LOCUS       BGC0001583             21067 bp    DNA     linear   PLN 18-MAY-2018
DEFINITION  TPA_exp: Escovopsis weberi emodin biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0001583
VERSION     BGC0001583
KEYWORDS    .
SOURCE      Escovopsis weberi
  ORGANISM  Escovopsis weberi
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreaceae;
            Escovopsis.
COMMENT     THIRD PARTY DATABASE: This TPA record uses data from
            DDBJ/EMBL/GenBank entry LGSR01000019.1
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 02:42:33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21067
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..21067
                     /db_xref="taxon:150374"
                     /mol_type="genomic DNA"
                     /organism="Escovopsis weberi"
     misc_feature    1..21067
                     /note="emodin biosynthesis gene cluster"
     subregion       1..21067
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Polyketide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21067
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    101..615
                     /note="hypothetical protein 1"
     misc_feature    2278..2710
                     /note="hypothetical protein 2"
     mRNA            complement(join(<3201..4139,4208..4543,4630..4911,
                     5020..>5205))
                     /product="MFS transporter"
     CDS             complement(join(3201..4139,4208..4543,4630..4911,
                     5020..5205))
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 373.4; E-value:
                     2.1e-113)"
                     /gene_kind="transport"
                     /product="MFS transporter"
                     /protein_id="DAB41650.1"
                     /transl_table=1
                     /translation="MLSKKPAGADPPPPDSPPAVVETRGAEAVAPTEHEDDTQYPRGLK
                     LFLIMSSTFVGMFLVALDRLIISTAVPEITDEFHSAGDIGWYGTAYLLTNCSFQLVFGK
                     LYSLFRVKTIFMLSIVLFEIGSALCGAAPDSKSFIVGRAIAGLGSGGIMSGAIVIIVYA
                     LPLHKRPKYQGLFGAVFGVSSVLGPLVGGAFTTNVTWRWCFYINLPIGGVVMVFIFFLL
                     HVHQPAREPISLKEGLTRINALGIAVLLPGVVCLCLALQWGGSIYPWSSGRVVALLVVA
                     IVLLIAFGLIQVLQPKHAILPPAIVTQRSIASAFWVASCLGSHQTVFVYFLPIWFQAIK
                     HSSAIKSGIDLLPMVLPIVASSILNGQLVSRIGYYTPPMLVGICLSTVGAGLLTTLTVD
                     AAAAHWIGYQVVYGLGLGLCFQGPNMAAQTVLPRDQVAIGASLMFFGQQLFGSVFIAVG
                     QNLFNNQLARRLGHIPGVTGQMIQNTGATDLLEMIPERYFAQALEGYNEALRVCFRLGL
                     VVASIAILGGVGMEWLSVKKNIPSKVQDGRDKAERGARGEGPAEKVASEDVSEKDKETT
                     DVKS"
     mRNA            complement(join(<5953..6010,6070..6266,6337..>6513))
                     /gene="EmoH"
                     /product="putative decarboxylase"
     gene            complement(<5953..>6513)
                     /gene="EmoH"
     CDS             complement(join(5953..6010,6070..6266,6337..6513))
                     /codon_start=1
                     /gene="EmoH"
                     /product="putative decarboxylase"
                     /protein_id="DAB41651.1"
                     /transl_table=1
                     /translation="MDHLDVPESAPEGKLLCLTICGYRKPGMTEEAYRNHMVNVSAPLS
                     RDLMVKYGVKRWTQVHNQAATRALMAQLFDSHMQNLAGYDCFSQVVFESVDGFRRMRED
                     PWYKEHVARDHENFADVERSSMTIGWVEEFIRDGKVVDA"
     mRNA            join(<7455..7575,7671..>8128)
                     /gene="EmoM"
                     /product="monooxygenase"
     gene            <7455..>8128
                     /gene="EmoM"
     CDS             join(7455..7575,7671..8128)
                     /codon_start=1
                     /gene="EmoM"
                     /product="monooxygenase"
                     /protein_id="DAB41652.1"
                     /transl_table=1
                     /translation="MPRKSASKDRKEARPPASIPRKEARVLVRASAAMTACFLSGAMTG
                     ISAITVPVLLDTTAHPAQLLSQWSRLYHYGHIMMPSVAVATTGLFALLALRSKQRQFQL
                     VYAVAGAATIGIVPFTLLFMVATNDALFRLEKLALAAQVGADVASQAVDLIFARELVVK
                     WARLHAIRSLFPLLGGILGMVGLVQELRQ"
     misc_feature    complement(join(8345..9121,9199..9243))
                     /note="hydrolase"
     mRNA            join(<10364..10494,10747..14116,14231..14533,14731..15367,
                     15617..>15837)
                     /gene="EmoG"
                     /product="polyketide synthase"
     gene            <10364..>15837
                     /gene="EmoG"
     CDS             join(10364..10494,10747..14116,14231..14533,14731..15367,
                     15617..15837)
                     /NRPS_PKS="Domain: SAT (1-192). E-value: 1.2e-47. Score:
                     154.3. Matches aSDomain: nrpspksdomains_EmoG_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (337-771). E-value:
                     1.7e-143. Score: 470.4. Matches aSDomain:
                     nrpspksdomains_EmoG_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (874-1165). E-value: 5.6e-82.
                     Score: 267.3. Matches aSDomain:
                     nrpspksdomains_EmoG_PKS_AT.1"
                     /NRPS_PKS="Domain: PT (1268-1480). E-value: 1.2e-64. Score:
                     210.4. Matches aSDomain: nrpspksdomains_EmoG_PT.1"
                     /NRPS_PKS="Domain: ACP (1487-1549). E-value: 7.4e-14.
