LOCUS       BGC0001531             11264 bp    DNA     linear   BCT 01-APR-2017
DEFINITION  Tenacibaculum mesophilum DNA, bisucaberin B biosynthetic gene
            cluster, complete sequence, strain: PS-1.
ACCESSION   BGC0001531
VERSION     BGC0001531
KEYWORDS    .
SOURCE      Tenacibaculum mesophilum
  ORGANISM  Tenacibaculum mesophilum
            Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
            Flavobacteriaceae; Tenacibaculum.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 02:21:27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11264
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..11264
                     /collected_by="Masaki J. Fujita"
                     /collection_date="2012-03"
                     /country="Palau"
                     /db_xref="taxon:104268"
                     /isolation_source="marine sponge"
                     /lat_lon="7.31 N 134.50 E"
                     /mol_type="genomic DNA"
                     /organism="Tenacibaculum mesophilum"
                     /strain="PS-1"
     misc_feature    1..11264
                     /note="bisucaberin B biosynthetic gene cluster"
     subregion       1..11264
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11264
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1113..2621
                     /gene="bsbA"
     CDS             1113..2621
                     /NRPS_PKS="Domain: Beta_elim_lyase (197-344). E-value:
                     1.9e-10. Score: 32.2. Matches aSDomain:
                     nrpspksdomains_bsbA_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene="bsbA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 370.7;
                     E-value: 1.6e-112)"
                     /gene_kind="biosynthetic-additional"
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="BAX07665.1"
                     /transl_table=11
                     /translation="MILKTPPSLKELSLNSYLFSDESVKLYEEYIQKTFSYIERFLSNR
                     TFYKGDELAEILKNKEQAKLINIEETQAIDSVLEELNNLYIKNAIAFHNPTYVAHLNCP
                     ITLPSIVAEMIATTINTAVETWDQSTSATFIEEEVIQWTSKVFNMSDNSDGVFTSGGTQ
                     SNFMAMLMARDDYAFKHFGINIKQHGWSNEISKFRIFCSEKAHFSIQKSAALLGMGYDS
                     VIPVRVDERMQMDTNELVLAIEKTKQEDNIPIAIVATLGTTDYGSFDSIKIIGKIAKEN
                     QMWLHADGAYGGAYALTNTHKEYFNGIEMVNSITVDFHKTLFQPVSCSAFLVNNKQYFK
                     YVSYYADYLNPIEEKDSQRPNLIEKSIQTTRRFDALKVWLTLKTLGTKTIANYLEEVHY
                     LAKNVYLEIKDKDCFETVHEPELSTLVFRYKAQGIKENRIHDAINLYIKNTLYKAGKAS
                     IASTKLNGNIYLKFTLLNPKNTINNLLYIIEMIQTTGEQYKITN"
     aSDomain        1704..2144
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_bsbA_Beta_elim_lyase.1"
                     /evalue="1.90E-10"
                     /label="bsbA_Beta_elim_lyase.1"
                     /locus_tag="bsbA"
                     /protein_end="344"
