LOCUS       BGC0001651             10711 bp    DNA     linear   BCT 30-APR-2015
DEFINITION  Tannerella forsythia 92A2, complete genome.
ACCESSION   BGC0001651
VERSION     BGC0001651
KEYWORDS    .
SOURCE      Tannerella forsythia 92A2
  ORGANISM  Tannerella forsythia 92A2
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae;
            Tannerella.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 03:14:02
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10711
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..693)
                     /codon_start=1
                     /locus_tag="BFO_1063"
                     /note="identified by match to protein family HMM PF02348"
                     /product="putative N-acylneuraminate cytidylyltransferase"
                     /protein_id="AEW21153.1"
                     /transl_table=11
                     /translation="MINTDKKILAVIPARGGSKGLPGKNIKLLHGKPLICYSIDAARGV
                     LSDEHICVSTDDKEIIQIVENYGLYVPFIRPDELATDRSSVNDVLLHALDFYKQRSIDY
                     DVVLLLQPTSPLRTSQDIEKAFSLYDDSIDMVVSVSISHAPSVLCKENQSGFVELMLNP
                     TAGRRQNIPVYYEYNGAIYIINPKSLREKGISNFEKKIKYIMPKHRSIDIDDQYDFMYA
                     ETILAYER"
     subregion       1..10711
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001651"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10711
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..693)
                     /locus_tag="BFO_1063"
     gene            complement(690..1727)
                     /locus_tag="BFO_1064"
     CDS             complement(690..1727)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 140.6; E-value:
                     9.7e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="BFO_1064"
                     /note="identified by match to protein family HMM PF00483"
                     /product="nucleotidyl transferase"
                     /protein_id="AEW21762.1"
                     /transl_table=11
                     /translation="MERFAKYLIEDTATIKDALVALNKLSIDPLTLFVINNNKVMTGTL
                     TDGDIRRWLVAGGSLEDCVREAMEKKFHFLEKKIDVNQVKYLRENQITLVPYLDSEGKV
                     VKIYDLKIKRSILPIDAVLMAGGKGERLRPLTEKVPKPLLPVGDKTIIDYNIERLLSYG
                     VEHISITVNYLREQIESHFKDKRENIQVECVREPTYLGTIGSVKFVPTFHHDTILVMNS
                     DLFTNIDYEEFYLHFRKYNADMSVAAVPYSHSVPYGVFELDGHDILGIKEKPVFNYYAN
                     AGIYLIKRSLIGLIPDNVYCDATDLMDLLIKRRKKIIRFPLMGFWVDIGKKEDYAKVRE
                     IAKYL"
     gene            complement(1728..2882)
                     /gene="neuC"
                     /locus_tag="BFO_1065"
     CDS             complement(1728..2882)
                     /EC_number="3.1.4.-"
                     /EC_number="5.1.3.-"
                     /codon_start=1
                     /gene="neuC"
                     /locus_tag="BFO_1065"
                     /note="identified by match to protein family HMM PF02350;
                     match to protein family HMM TIGR03568"
                     /product="UDP-N-acetyl-D-glucosamine 2-epimerase,
                     UDP-hydrolysing"
                     /protein_id="AEW22424.1"
                     /transl_table=11
                     /translation="MRKVCVVTGTRAEYGLLSRLMWLIRADHDLTLQIIATNMHLSPEF
                     GLTYKEIEADGFTIDKKVPMHKLADTSNGIVKSMAVELSGIADAYEELRPDLIVLLGDR
                     YEMLIAATAALVYKIPIAHIHGGEITEGAFDDAIRHAITKMSHLHFTSTEEYRRRVIQL
                     GEQPDRVFNVGSLGVENIKKMTLMSKDEIEKSLGFELNKKTVIATYHPVTLTKGNNRIE
                     MDEFLTALDEEKNIRVLFTMPNSDPEGTYISERISEFTTRNRERAIAFTSLGMKRYLSV
                     IKHVAAVIGNSSSGIIEAPSLRIPTLNIGDRQKGRVTCDSIISCYSDKDSIRKGLKKVL
                     SEEMAEIAKEVRNPYEKKKTAQSIFNVIKGYPLNDLAQKSFYNL"
     gene            complement(2879..3889)
                     /gene="neuB"
                     /locus_tag="BFO_1066"
     CDS             complement(2879..3889)
                     /EC_number="2.5.1.56"
                     /codon_start=1
                     /gene="neuB"
                     /locus_tag="BFO_1066"
                     /note="identified by match to protein family HMM PF03102;
                     match to protein family HMM PF08666; match to protein
                     family HMM TIGR03569"
