BGC0001728: paenilipoheptin biosynthetic gene cluster from Paenibacillus polymyxa E681
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Location: 2,550,215 - 2,616,852 nt. (total: 66,638 nt).
This entry is originally from NCBI GenBank NC_014483.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001728
Short description paenilipoheptin biosynthetic gene cluster from Paenibacillus polymyxa E681
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: NC_014483.2
Compounds
  • paenilipoheptin
Species Paenibacillus polymyxa E681 [taxonomy]
References
Chemical products information
paenilipoheptin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PPE_RS11400
  • WP_013310324.1
 2550215 - 2551684 (+) efflux RND transporter periplasmic adaptor subunit
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  • PPE_RS11405
  • WP_013310325.1
 2551681 - 2552418 (+) ABC transporter ATP-binding protein
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  • PPE_RS11410
  • WP_013310326.1
 2552415 - 2553629 (+) ABC transporter permease
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  • PPE_RS11415
 2553739 - 2554505 (+) polysaccharide deacetylase
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  • PPE_RS11420
  • WP_013310330.1
 2554546 - 2555022 (+) RNA polymerase sigma factor
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  • PPE_RS11425
  • WP_013310331.1
 2555264 - 2556865 (+) alpha-amylase family glycosyl hydrolase
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  • PPE_RS11430
  • WP_013310332.1
 2557229 - 2557981 (-) HAD family phosphatase
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  • PPE_RS11435
  • WP_013310333.1
  • gutB1
 2558011 - 2559060 (-) 2-amino-2-deoxy-D-mannitol dehydrogenase GutB1
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  • PPE_RS11440
  • WP_013310334.1
 2559094 - 2560332 (-) aspartate aminotransferase family protein
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  • PPE_RS11445
  • WP_013310335.1
 2560531 - 2561739 (-) MFS transporter
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  • PPE_RS11450
  • WP_013310336.1
 2562136 - 2563044 (+) AraC family transcriptional regulator
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  • PPE_RS11455
  • WP_013310337.1
 2563162 - 2564226 (+) Gfo/Idh/MocA family oxidoreductase
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  • PPE_RS11460
  • WP_013310338.1
 2564658 - 2567498 (+) alpha-amylase family glycosyl hydrolase
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  • PPE_RS11465
  • WP_013310339.1
 2568064 - 2568849 (+) S-layer homology domain-containing protein
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  • PPE_RS11470
  • WP_013310340.1
  • fabD
 2569479 - 2570699 (+) ACP S-malonyltransferase
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  • PPE_RS11475
  • WP_013310341.1
 2570674 - 2576763 (+) aminotransferase class III-fold pyridoxal phosphate-dependent enzyme
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  • PPE_RS11480
  • WP_013310342.1
 2577404 - 2586283 (+) non-ribosomal peptide synthetase
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  • PPE_RS24095
  • WP_013310343.1
 2586307 - 2590932 (+) non-ribosomal peptide synthetase
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  • PPE_RS24100
  • WP_043882190.1
 2590965 - 2611964 (+) non-ribosomal peptide synthetase
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  • PPE_RS11495
  • WP_013310345.1
 2612245 - 2613630 (-) MFS transporter
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  • PPE_RS11500
  • WP_043882191.1
 2613741 - 2614628 (+) LysR family transcriptional regulator
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  • PPE_RS11505
  • WP_013310347.1
 2614796 - 2615068 (-) helix-turn-helix transcriptional regulator
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  • PPE_RS25760
 2615268 - >2615417 (+) beta-galactosidase
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  • PPE_RS11515
  • WP_013310350.1
 2615674 - 2616015 (-) helix-turn-helix transcriptional regulator
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  • PPE_RS11520
 2616137 - >2616427 (+) arginase family protein
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  • PPE_RS11525
 2616460 - 2616852 (+) glycoside hydrolase family 26 protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
PPE_RS11480
Module ?
Specificity: serine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
PPE_RS24095
Module ?
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
PPE_RS24100
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
Module ?
Specificity: valine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
Module ?
Specificity: glutamic acid
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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