcg cgccctactg ggagggcaat ctcgaggccg ccggttggag
     2401 cgtcggccgg gccacccgca ccggcgtcgg tgaactgcgc gggacaccat cgtccccggg
     2461 cgtcacgacc gggcgggtcg tcgtcacgac gcgacctcag gacgtcaacg gcggcatcat
     2521 cgtggcctac agcaccgacc cggggtgggt cgccgcacta ccgtcagcga ccggactgat
     2581 catcgagcgg ggaagcccgc tgacccacgt cgcgatcgtg gcgcgcgagc tgggcgtgcc
     2641 gacgatcgtc aaggccaagg gtgccaccca ggaactggag accggcatga ccgtccggat
     2701 ggacggcggc accggcacga tcacgatcct caacgacacg gaggggacgt ccgcgtgacc
     2761 accaccctgg ctttcagcga tgtgcgcaac tggctggtcg atccccggac cgacaagggg
     2821 atccggttcc tcggtgacgg aggcgactgg gactaccact cgtacgcgga cctgtctctc
     2881 gcggcacgac gcagcgcggc ggcgatgacc gctgccggcg cccagcccgg ggaggtggtc
     2941 tgcctgctca tgccgacgag ctacccgacg ctctgcgcgt acttcggggc ctgggccgcg
     3001 ggcctcaccc cctgcatgat caccccaccc agtctcacca gcagcaccga gtacgtcgag
     3061 ctcgtctcga gcattctgcg tcgggcgcaa ccggtactga tgatcaccac cgagcgctac
     3121 caggacatcg ccgactcggc tctggccgcg gcggacctgc ccggccgcgc ctttctacac
     3181 agggaggcag aggaaccggt cgaggttccc aaagccggcc ccgacgacct ggcgatcctc
     3241 cagttcacct ccggctccac cggcgtcccg cgaggagtgc cggtcacctg gcagaacctc
     3301 gccgtcaacg tctcctgcac ccgggcgtgg agcgcctggg gcgaggacga ctcggtggcc
     3361 tcctggctgc cgctctatca cgacatgggc ctcgtcggca cgctactcgc cgccgtctgt
     3421 agtcaggccg acctgtggct gatgcagccc gcgcagttcc tgcgcgaccc gggcagatgg
     3481 ttggagtgca tgacccgggc cacgatcacg gccgcgccgc cgttcgcata cgagtacgcg
     3541 gtggagcgga tctccgcaga gcggatcgcc agctgggacc tgtccggatg gcggaccgcg
     3601 ttcgtcggcg cgcagaccat caaccccgcg gtgctcgaca gcttcgtgga ggctaccgcc
     3661 gctgcgggct tcaaccgcgg cacgctcacc cctgccttcg ggatggcgga gacgacgctc
     3721 ggggtaaccg gcactgacca cggtgtccct ccgctggtgg tgcaggtgag gccggacact
     3781 ctgcgattcg gccagcgggt cgagttgacc cggcagttcc acctcggtga ggagccggtg
     3841 ccgacacgca acggttggct caccggctgt ggcggcccgc gcctcggcac ccggatcagc
     3901 atcgtcgacc aggatggcgt cgagttgccg ccaggccatc tcggtgagat caaggtcagc
     3961 ggggaaacgg tcaccgcggg ctacaccaac gacgccgact ccggcggcac ccgcttcacc
     4021 ccggacggcc tgcgcaccgg cgacgccggg ttcctccacg ccggccagct gttcgtgctg
     4081 ggccggatgg gcgacagcct caagatccgg ggacgcaacg tctacgtcga ggacctcgag
     4141 gcggcggtcg tcggggcgac cggcctgtcc cccagtcgct gtgtggtgat cagcgcgccg
     4201 gaaaccgagc gtgccggcgt tctgctgctc gtcgagggcg ggcgccgcgg ctgggaggag
     4261 agcgcctacc acaccctccg ctcccgcctg ggtgtcgagc cgcgagtccg gttcgcggtc
     4321 ggaagccgtg gcctgatcca gcacaccacc agtggaaagc cacgccgccg tgacatgtgg
     4381 cagcgcctcc aggagggaac cctgaaagcg tcgatcgtcg agccggaggt ccccgcatga
     4441 tcctcgacga ggccgagatc aattcactcg cggccgagac gctggagcgt atcggtcacc
     4501 ccagaagtgt cgcgctgatc ctggaaggct ccatcgccga gggtttcggc aactctcgct
     4561 ccgacatcga cttcctcctg atcgccgacc aggaggccga cctgccgacg atgcccacga