                     /product="N-acetylneuraminate synthase"
                     /protein_id="AEW22517.1"
                     /transl_table=11
                     /translation="MNKTIIIAEAGVNHNGDIRIAKQLVDAAAMAGADYVKFQTFKTEA
                     LVSKDARKANYQQQNMFSTDDTSQYSMLKKLELSREHHYELVTYCNRKKIKFLSTPFDL
                     SSIDFLASLHLGLWKIPSGEITNYPYLKRIALWHEPVIFSTGMCEMTEIEEAMKVLLRN
                     GLTKEQLTVLHCNTEYPTPMRDVHLHAMKTIADQLGVKVGYSDHTLGIEIPIAAVALGA
                     CVIEKHFTLDREMDGPDHRASLEPKELTQMVSAIRNVEKALGGTEKKVSASEEKNRCIV
                     RKSIVAAYDIKKGDVFTEENLTVKRPGDGISPMQWEHVLGKEAKQDFATDDLIVL"
     gene            complement(3886..4065)
                     /locus_tag="BFO_1067"
     CDS             complement(3886..4065)
                     /codon_start=1
                     /locus_tag="BFO_1067"
                     /product="hypothetical protein"
                     /protein_id="AEW20712.1"
                     /transl_table=11
                     /translation="MVNGNCCVGEASFLGSQSVMVNGTSITDGCVIAAGSVVRKDIKIR
                     GIYSGNPALLKVRL"
     gene            complement(4518..5552)
                     /locus_tag="BFO_1068"
     CDS             complement(4518..5552)
                     /codon_start=1
                     /locus_tag="BFO_1068"
                     /note="identified by match to protein family HMM PF01522"
                     /product="polysaccharide deacetylase"
                     /protein_id="AEW21549.1"
                     /transl_table=11
                     /translation="MRETKLTIIMYHYIRDLKKSRYPRIKGLDIHLFKEQLEYLKKHYN
                     FVTIEQIIAAFDGKMDGENMLTGGGLPPNPVLLTFDDAYIDHFINVFPVLKKYHIQGAF
                     YPPVKAITEHRVLDVNKIHFILALTSEDKFPCLLNEIKQLLLKYQEEFDLRSFDYYFEK
                     LATANRFDNKETIFVKRLLQVELQEKLRKQITDELFANVVGIDEESFSHELYMNIDQLQ
                     CMADCGMHVGSHGYDHLWLGTLNKEQQKYEIEKSREFIQRINGNLNHWTISYPYGSYND
                     DTISLLKTYGCKLGLTTEVSLCSVSSVQDSIYKLPRLDTNDIPKDANAVVNKWYVESND
                     TNIA"
     gene            complement(5549..6484)
                     /locus_tag="BFO_1069"
     CDS             complement(5549..6484)
                     /codon_start=1
                     /locus_tag="BFO_1069"
                     /product="hypothetical protein"
                     /protein_id="AEW21992.1"
                     /transl_table=11
                     /translation="MSKEVLDFQHLNPLNQNYNFIIAVNNTTNEVDALLGFIPTYQYDK
                     ELFKEGDYWGAIWKVRTDVQNAEIKNLGLTIWEKLFELDNFQSWAAIGISEIAKKIYAI
                     SGMQIGELAHYYLPNINVKNFYIAEHVDVKQVSFPQYPGDIAIREVRIEQIQERIDCTY
                     RPRKSISYLKNRYLNHPFYKYCFWGIFDSERLVSIWTLRIIKMNKSRAIRIVDILGNIE
                     YLPCLSAELQKMLVDIGAEYMDILNYGINEEVFFNLGFLKLNPIGDVIIPNYFEPFERK
                     NIRIEFAYKADFNYVIFKGDSDQDRPNIIQ"
     gene            complement(6580..7575)
                     /gene="fabHA_2"
                     /locus_tag="BFO_1070"
     CDS             complement(6580..7575)
                     /EC_number="2.3.1.180"
                     /codon_start=1
                     /gene="fabHA_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 265.9; E-value: 7.2e-81)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="BFO_1070"
                     /note="identified by match to protein family HMM PF08541;
                     match to protein family HMM PF08545"
                     /product="beta-ketoacyl-acyl-carrier-protein synthase III"
                     /protein_id="AEW19766.1"
                     /transl_table=11
                     /translation="MEAYIKAISYYLPQKTVSNEQLAEEFPEWSVEKITSKIGVTQRHL
                     AAEDETATDMAISAAKRLFDEHCIDKKTIDFVLLCTQSPDYFLPTSSCIIQNELGLPTS
                     CGAVDYNLGCSGFIYGLSIAKGLIAIGVARNVLLITAETYNKHIHYKDKGNRAIFGDAA
                     SACLISTDGFAEIKDFSLGTDGRGAENLIVRTGAFRNKSPRNDLTFDSSGNPISGDYLY
                     MNGGEIFNFTAEVVPVLIEDVLKINQLTRDDIDLYVFHQANKYMINYLRKLLELPKDKF
                     YICLEETGNTVSSTIPIALYQAKKENKLLGNILLAGFGVGYSWGGVMLKI"
     gene            complement(7591..8340)
                     /locus_tag="BFO_1071"
     CDS             complement(7591..8340)
                     /NRPS_PKS="Domain: PKS_KR (11-166). E-value: 3.9e-15.
