BGC0001623: ishigamide biosynthetic gene cluster from Streptomyces sp. MSC090213JE08
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 37,581 nt. (total: 37,581 nt).
This entry is originally from NCBI GenBank LC269948.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001623
Short description ishigamide biosynthetic gene cluster from Streptomyces sp. MSC090213JE08
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: LC269948.1
Compounds
  • ishigamide
Species Streptomyces sp. MSC090213JE08 [taxonomy]
References
Chemical products information
ishigamide
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAX64242.1
  • iga1
 462 - 758 (+) LuxR family regulator
copy AA seq
copy Nt seq
  • BAX64243.1
  • iga2
 891 - 1649 (+) SARP family transcriptional regulator
copy AA seq
copy Nt seq
  • BAX64244.1
  • iga3
 1735 - 9360 (-) NRPS
copy AA seq
copy Nt seq
  • BAX64245.1
  • iga4
 9697 - 10734 (+) cysteine synthase
copy AA seq
copy Nt seq
  • BAX64246.1
  • iga5
 10753 - 18882 (+) NRPS
copy AA seq
copy Nt seq
  • BAX64247.1
  • iga6
 18879 - 26222 (+) NRPS
copy AA seq
copy Nt seq
  • BAX64248.1
  • iga7
 26237 - 26479 (+) MbtH-like protein
copy AA seq
copy Nt seq
  • BAX64249.1
  • iga8
 26482 - 27447 (+) ABC transporter
copy AA seq
copy Nt seq
  • BAX64250.1
  • iga9
 27444 - 28286 (+) ABC transporter
copy AA seq
copy Nt seq
  • BAX64251.1
  • iga10
 28389 - 28640 (+) ACP
copy AA seq
copy Nt seq
  • BAX64252.1
  • iga11
 28670 - 29899 (+) ketosynthase
copy AA seq
copy Nt seq
  • BAX64253.1
  • iga12
 29900 - 31036 (+) ketosynthase
copy AA seq
copy Nt seq
  • BAX64254.1
  • iga13
 31033 - 31761 (+) ketoreductase
copy AA seq
copy Nt seq
  • BAX64255.1
  • iga14
 31761 - 33488 (+) flavin-dependent oxidoreductase
copy AA seq
copy Nt seq
  • BAX64256.1
  • iga15
 33544 - 34575 (+) alanine dehydrogenase
copy AA seq
copy Nt seq
  • BAX64257.1
  • iga16
 34687 - 35163 (+) MaoC dehydratase
copy AA seq
copy Nt seq
  • BAX64258.1
  • iga17
 35295 - 36614 (+) histidine kinse
copy AA seq
copy Nt seq
  • BAX64259.1
  • iga18
 36578 - 37222 (+) LuxR family regulator
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
iga3
Module ?
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
iga5
Module ?
Specificity: serine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: serine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
iga6
Module ?
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: isoleucine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.