     4621 tcttcttcat cgcgggacgt cgggtggaga tccgcacccg atccgtcggc cagatcgtgg
     4681 accacctccg agaggtcaac gggtacgtcg aacgcacccc gcgccatgtc gccacactgg
     4741 acgagcacct gctcaaccgg tgccaacggc tactccgagc gcatgtcgtg taccgcccgg
     4801 acctggtcga gaagatccgt gaccacctcg cgtacgacga cttcgccgtc gtcatgacca
     4861 agtggtgggc ggaacacgca cggcagtcca tccgatactc catcgcgctg ctcgccctgg
     4921 accaggtgga gtcggccgcc gtgtgggccc gggcgggact tcagcaggcc gccaagagct
     4981 acctggcacg ccacggcgag acatacttcg agccgaagtg gctctcgctg cagctcgacc
     5041 ggctcgccgg ggatccgctg gtcgaacgct actggcagac catcaacgcg gagcccggtg
     5101 ccggcgggga gatcgagcac acgcgcgact gcatacgcct ggtcgcggag ctcggcgtgc
     5161 cgggctgcgc tgatgatccg cagcggctgg tcgttgcacg agtgccggca gtgaccacct
     5221 ggcagatcga cgaccaggta catctggtgc gtgaccgacg tgacgtgttc gtcctcggcg
     5281 acgccgccac acgggtgtgg cggtgcatcg tctgggggcg accactcgcg gcgctgaggg
     5341 ccgacaccga gcggacgggc gtcgccgacc cgggtgagct gatcgccgcc tacctccggt
     5401 acggcctgat ccggatcacc tggcagggtg ctccgatctc gccacggatt ccgatggccg
     5461 caccgctcgg ccccatcacc cccgccccgg cggccagcag cccgatcctg ggtatcgccg
     5521 gcgccgagcc gccgcatccc cgcgcgatcg cgttgctacc gctgccggcg ccgcgcttcg
     5581 ccgccgccgc gatggcactg atgtggggca acttcatgat cgaaaatgct ctggaggacc
     5641 tgcagggcgc actcgaccgc gaacagtgga gggtcgctgc actcaccacg gtgcgcgcgg
     5701 tcaacggcgg gctgcgtgcc ctgctcagcg cgcacggtgt gagtccgttg ccgccggatc
     5761 ccgagctgct acaccgactc gatctgctgt ccgacgggca ctcgcatatc cgtgtcctcg
     5821 ccgaacggct gtacgcgacc gtggccacga ccgaggagga ggcccggctt ctgctcaccc
     5881 tcctgcacga gtacgtgacc aatatccgga aggcctcggg cggagaggcg ttcccgtcgt
     5941 cgttcgactc cgcggacggc tggcagcgca ccctcgacat cggctacgac ctgctgcgtc
     6001 tcggcgcata tctggaccag caactccccc tcgacgaggc gcaggacctg ctctccagcg
     6061 gcggtgtgca gccgcacgca cgggccggcg ccgcagcagc acaggagacg tgatggacaa
     6121 cgcgttcgac gaatcgaccg gttacgcgat tatcgccgcg atggcgccgc acccactccc
     6181 ccgcatcggg gcggagaccc atctgcgcga cgacctgatg ttcgactcga tccggctgat
     6241 cgagctggcg atagccctgg aacggcagtt cctgctgccc tcgctcgacc tgaacgagtc
     6301 gacggacctg acgaccgccg gagacgtcct gaacctggtt cggcaacaac tgaagaccgg
     6361 aggaggggca tgagcacgcc gaagcggatc ctggtcaccg gggcagccgg cctggtcggc
     6421 gccgaggtct gcgcccgcct gctgaaggcc gggcaccgag tgtccggcct ggtgcaccac
     6481 acccgagtgc tgatcgccaa caacggccgg gccgtcgcgt cggcgacgga cgacagggcg
     6541 ggcaccgtac ggctggtcac cggtgacgtc accgttccac ggctgggcct cgacgacgac
     6601 acctggacgg acctggcgaa cgggctcgac ctgatcgtgc attctgctgc gatcaccgac
     6661 ttcggtcacc cccgggaggt ctaccaggcg atcaacacga ccggcacggc tcacgtgctg
     6721 gagctggccc gcgagcgatc caccccgctg gtgcacgtca gcaccgccta cgtgtgcggc
     6781 gaacgggacg gcatgatcct ggagtcccag ctcgacgtcg ggcagcggtt cggcaacccg
