BGC0001737 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001737 (Corallococcus coralloides)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	53,488	phenalamide A2	NRP + Polyketide	83%

BGC0001737 - Region 1 - NRPS,T1PKS

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Location: 1 - 53,488 nt. (total: 53,488 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 53,489
Label		BGC0001737

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001737.1	1.06	NRP, Polyketide	phenalamide	Corallococcus coralloides
BGC0001394.1	0.72	NRP, Polyketide	phenalamide A2	Myxococcus stipitatus DSM 14675
BGC0001187.1	0.54	NRP, Polyketide	xenolozoyenone	Glarea lozoyensis
BGC0001164.1	0.53	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001235.1	0.51	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001273.1	0.48	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001022.1	0.48	NRP, Polyketide	myxalamid	Stigmatella aurantiaca
BGC0001874.1	0.48	NRP, Polyketide	cyclopiazonic acid	Aspergillus flavus
BGC0001276.1	0.48	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001844.1	0.47	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001737.1	0.93	NRP, Polyketide	phenalamide	Corallococcus coralloides
BGC0001394.1	0.81	NRP, Polyketide	phenalamide A2	Myxococcus stipitatus DSM 14675
BGC0001535.1	0.68	Other	branched-chain fatty acids	Streptomyces filamentosus
BGC0001164.1	0.68	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001022.1	0.65	NRP, Polyketide	myxalamid	Stigmatella aurantiaca
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000041.1	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 53488:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-ccmal) + (Me-ccmal) + (Me-ccmal) + (pk - pk - ccmal) + (Me-redmal) + (ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

phaG

PKS_AT (533..829): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 83.3%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.6
Ethylmalonyl-CoA: 178.4
Methoxymalonyl-CoA: 154.0
Isobutyryl-CoA: 134.4
Benzoyl-CoA: 124.2
Malonyl-CoA: 112.5
2-Methylbutyryl-CoA: 103.3
Acetyl-CoA: 91.2
Propionyl-CoA: 90.1
trans-1,2-CPDA: 89.5
CHC-CoA: 72.8
3-Methylbutyryl-CoA: 51.6
fatty_acid: 36.1
inactive: 29.2

phaF

PKS_AT (558..853): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.9
Ethylmalonyl-CoA: 179.3
Methoxymalonyl-CoA: 151.6
Isobutyryl-CoA: 114.3
Malonyl-CoA: 103.5
Benzoyl-CoA: 94.7
2-Methylbutyryl-CoA: 92.9
trans-1,2-CPDA: 92.4
Propionyl-CoA: 89.6
CHC-CoA: 76.0
fatty_acid: 65.6
Acetyl-CoA: 65.6
3-Methylbutyryl-CoA: 40.5
inactive: 22.5

phaE

PKS_AT (560..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 83.3%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 180.4
Ethylmalonyl-CoA: 151.6
Methoxymalonyl-CoA: 139.7
Malonyl-CoA: 108.9
Isobutyryl-CoA: 108.1
Benzoyl-CoA: 89.7
trans-1,2-CPDA: 85.7
2-Methylbutyryl-CoA: 81.8
Acetyl-CoA: 70.6
Propionyl-CoA: 63.2
CHC-CoA: 57.5
3-Methylbutyryl-CoA: 51.4
inactive: 24.8
fatty_acid: 19.8

phaD

PKS_AT (567..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 181.1
Ethylmalonyl-CoA: 163.5
Methoxymalonyl-CoA: 138.0
Malonyl-CoA: 104.6
Isobutyryl-CoA: 90.6
trans-1,2-CPDA: 86.4
Benzoyl-CoA: 86.2
Acetyl-CoA: 77.3
2-Methylbutyryl-CoA: 74.0
Propionyl-CoA: 58.2
CHC-CoA: 55.0
3-Methylbutyryl-CoA: 47.6
inactive: 37.5
fatty_acid: 20.3

phaC

PKS_AT (561..859): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; Methylmalonyl-CoA: 83.3%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 144.1
Malonyl-CoA: 128.2
Ethylmalonyl-CoA: 122.9
Methoxymalonyl-CoA: 109.7
Acetyl-CoA: 94.4
Isobutyryl-CoA: 86.9
2-Methylbutyryl-CoA: 83.1
Benzoyl-CoA: 80.2
Propionyl-CoA: 61.4
trans-1,2-CPDA: 56.6
CHC-CoA: 37.6
inactive: 35.2
3-Methylbutyryl-CoA: 33.3
fatty_acid: 28.5

PKS_AT (2370..2666): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 141.6
Methoxymalonyl-CoA: 129.0
Malonyl-CoA: 125.6
Isobutyryl-CoA: 122.5
Ethylmalonyl-CoA: 108.1
Acetyl-CoA: 77.0
Propionyl-CoA: 70.5
2-Methylbutyryl-CoA: 70.4
Benzoyl-CoA: 68.8
3-Methylbutyryl-CoA: 67.0
trans-1,2-CPDA: 62.2
inactive: 54.5
CHC-CoA: 50.0
fatty_acid: 35.0

PKS_AT (3890..4183): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.1
inactive: 165.7
Methoxymalonyl-CoA: 87.2
Methylmalonyl-CoA: 80.8
Propionyl-CoA: 70.1
Ethylmalonyl-CoA: 55.8
2-Methylbutyryl-CoA: 48.8
Isobutyryl-CoA: 41.1
CHC-CoA: 37.7
Benzoyl-CoA: 33.7
trans-1,2-CPDA: 30.3
Acetyl-CoA: 26.2
3-Methylbutyryl-CoA: 20.1
fatty_acid: 12.3

phaB

PKS_AT (569..867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 180.2
Ethylmalonyl-CoA: 158.6
Methoxymalonyl-CoA: 144.1
Malonyl-CoA: 107.7
Isobutyryl-CoA: 100.9
2-Methylbutyryl-CoA: 100.4
trans-1,2-CPDA: 91.8
Propionyl-CoA: 85.8
Benzoyl-CoA: 84.5
CHC-CoA: 79.1
Acetyl-CoA: 72.1
fatty_acid: 49.3
3-Methylbutyryl-CoA: 39.8
inactive: 26.2

phaA

Search NORINE for peptide: strict or relaxed

AMP-binding (541..931): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)