                     Score: 43.7. Matches aSDomain: nrpspksdomains_EmoG_ACP.1"
                     /codon_start=1
                     /gene="EmoG"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 74.8; E-value:
                     9.3e-23)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="DAB41653.1"
                     /sec_met_domain="PP-binding (E-value: 3.3e-14, bitscore:
                     41.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.1e-83, bitscore: 267.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 8.9e-158, bitscore:
                     513.5, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MKHLFPPFETIFLWAEDDKLRQGLLGSAVEGALLIVLQIATYIGY
                     AEIHHRKNLTPSAPCLTGLGVGLLASAAVSVSSTLSDLVLAGADAIRLAFRLGVHVQSV
                     SQNIEARDPSESADPWAFVIHNVDPETVQRELDLAHSQAEKPSTARIFISAVSKKAVTV
                     SGPPERLKALFLKSTFFREARSIALPVYGGLCHAPHIYGPQDVEAIVHSGFSDASDGTS
                     FQSWRLVPITPTFSTSTGMPFPATNAVETFECVVSELLTQAIEWDRVVDGVVESALCSS
                     ASEIEIFCFGNSISLDELHTALKANIDHVSLSSMTPWISQVELSGISPRGTAQSKLAIV
                     GMSCRLPGGATDTEKFWEILEKGLDVSRKIPSDRFDIDSHHDTTGTQLNKTMTQFGCFI
                     DEPGLFDAPFFNMSPKEALTVDPQMRLALVTAYEALERAGYVGNRTASTRSERIGTFYG
                     QTADDYREVNMGQEVDTYYTPGGCRAFGPGRINYFFKFAGPSYIIDTACSSGLAAIELA
                     CQALWKGEVDTAVAGGVNVLTNCDGFTGLCKGHFLTKGHNACKTWDATADGYCRADGIG
                     SLVIKRLEDAQADNDNILGVILGAGTNHSAQAISITHPHGGHQAYLARQVLRQAGVDPL
                     EVSYVELHGTGTQAGDVEEMKGITEVYAPLTRRRVKDQPLHIGAVKANIGHGESVAGTT
                     ALIKVLLMLQKNAIPPHVGIKTEINPKLNPKDLEKRNIRIPFSMTPWTGEPGKKRITAI
                     NNFGAAGGNTTLILEEAPDRGVTERDPRGSHVFALSAKTMTSLKGNIERLLAYLDRDGN
                     QDANLANLSYTMTARRSHYSYRLAVAASNMAQLRKALVSRLEKVDSIKPTSKLSDPPSV
                     AFTFTGQGASYKSMSLELYRDVPEFRSHIQHLDSLARGQGFPSFIPALDGSHWKDEAHS
                     PVVTQLALVCTEMALAKYWSSLLGVKPDIVMGHSLGEYAAMHVAGVTTASDTIFMVGRR
                     AQIMEARCQAGSHTMMAVRASLTQIAENCEGREYTIACINGPFDTVLSGTKDQMDAVSV
                     PLEAAGFQCIRLDVAYAFHSEQTDPILDDFEALCKSAVLFHEPKLPVISPLLGKVIFDG
                     KTLNANYVRRGTRETVDFLSALNNAQTISAIGEDTIWIEIGPHPVCTGFVKSTIPGVKL
                     AKSLRLLDLPTYAWNEKNYWFQYKGDWTLTKGNTFYGSESKADRNTVVKTTHGCETSTV
                     QQILEESVNGSVGTVVMQSDLMQPDFLAAAHGHKMNNCGVVTSKTPQLIRVTATTADIY
                     SGTMELAWQCLDRNGNIDEPFATARILFRDGASYEWLSSWSPMAHLVQGRIDDLERLAQ
                     QGIASRFSRNMAYTLFASNLVTYADKYRGMQSVVMHGLEGFADVELTAHGSGSWTVPPF
                     FIDSVAHLAGFVMNCSDALDTKGYYSVTPGWKSMRFARPLLPGAKYRSYVKMIPSVEDA
                     TAYFGDVYVMQDGLIVGMVAIKALILIAEEAGLELSDLQDDAGFANLGIDSLMSLVIAE
                     KLKRELDVKVSGSLFLDYPTVGDLRKWLEEYYD"
     aSDomain        join(10367..10494,10747..11191)
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EmoG_SAT.1"
                     /evalue="1.20E-47"
                     /label="EmoG_SAT.1"
                     /locus_tag="EmoG"
                     /protein_end="192"
                     /protein_start="1"
                     /score="154.3"
                     /tool="antismash"
                     /translation="KHLFPPFETIFLWAEDDKLRQGLLGSAVEGALLIVLQIATYIGYA
                     EIHHRKNLTPSAPCLTGLGVGLLASAAVSVSSTLSDLVLAGADAIRLAFRLGVHVQSVS
                     QNIEARDPSESADPWAFVIHNVDPETVQRELDLAHSQAEKPSTARIFISAVSKKAVTVS
                     GPPERLKALFLKSTFFREARSIALPVYG"
     CDS_motif       11519..11551
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EmoG_0001"
                     /evalue="6.50E+01"
                     /label="PKSI-KS_m6"
                     /locus_tag="EmoG"
                     /protein_end="312"
                     /protein_start="301"
                     /score="-1.4"
                     /tool="antismash"
                     /translation="ALKANIDHVSL"
     aSDomain        11627..12928
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EmoG_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="1.70E-143"
                     /label="EmoG_PKS_KS.1"
                     /locus_tag="EmoG"
                     /protein_end="771"
                     /protein_start="337"
                     /score="470.4"
                     /tool="antismash"
                     /translation="AIVGMSCRLPGGATDTEKFWEILEKGLDVSRKIPSDRFDIDSHHD
                     TTGTQLNKTMTQFGCFIDEPGLFDAPFFNMSPKEALTVDPQMRLALVTAYEALERAGYV
                     GNRTASTRSERIGTFYGQTADDYREVNMGQEVDTYYTPGGCRAFGPGRINYFFKFAGPS
                     YIIDTACSSGLAAIELACQALWKGEVDTAVAGGVNVLTNCDGFTGLCKGHFLTKGHNAC
                     KTWDATADGYCRADGIGSLVIKRLEDAQADNDNILGVILGAGTNHSAQAISITHPHGGH
                     QAYLARQVLRQAGVDPLEVSYVELHGTGTQAGDVEEMKGITEVYAPLTRRRVKDQPLHI
                     GAVKANIGHGESVAGTTALIKVLLMLQKNAIPPHVGIKTEINPKLNPKDLEKRNIRIPF
                     SMTPWTGEPGKKRITAINNFGAAGGNTTLILEEAP"
     aSModule        11627..15822
                     /complete
                     /domains="nrpspksdomains_EmoG_PKS_KS.1"
                     /domains="nrpspksdomains_EmoG_PKS_AT.1"
                     /domains="nrpspksdomains_EmoG_PT.1"
                     /domains="nrpspksdomains_EmoG_ACP.1"
                     /iterative