                     /protein_start="197"
                     /score="32.2"
                     /tool="antismash"
                     /translation="RIFCSEKAHFSIQKSAALLGMGYDSVIPVRVDERMQMDTNELVLA
                     IEKTKQEDNIPIAIVATLGTTDYGSFDSIKIIGKIAKENQMWLHADGAYGGAYALTNTH
                     KEYFNGIEMVNSITVDFHKTLFQPVSCSAFLVNNKQYFKYVSY"
     gene            2627..3949
                     /gene="bsbB"
     CDS             2627..3949
                     /codon_start=1
                     /gene="bsbB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 421.8;
                     E-value: 4.5e-128)"
                     /gene_kind="biosynthetic-additional"
                     /product="lysine-6-monooxygenase"
                     /protein_id="BAX07666.1"
                     /transl_table=11
                     /translation="MKNNTVDFIAIGVGPFNLGLACLSEPIEDLNGVFLDKKEKFDWHP
                     GMLLEDTTLQVPFMADLVTLADPTNPFSFLNYIKEQGRIYSFYIRENFLLLRNEYNHYC
                     QWVISKLSNIYFNTEVTNIDYDQKDGIYVVTSVCTKTQEIKIYKAKKLVLGTGTQPYIP
                     ACCKKLKDAAVHSSQYLPNKEQLQNKKRITVLGSGQSAAEIFFDLLQEIDTKGYELNWI
                     TRSPRFFPLEYAKLTLEMTSPEYVDYFYNLPASKRDALIKNQKHLYKGINQDLIGAIHD
                     TLYAKRVLSKEPLKVSLRTNSELKTTKVSDEGIKLELHQVEQDKYFEHETDGLVLATGY
                     EYKLPEFIEGISNRILWDVKNRFDVQRNYSIDENHNEIFVQNVELYTHGFVTPDLGMAA
                     YRNSYIIKEITGVEHYPIEQKIAFQQFEVTQEEEIELNVFA"
     gene            3936..5129
                     /gene="bsbE"
     CDS             3936..5129
                     /codon_start=1
                     /gene="bsbE"
                     /product="MFS transporter"
                     /protein_id="BAX07667.1"
                     /transl_table=11
                     /translation="MSLHKGMKLKTFLIVMTLVAVVSDYLLHPFYPQFFELRFGMTNPK
                     NVGYYFAAICFMVMIAFPFWAYISKKISELNILVYTQAVAGVLALYCYYTTSYINFWVV
                     SLIMVLFKGSYLLVYPYILKIITKEEHPSTIGLLSVVVHLGGILGAVLGGITVDYINPS
                     SIFLIMAAGDFIQMAMSGYLLKSKKYATDLIISEESTATDKKIIPKGFILKLGLITLIL
                     YFSDFLIRPFFSSYWESFSTYKSKLVSGTIYAIPGFVALVALWINNKRKSKGHEGIINA
                     LFIGLIGLTLQGIPNESVVVLGRIIYGWAIFQGVVKFDILLFELSTPESYSVDYSKIHF
                     FQNLGVLLASLNVGVIVDSFDLRMPFIIALGGFTLTLVLYFIVFKSVRKVHKQLAKT"
     gene            5133..7550
                     /gene="bsbCD1"
     CDS             5133..7550
                     /codon_start=1
                     /gene="bsbCD1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     95; E-value: 1.1e-28)"
                     /gene_kind="biosynthetic"
                     /product="IucA/IucC"
                     /protein_id="BAX07668.1"
                     /sec_met_domain="IucA_IucC (E-value: 9.9e-77, bitscore:
                     246.4, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITTDAIVFSKEYKGLGTITIRPFQIKKDSVFLQQWVTQEYAVFW