                     Score: 48.0. Matches aSDomain:
                     nrpspksdomains_BFO_1071_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     182.6; E-value: 1.6e-55)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="BFO_1071"
                     /note="identified by match to protein family HMM PF00106;
                     match to protein family HMM PF01370; match to protein
                     family HMM PF08659"
                     /product="oxidoreductase, short chain
                     dehydrogenase/reductase family protein"
                     /protein_id="AEW19840.1"
                     /transl_table=11
                     /translation="MEQNPFSLSNKTVLVTGASSGIGRAISIRCSEMGANIILTARNQS
                     RLQETLYQMSGKNHIELAADLTDKASMDNLVEQLPDLDGIVHCAGVNHRIVTKLIEPAD
                     IEQTISPNLVAPILLQTALLKAKKIKKEASIVFIASRAAYAPSVGNALYSASKGAMISY
                     AKVLALELAPRQIRVNCICPAMVLTNMISNIGFNHDKLNEAQQKYPLKRYGTPDDIAYL
                     SIYLLSSKSSWMTGSCIDITGGGEGVL"
     aSDomain        complement(7843..8307)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BFO_1071_PKS_KR.1"
                     /evalue="3.90E-15"
                     /label="BFO_1071_PKS_KR.1"
                     /locus_tag="BFO_1071"
                     /protein_end="166"
                     /protein_start="11"
                     /score="48.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGRAISIRCSEMGANIILTARNQSRLQETLYQMSG
                     KNHIELAADLTDKASMDNLVEQLPDLDGIVHCAGVNHRIVTKLIEPADIEQTISPNLVA
                     PILLQTALLKAKKIKKEASIVFIASRAAYAPSVGNALYSASKGAMISYAKV"
     CDS_motif       complement(8212..8307)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BFO_1071_0001"
                     /evalue="6.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="BFO_1071"
                     /protein_end="43"
                     /protein_start="11"
                     /score="12.5"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGRAISIRCSEMGANIILTARN"
     gene            complement(8340..8570)
                     /locus_tag="BFO_1072"
     CDS             complement(8340..8570)
                     /NRPS_PKS="Domain: PP-binding (5-72). E-value: 4.7e-11.
                     Score: 35.0. Matches aSDomain:
                     nrpspksdomains_BFO_1072_PP-binding.1"
                     /codon_start=1
                     /locus_tag="BFO_1072"
                     /product="hypothetical protein"
                     /protein_id="AEW20475.1"
                     /transl_table=11
                     /translation="MELKEFIERIADQFDDTDISEFVPTTNFKELEEWSSLTALAVLNM
                     IAKKYNVNIKNSDLLEINSIEELFNYVLSKQ"
     aSDomain        complement(8355..8555)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BFO_1072_PP-binding.1"
                     /evalue="4.70E-11"
                     /label="BFO_1072_PP-binding.1"
                     /locus_tag="BFO_1072"
                     /protein_end="72"
                     /protein_start="5"
                     /score="35.0"
                     /tool="antismash"
                     /translation="FIERIADQFDDTDISEFVPTTNFKELEEWSSLTALAVLNMIAKKY
                     NVNIKNSDLLEINSIEELFNYV"
     gene            complement(8574..9728)
                     /locus_tag="BFO_1073"
     CDS             complement(8574..9728)
                     /NRPS_PKS="Domain: Beta_elim_lyase (51-296). E-value:
                     1.4e-07. Score: 22.8. Matches aSDomain:
                     nrpspksdomains_BFO_1073_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     254.5; E-value: 2.8e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="BFO_1073"
                     /note="identified by match to protein family HMM PF01041"
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="AEW19965.1"
                     /transl_table=11
                     /translation="MESSYKKITDFIHDLYGAPEVPLHAPCFIGNEKKYLAECVDTTFV
                     SSVGQFVDRFEEKMAQYTGAARAVTCVNGTNALHLALLLVGVARGDEVLTQALTFIATC
                     NAIRYIDAHPVFLDVDQSTMGLSPDAMRDWLFRNAEMKDSQCFNKNTQRRIKACVPMHT
                     FGHPARIDEIAAVCEEYHIELVEDAAESLGSLYKGQHTGLFGRVGVISFNGNKTITTGG
                     GGMLLLNNEELGAQAKHLTTQAKVPHRWEFIHDRVGYNYRMPNINAALGCAQLEHLEEF
                     VLNKRETAEKYHAFFATIDDMDYFLEPENCRSNYWLNTILLKDRQAQQDFLQYTNAHGI
                     MTRPAWQLMNRLEMFKGCETDGLKHTQWLEERIVNIPSSVNLKK"
     aSDomain        complement(8841..9575)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BFO_1073_Beta_elim_lyase.1"
                     /evalue="1.40E-07"
                     /label="BFO_1073_Beta_elim_lyase.1"
                     /locus_tag="BFO_1073"
                     /protein_end="296"
                     /protein_start="51"
                     /score="22.8"
                     /tool="antismash"
                     /translation="VDRFEEKMAQYTGAARAVTCVNGTNALHLALLLVGVARGDEVLTQ
                     ALTFIATCNAIRYIDAHPVFLDVDQSTMGLSPDAMRDWLFRNAEMKDSQCFNKNTQRRI
                     KACVPMHTFGHPARIDEIAAVCEEYHIELVEDAAESLGSLYKGQHTGLFGRVGVISFNG
                     NKTITTGGGGMLLLNNEELGAQAKHLTTQAKVPHRWEFIHDRVGYNYRMPNINAALGCA
                     QLEHLEEFVLNKRETAEKYHAFF"
     gene            complement(9734..10711)
                     /locus_tag="BFO_1074"
     CDS             complement(9734..10711)
                     /NRPS_PKS="Domain: NAD_binding_4 (5-197). E-value: 2.6e-20.