                     /locus_tags="EmoG"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       12107..12154
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EmoG_0002"
                     /evalue="1.00E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="EmoG"
                     /protein_end="513"
                     /protein_start="497"
                     /score="17.7"
                     /tool="antismash"
                     /translation="GPSYIIDTACSSGLAA"
     CDS_motif       12299..12337
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EmoG_0003"
                     /evalue="1.90E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="EmoG"
                     /protein_end="574"
                     /protein_start="561"
                     /score="11.5"
                     /tool="antismash"
                     /translation="WDATADGYCRADG"
     CDS_motif       12530..12577
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EmoG_0004"
                     /evalue="2.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="EmoG"
                     /protein_end="654"
                     /protein_start="638"
                     /score="10.6"
                     /tool="antismash"
                     /translation="YVELHGTGTQAGDVEE"
     CDS_motif       12647..12691
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EmoG_0005"
                     /evalue="2.40E-02"
                     /label="PKSI-KS_m6"
                     /locus_tag="EmoG"
                     /protein_end="692"
                     /protein_start="677"
                     /score="7.9"
                     /tool="antismash"
                     /translation="GAVKANIGHGESVAG"
     CDS_motif       13238..13285
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EmoG_0006"
                     /evalue="1.50E-03"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="EmoG"
                     /protein_end="890"
                     /protein_start="874"
                     /score="11.5"
                     /tool="antismash"
                     /translation="FTGQGASYKSMSLELY"
     aSDomain        13238..14110
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EmoG_PKS_AT.1"
                     /evalue="5.60E-82"
                     /label="EmoG_PKS_AT.1"
                     /locus_tag="EmoG"
                     /protein_end="1165"
                     /protein_start="874"
                     /score="267.3"
                     /tool="antismash"
                     /translation="FTGQGASYKSMSLELYRDVPEFRSHIQHLDSLARGQGFPSFIPAL
                     DGSHWKDEAHSPVVTQLALVCTEMALAKYWSSLLGVKPDIVMGHSLGEYAAMHVAGVTT
                     ASDTIFMVGRRAQIMEARCQAGSHTMMAVRASLTQIAENCEGREYTIACINGPFDTVLS
                     GTKDQMDAVSVPLEAAGFQCIRLDVAYAFHSEQTDPILDDFEALCKSAVLFHEPKLPVI
                     SPLLGKVIFDGKTLNANYVRRGTRETVDFLSALNNAQTISAIGEDTIWIEIGPHPVCTG
                     FVKSTIPGVK"
     CDS_motif       13475..13597
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EmoG_0007"
                     /evalue="7.40E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="EmoG"
                     /protein_end="994"
                     /protein_start="953"
                     /score="53.4"
                     /tool="antismash"
                     /translation="GVKPDIVMGHSLGEYAAMHVAGVTTASDTIFMVGRRAQIME"
     aSDomain        14731..15366
                     /aSDomain="PT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EmoG_PT.1"
                     /evalue="1.20E-64"
                     /label="EmoG_PT.1"
                     /locus_tag="EmoG"
                     /protein_end="1480"
                     /protein_start="1268"
                     /score="210.4"
                     /tool="antismash"
                     /translation="KTPQLIRVTATTADIYSGTMELAWQCLDRNGNIDEPFATARILFR
                     DGASYEWLSSWSPMAHLVQGRIDDLERLAQQGIASRFSRNMAYTLFASNLVTYADKYRG
                     MQSVVMHGLEGFADVELTAHGSGSWTVPPFFIDSVAHLAGFVMNCSDALDTKGYYSVTP
                     GWKSMRFARPLLPGAKYRSYVKMIPSVEDATAYFGDVYVMQDGLIVGMV"
     aSDomain        15637..15822
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EmoG_ACP.1"
                     /evalue="7.40E-14"
                     /label="EmoG_ACP.1"
                     /locus_tag="EmoG"
                     /protein_end="1549"
                     /protein_start="1487"
                     /score="43.7"
                     /tool="antismash"
                     /translation="IAEEAGLELSDLQDDAGFANLGIDSLMSLVIAEKLKRELDVKVSG
                     SLFLDYPTVGDLRKWLE"
     misc_feature    complement(join(19908..19918,20005..20571,20649..20967))
                     /note="hypothetical protein 4"
ORIGIN
        1 aacaagcctc ttcgcaacaa gccaagcttc tctccaagaa aacaccttca catccagccc
       61 ttcagagcaa tctctttgct tcaacctcca agccttcacc atgttctcca agaccgtcct
      121 cgttgttctc ggcctcgccg cctccgtcct cgccgcccct cagcccatcc aggttgaagt
      181 cgccgcccct gacgccctca acgccaccct gtctgcccag gccgccgact accagaagtg
      241 agtcttaaac taccaaattc tacatcaata caaagtacca tagatatcct gaccttccat
      301 cgcagccact ggggaaccgg caccgtctac gaccagcagg gcggctacgg ctcctgcggc
      361 cagatgcaca gcgactggga catgattgtc gccatgacct ttgcctacca gggccacagc