                     GMQNATVKEVEEEYTQLIAPEHYDVFVGMFNGEPAFIVERYNPQLDIINGFYKAKISDC
                     GVHIIVAPPKITKTPNFTWFMFRAIMDFVFTNPIINRIVVEPDIRNKKMFALCQSIGFQ
                     LGKVIELPNKTAQLAFLTKTNYQQKIQSFSPFKRSAMNTLDNVVSPQQSTQHIQPKVWQ
                     KANLLLVKKALCEFSHELLIQPVIIQEVDNGYKLYKVYADDTEIQYEFKAKPMALNHLM
                     IDENSIRKYIKEVEEEIDAITFIKEFRKALGIADEKMPVYLEEVISTLYGSAFKITKGN
                     PTVEELATADFQTIEQSMTEGHPGFVANNGRIGFDSSDYRSYAPEAGNSFSLLWLAGHK
                     LKAVFSAIEALPYESLIRQELDVDTIAQFNKIIEEKGFSPKDYLFIPVHPWQWFNKLAT
                     IFASEVAKGDLICLGYGPDQYLAQQSIRTLFNISNPQKFYTKSALSILNMGFMRGLPLY
                     YLGTAPKMAVWLENLLYNDAYIKTNGFRMLSEIGSVSYVNPYFEEFGPHNDYNKMLASL
                     WRESPYSVVKENQKPLTMAALLHIDHYGKALLPEMIKDSGISIDNWLRSYLKAYLSPML
                     HCFYYYDLVFMPHGENIILVLENNIPVYALLKDITEEACILNPEVELPEELKRMYALVP
                     EDVKLLSIFTDMFDGFFRFLAPILEKHANYGEHRFWELVAENIHEYQEQFPELSGKFKQ
                     YDLFAEDFKLSCLNRLQLNNHKQMIDLDDPVALLQFAGKLKNPIAVFKNQEV"
     gene            7553..8143
                     /gene="bsbC2"
     CDS             7553..8143
                     /codon_start=1
                     /gene="bsbC2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     150.9; E-value: 1.1e-45)"
                     /gene_kind="biosynthetic-additional"
                     /product="acetyltransferase"
                     /protein_id="BAX07669.1"
                     /transl_table=11
                     /translation="MVQTYQKIFSKEIIGLGVINIRPFQLETDTPMLHRWVTQPYAKYW
                     GMLNKSVEEVHAEYQEIENNPHHYSYVGMIGSTPVFLMERYKASKDNIADYYDVQENDY
                     GMHVLVAPVEKRIPQFTWHVFSTIIDYFFSLPQVERIVVEPDVNNEKIHTLNKKAGFKY
                     QKEIELPHKKAALAFCTRETYQSALIKLEQHDK"
     gene            8133..9953
                     /gene="bsbD2"
     CDS             8133..9953
                     /codon_start=1
                     /gene="bsbD2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /product="IucA/IucC"
                     /protein_id="BAX07670.1"
                     /sec_met_domain="IucA_IucC (E-value: 2.2e-80, bitscore:
                     258.4, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNNIAHLQPKVWSFVNRQLIKKAISEFSHELILTPEFILEETDG
                     CIYLITSDNNEFTYQFKAKKYALDHWLVDEKSIIKKNNISNEVYLDALHFITEFQNTLG
                     IPDEFLATYLEEITSTLSGAAYKYVNEKFSANELAEKTFQEIEHAMTEGHPCFVANNGR
                     IGFNIKDYQKYAPESNQSFKLLWIAAHKKYATYTAVKNYEYEKLLESELGKEKLASFKE
                     VVKKQNVATENYIFMPVHPWQWKNKIVAVFGADIAQKNIISVGESDDEFSAQQSIRTLF
                     NASHPEKLYTKTALSILNMGFMRGLSPYYMQSTPHITQWITDLLADDIYLQNNGFTMLG
                     EVATAGYHNHYYETLGKTNPHNKMLSALWRESPFTKISSNQRVFTMAALLHIDYQDKSL
                     LAALIEASPYNTTTWIQRYLKAYLAPLLHCFYKYDFVFMPHGENLILVLEENTPVHVLM
                     KDITEEVIVFNETMHLPEHAKRLFVKTSDKMKVLSIFTDVFDCFFRFMAQQLDCYSSFS
