BGC0001477: lydicamycin biosynthetic gene cluster from Streptomyces sp. ID38640
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 116,700 nt. (total: 116,700 nt).
This entry is originally from NCBI GenBank MG459168.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001477
Short description lydicamycin biosynthetic gene cluster from Streptomyces sp. ID38640
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: MG459168.1
Compounds
  • lydicamycin
Species Streptomyces sp. ID38640 [taxonomy]
References
Chemical products information
lydicamycin
Copy SMILES
C47H74N4O10
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AVV61973.1
 142 - 2931 (+) response regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61974.1
 3015 - 3839 (-) hypothetical protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61975.1
 4355 - 6253 (+) putative signal transduction histidine kinase
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61976.1
 6235 - 6891 (+) LuxR family DNA-binding response regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61977.1
 6945 - 7955 (-) malonyl CoA-acyl carrier protein transacylase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61978.1
 7958 - 8329 (-) putative secreted protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61979.1
 9141 - 19934 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61980.1
 19975 - 41175 (+) type I modular PKS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61981.1
 41219 - 51922 (+) type I modular PKS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61982.1
 51969 - 57500 (+) type I modular PKS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61983.1
 57508 - 74646 (+) type I modular polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61984.1
 74694 - 85661 (+) type I modular polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61985.1
 85698 - 95495 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61986.1
 95668 - 96480 (+) hypothetical protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61987.1
 96517 - 99612 (+) putative non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61988.1
 99673 - 100575 (+) hypothetical protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61989.1
 100607 - 106378 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61990.1
 106449 - 107738 (-) cytochrome P450
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61991.1
 108215 - 108307 (+) hypothetical protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61992.1
 108304 - 109083 (+) putative membrane protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61993.1
 109436 - 110197 (+) biosynthesis thioesterase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61994.1
 110270 - 111925 (-) amine oxidase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61995.1
 112369 - 113403 (+) AsnC family transcriptional regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61996.1
 113393 - 114853 (-) amidase
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • AVV61997.1
 114894 - 116447 (-) AbgT transporter
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
AVV61981.1
+
AVV61989.1
+
AVV61979.1
+
AVV61980.1
+
AVV61983.1
+
AVV61982.1
+
AVV61985.1
+
AVV61984.1 		Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61979.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61979.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61980.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61980.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61980.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61980.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61981.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61981.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61982.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61983.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 11
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61983.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 12
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61983.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 13
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61984.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 14
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61984.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 15
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61985.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 16
Specificity: Hydroxymalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61985.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 18
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AVV61989.1
Core domains: Thiolation (ACP/PCP), Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AVV61977.1
Module 0
AVV61987.1
Module 17
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: LOOLDPJUN4VZBEJ3W5R2EHIG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fix DOI
  • Corrected NRP module activity
  • Removed gene names of 'No gene ID'
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.