      421 tggccccccg ccatgtgcgg ccgccaggtc gtcatcacca acacgggcaa cggcaacaag
      481 atcaccgcga ccgtcgccga cacctgcccc ggatgccgca ccgccgacag catcgacctg
      541 tcccgcggtg cttggaacgc cctgaccaac ggtgccgccc ccggcgtcat caacattcag
      601 tggtacatgc tctaagtgcc atttgaagag tatgtctgaa ggcaccggtg gcctttggac
      661 aggggatatc atagatggct ggatcaacat cttctcttct tgcacatgtg tcatgggctc
      721 tgagcctgta cataccaact tttccgatgt atattgcgcg cgtatataag accagatcga
      781 atcaagactt gattatacag actctgaagt tcctcaatca aaatgaccaa tcgcacccct
      841 gcgaagcgga ggatgaccga ttcttcggaa ctcttcatgc gagtcaatgc aactcctctc
      901 atagtctcgt actctagaac tcgcaatgag ctgacagggc caacaaagat agatgacttt
      961 cccgatccgt gcctggttat gacgaacgat gcaaccaaca cacagacaca cattgatggt
     1021 tgtctccgag ctcgaggctt accacgccgt atgaggataa gtctgacgta tccacaaggt
     1081 cctgcatcat aacgcagcgc ggggaacgca actctaagag attggcaaag atcaaagggg
     1141 gcaaatcctg atactcgttg gcgagataat agatcaagtt gcattgtctt tataagtatg
     1201 gccaagggtc tcgcattgat gaggtttttg ttttcagggg ctgaaagggg ttactttgag
     1261 gttgaaaaat gacaatagat caatacatgg acgaacctcg tgtagtccta tcgatatttg
     1321 cttaagtcat gttgaagtgt caactcctga cttcacttcg cgacccgcga ataaaaatga
     1381 ctcagaaagg tatattatga gggtaaatca atatatcttc gctgatacag tcaattcata
     1441 ggaaagactg ggaagtgtgt aactcgtcga agtgccttaa cggcggaagg agaggatgaa
     1501 tacttaacca agacaaaggt cgatcgcgga gactcgctct tacaagattg gtctcggaag
     1561 ggaggacgag ttttcgaagg gcatatttca tattaaaaac cgtgattgga tcaccgggca
     1621 ccatgcagca tgagttgtct gctcaggcgc tgcccgatga tgcgcatggt aactctgcat
     1681 gatatagatg ggccaagccc gaggacatga gaccgccgag cccaagcaga gcaagtcttg
     1741 ttcgaatatc agcattaaag gtgggttgcc ggcggagaaa caacagtgtg agctatcaca
     1801 gcaccatgac agcgttccag ttcgacgaca ttgccatatg gcccatagcc tcggcggccg
     1861 acgccatgct tgcccaagac gggcatgacc tcatcttccg agaaggcctc tgtctatact
     1921 tgagacagtg gaccaggaaa ggcctttctg ggaagaccct caccgtcgaa aacattcctc
     1981 gtcacgcgcc ggtggctttt catcgcgatc aagtgagtct gaagaaaatt tcaaagcgcg
     2041 ccaaacagcg ttaggaaaaa aacaataatt cttatcagtg ccacgaagct cttcactgtc
     2101 gattccaagc atgctctgag atgctacgtc aagccgagcg gcgctacctc caacgagggg
     2161 ctttggcctg agaagaaact cgggacggga cacgttcaga tgcaaccgag gagccacttt
     2221 atcatcagaa agagcttcgg ccgcgcatgg gtctattacc aagacccgga cggagagatg
     2281 aagttgctcc aggagcggcc cggggccggg tggagagttg tcgccatgag gatcggcacg
     2341 ccgctgacct tgcaaagatt caagaagagc gagcaggtca tagataaatc agtggatggg
     2401 aaagtccatt tcctgaagag acgtttcatc tacctggggg accggcaagg tcggtttgcc
     2461 cgcttgtgac acatttcagc tttctcacaa ccagctattt cacatcggct cccacttaca
     2521 tcgatgcgtt tccaaagata ctcttttctc gccagcgagg ctcccgggcc taatctccaa
     2581 gacggtggcc atacccgcga tcgacgaccc ggaccgggaa ctgctctatc tattctgcat
     2641 catcaagggc gacatggtcc tggtcaaggc gggggcaacc gagtgcatcg tcctcggacc
     2701 agtgccttaa tggtggccgc tgagcagcga cgacggccag catcatcgac aagatctaca
     2761 taaatctcaa gaggcaacga agctgaggag ggtttcggcg gcgatggcgg agagaagcgt
     2821 tctgaggccg gacgttgcgg atgacttgct tcgcgcggct cgagtgaggg agagagaaga
     2881 acggccgatt tggctgatgg ctgcattcag tctaggcgta aacccgcccg ggaggaattc
     2941 gtttcctcag tgccggatgg tctacgacgc tcctcagaga tggtcgacga aatgggttga
     3001 caccgcgagg agatccggaa tgtggacgcc agatgaagca tcgtgacaat tcaatgatga
     3061 gacgagaaag actattgtat ggtactgagc ttgaagcttc aattctattc catgtagtct
     3121 atcgtttgat attcatgtat attcattagg tgtgtgagtg tatgcaaaat tttaaatctt
     3181 gatcttcatt atatcattgc tcatgacttg acgtcagttg tctccttatc cttctctgag
     3241 acatcttcag acgccacctt ctcggcggga ccctcccccc gagcgcccct ctctgccttg
     3301 tcccgcccgt cctggacctt tgaagggata ttcttcttca cgctgagcca ctccatgccg
     3361 acgcccccaa gaatagcgat ggaagcaacg acgagcccga gcctgaagca aacgcgcaag
     3421 gcctcgttgt acccctcgag ggcctgggcg aaataccgct cggggatcat ctcgaggagg
     3481 tccgtcgcgc ccgtgttctg gatcatctgg cccgtgacgc ccgggatgtg gcccagcctg
     3541 cgtgcgagct ggttgttgaa gaggttctgc ccgacggcga tgaagacgga cccgaagagc
     3601 tgctggccga agaacatgag ggacgcgccg atggcgacct ggtcgcgcgg cagcacggtc
     3661 tgggcggcca tgttgggccc ctggaagcac aggcccaggc caaggccgta gaccacctgg
     3721 tagccgatcc agtgggcggc ggcggcgtcg acggtgagcg tggtcagcag gccggcgccg
     3781 acggtagaga ggcagatgcc gacgagcatg gggggcgtgt agtagccgat gcgggagacg
     3841 agctggccgt tgaggatgga ggaggcgacg atggggagga ccatgggcag caggtcgatg
     3901 ccgctcttaa tggcggacga gtgcttgatg gcctggaacc agatcgggag gaagtagacg
     3961 aagacggtct ggtgggagcc gaggcacgag gcgacccaga aggcggaggc gatgctgcgc
     4021 tgggtgacaa tggccggcgg caggatggcg tgcttgggct ggaggacctg gatcaggcca
     4081 aaggcgatga gcaggacgat ggcgacgacg aggagggcga cgacgcgccc gctcgaccac
     4141 tgatagtcaa tcgtttgtca gctcaaagag tcaaagtatg ggattccgtt agcaactcag
     4201 aactcacggg atagatggag cccccccatt ggagggccag gcagagacag acgacgcccg
     4261 gaagaaggac cgcgatcccg agggcgttga tgcgggtcag gccctccttg aggctgatgg
     4321 gctcgcgggc tggctggtgg acgtgcagga ggaagaagat gaagaccatt acgacaccgc
     4381 cgatgggcag attgatatag aagcaccagc gccaggtgac gtttgtggtg aaggcgccgc
     4441 cgacaagggg cccgaggacg gatgagacgc cgaagacggc gccaaagagg ccctggtact
     4501 tgggacgttt atgcagcggg agcgcgtaga cgatgatgac gatctgcgaa aaacaaaatt