                     EDNFWQLVADCVYEYQEQHPEFSEKYKQYDLFVKEFDRCCLNRLQLSNTKQMLSLANPI
                     ESLKLEGVLKNPLARFKKETVKTVQSLESI"
ORIGIN
        1 cttattactg gtttcaccga ttaaatcacg aagtacgttt gttttgggca ggtcatgtac
       61 cacatcattc atcggtgcat atgaatttag gaacagcatt gcgtcaagga gtcggtgaac
      121 gtatccataa atttttcttt tggatgtgga ttcctttatt aggatttgat ccattaatga
      181 tgtttactat gatgggaatc agtttaattt atcagttttt tgtgcataca gaattggtag
      241 ataaacttcc gaagcctatt gaattaattt tcaatacacc atcacatcat agagtacatc
      301 acgcatctaa tattcgttat ttagattgta atcatgcagg aattttaatt atttgggatc
      361 gtatctttgg tactttctct gaagaattaa aagaaattga taaaccagta tatggattaa
      421 ccgtaaatat tgaaacgttt aatccagtaa aagtggctac tcatgaatat gctgcaattt
      481 ggaaggatgt taaaagagct gatacatgga gtgataagct aaattatatc tttaactcac
      541 ccggttggac acatgatgga gaagataaaa gagcaaaaac acttcgaaaa aaaatgaacc
      601 tgtaaaataa aatggaacaa gatattacta taaaaattac tgatcgtgac ggggtaacgc
      661 atgagataca agcacccaca gatatggcaa tgaatttgat ggaagtggtt cgttcgtacg
      721 aattagctcc tgaaggaact attggaattt gtggtggaat ggcaatgtgt gcttcttgtc
      781 aatgctatgt aaaatcagat catgaattgc cagaaatggg agatgatgaa gaagcaatgt
      841 tagcagaggc tttttatgta gaagataata gccgattagg gtgtcaaata caaatgaccc
      901 cagatttaga tggtttagaa gttgagttag ctccagagag ttaagaacaa aagaataaaa
      961 tttttaaagc gcagtattta gtgtacacta aatactgcgc tttcttttta taaaatatac
     1021 cacttacgtc attttaaatt ccatttgcgt catttaattt gtttggtcta aatatatttt
     1081 tgcttcaaat tattaagact aaataaaaat aaatgattct aaaaactccc ccttcattaa
     1141 aagaattgtc attaaatagt tatttgttta gtgatgagtc tgtaaagtta tatgaagaat
     1201 acattcaaaa aacattttct tatatagagc ggtttttatc taacagaact ttttataaag
     1261 gagatgagct tgcagaaatt ctaaaaaaca aagaacaagc taagctaata aatattgagg
     1321 aaacacaagc gatagatagt gttttagaag agctaaacaa tttatatata aaaaatgcta
     1381 ttgcttttca caatccaact tatgtagcac acctaaattg tccaattaca ctcccttcta
     1441 ttgtagcaga aatgattgca actacaatta atacagccgt tgaaacatgg gatcagagta
     1501 cttcggcaac ttttatagaa gaagaagtaa ttcaatggac ttcaaaagta tttaatatgt
     1561 ctgataattc agatggagta ttcacaagtg gaggaacaca gtctaacttt atggcaatgt
     1621 taatggccag agacgattat gctttcaaac attttggcat aaacattaag caacatgggt
     1681 ggagtaatga aataagtaag tttagaattt tttgttctga aaaagcccac tttagtattc
     1741 aaaagagtgc agctctttta ggtatgggat atgattctgt tattccagta agagtagatg
     1801 aaagaatgca aatggatact aacgagttag tcttggctat agaaaaaaca aaacaagaag
     1861 ataatattcc aattgcaata gtagctacat taggaactac cgattacggt agttttgatt
     1921 caattaaaat catagggaaa attgctaaag aaaatcaaat gtggctacat gcagatggag
     1981 catatggagg agcctatgca ctaacgaaca cgcataaaga atattttaat ggtattgaaa
     2041 tggttaattc aataacggtt gattttcata aaactctgtt tcaaccagta agttgtagtg
     2101 cttttttggt aaataataaa caatatttta agtacgtatc atattatgca gattatttaa