                     Score: 64.4. Matches aSDomain:
                     nrpspksdomains_BFO_1074_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     274.8; E-value: 1.6e-83)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="BFO_1074"
                     /note="identified by match to protein family HMM PF00106;
                     match to protein family HMM PF01073; match to protein
                     family HMM PF01370; match to protein family HMM PF02719;
                     match to protein family HMM PF07993"
                     /product="NAD dependent epimerase/dehydratase family
                     protein"
                     /protein_id="AEW22543.1"
                     /transl_table=11
                     /translation="MQTILVTGADGFIGSHLTEMLLEEGHHVRALSYYNSFNDWGWLEG
                     LDHPELEVVTGDVRDPYFCKHLSKDVDTIFHLAALIAIPYSYIAPDSYVDTNIKGTLNI
                     CQAAKENGVKKVLITSTSETYGTAQYVPIDEKHPKQPQSPYSATKIAADAMAMSFYNTF
                     ELPVIVVRPFNTYGPRQSARAIIPTIITQIMSGMKEIRLGDLSPTRDFNYVKDTCRGFI
                     ELSNCDQAIGQEINICSNYEISMRDTFELVARLMLADVKFIEDAQRLRPAGSEVFRLWG
                     DNTKLKSLTGFTPSYSIEEGLKETIEWFKNDKNLVKYKSGIYNV"
     aSDomain        complement(10121..10696)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BFO_1074_NAD_binding_4.1"
                     /evalue="2.60E-20"
                     /label="BFO_1074_NAD_binding_4.1"
                     /locus_tag="BFO_1074"
                     /protein_end="197"
                     /protein_start="5"
                     /score="64.4"
                     /tool="antismash"
                     /translation="VTGADGFIGSHLTEMLLEEGHHVRALSYYNSFNDWGWLEGLDHPE
                     LEVVTGDVRDPYFCKHLSKDVDTIFHLAALIAIPYSYIAPDSYVDTNIKGTLNICQAAK
                     ENGVKKVLITSTSETYGTAQYVPIDEKHPKQPQSPYSATKIAADAMAMSFYNTFELPVI
                     VVRPFNTYGPRQSARAIIPTIITQIMSGM"
ORIGIN
        1 ctaacgttca taagctaaaa ttgtttctgc atacataaaa tcatattgat cgtcaatatc
       61 aatagatcga tgcttgggca taatgtactt tattttcttt tcaaagtttg aaatcccttt
      121 ttctcgtaaa gacttcggat tgatgatata gattgctcca ttatattcgt aataaacagg
      181 tatgttttgg cgtcttcctg cggtcggatt cagcatcaac tccacaaaac cggattggtt
      241 ctctttacat aaaacagaag gagcgtgtga tatgctaacg gatacgacca tatcgatgga
      301 gtcgtcgtac aagctgaacg ccttttctat atcttgagat gttcttagag gagaagtcgg
      361 ttgaagcaat aaaacaacat cgtaatcgat acttctctgt ttgtaaaaat caagagcatg
      421 taagagcaca tcattaacgg aagacctgtc agttgctaat tcgtccggac gaataaaagg
      481 aacgtataaa ccataatttt ctacaatctg aatgatctct ttatcgtccg tagagacaca
      541 gatatgctca tccgataaaa ctcctcttgc agcatcaata gaataacaaa tcaaaggttt
      601 tccgtgcaaa agtttgatgt ttttaccggg tagtcctttg ctcccccctc ttgccggaat
      661 tacagccaaa atctttttat ccgtatttat catagatatt tagcgatctc tcgtactttc
      721 gcgtaatctt cttttttacc aatatcaacc caaaaaccca ttaaaggaaa acggataatt
      781 ttctttcttc tttttatcaa taaatccatc aaatcagttg catcacagta tacattatcc
      841 ggtattaatc cgataagaga tctcttgatt aaatatatac cagcattggc atagtaatta
      901 aaaaccggtt tctcttttat tcccagaata tcatggccat ccaactcaaa cacgccataa