     4561 atgttggcat gactggaccg cgaagggcga gaaaattcag gggaattcaa gggggggatg
     4621 ggagcataca gcaccggaca tgatgccgcc ggagccgagg ccggcgatgg cccggccgac
     4681 gatgaaggac ttggagtcgg gggcggcgcc gcaaagggct gagccgatct cgaacagcac
     4741 gatggagagc atgaagatgg tcttgacgcg gaagagggag tagagcttgc cgaagacgag
     4801 ctggaacgag cagttggtca ggaggtaggc ggtgccgtac cagccgatgt cgccggcgga
     4861 gtggaactca tccgtgatct cggggacggc cgtcgagatg atgaggcggt cctggtgaca
     4921 tgcagccttt gtcaatcctc tggtctcgta gacaggcact acctaggtaa tgttctcttc
     4981 aagatccttc cagtaaggat ccggatggga gggacgtacc agtgcgacga ggaacatgcc
     5041 cacaaaggtg ctggacatga ttaggaacag cttcaggccc ctcgggtact gcgtgtcgtc
     5101 ctcatgctcg gtcggggcaa cagcttcggc gccgcgagtc tcgacgacgg cgggcggcga
     5161 atccggcggt ggaggatccg cccctgcggg cttcttggag agcatcttga ctcttctctc
     5221 cttttcctat tttttttttg tctttttctc gacagaggac aaaatgctgt cagcggatga
     5281 gaacgagcga cgtccacggc acgcaagaca cacaacgata acgagagacg aggccgtggt
     5341 gaaaaaaaaa acgagtgagg agtgaagagg cggtcatgat gtatgtacgg agtatggatg
     5401 taaggggtac tcgtacattt tatgcaaagg acttccagac gcgatctact acgagtacta
     5461 gggctccgat gaggtaggac ctcaaacaat gagtcgtgct gtttgtgccg acaactacgg
     5521 agtgctatcc gtacagtgtc ttgatcagtc cacatgcgga cgatgtcgat ttctctcaga
     5581 cctgtcgata tgtacgacgg ggcggatgta agaggttata tccggattca cgctcaggcg
     5641 gtgtcctcat cgtccccgcg tcatcggatc tcgggctcgt ggtggtgcga ccggccatcg
     5701 tgggcccctt taggatggag tgcacggagc gagcagaggc cgatggccga catgtcaggg
     5761 caggggcagc gagacgaggg cgcttttggc cttgggctgc aaggggatcc ttgctagcgt
     5821 cgccggtgtg acgactcgag gacaaattca tcacgatggt cgttgatttg gttctgcctc
     5881 ctccgcgttt gcatcgccag ggttagggtt atggcgtcct ccatcgccgt cctcgtccga
     5941 aatattcatg gctcaggcat ccacaacctt gccgtctctg atgaattcct ccacccatcc
     6001 aatcgtcatg ctagaggttg tgagccgtgg atctcccaga agtcacatcc aggggaggca
     6061 aagacaaacc tgcttcgctc gacgtctgca aaattctcat gatcgcgggc cacgtgctcc
     6121 ttgtaccacg gatcctcccg catgcgcctg aagccgtcca cgctctcgaa gacgacctgg
     6181 ctgaagcagt cgtagccggc caagttctgc atgtgagagt cgaacagctg agccatgagg
     6241 gcgcgggtcg cggcctggtt gtggaccttg gcaaaagcat gagacaatgg acaccccaag
     6301 aaatgcttta tttagtactt cacaacagag acatacctgg gtccatcgct tgacgccgta
     6361 cttaaccatg aggtcccggc tcaacggcgc agagacgttg accatgtggt tgcggtacgc
     6421 ctcctcggtc atgccgggct tgcggtagcc gcagatggtc aggcagagga gtttgccctc
     6481 tggggcggac tcggggacgt cgagatggtc catggtgagc tcggtactca atgtctgatg
     6541 gagcgccggt gacgagtcaa gactgctcga gagcctggat gaacagctgt cggtccattt
     6601 tgatggcctg agctccagga ttatataggc cttcactaga tctaaacaga gtacttctta
     6661 tcccataaca cggcgtcggt gtattactca agaggatcga atattatacc gaaggggtcg
     6721 tcgggatgat cctcagaaag ccagaggaag cgagtatgaa acgaacaacg acccgcccgt
     6781 gcgattcaaa atcctcacac gaaggaaggc ccagaatctt attcgcttgt caacgagcgg
     6841 cattggtcga tcatctgctt ctactacatc cacgattctt cgtgcaagag ccacgacagt
     6901 catagttaat cctgtcaatg ttccggggcg tcttcacaaa ggagcaggat cagggtgtct
     6961 tgaatcttcg gtacaaacaa agatccattg atccatgtgg tactccgtac tcgtagatat
     7021 cctttttttt tccttgggca aagatcccct gtgcgtgatg gctgcggctc gctgatcggc
     7081 atcgacgtca tgccgatgcg atgtcgagat cgagatagta tcaatgtaca taaatctacg
     7141 gactacggac tacggactaa atatggattg tatggactta ctccgatgtg aaatggcttg
     7201 agaatgttcc atgcccgctt cttggacccg cagggcccga atgaacccgg gatggcgtca
     7261 ctcttagtcc cggaaaagct caagtctagt cgacggcttc tactccgtac atacctgtag
     7321 cttcattctc gagctctctt caccttgctc cagctgtcta aaatattcaa gattgtccca
     7381 cctcaccaga acgagcccga cctttgaagc tgaaagtccc cagtcgtccc agaccgagca
     7441 aagaagattg aatcatgccg cgcaagtctg cctccaagga ccgcaaggag gcccgccctc
     7501 ccgcctcaat cccccgaaag gaagcgcgcg tgctcgtccg cgcctcggcc gcgatgacgg
     7561 cctgcttctt gtccggtgag tattgaacaa cctgcgaatc gcactccaaa tcgcacttca
     7621 aaattgcttt gcatagggca tcatcaagct cacagacttg ccattcccag gcgccatgac
     7681 cggcatctcg gccatcaccg tccccgtcct gctcgacacc accgcgcacc cggcccagct
     7741 gctctcccag tggtcccgcc tttaccacta cggccacatc atgatgccct ccgtcgccgt
     7801 cgcgaccacc gggctcttcg ccctcctcgc cctgcgcagc aagcagcgcc agttccagct
     7861 cgtctatgcc gtcgccggcg ccgccaccat cggcatcgtg ccgttcacgc tgctcttcat
     7921 ggtggcgaca aacgacgccc tcttcaggct cgagaagctc gccctcgcgg cgcaggtcgg
     7981 ggccgacgtc gcctcgcagg ccgtggacct gatcttcgcc cgcgagctcg tcgtcaagtg
     8041 ggctcgtctg catgctatcc ggtccctttt ccctcttctc ggaggtatcc tcggcatggt
     8101 ggggttggtc caggaattga ggcagtaatc tcatgtacat atcattcatt gacatcgatc
     8161 tatgttcacc tcacatcttc actccgtcgc ctgtcaacat catcacctgt tggcttcaac
     8221 tctctcgagc aatcggatcc agaggggatc ttccaattgt atatacgtgc tcagagcttt
     8281 gttttgcacc ttatcaagtc tcgcgcgagt ccctaccttg tctcagccga gggtgtcaca
     8341 gacatcaggc caccacggaa taccactttc tcttcccccc gcgcatctca aacgccacca
     8401 tcccgtcccc ggccagcttc ctcagcacct ccgcgacaaa tggctcgagc gcaagggtcc
     8461 tcgtctcctc gtccagttga gcgccgtaca cctcgccgac aatgtccctc accgaggcgc
     8521 tcttcccgcc cctgctgcgc acctccccga gcgccctcat cacctgcccc tcgcgccgcg
     8581 tcttggccgt cagctccgcg tccagcttcg cctgcaggtc cgcaatcgcc accccgtgcg
     8641 cagaataccc ggtccggcag ccctgtgcgt gcatcctgcg cagcgttgcc atgaaggtgc
