LOCUS       BGC0001793             22998 bp    DNA     linear   PLN 27-APR-2017
DEFINITION  Chaetothyriaceae sp. swainsonine biosynthesis gene cluster, complete
            sequence.
ACCESSION   BGC0001793
VERSION     BGC0001793
KEYWORDS    .
SOURCE      Chaetothyriaceae sp
  ORGANISM  Chaetothyriaceae sp.
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Chaetothyriomycetidae; Chaetothyriales;
            Chaetothyriaceae; unclassified Chaetothyriaceae.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 04:29:45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22998
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..22998
                     /db_xref="taxon:1963369"
                     /host="Ipomoea carnea"
                     /mol_type="genomic DNA"
                     /organism="Chaetothyriaceae sp."
     misc_feature    1..22998
                     /note="swainsonine biosynthesis gene cluster"
     protocluster    1..22998
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[10623:18126]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10624..18126
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     protocluster    1..22998
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[10623:18126]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10624..18126
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..22998
                     /SMILES="NC([*])C(=O)CC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="chemical_hybrid"
                     /product="NRPS-like"
                     /product="T1PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..22998
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001793"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22998
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            complement(<539..>2059)
                     /gene="swnA"
                     /product="putative aminotransferase"
     gene            complement(<539..>2059)
                     /gene="swnA"
     CDS             complement(539..2059)
                     /NRPS_PKS="Domain: Aminotran_1_2 (116-492). E-value:
                     1.7e-23. Score: 75.2. Matches aSDomain:
                     nrpspksdomains_swnA_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="swnA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 286.2; E-value:
                     6.7e-87)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aminotransferase"
                     /protein_id="AQV04223.1"
                     /transl_table=1
                     /translation="MGRMSISDVKALRSASHSSFAAALSYKQYDAYKSARSLAKPASKI
                     SQCHLSKESRQFSGASLKKMATPNPGSVIIPLGTGRPNAEFFPWESLVIQNEKFADPQP
                     WSINGGAAHKVPKRDGIYDLTSVLDYGYAAGAPQLLRFITEHVELVHDPPYSDWGTCLS
                     AGSTSALEIALRIFCNRGDTILAEQLTYPGFLEAAELLGVAVRGIEMDAEGIKPESLSK
                     TLRNWNEADGRKPSMLYTIPSGHNPTGTSQTYERKLEVYSIAEEHDLIIIEDDPYYFLQ
                     LNFCKTSGGNGQDFLKSLIPSYVSIDTSGRVVRLDSTSKILAPGLRAGWVTANDCIIDK
                     FLSYHEVSTAFVNGPSQLMLYKLLEESWGHLGFLNWLADLSARYRQRREIMVQACQTHL
                     PRTLCTWSVPPHGLFLWIHVNITKHHEFGSSRAVENGGLHRSIEERIMASAYEKGVQVT
                     NGSMFQVSHHLDNEIGFRFTFATADESELDTGVRFFAEAVKDVFSVTH"
     aSDomain        complement(584..1711)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnA_Aminotran_1_2.1"
                     /evalue="1.70E-23"
                     /label="swnA_Aminotran_1_2.1"
                     /locus_tag="swnA"
                     /protein_end="492"
                     /protein_start="116"
                     /score="75.2"
                     /tool="antismash"
                     /translation="KRDGIYDLTSVLDYGYAAGAPQLLRFITEHVELVHDPPYSDWGTC
                     LSAGSTSALEIALRIFCNRGDTILAEQLTYPGFLEAAELLGVAVRGIEMDAEGIKPESL
                     SKTLRNWNEADGRKPSMLYTIPSGHNPTGTSQTYERKLEVYSIAEEHDLIIIEDDPYYF
                     LQLNFCKTSGGNGQDFLKSLIPSYVSIDTSGRVVRLDSTSKILAPGLRAGWVTANDCII