     2161 accctattga agagaaagat tctcaaagac caaatcttat agaaaaatct attcaaacga
     2221 cacgtcgttt cgatgcctta aaagtttggt taactttaaa aactctagga acaaaaacaa
     2281 ttgctaacta cttagaagaa gtacattacc tagctaaaaa tgtatactta gaaattaaag
     2341 ataaagactg ttttgaaact gtacatgaac cagaattaag cacactagta tttaggtata
     2401 aagcacaagg tattaaagag aacaggattc atgatgctat aaatttatat ataaagaaca
     2461 ctttatacaa agcaggaaaa gcatccatag caagtaccaa attaaatggt aacatatatc
     2521 taaaatttac gctactaaac cctaaaaata caattaacaa tctcctatac attatagaaa
     2581 tgattcaaac tacaggagaa caatacaaaa taacaaacta gaaaaaatga agaataatac
     2641 agttgatttt atagccatag gtgtaggacc ttttaactta ggtttagctt gcttatcaga
     2701 accaattgaa gatttaaatg gagtgtttct tgataaaaaa gaaaaatttg attggcatcc
     2761 aggaatgtta ttagaagata caactttaca agttcctttc atggcagatc tagtaactct
     2821 tgctgatcct acaaatcctt ttagtttttt aaattatatt aaagaacagg gcagaatata
     2881 ttctttttac atacgagaaa atttcttatt acttagaaac gaatacaatc attattgtca
     2941 gtgggtaatt agtaaacttt ctaatatata ttttaataca gaagtaacga atatagacta
     3001 cgatcaaaaa gacggcattt atgtagttac tagtgtttgc acaaaaacac aagaaattaa
     3061 aatttataaa gcaaaaaaac tggttctagg aacaggaaca caaccttaca ttcctgcttg
     3121 ttgtaaaaag ctaaaagatg ctgctgttca ttcatcacaa tacttaccta acaaagagca
     3181 actacaaaat aaaaaaagga taacagtatt gggaagcgga caaagtgctg ctgaaatatt
     3241 ttttgattta ttacaagaaa tagatactaa aggatatgaa ttgaattgga ttacccgctc
     3301 accacgtttc tttcctttag agtatgctaa gctaacatta gaaatgactt ctccagagta
     3361 tgtagattac ttttacaact taccagcatc caaaagagat gcactcatta aaaatcaaaa
     3421 gcatttatac aaagggataa atcaagattt aataggagct attcacgata cattatacgc
     3481 aaaaagagtc ctatcaaaag aaccattaaa agtttcatta cgtactaact ctgaattgaa
     3541 aactaccaag gtatcagatg aaggcattaa actagaactt caccaagtag aacaagacaa
     3601 atattttgaa catgaaacag atggacttgt ccttgctaca ggatatgaat ataaattacc
     3661 agagtttatt gaaggaattt caaatagaat tctatgggat gttaaaaatc gatttgatgt
     3721 acagcgtaac tattcaattg atgaaaatca taatgaaatt tttgttcaaa atgtagaatt
     3781 atatacacat ggatttgtta caccagattt agggatggct gcttacagaa attcttatat
     3841 aatcaaagaa ataacaggag tagagcatta tcctattgag caaaagatag catttcagca
     3901 gtttgaggtt acacaagagg aagaaataga actcaatgtc tttgcataaa ggtatgaagt
     3961 taaaaacatt tttaatagta atgacgttgg ttgcagtagt aagtgattat ttactgcatc
     4021 cattttatcc acaatttttt gagcttcgtt ttggaatgac aaaccctaaa aatgtaggat
     4081 attactttgc agccatctgt tttatggtaa tgattgcatt tccattttgg gcatatattt
     4141 ctaaaaaaat atcagaatta aatattctag tgtacaccca agcagttgca ggcgtattag
     4201 cattgtattg ttactacact acatcgtaca ttaatttttg ggtagtatct cttatcatgg
     4261 tactatttaa aggaagttat ttactggtat atccgtacat tttaaaaatc attacaaaag
     4321 aagaacatcc aagtacaatc ggattgcttt cagtagtggt acatttagga ggtattttag
     4381 gagctgtgct tggaggtata acggtagatt atataaaccc aagtagcatt tttttaataa