     8701 cgaggtcctc caccgcgctg gtcccgtgcc cgagcacgtt gtcgcccgtg aacatggcct
     8761 gctcctcctc caacacgaag cacatgtggt cctcgctgtg cccgggcgtg tgcagcgccc
     8821 gcaccgtcgc gccctccacc gggaacacct gcccgtccga gatgccccgc tggatgccct
     8881 cggggtcgtg cttgaagatg cccccgcgct cgaggtgagg gtacatgcgc accaggtccg
     8941 gcacgccccc cgtgtggtcg ccatgccagt gcgtcaggag cacgtgggag aggctgatcc
     9001 cgcgggacgc gagcgtcgat gagatcagct cggcccactc gggttcgccc ccggaggtgt
     9061 cgacgaggag gcgctcggcg ccagtgccga caatgtacgt gttcgtccct tggaacgtga
     9121 actgcctctg gatgtcagcc agctgaaaaa tgtatataca gaatgagtct gtctgaaggt
     9181 agtagcagcc actctcacct ttcctggatt ctggccgaga acgcggagga ccctgggaga
     9241 catctgctcc acgtcggcca gccggggaag gcgtgctgtc tggccctgga gatactcatc
     9301 aaaggcgcaa atattgaggg ccttgttgat ctggcgatac ccccctttgt cttttctgac
     9361 ggcagatgct ctgtcgtcat ccagtccaag gctacccatt gcttcggtca agctgagcca
     9421 gagacagcct gaatcttgag aaagagagat gatgagaaga atttcagcgt cgtcctctgc
     9481 tccccgatga gtctggtcag ctattcgaga tcccggcatc gtttgaggta cttaaatatg
     9541 cttcattgac tggaaatgtc ggcaccagac agtatccgcc aggagggaat cgcgccgata
     9601 gcgtgggaag ccaggagccg atccttcgtt cctgatgcct tgcgcccaat tcctagtatc
     9661 cattcatcca atcgaagacg acaaaacatg atagtcatcg ggcaattgtc agagccactc
     9721 ggatgaagtt tcaaggctct tgacaattga ctcattaccg agcgcgcgcg gagaggctca
     9781 tcaggggcaa tagaccaatc tggagcttac cagtgttaag gctgagacgc tggagcctcg
     9841 atggatgtca tcgggaggaa tctcacaacc cctgtggtgg aactcgactc ggcgcgatct
     9901 tggccattgc gatgtgagac ttcgagatgg agcctgggtc tgaggctctg cgacgttcaa
     9961 catggtcagc ccttcaacta cctcgttcca tatatgacct tgggcaaccc ccaatgagga
    10021 ggttatcgag tcaacaaacg tctttggaga agatcttcct ttggtggcag caactcaccc
    10081 catccgaaca ctcattgaag tcgcatttta ttccaaactc tcaagccagc ttccaatggc
    10141 gagcttttct ccttccccaa ccttctcctc cgacacctct ggcgaggata ctcgcaagat
    10201 ggacgtcgtc ttcttcagca atgatttccc gaaaggcgat cttcaaggac tcctgcgtcg
    10261 cttgcacgac cacagcaaag atcggcgtca tccgatgctg gctcacttta tcgaggaggc
    10321 cacccgtgtc gtcaaagagg aagtcagact gctgccggcc gagatgaagc atctgtttcc
    10381 ccccttcgag acaatcttcc tctgggccga ggacgacaag ctccggcaag gtctcctcgg
    10441 aagtgccgtg gagggagcgc tcttgatcgt gctccagatc gccacgtata tcgggtgggt
    10501 ggctcctgcc ttattcgccc ttaccgttcc cacttccttc tattgcacat ttatcacgct
    10561 ccttccctct tctcagaact cactcgcctt ctccttccct ctaatgaaac accccttcta
    10621 gagctttcta gaaagttcat ttctccttct cccaaactca tgtgattcta acctcatgtc
    10681 ttcctcaacg tccaaccgaa ggtttttttt atcaccaacg agttctcatg agctgacata
    10741 atgcagatat gccgagattc accaccggaa gaatctgacg ccctccgctc catgcctcac
    10801 cgggctcggt gttggccttc tcgcatcggc tgccgtctct gtatcatcga ctctcagcga
    10861 cctcgtcctc gccggggctg acgccatccg cttggccttc aggcttggcg tccacgttca
    10921 gtccgtctca caaaacatcg aggctcgcga cccgtcagag agcgcagacc cgtgggcatt
    10981 tgtcatccac aatgtcgacc cggagacggt ccagagagag ttggacctcg cacactcgca
    11041 agctgagaag ccaagtacgg ccaggatctt catcagcgct gtgagcaaga aggctgtcac
    11101 cgtaagtggc ccgcctgagc ggttgaaggc tctattcctc aagtcgacct tcttccgcga
    11161 ggcgaggtcc attgctctgc ccgtctacgg gggcctgtgc cacgcaccgc acatctacgg
    11221 cccgcaagac gttgaggcga ttgtccattc agggtttagc gatgcttccg atggcacatc
    11281 ctttcaatca tggcgtcttg tgcccataac acccaccttt tcgacgagca caggcatgcc
    11341 ttttcccgca accaatgccg tcgagacttt cgagtgtgtc gtctccgagc ttctcaccca
    11401 ggccatcgaa tgggatcgtg ttgttgacgg tgtcgtcgaa agcgcccttt gctcttccgc
    11461 ctccgaaatc gagatcttct gcttcggaaa ctccatctca ctcgatgagc ttcataccgc
    11521 cctcaaggcg aacattgatc acgtctccct atcctccatg actccatgga tctcgcaagt
    11581 cgaactgagc ggtatctcgc ctcgcggtac ggcgcagtca aagctcgcca tcgtcggcat
    11641 gtcatgccgc ctgcccggag gagcgacaga cacggagaaa ttttgggaga tcctcgaaaa
    11701 ggggctcgac gtctctcgca agatccctag cgatagattc gatattgatt ctcaccatga
    11761 tacgacgggc acacagttga acaagacaat gacgcagttt ggttgtttca ttgacgagcc
    11821 cggcttgttt gacgcaccct tcttcaatat gtcgcccaaa gaggcactca ctgtcgaccc
    11881 ccagatgcgg cttgcccttg tcactgcata cgaggccctg gagcgtgccg ggtacgtcgg
    11941 aaaccgcacc gcctctaccc gctcggagag aatcgggaca ttctatggtc aaacggccga
    12001 cgactatcgc gaggtcaaca tgggtcagga ggtggacacg tattacaccc caggcggatg
    12061 cagagccttt ggtcccggcc gcatcaacta tttctttaag tttgccggcc cgagctacat
    12121 catcgacacg gcttgctctt cgggcctggc cgccattgaa ctggcctgcc aagcgctttg
    12181 gaagggagaa gtcgataccg ccgtcgccgg cggtgtcaat gttctgacca actgtgatgg
    12241 ctttaccggc ttatgcaagg gccacttcct cacaaagggg cacaatgctt gcaagacgtg
    12301 ggatgccacg gccgacggct actgccgggc ggacggtatc ggatctctcg tcatcaaacg
    12361 cctcgaggat gctcaggctg ataacgataa cattctcggc gtgatactag gcgccgggac
    12421 gaaccactcc gcgcaagcca tctccatcac ccacccccat ggcggacatc aagcgtatct
    12481 ggctcgacag gtcctccgcc aggcgggcgt ggaccctctg gaagtctcat acgtcgagct
    12541 ccatggcacg ggcacccagg ctggggatgt cgaggagatg aaaggcatca ccgaggtcta
    12601 cgcacccctg acaagacgtc gagtaaagga ccagccgctg cacattggag ccgtcaaggc
    12661 aaacataggt cacggtgaat ctgtggctgg tactacggcg ttgatcaagg tcttgctcat
    12721 gctccagaag aacgccatac cgcctcacgt tgggatcaag acggagatca acccaaagct