      961 gggacggaat gtgaatacgg aacggctgca acagacatgt cggcattata tttacgaaaa
     1021 tgcagataaa actcttcata atcgatgttc gtgaataagt ctgaattcat gactaagatg
     1081 gtatcatggt gaaaagtcgg aacaaatttc accgaaccaa tcgttcctaa ataggttggt
     1141 tctcgtacac attccacttg tatgttttct cgtttatcct taaaatgaga ctctatttgt
     1201 tctctcagat agtttacagt gatagagata tgttctacgc cataagaaag aagacgttca
     1261 atattatagt cgataatggt tttgtcacca acgggaagaa gaggcttcgg cactttttcc
     1321 gttaaagggc gcaatcgttc gcctttccct cctgccataa gcacagcgtc aatcggcaaa
     1381 attgatcttt ttatttttag atcatatatt tttacgacct ttccttcaga atccaaatat
     1441 gggactaatg tgatttgatt ttcccttaaa tacttaacct gattgacatc tatttttttc
     1501 tcaagaaaat ggaatttttt ctccattgct tcccgcacac aatcctctaa agagccgcct
     1561 gcaactaacc atctgcgaat atccccatca gttaatgtcc cggtcataac tttattgtta
     1621 ttgataacaa ataaggtcag gggatcaata gaaagtttgt tcaatgcgac caacgcatct
     1681 tttattgttg cggtatcttc aatcagatac tttgcaaatc tttccattca aagattgtaa
     1741 aaagattttt gagccaaatc atttaacggg taacctttaa tcacattaaa aatcgattgt
     1801 gccgtttttt ttttctcata cggattacga acctctttcg cgatttcagc catctcttcc
     1861 gataagactt ttttaagtcc ctttcttata gagtctttat cgctatagca gcttataatg
     1921 ctatcacaag tcacccgacc tttctgacgg tcaccaatat tcagtgtagg gattctcaat
     1981 gaaggagctt caataattcc actcgatgag tttccaatga cagccgcaac atgctttatc
     2041 acagataaat atcgtttcat tcccaatgat gtgaaagcga tagcacgttc tctatttctt
     2101 gtcgtgaatt cgctgatcct ctctgagatg tatgttccct ccggatcgga gttaggcatt
     2161 gtaaaaagaa cacgtatgtt tttttcttca tccaatgccg taagaaattc atccatttct
     2221 attcgattgt ttccttttgt caatgttaca ggatgatacg tcgcaataac agtcttttta
     2281 ttcaattcaa aacctaatga tttttcgatt tcatctttac tcatcaaagt catcttcttg
     2341 atgttttcaa cgccaagaga accaacatta aagacacggt ccggttgctc gccaagttga
     2401 atgacacgtc tgcgatattc ctccgtagaa gtaaaatgca aatggctcat tttcgtaatt
     2461 gcatgacgga tggcgtcatc gaatgctcct tccgtaattt ctcctccatg gatgtgagct
     2521 atcgggatct tatagactaa cgctgccgta gctgcaatca acatttcgta tcgatcgcca
     2581 agtaagacga ttaaatccgg tctcaattct tcataagcat ctgcgatacc tgaaagttct
     2641 actgccatag actttacaat accattactc gtgtcagcaa gcttgtgcat cggcaccttt
     2701 ttatcaatag taaaaccatc cgcttctatt tctttatagg tcagaccaaa ctccggagac
     2761 agatgcatat tagtcgcaat gatctgaagc gttaaatcat gatccgcccg gataagccac
     2821 atcaagcggc ttaacaggcc atattcggca cgggttcctg taacaacaca aaccttcctc
     2881 ataatacgat taaatcatcc gtcgcaaagt cttgcttcgc ttctttccct aagacatgtt
     2941 cccattgcat cggcgaaatg ccgtctcccg gacgcttcac agtgagattc tcttctgtaa
     3001 agacgtctcc ttttttaatg tcgtatgccg caacgatgct ctttcgaaca atacatctgt
     3061 ttttctcttc cgatgcactg actttcttct ctgtgcctcc taatgctttc tctacattcc
     3121 gaatggctga caccatttgg gtaagttctt tcggctccaa ggacgctcta tgatccggtc
     3181 cgtccatctc tcggtcgagt gtaaaatgtt tctcgatgac acatgctcca agtgcaacgg
     3241 ccgcaatggg tatctcaatc cccaaagtat gatccgaata tcctacttta actcctaatt
     3301 gatctgcgat tgttttcatt gcgtgcaaat gcacatcgcg catcggcgtg ggatattccg
