BGC0001519: aurantimycin A biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
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Location: 1 - 64,790 nt. (total: 64,790 nt).
This entry is originally from NCBI GenBank AOPZ01000014.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001519
Short description aurantimycin A biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AOPZ01000014.1
Compounds
  • aurantimycin A
Species Streptomyces aurantiacus JA 4570 [taxonomy]
References
Chemical products information
aurantimycin A
Copy SMILES
C38H64N8O14
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • STRAU_0320
  • EPH46581.1
 37 - 621 (+) putative metabolite transport protein YyaJ
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  • STRAU_0321
  • EPH46582.1
 726 - 980 (-) putative Polyketide synthase PksN
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  • STRAU_0322
  • EPH46583.1
 1246 - 1791 (+) putative NADH:riboflavin 5'-phosphate oxidoreductase
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  • STRAU_0323
  • EPH46584.1
 1894 - 3075 (+) putative Cytochrome-SU2
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  • STRAU_0324
  • EPH46585.1
 3188 - 4324 (-) hypothetical protein
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  • STRAU_0325
  • EPH46586.1
 4408 - 5346 (-) putative 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2
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  • STRAU_0326
  • EPH46587.1
 5343 - 5591 (-) hypothetical protein
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  • STRAU_0327
  • EPH46588.1
 5653 - 5886 (-) putative dehydrogenase
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  • STRAU_0328
  • EPH46589.1
 5898 - 6878 (-) putative Pyruvate dehydrogenase E1 component subunit beta
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  • STRAU_0329
  • EPH46590.1
 6878 - 7717 (-) putative 3-methyl-2-oxobutanoate dehydrogenase subunit alpha
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  • STRAU_0330
  • EPH46591.1
 8471 - 8686 (+) putative protein MbtH
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  • STRAU_0331
  • EPH46592.1
 8818 - 9540 (+) hypothetical protein
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  • STRAU_0332
  • EPH46593.1
 9633 - 11225 (+) putative Bacitracin synthase 3
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  • STRAU_0333
  • EPH46594.1
 11256 - 11489 (+) hypothetical protein
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  • STRAU_0334
  • EPH46595.1
 11776 - 12963 (+) putative Digeranylgeranylglycerophospholipid reductase 1
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  • STRAU_0335
  • EPH46596.1
 13008 - 21656 (+) putative Linear gramicidin synthase subunit C
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  • STRAU_0336
  • EPH46597.1
 21668 - 29392 (+) putative Linear gramicidin synthase subunit C
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  • STRAU_0337
  • EPH46598.1
 29397 - 33221 (+) putative Dimodular nonribosomal peptide synthase
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  • STRAU_0338
  • EPH46599.1
 33280 - 34026 (+) putative cadicidin biosynthesis thioesterase
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  • STRAU_0339
  • EPH46600.1
 34151 - 35089 (+) putative Daunorubicin/doxorubicin resistance ATP-binding protein DrrA
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  • STRAU_0340
  • EPH46601.1
 35086 - 35847 (+) putative Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrB
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  • STRAU_0341
  • EPH46602.1
 37018 - 37239 (+) putative Surfactin synthase subunit 1
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  • STRAU_0342
  • EPH46603.1
 37236 - 38486 (+) putative cytochrome
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  • STRAU_0343
  • EPH46604.1
 38483 - 39220 (+) putative Linear gramicidin dehydrogenase LgrE
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  • STRAU_0344
  • EPH46605.1
 39330 - 42434 (+) putative Oleandomycin polyketide synthase, modules 5 and 6
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  • STRAU_0345
  • EPH46606.1
 42459 - 48158 (+) putative Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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  • STRAU_0346
  • EPH46607.1
 48169 - 54768 (+) putative Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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  • STRAU_0347
  • EPH46608.1
 54770 - 57892 (+) putative Erythronolide synthase, modules 3 and 4
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  • STRAU_0348
  • EPH46609.1
 57889 - 58008 (+) hypothetical protein
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  • STRAU_0349
  • EPH46610.1
 58137 - 61322 (+) putative Dimodular nonribosomal peptide synthase
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  • STRAU_0350
  • EPH46611.1
 61459 - 62205 (-) hypothetical protein
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  • STRAU_0351
  • EPH46612.1
 62280 - 63062 (-) hypothetical protein
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  • STRAU_0352
  • EPH46613.1
 63753 - 64103 (-) hypothetical protein
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  • STRAU_0353
  • EPH46614.1
 64160 - 64789 (-) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
STRAU_0332
Module ?
Specificity: valine / serine / leucine
Evidence for specificity:
  • ATP-PPi exchange assay
STRAU_0335
Module ?
Specificity: piperazic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Homology
Module ?
Specificity: serine / alanine / phenylalanine
Evidence for specificity:
  • ATP-PPi exchange assay
STRAU_0336
Module ?
Specificity: glycine / valine / alanine / serine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: piperazic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Homology
STRAU_0337
Module ?
Specificity: alanine
Evidence for specificity:
  • ATP-PPi exchange assay
STRAU_0349
Module ?
Specificity: 3S-hydroxyleucine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
  • Switch to GenBank accessions
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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