     6841 tacgaggaga gcaaactcgc cgcggagcaa ctggtgcgaa aggccgccgc ggagagcctg
     6901 ccaaccgtgg tgatccggcc cagtgtcgtc gtcggcgccg cccgcaccgg cgcggtccgt
     6961 gacttcaaga acctgtacgt cgtgctgaag ctcctgtccg agggtcggat cggctcgatc
     7021 ccgggctact tcgacgcctg cgtcgacctc gtgccggtcg accatgtggc ggcgttgatc
     7081 accgctgtgg ttgacgactt cgaccgggcc agggaccgca cactgcacgc cgtgggatcg
     7141 tcggtgcgga tgcgccacat ctccgatgtg ctcgccgaat acccatcgtt ccacgttccc
     7201 cgctacatcg ccccggccaa cttcgaccct gccatgctgt cggacctcga acgcgcctac
     7261 tggcaccggg tcatgtcgct gtacgagagc tacttccgcc gccagcagca cttcgacgac
     7321 accgtcgcgg ccgggttccg aggacacaag cgactaccca gcgggccgaa ccacctccgg
     7381 cggatcatcg actacgcggt cagggccgac tacctcggcg cgcccctgcc gggcgtggcg
     7441 gaggccctga gccgggtcaa ccagcgatga gcagtatcgc ggcctacgga ccgccgttcc
     7501 ccgaaggcct gacccacgat ccggacaagc agcgttatca cggcaccgac agctacttcc
     7561 tggaggcgta cgagcagctg tccacgctga cacccgaccc ggtgcgattc gcgtacgagc
     7621 acgccatgct gttgatgaag cctgatgcgg tggcgtcgcg ttcgatcgaa cgtgtcatcg
     7681 aatggctgcg cgaagcacac ttccggatcg tggcagtgcg gcgactgcgg atgcgccgtg
     7741 agtcggtccg ggcgatctgg cactaccagc tgaaccgagc gacaccccag cgctgtctac
     7801 tcgctgacgc gctgtgtgaa cagtccgact cgttggtgat cctggcccgc cccgccgacc
     7861 ccgtcgatgt gccggccacg gtggcgctca gcgtcaacaa gggaccggcc gatccggcgc
     7921 ggcgccgtcc gggccagctg cgtgcccggc tcggcgactt cggcttcctc ctcaacctgg
     7981 tgcacgcctc ggacgagccg gccgacctcg tccgggagct tggcatcctg ctggaacacc
     8041 gggagcgacg cgcactgatc ggccaggcgc tggcgaacac ggaccagcat gatcagacga
     8101 ccgcgatcgc ccgaaagctg tacgccgctc accccccgca tgacctggac ttcgttgcct
     8161 cgacccgccg cctgaccagg gctgtgcagg acctcctcgc cacgacggcc ctgccggacg
     8221 aggtacgccg ggccctgtgt cgcacgctgg cctcgacgag cagcgaaccg gcgagctggg
     8281 cgccgctggt caacgtgatc tggtcggcgg acctgccgct caacggttgg gatttcatcg
     8341 tggtgggctg ccacgcggtt tcgctctctc gcccagggta cggacagctg ctggccggag
     8401 ccgatcccgg ccggtggcgg tccctggcca ccgtggcagc gtcatgagca gcgccgtcgg
     8461 gcaggccccg gcactgctgc gctaccgcgc gttcctgggc gctgtcttcg cgccgggagt
     8521 gcacgtcacc tacgcagtgc tgtgggcgtg tgcatacgag gccgccgcgg tcatgacagc
     8581 ggggggcgtc tggcggccgt cggtcgggtc gctggtccga gccatgacga tcatcgtggt
     8641 cctgctacac ctgcggctcg ccgacgagcg tatggacgag tcgtacgacc ggatccacaa
     8701 cccggaccgt ccgctgatca ccggtctggt cagcgtgcgc gagctgcgcc gcgccggttg
     8761 ggcgacggcc gccctggcga tcgtcgtcaa cgttccgctc gccccctggt cggcggtgac
     8821 cgtggcgctt ctcgtgggct acaccgagct aatcactcgg ctcacgctgc actcgccgag
     8881 gctgcgtgac cgggcgctgc tctacatcgt cgtggcgtac ccggtgcagt tgctgatcgg
     8941 tgtctacctg tacacgtccg tgaccggcgc gaaggtggta cagccgggga tccgcccagc
     9001 cctgctgatc attgtgttcg ccgccgcgtt cctgcacttc gagttcgccc gcaagacagt