     4441 tggcagcagg agattttatt caaatggcta tgagtggtta tttattaaaa agtaaaaagt
     4501 atgctaccga tttaatcatt tcagaagaat ctaccgctac tgataaaaag ataattccga
     4561 aaggatttat cttgaaatta ggactaatta cgttgatatt atacttcagc gactttttaa
     4621 ttaggccttt cttttcatca tattgggaaa gtttttcaac gtacaaaagc aaattggttt
     4681 caggtactat atacgctatc ccgggctttg tagccttagt agccttgtgg attaataata
     4741 agcgaaaatc aaaagggcat gaaggaatta taaatgcctt gtttataggg ttaattggac
     4801 ttacgctaca aggaataccc aatgaatcag tggttgtttt agggcgaatt atttatggct
     4861 gggcaatttt tcaaggagtt gtgaaattcg acattttatt atttgaatta agcacgccag
     4921 aatcatactc ggttgattat agtaaaatac atttcttcca aaacttaggt gtattactag
     4981 cttctttaaa tgtaggagtt atagtcgata gtttcgattt acgaatgcct tttattattg
     5041 cattaggcgg atttacactc acattggtct tgtactttat tgtatttaaa tcggtaagaa
     5101 aagtacataa acaactagct aaaacctaaa ttatgataac aactgatgcc atagtttttt
     5161 caaaagagta taaaggttta ggaacaataa ccattcgtcc ttttcaaata aaaaaagaca
     5221 gtgttttttt acagcaatgg gtaactcaag aatatgctgt tttttggggg atgcaaaacg
     5281 caacagtaaa agaagttgaa gaagaatata cccaactcat agccccagaa cattacgatg
     5341 tttttgtagg aatgtttaat ggcgaaccgg catttatagt agaacgttac aacccgcaat
     5401 tagatattat taatggtttt tataaagcta aaatatccga ttgtggtgta catattattg
     5461 tagcaccgcc aaaaatcact aaaacaccaa actttacgtg gtttatgttt cgagcaatta
     5521 tggattttgt ttttacaaac ccaattatta acagaatagt agtagagcca gatattcgaa
     5581 acaaaaaaat gtttgcgctg tgtcaaagca taggttttca actgggaaag gtgatagaac
     5641 ttcctaacaa aacagcacaa ttagcatttt taaccaagac caattaccaa caaaaaatcc
     5701 aatccttttc accatttaaa agaagtgcca tgaatacctt agataatgtg gtttctccac
     5761 aacaatcaac acaacatata caaccaaaag tgtggcaaaa agccaactta ttactagtga
     5821 aaaaagcatt gtgtgagttt tcgcatgaac tattaataca accagtaata attcaagaag
     5881 tagataacgg atataaactg tataaagttt atgcagatga cacagaaatt caatatgagt
     5941 ttaaagcaaa accaatggct ttgaatcatt tgatgattga tgaaaactcc ataagaaaat
     6001 atataaaaga agttgaagaa gaaattgatg caattacatt tataaaagaa tttagaaaag
     6061 cgttaggaat tgctgatgaa aaaatgcctg tgtatttaga agaagttata agtacactat
     6121 acggaagtgc atttaaaatt accaaaggaa accctactgt agaagaatta gcaacggccg
     6181 attttcaaac gatagaacaa tctatgaccg aagggcatcc agggtttgta gcaaataatg
     6241 gtagaatagg gtttgacagc agcgattatc gttcttatgc accagaagcg ggaaattctt
     6301 tttcgttatt atggttggca ggacataagt taaaagcagt tttttcagcg atagaagcat
     6361 tgccttatga aagcctaata cgtcaggaat tagatgttga taccatagca caattcaaca
     6421 aaataattga agaaaaaggc ttcagtccaa aagactactt gtttatacct gttcatccat
     6481 ggcaatggtt taacaaacta gctacaattt ttgcttcaga agtagcaaaa ggagatttaa
     6541 tttgcttagg atacggacca gatcaatact tagcacaaca atcaattaga acgttattca
     6601 atataagcaa tccgcagaaa ttttatacca aatcggcatt atctatttta aacatgggct
     6661 ttatgagagg attgccttta tactacttag gaacagctcc aaaaatggca gtttggttag
