BGC0001792: surugamide A biosynthetic gene cluster from Streptomyces albidoflavus
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Location: 3,888,752 - 3,971,215 nt. (total: 82,464 nt).
This entry is originally from NCBI GenBank CP004370.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001792
Short description surugamide A biosynthetic gene cluster from Streptomyces albidoflavus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CP004370.1
Compounds
  • surugamide A
  • surugamide D
Species Streptomyces albidoflavus [taxonomy]
References
Chemical products information
surugamide A
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C48H81N9O8
Chemical database entries
NPAtlas
surugamide D
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C47H79N9O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XNR_3438
  • AGI89780.1
 3888752 - 3889462 (+) ABC transporter permease
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  • XNR_3439
  • AGI89781.1
 3889459 - 3890220 (+) ABC transporter permease
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  • XNR_3440
  • AGI89782.1
 3890301 - 3891290 (+) Amino acid ABC transporter amino acid-binding protein
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  • XNR_3441
  • AGI89783.1
 3891563 - 3892783 (+) Secreted protein
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  • XNR_3442
  • AGI89784.1
 3893050 - 3894624 (+) major facilitator superfamily permease
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  • XNR_3443
  • AGI89785.1
 3894724 - 3895032 (+) Hypothetical protein
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  • XNR_3444
  • AGI89786.1
 3895094 - 3895705 (+) TetR family transcriptional regulator
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  • XNR_3445
  • AGI89787.1
 3895714 - 3897060 (+) Drug resistance transporter EmrB/QacA subfamily protein
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  • XNR_3446
  • AGI89788.1
 3897105 - 3909449 (-) Nonribosomal peptide synthetase
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  • XNR_3447
  • AGI89789.1
 3909503 - 3932578 (-) Nonribosomal peptide synthetase
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  • XNR_3448
  • AGI89790.1
 3932743 - 3945540 (-) ATP-dependent valine adenylase
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  • XNR_3449
  • AGI89791.1
 3945597 - 3962798 (-) Nonribosomal peptide synthetase
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  • XNR_3450
  • AGI89792.1
 3962919 - 3964274 (-) Alpha/beta hydrolase MppK
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  • XNR_3451
  • AGI89793.1
 3964523 - 3965620 (-) putative membrane protein
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  • XNR_3452
  • AGI89794.1
 3965830 - 3966246 (-) Transcriptional regulator, GntR family
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  • XNR_3453
  • AGI89795.1
 3966342 - 3966713 (+) Hypothetical protein
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  • XNR_3454
  • AGI89796.1
 3966710 - 3967651 (+) ABC transporter ATP-binding protein
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  • XNR_3455
  • AGI89797.1
 3967648 - 3968445 (+) ABC transport system membrane protein
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  • XNR_3456
  • AGI89798.1
 3968509 - 3968766 (-) MbtH domain-containing protein
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  • XNR_3457
  • AGI89799.1
 3968942 - 3969751 (-) LipE
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  • XNR_3458
  • AGI89800.1
 3969788 - 3971215 (-) Succinate-semialdehyde dehydrogenase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
XNR_3446
Module ?
Specificity: isoleucine / valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
XNR_3447
Module ?
Specificity: isoleucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
XNR_3448
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
XNR_3449
Module ?
Specificity: isoleucine / valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: isoleucine / valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: allo-isoleucine / valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
  • Switch to GenBank accessions
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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