     9061 acgcgatccc cgctccgggg gccggacata ctcggccacc gcactcggga tcaccggcag
     9121 cggtgtgctc acgctcggct gggccctgct cgcgtgcacc ctgctggccg cgatcaccga
     9181 gccgtggcac atgtcggacg cggcgctact gccctacgtg gctctcgtct tcccggtcgc
     9241 gggcgccttc tcctacctca gcggcaggga acagaggtgg cccacgtcgc tcgccatgct
     9301 ctatctgatc gtgctcgacg cggcgctcgt caccagtggg tggctcggat gatggagatc
     9361 ggcgtggtcc tgccccaagg cgagctgcac ggcgggccac gagccctacg cgagtatgcg
     9421 agcgtggcgc aggagctggg attccggcac ctcctcgcgt atgaccacgt gctcggtgcc
     9481 gacccagccg ggcatccgaa ctggcagggt gtatacgacg cggatgatcc gttccacgag
     9541 ccgctggtgc tcttcggcta cctcgcggcg gtgtgcgacc tcgacctggt gaccagtgtt
     9601 ctggtcctgc cgcaacgaca gaccgcgctg gtcgccaagc aggcggccga gatcgacctt
     9661 ctctccgacg gccggctacg gctgggggtt ggcatcggct ggaacacggt ggagtacgag
     9721 gctctgggcc ggcccatgca gtctcgaggt gagcggctcg accagcagat caccctgttg
     9781 cggtcactat ggacacaccg gtcggtcagc ttcgaacact ccggggaacg aatcgtcgcg
     9841 gccgggatca acccacgacc gaaacggccg attcccatct ggattggcgg cgccagccca
     9901 gctgcctacc gccgggcggg tcgtaccggc gacggctgga tgccccgcct ccagcccggg
     9961 ccggagctca cagcggcccg aatgatcgtg acgaaggcgg cggaggcagc cggtcgaccc
    10021 cccgaggcga tcggcatgca cggccgggtc cgctacctcg acggcggcgc ggtcggtgtt
    10081 gccgcagcgg cccgccggtg gcgtgaagcc cacgccacac acctggccgt gagcacgctc
    10141 ggcgccggat tcacgtcgct cagcgaacac ctcgaagcgc tcaccgcgat cgcccgcacg
    10201 ggactcctcg acgagaacat ggaagggccc aatcgatgac cgacacccgg ctactgaccc
    10261 agcctcacac gaccgtcgaa ccgggggctg tccatcgtcg tcatgctgac accgtcttcc
    10321 tcgccgatgt ccacccggac ggcacggacg gatatgtggc gacggcgttg ctgcccgaga
    10381 gccacacgta ctattcagca cacaccgcgg aggcgaatcg tcgtctcgat ccgatgctgc
    10441 tactggaggc ctgccggcag gtcgtcatct acatcggcca caacagcctc ggcctggcca
    10501 acgacacccg attcctgatg gactcctgcg agatctccgt gccggccgac gcgtatgtgc
    10561 aacggcccga cggcggttcg accacgctga cgatgcgcgt caccgtagcg gcggtccggg
    10621 tcggcagccg gctccgcgcg ttcacgtccc ggtacgagct gtcactcggt gcggtgccga
    10681 tcggatcaac agtcatcacc tcgtcggtcg tgtccccggc cgcctacacg cggctgcgcc
    10741 gccgggcttg cggcgggtca ccgccgcctt ggtccgacca actgtgcccg tacctggacg
    10801 gggcggtttc cccctcgact gtcggccgcc ttgtacccgc cgacgtgctg ttggccgagg
    10861 ttcgttctga ctcggataag accaccgcac gggtgctgct gcctttcgac cacctgggct
    10921 tgttcgacca ccggcaggac cacgttccgg gaaccctcct catcgaggcg gcccgtcagc
    10981 tcggcgccgc actcagtccc gagccagacg cggcggtgat gaccgggctt gccggcacgt
    11041 tcgatgcgtt cgtcgaactg gacgctccgg tgcacctcgt ggcccgggca ggcacgactg
    11101 acgatgagcg gtcggtcgag gtggtgcagg gcggcaccgt gctcgcaacg atcaaggttg
    11161 ctacctcccg agcacacagc gggccgccaa ggtgatcatc gatggcaccc tgtcgacgac
    11221 acggcccacg tagcgaggaa cagcgtgtgc cgtgccagaa ctctgtttgt ggctgtgagc
    11281 tggcgctttg aagat
//