     6721 aaaacctatt atataacgat gcttatataa agacaaacgg atttagaatg ttaagtgaaa
     6781 taggttcggt tagctatgtg aatccatatt ttgaagagtt tggaccacat aacgattaca
     6841 ataaaatgct agcttcatta tggagagaaa gtccatattc tgtggttaaa gaaaaccaaa
     6901 aaccactaac gatggcagca ttattacata tagatcatta cggaaaagca ttgttgccgg
     6961 aaatgattaa agactcaggt atttcaatag ataattggtt acgtagctat ttaaaagcgt
     7021 acttaagccc aatgttacac tgtttttact attacgattt agtgtttatg ccacatgggg
     7081 aaaacattat tttggtatta gaaaataaca ttcctgtata tgctttacta aaggatatta
     7141 cagaagaagc atgtatttta aatcctgaag ttgagctacc agaagagtta aaaagaatgt
     7201 atgcgctagt accagaagat gtcaagttac tatccatatt tacagatatg tttgatgggt
     7261 tctttcgctt tttagcccca attttagaaa aacatgcgaa ttatggagag catcgttttt
     7321 gggaactcgt agcagaaaat attcatgaat atcaagagca gtttcctgaa ctgtcaggca
     7381 agtttaaaca gtatgattta tttgctgaag attttaaact ttcgtgttta aataggttgc
     7441 aattaaataa tcataaacaa atgattgatt tagatgaccc tgttgcccta ctccaatttg
     7501 caggaaagtt aaaaaaccca atagcggtat ttaaaaacca agaagtataa ttatggttca
     7561 aacgtatcaa aaaatattta gtaaagaaat tattgggttg ggggtaatca acattcgtcc
     7621 atttcaatta gaaacagata caccaatgtt acatcgttgg gtaactcaac cctatgcaaa
     7681 atactgggga atgttaaata agtctgtaga agaagtacat gctgaatacc aagaaataga
     7741 aaataatccg catcattata gttatgtagg aatgataggg agtaccccag tgtttttaat
     7801 ggagcgttac aaagcttcaa aagataacat agcagactat tacgatgtac aagaaaatga
     7861 ttatggtatg catgttttag tagcgcctgt agaaaaaaga ataccacagt ttacatggca
     7921 tgtgttttca actattatcg attatttttt cagtttacca caagtggaaa gaattgttgt
     7981 agaacccgat gtgaataatg aaaaaattca tacgctaaat aaaaaagctg gttttaaata
     8041 ccaaaaagaa attgagttac ctcataaaaa agcagcctta gctttttgta caagagagac
     8101 gtatcaatca gctttaatta aactagaaca acatgacaaa taatatagcc catttacaac
     8161 caaaggtatg gagttttgta aatcgtcaat taataaaaaa agcaatcagt gaattttcac
     8221 atgagcttat tttaactcct gagtttattt tagaagaaac agatggctgt atatacctga
     8281 ttacctcaga taataatgag ttcacgtatc aatttaaagc aaaaaagtat gctctcgatc
     8341 attggttggt tgatgaaaaa agcattatta aaaaaaataa tatatcgaat gaagtttatt
     8401 tagatgcact acattttata acagagtttc aaaatactct tggtattcct gatgagtttt
     8461 tagcaactta tttagaggaa ataacaagta cactttcagg agcagcatat aagtatgtta
     8521 acgagaaatt ttcagccaat gaattagctg aaaaaacctt tcaagaaatt gaacacgcga
     8581 tgactgaagg tcacccctgt tttgtagcga acaatgggag aatagggttc aatattaaag
     8641 attatcaaaa atatgcacca gaaagtaatc aatcgtttaa acttttatgg atagcagctc
     8701 ataaaaaata tgctacctac acggctgtta aaaattatga gtatgaaaaa cttttagaga
     8761 gcgaattagg aaaagaaaaa ttagcatcat ttaaagaagt tgtaaagaag caaaatgtag
     8821 ctactgaaaa ttacattttt atgcctgtac atccatggca atggaaaaac aaaattgtag
     8881 ctgtttttgg agcagatatt gctcaaaaaa atatcatctc agtaggagaa agtgatgatg
     8941 aattctctgc gcagcaatct attagaacac tttttaatgc gtcacatcca gaaaagttat