     3361 tattacaatg cagcacggtt agttgttctt tcgtcaatcc gtttcgtaat aagaccttca
     3421 tagcctcttc tatttctgtc atttcgcaca tacctgtaga aaaaatcaca ggttcatgcc
     3481 acaatgcaat cctctttaaa tacggataat tcgttatttc tccggacggg attttccata
     3541 aacccaaatg cagcgaagcc aagaaatcga tgcttgacaa atcgaatgga gtggaaagaa
     3601 actttatttt tttccggtta caatatgtga ctaattcgta gtggtgctct ctggacaatt
     3661 ccagcttctt caacatcgaa tattgcgagg tatcgtcagt cgaaaacata ttctgttgtt
     3721 gatagtttgc ttttcgggca tcttttgaaa cgagcgcctc agtcttaaat gtctgaaact
     3781 tcacataatc agcccctgcc attgctgcag catcgaccaa ttgcttggca atccgtatat
     3841 cgccattatg atttacacca gcttctgcaa tgatgatagt tttattcata gtctgacttt
     3901 taataaagcg ggatttcctg agtagatacc tcttattttt atatcttttc ttacgacaga
     3961 tcccgcagca atcacgcacc cgtccgtaat gcttgttcca tttaccatta ccgactgact
     4021 gcccaaaaaa gaagcttctc ctacacaaca atttccattt accattgttc ccgtagacac
     4081 atgtgcgtaa tctcctatta cagaatcatg ctctatgttc gcaaatgtat ttataataca
     4141 ccctctccca atgcagacat ctgcatttac taccgcctgg tgcatgatta cggagccttc
     4201 tcctatatca gcatagcgag aaataatagc cgtaggagag atgagggtag ctaatgttcc
     4261 atttttgcgg aggacctttt catgtaactt tatccgcaaa gaagcatcct ttatatgacc
     4321 gacggtaaca ataaaagaag cataatcgat gagtctgcaa atatcctcat ccgtaccaat
     4381 aacttcataa ttaagtactt tcccccctat atgttctgcc gtatccaaaa ttccaagaat
     4441 acgaaaccct gcagattcag caacatttat aacagatttg caatgccccc cacctccaat
     4501 aagaacgata ctccggttca tgcgatgttt gtatcattag attccacata ccatttattg
     4561 acaacggcat ttgcatcttt cgggatatca ttggtatcta accgaggtaa tttgtagatc
     4621 gaatcttgta cagaagatac ggaacataga gaaacttccg tcgttagccc taacttacat
     4681 ccatatgtct ttaataaaga aatggtatca tcattataac ttccataagg ataagaaatc
     4741 gtccaatggt ttaaattgcc atttattcgt tgtatgaatt ctcttgattt ctcaatttcg
     4801 tatttttgct gttccttatt cagcgtccct aaccacaaat gatcatatcc gtgactccca
     4861 acatgcatac cacagtctgc catacattga agctgatcaa tgttcatata caattcatga
     4921 ctgaaagatt cctcatctat acccacaaca ttggcgaata actcgtctgt tatttgcttt
     4981 cgtaattttt cctgtaattc aacttgcaat aaacgcttta caaaaatagt ctctttgttg
     5041 tcaaatctat ttgcggttgc aagtttctca aagtaataat caaatgatct taaatcaaac
     5101 tcttcttgat atttcaacag caattgcttt atttcattga gcaaacaggg gaatttgtct
     5161 tctgaagtta atgccaagat aaagtgtatt ttgtttacat ccaatactct gtgctccgtt
     5221 attgctttca caggcggata aaaagcgcct tgtatatgat acttcttaag aacaggaaaa
     5281 acatttataa aatgatctat ataagcatca tcaaaagtca gcagaacagg attagggggc
     5341 aagccccccc ccgttaacat attttcacca tccatcttgc catcaaatgc tgcaataatt
     5401 tgttctatcg taacaaagtt gtaatgcttc ttcaaatatt ccaactgttc tttaaacaaa
     5461 tgaatatcta aacctttaat tcgaggatat cgcgatttct ttaaatcacg aatataatga
     5521 tacattatta tcgtcagttt agtctctctc attgtataat attaggtcga tcttgatcag
     5581 aatcaccttt aaaaattaca tagttaaaat ccgctttgta tgcaaattca attcttatat
     5641 tctttctttc aaacggttcg aaataatttg gaataatcac atctccgatt ggattcaact
     5701 taagaaatcc aaggttaaaa aagacctctt cgtttattcc gtaattaagg atatccatat
     5761 attcagcccc aatatctacc aacatttttt gtaattcagc cgacaagcaa gggagatatt