                     DKFLSYHEVSTAFVNGPSQLMLYKLLEESWGHLGFLNWLADLSARYRQRREIMVQACQT
                     HLPRTLCTWSVPPHGLFLWIHVNITKHHEFGSSRAVENGGLHRSIEERIMASAYEKGVQ
                     VTNGSMFQVSHHLDNEIGFRFTFATADESELDTGVR"
     mRNA            complement(join(<3005..3294,3372..>4002))
                     /gene="swnH1"
                     /product="SwnH1"
     gene            complement(<3005..>4002)
                     /gene="swnH1"
     CDS             complement(join(3005..3294,3372..4002))
                     /codon_start=1
                     /function="acting on 1-hydroxyindolizidine"
                     /gene="swnH1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /note="2-oxoglutarate and Fe(II) dependent dioxygenase"
                     /product="SwnH1"
                     /protein_id="AQV04219.1"
                     /sec_met_domain="PhyH (E-value: 1.3e-25, bitscore: 79.7,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAAFPPPIDPSYVPSVSFTKIPATAPIEDIIAVLERDGALILTDL
                     VSSQDVAAINEEVEPYIQKAKADDHDAYDLCPKQTIMVPGVVGKSPTMARIAEFEVIDK
                     LRTLVLSKKCTATWEDRTEEFTISPLLNSSLTYHISHGGPRQRLHRDDMIHGIYHKGEY
                     SLSNETMLGFMIAGSRTTRANGATMAIPGSHKWDHTRVPRTDEVCFAEMDPGSALVFLG
                     TVYHGAGNNTVPDQVRKLYGLFFIPGTLRPEENQFFAIPRSKVLGMSDTMLSLLGYKKP
                     ETWLGIVNNADPAENLPEVFAMANA"
     gene            6142..7446
                     /gene="swnT"
                     /note="transmembrane transport protein"
                     /pseudogene="unitary"
     CDS             join(6142..6513,6685..7446)
                     /codon_start=1
                     /gene="swnT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038:phenylalanine-specific permease (Score: 92.7;
                     E-value: 2.9e-28)"
                     /gene_kind="biosynthetic-additional"
                     /note="SwnT; similar to choline transporter"
                     /pseudogene="unitary"
                     /transl_table=1
                     /translation="MPYGGSPQVFWGFLIQAVVALATATTLAELISAMPHPGGQYIWVH
                     KLAPERYRRGLSFTTAMIAWIAAIAAGSSGNLSVPVNAFGIVTLLNPNFAYQRWMGFVV
                     FQVINVTTCLGACFEHALPKCFSCLDVATHLAEEIPSPSTNIPKSLIWTVIVGTSSGLL
                     MVLAILVNLGAVDTTDYSGISIFHQITGVKGAAIGLWVPVLFLVYASVWAIQTWQSRLA
                     WTLSRESGFPLHRHFSKIFPAPFYTPIWSLIGSACGTALFGCLYLASALAFNSLTATGI
                     LLQYVSYSIPTVLVLWQGRANFRHGPFWYPRLGLLANVVMISWTVVAFVFYCFPAYSQV
                     VASEMNYVSGVFVVIALLVASLWFLYARGNYEVIERL"
     mRNA            complement(join(<7610..7902,7968..>8634))
                     /gene="swnH2"
                     /product="SwnH2"
     gene            complement(<7610..>8634)
                     /gene="swnH2"
     CDS             complement(join(7610..7902,7968..8634))
                     /codon_start=1
                     /gene="swnH2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /note="putative 2-oxoglutarate and Fe(II) dependent
                     dioxygenase"
                     /product="SwnH2"
                     /protein_id="AQV04220.1"
                     /sec_met_domain="PhyH (E-value: 7.7e-23, bitscore: 70.7,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MEKRMESDKMASTRLLTPIPAFYQPARSIPKIPATSSLETILEHL
                     DADGGVILTDFVSQETLDQIATELEPYTSKPIVANDQYDDFIGKKTQVIPGLVSKSDTI
                     ANIIDTNETIDQLLKIILTERYPAVFETHTEDLVVDPLVSIAMAFHVGHGSPRQALHRD
                     DMVFASKHHPNMKINEVDGFSCFLAGTKITRENGGTMIILGSHKWEHDRRGKPEEVSFL
                     EMDRGDAFIFLSTVAHGAGYNTIPGEIRKIMNLVFCRGTLRTEENQFLCNPRSKVLKMS
                     PKMQSLLGFKKPATNWLGMVENEDPTKDLAAIYEKVLA"
     mRNA            <10624..>18126
                     /gene="swnK"
                     /product="SwnK"
     gene            <10624..>18126
                     /gene="swnK"
     CDS             10624..18126
                     /NRPS_PKS="Domain: AMP-binding (38-428). E-value: 1.5e-97.