     9001 acacaaaaac agctctgtct attttaaata tgggctttat gcgtggactt tctccatatt
     9061 acatgcaaag tacgccgcat attacccaat ggataacaga tttgttagca gatgacattt
     9121 acctacaaaa caatgggttt accatgttag gagaagtggc aacagcgggg taccacaatc
     9181 attattatga aactttagga aaaacgaatc cgcataacaa aatgttatca gctttgtggc
     9241 gtgagagccc gtttacaaaa ataagctcta atcaacgcgt gtttacgatg gctgctttat
     9301 tgcatataga ttaccaagac aaatcattgt tagcggcttt aatagaagct tcaccttata
     9361 acacaactac ctggattcaa cgttatttaa aagcctattt agcaccttta ttacactgtt
     9421 tttataagta cgactttgtc tttatgccac atggagaaaa cctaattcta gtgctagaag
     9481 aaaatacacc agtgcatgtg ttaatgaaag atattacaga agaggttatt gtttttaacg
     9541 aaacaatgca cttacctgag catgctaaaa gattgtttgt taagacttca gataaaatga
     9601 aagtgctttc aatttttact gatgtgtttg attgcttctt ccgttttatg gctcaacagt
     9661 tagattgtta ttcaagtttt tcagaggata atttttggca attagtggca gattgtgtgt
     9721 atgaatatca agaacaacat cctgagtttt cagaaaaata taagcaatac gatttatttg
     9781 ttaaagaatt tgatcgctgt tgtttgaaca ggttgcagtt aagtaatacc aagcaaatgc
     9841 tcagtttagc taatccgatt gaaagtctaa agttagaagg agtattaaaa aacccacttg
     9901 caaggtttaa aaaagaaaca gtaaaaacgg tacaatcttt agaaagtatt taatatgagt
     9961 tttaaacaga taactaaaat tatacaagaa cgaaaaacca cctacgcgta tgatttttcg
    10021 gatagaaaaa tagagaagga aacgattgaa gcaattgtaa ccaatgcgct atgggcacca
    10081 actcataaat taacccaacc ctggaggttt gtagtgttag aaggaaaaca tagagaagca
    10141 ttaggtgagt ttatggctaa ttattatcga aaaatatatt cagaagaaga attttctaac
    10201 gaacgttata aagaaacaaa aaggtatgcc agtaaagcca gcatgatagg agtgattttt
    10261 aaacctagta aaagagcaca actcccggaa tgggaagaaa ttgcagctat ttcaagcgca
    10321 gtacaaaaca tgtggttaag ctgtacaagt ctaaatttag gaagctattg ggataccagt
    10381 atagcaacta taaagtatgg tgaaaaagaa attagtttag aagaaaatga acaattttta
    10441 ggtgtttttt ttataggaca tgtaaaagaa aatcttccta aagtaaatag aaaacgaaag
    10501 ccactatcta aaaaattaag ctggcatttt aaagaataaa aaatggaaca aaaaaagaga
    10561 gtattagcca tagatatggc gagaggaatt agtgttttat ctatgatacc tgttcattcc
    10621 atgattatat attcgacaat ggatacttgg aacaattctt ttttagggaa ggtagctcaa
    10681 gtattagaaa aaggaactcc tatgttttta gtcgtgatgg ggttttcttt tgtgttttca
    10741 agtaagttaa gcatgtttaa aatctttaaa agaggaataa acattttagc aaaagggtat
    10801 ttacttaata ttttaagatt tgcagtaccc atgttgttat ttggaggatt ccctagagct
    10861 tttatagaag gtaatgggct aactctagga gattcatata attatctgtt ttttatttta
    10921 ttgggagata tcttgcagtt agctgggatt tccttgatta taatgggagt tataatcaag
    10981 tttattaaaa acaagtatgc agctttaacc ttagcattac ttattgtttt tttcacagga
    11041 gaattaagtg gttataaacc taacattgtt ggggtagatt atatatgtga tttattatgg
    11101 ggaaaaacct acaatattta ctttcctgta tttccatgga tgtcgtttat tttaatagga
    11161 ttattctttg gaatgtggta tcaagaaagt aataataata ttgttttaac atataaaaga
    11221 atgctagttt caggtgtttt atttatgtgc aggaattcga tatc
//