     5821 cgatatttcc taatatatcg acaatcctaa tcgccctcga tttattcatt tttatgattc
     5881 gtaaagtcca tatcgataca agtcgttctg aatcaaaaat tccccaaaag caatatttat
     5941 aaaaaggatg atttaagtat cgatttttca agtatgaaat tgatttcctc ggccgataag
     6001 tacagtcaat cctttcttgt atctgctcta tacgaacttc cctaatcgca atatctccgg
     6061 gatattgggg gaacgatact tgttttacat ctacatgttc agcaatataa aaattcttga
     6121 catttatatt aggcaagtaa taatgtgcca actctccgat ctgcataccg gaaattgcat
     6181 aaattttttt agcaatttca ctaatgccta tagccgccca agattggaaa ttatctaatt
     6241 caaataattt ctcccaaata gtaagaccta aatttttaat ttcggcattt tgtacatctg
     6301 tgcgcacttt ccaaatggcc ccccaataat ctccttcctt aaaaagctct ttgtcatatt
     6361 gatatgtcgg tataaaacct aataaagcgt caacttcgtt agtcgtatta ttaaccgcaa
     6421 taataaaatt atagttttga tttaacggat ttaaatgctg gaaatcaagc acttctttag
     6481 acaagcctaa gatgtgattt tgtttccaat gcttcttgat aaaagattgg atttttaggg
     6541 aatcactgtt ttctgcgtat ttaactgtgt aaatcattat tatatcttca acattactcc
     6601 tccccaagaa tatccaacac caaacccggc taacagtata ttacctaata acttattttc
     6661 tttctttgcc tgatataaag caatcggtat cgttgaggat accgtattcc ccgtttcttc
     6721 caaacatata tagaatttgt ctttaggcaa ctcaagcaat tttctcagat aatttatcat
     6781 atatttattt gcttgatgga atacatatag atcaatatca tctcgagtta gttgatttat
     6841 tttcaacaca tcctcaataa gaacgggaac aacctccgca gtaaaattaa agatttcacc
     6901 tccattcata tacagataat ctccggatat cggattccct gaactgtcaa aagtcagatc
     6961 gtttcggggg cttttattac ggaatgcccc tgttcttacg attaagtttt ccgccccacg
     7021 tccatccgtg cctaagctaa aatcctttat ttctgcaaat ccatcagtag atattagaca
     7081 tgcagaagca gcatctccaa aaatagctct gtttccttta tctttatagt gaatatgttt
     7141 attgtatgtt tccgccgtaa ttagcagcac attacgagcg actcctatcg caattaaccc
     7201 tttagcaata gataaaccat aaatgaaacc agagcatccc aaattgtaat ctacagcccc
     7261 acatgacgtc ggaagcccta actcgttctg aataatgcag gaagacgtgg gtaaaaaata
     7321 atccgggctt tgggtacaga gtaatacaaa atcaatcgtt tttttatcta tacaatgctc
     7381 atcaaagagt ctcttcgccg ctgatatcgc catgtctgtt gctgtttcat cttctgccgc
     7441 aagatgccgt tgagtcaccc caattttact tgttatcttc tctacagacc attccggaaa
     7501 ctcttcggcc aactgctcat ttgagactgt cttttggggt aaataatacg atatcgcttt
     7561 tatatacgct tccatctgtt gatacttacg ttataagaca ccttctcctc ctcccgttat
     7621 atcaatacag ctccccgtca tccacgaact tttggaggac aataaataaa tagacaaata
     7681 ggcgatatca tcgggtgtgc cataacgttt caatggatat ttctgctgcg cttcatttag
     7741 tttgtcatga ttaaaaccga tatttgatat catattcgtt aaaaccatgg caggacaaat
     7801 acaattcacc ctaatttgac gaggcgcgag ttctaaagcc aatacttttg catacgatat
     7861 catcgctcct tttgaggcgc tgtataaagc attcccgaca ctgggtgcat aagctgcacg
     7921 agaagcaatg aagacaatag acgcttcttt ttttattttt tttgccttca aaagagctgt
     7981 ttgcaacaag atcggagcaa caagattcgg agagattgtt tgttcaatgt cagcaggctc
     8041 aattaacttt gttacaatcc tatgattaac gcctgcacaa tgtactattc catctaaatc
     8101 gggaagctgt tccactaaat tatccattga tgctttgtca gtcaaatcgg cggcaagttc
     8161 tatgtgattt ttgcctgaca tttggtataa tgtctcttgc aaacgactct ggttacgtgc
     8221 agttaaaatt atatttgccc ccatttcaga acatcgtatg gatattgctc gcccaatacc