                     Score: 318.6. Matches aSDomain:
                     nrpspksdomains_swnK_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (534-602). E-value: 8e-17. Score:
                     53.1. Matches aSDomain: nrpspksdomains_swnK_PCP.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (625-1047). E-value:
                     1.1e-169. Score: 556.7. Matches aSDomain:
                     nrpspksdomains_swnK_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (1155-1456). E-value: 7.5e-106.
                     Score: 345.6. Matches aSDomain:
                     nrpspksdomains_swnK_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1729-1908). E-value: 1.6e-50.
                     Score: 163.4. Matches aSDomain:
                     nrpspksdomains_swnK_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (2012-2084). E-value: 1.1e-17.
                     Score: 56.0. Matches aSDomain: nrpspksdomains_swnK_ACP.1"
                     /NRPS_PKS="Domain: TD (2145-2377). E-value: 7.6e-52. Score:
                     167.8. Matches aSDomain: nrpspksdomains_swnK_TD.1"
                     /codon_start=1
                     /gene="swnK"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: NAD_binding_4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 255.9; E-value:
                     1.2e-77)"
                     /gene_kind="biosynthetic"
                     /note="multifunctional enzyme including amino acid
                     adenylylation and ketide synthase domains; involved in
                     swainsonine biosynthesis"
                     /product="SwnK"
                     /protein_id="AQV04224.1"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-105, bitscore:
                     341.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.6e-15, bitscore:
                     45.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 9.5e-107, bitscore:
                     345.6, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 1.5e-184, bitscore:
                     602.6, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 9.9e-52, bitscore:
                     164.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 9e-50, bitscore:
                     158.0, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAYQIKSNDISDQDYQALVNDFNATDDTSLLGNRLDQLFEEVVDR
                     FPNNVALIHNGTEISFSELNASANILARSLAKRGLEYGDVVGLAVSRSVDLVVVMLAVL
                     KLGAAYVPVDPSFPAARIDQMVEDAGPKLIILSGSPTKGLTRWKGLCLSVDEARDSSIT
                     DKINLRTEIRIQDLAYVIYTSGSTGRPKGVEISHGAATNFLSSLRKYEPGCNEDDRLLA
                     ITTISFDMSALELLLPILSGATMIIANASAVKDPRELIGLMRDYQVTILQATPATWTML
                     LESGWKGEPRLSKIICGGEPLSRQLADRLLASADSVWNVYGPSETTYGSVGKVTEGDIV
                     VGNPVANGRIYVLDDNMLPVPMGCEGEVYIGGGSVSNGYRNKAELTHSRFLSNPFHGGR
                     FFRTGDLARFIGPGKLQVIGRIDGVVKIRGHRIDVGDIEAILVDHPNVAEAVVISRDDR
                     LVAYCVLSAAFHGTTSLDGHLRPWVAERLPLYMLPTFFVKMDALPLSPNEKVNREALPD
                     PIEAIQSQTMIQPTSELEQQIQAIWSDILGHNHFGIEDNFFNIGGDSVRIIRMQAALEK
                     QLLRPVPTPKLFEHYTVKALAEYLAGTSDTTCKQESHTVDHGFTGSNEDIAVVSMACRL
                     PGGILTPEEFWQLLQSGGDTIVDVPKDRWNADKIYNSDPDVNGTSYCRKGGFLDSIYSF
                     DASFFGISPREAQAMDPMQHLMLELCWEGFERAGYTRGQLSGSTTGIFLGVSNNGTTNS
