BGC0001597: fluvirucin B2 biosynthetic gene cluster from Actinomadura fulva subsp. indica
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 71,515 nt. (total: 71,515 nt).
This entry is originally from NCBI GenBank LC095592.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001597
Short description fluvirucin B2 biosynthetic gene cluster from Actinomadura fulva subsp. indica
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: LC095592.1
Compounds
  • fluvirucin B2
Species Actinomadura fulva subsp. indica [taxonomy]
References
Chemical products information
fluvirucin B2
Copy SMILES
C25H48N2O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAV55985.1
 178 - 666 (+) hypothetical protein
copy AA seq
copy Nt seq
  • BAV55986.1
 702 - 1127 (+) hypothetical protein
copy AA seq
copy Nt seq
  • BAV55987.1
 1269 - 3059 (+) FAD-linked oxidase
copy AA seq
copy Nt seq
  • BAV55988.1
 3368 - 3793 (-) hypothetical protein
copy AA seq
copy Nt seq
  • BAV55989.1
  • flvA
 3809 - 4507 (-) 4'-phosphopantetheinyl transferase
copy AA seq
copy Nt seq
  • BAV55990.1
  • flvB
 4504 - 5331 (-) metallophosphoesterase
copy AA seq
copy Nt seq
  • BAV55991.1
  • flvC
 5328 - 6068 (-) thioesterase
copy AA seq
copy Nt seq
  • BAV55992.1
  • flvS1
 6120 - 7007 (-) dTDP-1-glucose synthase
copy AA seq
copy Nt seq
  • BAV55993.1
  • flvR1
 7205 - 9550 (-) PbsX family transcriptional regulator
copy AA seq
copy Nt seq
  • BAV55994.1
  • flvS2
 9607 - 10590 (-) dTDP-glucose 4,6-dehydratase
copy AA seq
copy Nt seq
  • BAV55995.1
  • flvE1
 11006 - 12436 (+) propionyl-CoA carboxylase subunit beta
copy AA seq
copy Nt seq
  • BAV55996.1
  • flvE2
 12511 - 13581 (+) 3-oxoacyl-ACP synthase
copy AA seq
copy Nt seq
  • BAV55997.1
  • flvE3
 13581 - 14441 (+) 3-hydroxybutyryl-CoA dehydrogenase
copy AA seq
copy Nt seq
  • BAV55998.1
  • flvS3
 14475 - 15086 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
copy AA seq
copy Nt seq
  • BAV55999.1
  • flvS4
 15118 - 16227 (+) NDP-sugar aminotransferase
copy AA seq
copy Nt seq
  • BBD71108.1
  • flvK
 16224 - 17195 (+) aminoacyl-ACP:ACP aminoacyltransferase
copy AA seq
copy Nt seq
  • BAV56000.1
  • flvL
 17253 - 17501 (-) acyl carrier protein
copy AA seq
copy Nt seq
  • BAV56002.1
  • flvM
 17640 - 19151 (+) ATP-dependent ligase
copy AA seq
copy Nt seq
  • BAV56003.1
  • flvD
 19194 - 20195 (-) esterase
copy AA seq
copy Nt seq
  • BAV56004.1
  • flvE4
 20266 - 21030 (-) short-chain dehydrogenase
copy AA seq
copy Nt seq
  • BAV56005.1
  • flvE5
 21099 - 22436 (-) crotonyl-CoA reductase
copy AA seq
copy Nt seq
  • BAV56006.1
  • flvP1
 22509 - 34280 (-) PKS (ACP-KS-AT-DH-ER-KR-ACP-KS-AT-KR-ACP)
copy AA seq
copy Nt seq
  • BAV56007.1
  • flvO
 34371 - 35645 (-) PLP-dependent decarboxylase
copy AA seq
copy Nt seq
  • BAV56008.1
  • flvJ
 35816 - 36769 (-) amidohydrolase
copy AA seq
copy Nt seq
  • BAV56009.1
  • flvR2
 37222 - 38142 (+) transcriptional regulator
copy AA seq
copy Nt seq
  • BAV56010.1
  • flvS5
 38335 - 39636 (+) glycosyltransferase
copy AA seq
copy Nt seq
  • BAV56011.1
  • flvP2
 39704 - 52564 (+) PKS (KS-AT-DH-ER-KR-ACP-KS-AT-DH-ER-KR-ACP)
copy AA seq
copy Nt seq
  • BAV56012.1
  • flvP3
 52628 - 60070 (+) PKS (KS-AT-DH-ER-KR-ACP-TE)
copy AA seq
copy Nt seq
  • BAV56013.1
  • flvR3
 60169 - 61092 (-) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • BAV56014.1
  • flvT1
 61349 - 62869 (+) MFS transporter
copy AA seq
copy Nt seq
  • BAV56015.1
  • flvE
 63078 - 63923 (+) methyltransferase
copy AA seq
copy Nt seq
  • BAV56016.1
  • flvR4
 63940 - 66783 (-) LuxR-family transcriptional regulator
copy AA seq
copy Nt seq
  • BAV56017.1
  • flvN
 68111 - 69685 (+) ATP-dependent b-aminoacyl-ACP synthetase
copy AA seq
copy Nt seq
  • BAV56018.1
  • flvR5
 69900 - 70598 (+) LexA-family transcriptional regulator
copy AA seq
copy Nt seq
  • BAV56019.1
 70696 - 71067 (-) hypothetical protein
copy AA seq
copy Nt seq
  • BAV56020.1
 71118 - 71501 (+) hypothetical protein
copy AA seq
copy Nt seq
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added AMP-binding domain substrate specificities
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.