     8281 ggacgacgct cccgtaacta acaccgtttt atttgacaaa gaaaatggat tttgttccat
     8341 tattgcttag acagaacata attaaacaat tcctcaatag agttgatctc taacaaatca
     8401 ctgtttttta tatttacgtt gtatttttta gcaatcatgt ttaaaacagc taaagctgtt
     8461 aatgaagacc attcttccaa ttctttaaaa ttagtagttg gtacgaattc actaatgtct
     8521 gtatcatcaa attggtctgc aattctttca ataaactctt ttaattccat aattcacttt
     8581 ttcagattta cactactagg gatatttacg attcgttctt cgagccattg tgtatgtttc
     8641 aagccatcgg tttcgcatcc tttaaacatt tccaatcgat tcataagctg ccatgcaggg
     8701 cgtgtcatga tgccatgggc gttcgtatac tgcaaaaaat cctgttgagc ttgtctgtct
     8761 ttcaacagga tggtgtttaa ccaataattc gatcgacagt tttcaggttc gaggaaataa
     8821 tccatatcat ctattgtcgc aaaaaacgcg tgatattttt cggccgtttc acgtttattc
     8881 aggacgaatt cttccaaatg ctctaattgc gcacatccca atgccgcatt gatattaggc
     8941 atacgataat tatagccgac cctgtcgtga ataaactccc aacgatgagg cactttcgcc
     9001 tgtgtcgtaa gatgcttggc ttgagctccc aattcttcgt tattcaataa taacattccg
     9061 ccaccaccgg tcgtgatcgt cttgtttccg ttaaaactaa tcacgccgac acgcccgaaa
     9121 agtccggtat gctgtccttt atatagacta ccaaggcttt ctgccgcatc ttcaactaat
     9181 tcgatatgat actcttcaca aacagccgca atttcatcga ttcttgcagg atgcccgaat
     9241 gtatgcatcg gcacacaggc ttttatccga cgttgggtgt ttttgttaaa gcactgcgaa
     9301 tctttcattt ccgcatttct gaagagccaa tcacgcatcg catccggcga aagtcccata
     9361 gtcgattgat caacatctaa gaagaccggg tgtgcatcga tataacgtat ggcattacat
     9421 gtggcgataa acgtaagcgc ttgagtcaag acttcgtctc ctcgcgctac tccgacaagc
     9481 aacagcgcca gatgcaaggc attggtgccg ttcacacaag taacagccct tgccgctccg
     9541 gtatattggg ccatcttttc ctcaaatcta tcaacaaatt gacctacgct ggatacaaat
     9601 gtcgtgtcaa cacattcggc caaatatttt ttttcatttc caataaaaca aggtgcatga
     9661 agaggaactt ccggagctcc gtataaatca tgaataaaat ctgttatttt cttatagctg
     9721 ctctccatag acgctacacg ttgtatatcc cggatttata tttcactaag ttcttgtcat
     9781 tcttaaacca ctcgatcgtt tctttaagtc cttcttcaat cgagtatgaa ggggtaaatc
     9841 cggtaagaga ctttaatttc gtattgtctc cccataaacg gaagacttca gaacctgcag
     9901 gacgcagacg ttgtgcatct tcaatgaatt ttacatctgc caacatgagt cgggctacca
     9961 gctcaaatgt atcacgcatg gatatctcat agttgctgca aatattgatt tcctgtccga
    10021 tagcctggtc acaattcgaa agttcgataa accctctgca agtatctttg acataattaa
    10081 agtcacgagt agggcttaga tcacccagtc gtatctcttt cattccactc ataatctgcg
    10141 ttatgatagt agggatgatg gctcgtgccg attggcgagg cccatacgta ttgaaagggc
    10201 gcacaacgat caccggcagt tcgaacgtat tgtaaaagct catcgccatg gcatcggccg
    10261 caatcttcgt tgccgaatag ggcgattgcg gttgcttcgg atgcttctca tcgatcggca
    10321 catattgcgc tgtgccgtac gtttcggaag tcgaagttat tagcaccttc ttcactccat
    10381 tttcttttgc tgcctgacag atattcaatg tccctttgat atttgtatct acgtagctgt
    10441 cgggagctat atacgaataa gggattgcga tgagggcagc cagatgaaaa atcgtatcca
    10501 catctttcga taggtgttta caaaagtacg ggtcgcgtac atcacccgtc accacttcca
    10561 actcaggatg atccaatcct tcaagccatc cccagtcatt aaatgaatta tagtaagaca
    10621 acgctcgtac atgatgacct tcctccaata acatttccgt taagtgagaa ccgataaatc
    10681 catctgctcc ggtaactagt attgtttgca t
//