    12781 caaccccaag gacctcgaga agcgcaacat tcgaatcccc ttctcaatga cgccttggac
    12841 aggtgagccc ggcaagaagc gcatcacagc catcaacaat tttggcgctg ccggtggcaa
    12901 cacgactttg attctcgaag aggcgccgga caggggtgtc acagaacgtg acccccgcgg
    12961 cagtcatgtc tttgccctct cggccaagac aatgacttct ctcaaaggca acatcgagcg
    13021 cctcttggct tacttggatc gagatgggaa tcaagatgcc aatcttgcaa acctttcgta
    13081 cacgatgacg gcacgtcgct cccattacag ctatcgtctt gctgttgcgg cgtcaaatat
    13141 ggctcaactc agaaaggctc ttgtgtcccg cctggaaaag gtcgactcaa tcaagcctac
    13201 atcgaaattg tctgatccgc cgtctgtggc ctttaccttt actggccaag gagcatctta
    13261 caagtcgatg agcttggagc tgtaccgtga cgtgcccgaa ttcagaagcc acattcaaca
    13321 tctggattct ctcgcccgcg gccagggatt tccctcgttc attccggctc ttgacggctc
    13381 tcactggaaa gacgaggcgc actcccctgt tgtgacgcaa cttgccttgg tgtgcaccga
    13441 gatggctttg gccaaatatt ggtcctcatt gcttggagtg aagccagaca ttgtcatggg
    13501 ccacagcctc ggcgagtacg ctgcgatgca tgtcgccggg gtcacgacag cgagcgatac
    13561 gatcttcatg gtcgggcgcc gtgcccaaat tatggaagcg agatgccaag ccgggagtca
    13621 cacgatgatg gccgttcgcg cctccttgac ccagatcgcc gagaattgcg aggggagaga
    13681 atacaccatt gcgtgcatca acggtccctt cgatacggtg ctcagcggga caaaggacca
    13741 gatggatgcc gtttccgtcc cgctcgaggc agccggtttc caatgcatca ggctggatgt
    13801 tgcctatgcc ttccactctg agcagacaga tcccattctc gatgacttcg aggctctctg
    13861 caagtctgcg gtcctcttcc atgaaccaaa gttgccagtc atctcacccc tgctggggaa
    13921 agtcatcttc gacggcaaga cgctgaacgc aaactacgtc cgtcgaggaa ccagagaaac
    13981 agtcgacttt ttgtccgccc tcaacaatgc tcaaacaatt tctgccatcg gcgaggacac
    14041 gatctggatc gagatcgggc ctcatcccgt ctgcactggc ttcgtcaagt cgaccattcc
    14101 cggggtgaag ctcgctgtac cgtcgatgcg ccgtggggaa gacaactgga agaccattgc
    14161 cgaagcattg gctgcattgc atgccgctga cgtcgatata tgttgggatg aatttcatcg
    14221 tccctttcag aagagcctcc gcctcctgga cttgccgacg tacgcgtgga atgagaagaa
    14281 ttactggttc caatataaag gcgactggac tctgacaaag ggtaacacct tctatggttc
    14341 cgagagcaaa gccgaccgga atacggtggt caagacaacc catggctgtg agacctcaac
    14401 agtacagcag atcttggagg agagcgtgaa tggctcggta gggacggtgg tgatgcagtc
    14461 cgatctgatg cagccggatt tcttggccgc tgctcacgga cacaagatga acaactgcgg
    14521 cgttgtcaca tctgtaagtt ggctgctgct tacactgttt gcaatttcaa tgactgatcg
    14581 atggccctat cctagtccat tcatgcggat atcgccttca ctctgagcgg ctacctctac
    14641 cgcagaatga cttccaaggc attgacatat ggaaatatga gcatgactga cttgcacgtt
    14701 tcgaaagccc ttgttgctca aaatgaccag aaaacgcctc agctgatccg cgttacggca
    14761 acaacggccg acatctactc ggggaccatg gagttggcgt ggcaatgctt ggaccgcaac
    14821 ggcaacattg acgagccatt tgccactgca agaatcctct tccgagacgg tgcctcttac
    14881 gagtggctct cgtcctggag cccgatggct catctcgtac agggccgcat cgacgacttg
    14941 gagcgtctgg ctcaacaggg catcgcaagt cggttctccc gcaacatggc ctacactctg
    15001 ttcgcaagca acctcgtcac ctacgcagac aaataccgtg gcatgcaatc cgtcgtgatg
    15061 catggactgg agggtttcgc ggacgtcgaa ctcacggccc acgggagcgg aagctggacc
    15121 gtgccgccct tcttcatcga tagtgtggct cacctggccg ggttcgtcat gaattgctcg
    15181 gatgccctcg acacgaaggg gtattactct gtcacgcctg gatggaaatc tatgaggttc
    15241 gcccggcctc ttctccccgg cgccaaatac cgatcatacg tgaagatgat cccctccgtt
    15301 gaagacgcga ctgcctactt cggcgacgtc tatgtcatgc aggacggctt gattgttgga
    15361 atggtcggtg ggatagagtt ccgaaggtat ccccgcattc tcatcgaccg attcttctcg
    15421 gcccctgaca agacacccgc cattgagagc agacgggagg gggcggtcgc cactctcccc
    15481 cctccagtca aggctcctca tgcggataag tctggaaaag ctcctagtat tgccgtactc
    15541 aagccggccc ctcttgtccc ctctcccaat cctgcaccct caaccccgaa acctacttcg
    15601 agcgccggtt ccacagcaat caaggcgctc atcctgattg ctgaggaagc ggggctcgag
    15661 ctatccgatc tgcaggacga cgccggcttc gcgaacctcg gaatcgatag cttgatgtcg
    15721 ttggtcattg cggagaagct gaagcgggag ctggacgtca aggtcagcgg gagcctgttc
    15781 ttggattatc ccactgttgg cgatctgcgg aagtggctgg aggaatatta tgactagtca
    15841 ggggggtggg gggggactgt gagcgaagga aggggggatt gggccattta gatggtggaa
    15901 gtgaggcttt tatacttgtt ctggactgga ctgcgtaagg agatcaaata gaaatgctcg
    15961 tgtgccacca acgtgggact gttgtcgccc tgtctcagat cagagcctgc atgatcttgc
    16021 ccaggatcaa aggggtctgc ccaatacaat gcctcgtcga agtcagtgtg tgcagacact
    16081 gtctcgaagc aggatacaag ctcaacaccc cttgaggtcc aagtgtctcg gagcaggatc
    16141 tatgctcagc accacttgcc gaggtccaca aatcaggagc ttcaactgat cggaaaagac
    16201 agtattgatg ccacgagaaa gccgagctcg aagaataagg cttcgggatc ggggatcttc
    16261 cttgacctgc tgctgctctt gagtcagagc ggtgctcgtt gaggatctca cggtgcggta
    16321 ggctactgtg tcgcttctgc aagagccgac accattagga catcattgct gagtggcaca
    16381 taccatctga agtcccagga ggccattcgt tgttatcaag tggatgccca gtcttaggca
    16441 cgggatccag aggtggagat gcggagatcc atagaccgag ccatccatcc tcgtgatggc
    16501 catccggggc cagcccgcct cgttacgggg actcttcaca tcatcgcggg ccagcgatgt
    16561 agggcgtgcc cgctcatccc aagtgtgcga cgatatatgt gctcactgct acccaggagt
    16621 gtcaaggtac atgtaagtta aggcccttat tctagcagcc agactttggc gggccttggg
    16681 tatcttggcg gatctcgtgt gttttcaggc tcttcgcgga gattttaaga aattcctgcc
    16741 ggatgtgcta gcgtctggag atgactggga ttcgagcctt gaattggaga atgtgggcaa
    16801 aataggggga gacggtgttc aagacttcag gtgactttcc gctgaccgag tttcggagaa
    16861 ggctatctct ttcttctctg atcgtacgag tatatctgct tgtaggatgg gcgtgactcc
