BGC0001635: kistamicin A biosynthetic gene cluster from Nonomuraea sp. ATCC 55076
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Location: 11,980,264 - 12,029,697 nt. (total: 49,434 nt).
This entry is originally from NCBI GenBank CP017717.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001635
Short description kistamicin A biosynthetic gene cluster from Nonomuraea sp. ATCC 55076
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: CP017717.1
Compounds
  • kistamicin A
Species Nonomuraea sp. ATCC 55076 [taxonomy]
References
  • . Nazari B et al., Medchemcomm (2017) PMID:28626548
Chemical products information
kistamicin A
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C61H51Cl1N8O15
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BKM31_54095
  • AQZ69220.1
 11980264 - 11981403 (+) prephenate dehydrogenase
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  • BKM31_54100
  • AQZ69221.1
 11981410 - 11982063 (+) DNA-binding response regulator
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  • BKM31_54105
  • AQZ69222.1
 11982177 - 11982674 (+) hypothetical protein
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  • BKM31_54110
  • AQZ69223.1
 11982704 - 11983729 (+) hypothetical protein
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  • BKM31_54115
  • AQZ69224.1
 11983726 - 11984463 (+) ABC transporter ATP-binding protein
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  • BKM31_54120
  • AQZ69225.1
 11984460 - 11985710 (+) ABC transporter permease
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  • BKM31_54125
  • AQZ69226.1
 11985723 - 11986904 (-) two-component sensor histidine kinase
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  • BKM31_54130
  • AQZ71346.1
 11987134 - 11989041 (+) ABC transporter
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  • BKM31_54135
  • AQZ71347.1
 11989581 - 11994080 (+) hypothetical protein
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  • BKM31_54140
  • AQZ69227.1
 11994291 - 11998691 (+) hypothetical protein
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  • BKM31_54145
  • AQZ69228.1
 11998733 - 12009577 (+) hypothetical protein
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  • BKM31_54150
  • AQZ69229.1
 12009574 - 12014871 (+) hypothetical protein
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  • BKM31_54155
  • AQZ69230.1
 12014882 - 12015112 (+) MbtH family protein
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  • BKM31_54160
  • AQZ69231.1
 12015208 - 12016371 (+) hypothetical protein
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  • BKM31_54165
  • AQZ69232.1
 12016439 - 12017719 (+) cytochrome
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  • BKM31_54170
  • AQZ69233.1
 12017688 - 12019010 (-) GntR family transcriptional regulator
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  • BKM31_54175
  • AQZ69234.1
 12019192 - 12020280 (+) type III polyketide synthase
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  • BKM31_54180
  • AQZ69235.1
 12020274 - 12020951 (+) enoyl-CoA hydratase
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  • BKM31_54185
  • AQZ71348.1
 12021029 - 12022237 (+) enoyl-CoA hydratase
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  • BKM31_54190
  • AQZ69236.1
 12022234 - 12023049 (+) enoyl-CoA hydratase
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  • BKM31_54195
  • AQZ69237.1
 12023141 - 12024625 (+) tryptophan halogenase
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  • BKM31_54200
  • AQZ69238.1
 12024622 - 12025902 (+) cation/H(+) antiporter
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  • BKM31_54205
  • AQZ69239.1
 12026051 - 12027133 (+) 4-hydroxyphenylpyruvate dioxygenase
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  • BKM31_54210
  • AQZ69240.1
 12027130 - 12028278 (+) alpha-hydroxy-acid oxidizing enzyme
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  • BKM31_54215
  • AQZ71349.1
 12028876 - 12029697 (+) streptomycin biosynthesis protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
BKM31_54140
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Homology
BKM31_54145
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
BKM31_54150
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Homology
BKM31_54135
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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