    16921 aggacgggca gacacggtgt cgagagacag aggaactgta tgatgtggca aggattcagg
    16981 ctgcaacagt tggacgtccc tcgacagtgc agggacaaaa ggtccttgag ctgtaatcat
    17041 atgcagtgac tgttacaggc aattcgccaa ctcttgacac atgaagaaga ttcagggtag
    17101 ggtgttgctt tctggggaaa ttccagcaac gacgatcaca gaagagcatg gaaactgttg
    17161 gacgatgtgg tgggagttct gaccgattag gctacgaagc gccatttcgg gactcgagat
    17221 cttcggagtc gcttcttgga aagactttcc ctctgctccg tatgccgcat gctccccact
    17281 tttgtgtgcc gtgtctcgat gccttgccag gagcagggga ttcggctatg cgatcccgcg
    17341 ccatccttgt cgcatcctgg gcccctaagt agctgaaacg aggtgggctg tactccgtat
    17401 gcgagatgta tgtacgccgc cgggatccaa ggtcacggct acggctctcg ctttggagaa
    17461 tgccttgctg ggcccatcgt gttgagcaga gacatcgtcg ccaaggccgt tgtgggaaca
    17521 ggagcgcgag accgagcttc gatatgagtc ctcgccacag ggtcggatga gattctgaga
    17581 catgaaaagg cgtgcggcgt gaggctctcg aggctgtacc gggtcaggtc cgccggtctc
    17641 tgcgtgcatc cgaacatgta cggaagtata aaggcttctc tgtacacgag ctccgtggtt
    17701 tccttggctt cgtcgatata ttcctgcgtc gttcaaacga tctattatat ctcttctttg
    17761 ttagcaaatc tcgactttca tcgtcgcact acagcatttc gaaacaagga gccacgcaat
    17821 gacagacttt ggaaaccccc cgttctatcc agggccgcaa tgccagtgga gggcttcatc
    17881 gggcggcagg tccgggatcc cgagcctgag agtccgcgag agctgccacg cctgcgccct
    17941 ctccaaagtc agatgcacca aggagaagcc atcatgctcg aagtgccgga accgcggcat
    18001 accgtgccag tatttctttg ctagacgccc ggggcgccgg ccggagaggc gcgggatgac
    18061 atccggtgca agtttgatgc tcaactcgac atcccatcgt ggccgatctt ttggcgacga
    18121 gaatgcggtg ctgtttgcgc accagaatct cgtgcacggc ttcgaaacgg acgtcactgt
    18181 cgatcgcttg gtctttccgg taacagacac tctgcgcttt aggttttctg atatcctcga
    18241 ctcagattcg cttccgatac aggatactcc cggccgagaa gctgaagact gctcgtccaa
    18301 cgcgcacgca ataaatacgc cttctatcca ggagtgtctg aattgcggca tctttgataa
    18361 cgaccttgac gaggaggata tgtggagact gtcgaccatg ggaagcgaag aggtgaccat
    18421 ctccacgcct cagccatgta tccaaccgtc tcagcgcttg gaactcgagc tggcttcaac
    18481 gatctcggac acgacttcta acggcgacta tctcggcaca tcgtttgggt catcgctgct
    18541 ggatccgcta cacggccaat ctccacatcg agcgatcgaa tccaggggtt cgatgagtgt
    18601 catgtcgtgt gcatgcttca tgcatgccct tgacgtcctc aagatgccac ccgcagctca
    18661 gctcggttcc cgcaatagac ctcatgtcca tgatggtgag actggagcga agagcaatcg
    18721 ctacgccata gaggtcgtta ggagtgggct gaggtgtctt tcgtgctctc gggacagttc
    18781 cttcctgatg atccttgcca tgatcgtcct cagagtcttg ggccgatacg tgatcatgga
    18841 cagacgggaa agctcagcca taacagctcc cacaggacca cggggcccaa agtcggtccg
    18901 ctgttacgcc gatgatgaca gcaacagagg gtcggtcgac atcgaagttg gacttgcgga
    18961 gatatatcat gtgcaagagg tggtcgggga tctgtgtcag agactcaacg atttgacaag
    19021 gacgggagga aaagatccgc ggtatgacaa tgggaccccg tcggatgatc gcagttgtaa
    19081 cgggatggga aagagaaaca ggtgcagaat agaggctagt ggattgttct cggcttcgac
    19141 gattcagcac atccagcttg atctgtgtag gcgactcggg tcactctcga cggaggtcgt
    19201 caactgtctc cgggagactt gaggcggtag acaaccttcc ctggagagat ggatgcatcg
    19261 atgtgtacat atttgataga ataatatctt gtggattgga caggggacat aattctagac
    19321 aatagaaccg tataattagg caaggatggg gaaagagtgg actgactcac cttgcctata
    19381 gaatcgaatt gttggtccct tatgcagcct tctcatcctt tctcttcata tccgtcacga
    19441 tatttcgagt gtttccagaa gcatcagcat tgccttctgc tttgaccttt tcgtcgcgtc
    19501 cccccttttc tctcttcaca cccccttctt tctctgtttc tttctccact tctctctcct
    19561 tccccttccc cttttctgtc tcttggaccg tctcatcatc tttctcgata tgctcccaat
    19621 cagagatgag cgcgttgtcc gcctcgccct cctcttctgg atcccatccc ctcagtaccc
    19681 tcgaagcggc ttctttcccg acaacaggca atttctccac gccgagattc cgggcctctt
    19741 ccgtcagcaa cttcgggtct agaaggccaa cttgaatcaa gacgcttgcc tgatcccaat
    19801 agacgtgctc gtgacagatc ttgcctcctt tcattgtgac gatgctgacg acgaggactt
    19861 gcactcgctt gtttgttggt gggacgctgg gaagaatcca aggcatctca tgcgtatgct
    19921 tgaagcgcac atggatctcg tcgactaccc gagttgcacc aatggttcga gacagcaatg
    19981 tgagccgcag agacgggggc gtaccgaaga aatcggcgta gaacttctcc agctcgtcct
    20041 cgccgatccc tcccgtcagc gtcggcagat acgtgacgtg aggattctcc cgcgtcgtga
    20101 aggagtccat tgttgccgtc aggttgcggc tccagaactt gccacgcagg ctgtgctcaa
    20161 cggcgagctc caggttctcg tggcggttga aggcctgcct ggcagaggcc agactgcggc
    20221 tccaggccag atctgccgcc acccggtcat actcttcgag atcgtgctct gaaaagccgg
    20281 ccttggcgtg gtaggcgtag ctcgagtagg ccatgttgag caggccaccc gtgccgatgc
    20341 cgctatcgac cgtccctcgg ctgacggtca gctttccctt catgccgtgc atctggctcc
    20401 tctgtgtgat gttgatcggt tctccggcaa tcagatgaac caggacgttg aggctgctcg
    20461 gaaaccggcc ttccggatgg gggatggacg agggatagta ggcaatgaga aacgcaagct
    20521 gaaatcccgg attattgtcc cagatgtggt agtgctcgag gcaaagcgta gctgcatctc
    20581 cgaatgcttc aagacattag caaggccttt gcgaaaggaa aaaaaaagaa tgaggagcaa
    20641 gttcataccg acgatgccga atgtctcgca aggccccctc tcgaccttgc tcaggtcgcg
    20701 gagagcacgg ttgtaggcct ctgtgtcgtt gcccatggga aaatactcga cgtcgaagcc
    20761 ctcattgcgc cagtctgcca aggtctcggg atcgaagtcg tcatcctcgg ctgtcaggta
    20821 aatcttggga gccgcccgag gaaagtcgct cgccagaaag tgatgatcgc ggtaattgac
    20881 attgcgatcg gagatgatcc tcgctgttct cccttcggag tcccccggga ccatgctttt
    20941 aatcagctcg ggcacgtcga cgttcatgat ggcagtgatg tatcagatag ctgattgcaa
    21001 agaggacaga agccatatac cgtcactgtc tgatagaaaa tacggttttt tccaaaagat
    21061 tgatgag
//