                     TAPDLEGYSITGSANATMSGRLSYTFGLQGPSLTVDTACSSSLVAAHLASNALRQGECN
                     MVLAGGVSLLLTPGIHIEFSKLRGLSADGRCRAFSEDADGTGFSEGAAIVVLKRLSDAQ
                     RDGNAIHAVLRGTAVMHGGHSAGLTAPSIPGQTTLIHNALGRAAMEPGDIDYIEAHGTA
                     TRLGDPIEATALAEVFGVGCRSSEPLRLGSAKSNIGHTQAAAGLVGLLKVVLSMQHNTL
                     PKTLHVSEPTRAIDWKSANMELVVANRPWLPNVSRLRRAGVSAFGIGGTNAHIVVEEPP
                     SLAVGEAGNITAPEIGATVPILLSGNSDSALRAQAEKLQLHIDSGIGKYDRLSDVAYSL
                     ATSRTHFHRRLVVTAGDKAQVLQKLASISSGSVKPPRMDETDTASLGMLFTGQGSQRPG
                     MGKDLYAVYPVFRDALDEIAARFTGLESPLLDIMWAEPGSASASLLNRTDFAQPALFAL
                     EVSLWRLWQSWGVKPAYLLGHSVGELAAAHVAGALDLFDACRLVTMRGRLMQAISCHGK
                     MASVEASSTEVAATIRKLGHSDKVEIAGYNTPSQTVISGDAETVEAVTAHIAQLGRKTK
                     MLDTSHAFHSHHMDGMLDEFKTIVQSVRFSAPKVPIISTMTGRLAVPGELEQAEYWVQQ
                     VRNPVRFSDAFQTLAKQGANVFLEIGPSPTLCGLGVACLADAPQVNTILWLPSLKPKKE
                     EVSVIQNSIAELHMRNVTIDWDEYFKPFGCRRVELPTYAFQRETFQPANKATWFSFIPQ
                     STDIDHAPQGVERMMFELNWSQVNVDRVQPRGSWGLVCPSGETLWTNKARKALSNTGIQ
                     LVPVTKLQEAEHLEGVLSLWDSDADVVQMAHDFTAKALSQLQEAIGIGFDMPVVWVTRH
                     AVGAGAGDRPVKVGAGPLWGLMGTARSEHPELHLRLIDVDEEADLATIGFALMLDDLPE
                     IAIRKEQLLTPHMVRAASITPRPIEQPLLRTDGAVLITGGLGDLGGRVARRLVSSHGIC
                     DLVLMSRRGMRSQGAEAFVSELAKLGAKATVVGGDIANFDGLRSVMQMFTADRPLRGVV
                     HAAGVVDSGVLSSLTPQKCATTFASKVDGLWNLHQLTKNMDLDLFMMFSSISGAMGLPG
                     LANYSAANSFVDVLAYLRRAQGLPATSVAYGVWGGDGMATTLVSTTRAHLSQLGMNFLE
                     PEAGLELLEQAVYQGRAFTIAADLDLDRLKAYYEEQGGVPSFLRSMLGQSKVEKPMDKA
                     VNLRDALTDAAPEQYGSIVLRMVQATIGKALGYVRVDDVDISRPLQELGIDSLTAVLVR
                     NHLATLTGMTLPPNIALLHPNLKSLSEFLLAQLLDDIGSGSSSPSETDDTTPNTEASAA
                     SYVDMAAIRRGILDPSIQFSNIVKHPTACSGTPRTVFVTGPTGFVGAFMVHELLRRGIT
                     VYCLVRADSLNQAHERLVTTLEQYSLWKPEYEALLNPVVGNLAQPLLGLDEAVFEDLAD
                     RVDAVLHSGALVDWMRPLENYVGPNILGTHEILRLASWGRGKAVHFISTISTLPIHVGY
                     GLTELDGEYGYGTSKYLAEKMVVAARFRGAKASSYRLPFVAASATNGHFRLDRGDFLNN
                     LITGSLDLGAFPSLDADLSTVLPVDYLCNTIAAIMTEDQQRIGEDYDFINSQAPTFNHF
                     FKIMGAASGGIDTVPFNEWYRRALKYAGAHPKSSLARITTIIDGYTDETAGALVKGNPV
                     GKHVFGVDDYPAPAIDEEYVRKYLDCINAAKAITCA"
     aSDomain        10738..11907
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnK_AMP-binding.1"
                     /evalue="1.50E-97"
                     /label="swnK_AMP-binding.1"
                     /locus_tag="swnK"
                     /protein_end="428"
                     /protein_start="38"
                     /score="318.6"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FEEVVDRFPNNVALIHNGTEISFSELNASANILARSLAKRGLEYG
                     DVVGLAVSRSVDLVVVMLAVLKLGAAYVPVDPSFPAARIDQMVEDAGPKLIILSGSPTK
                     GLTRWKGLCLSVDEARDSSITDKINLRTEIRIQDLAYVIYTSGSTGRPKGVEISHGAAT
                     NFLSSLRKYEPGCNEDDRLLAITTISFDMSALELLLPILSGATMIIANASAVKDPRELI
                     GLMRDYQVTILQATPATWTMLLESGWKGEPRLSKIICGGEPLSRQLADRLLASADSVWN
                     VYGPSETTYGSVGKVTEGDIVVGNPVANGRIYVLDDNMLPVPMGCEGEVYIGGGSVSNG
                     YRNKAELTHSRFLSNPFHGGRFFRTGDLARFIGPGKLQVIGRIDGVVKIR"
     aSModule        10738..12429
                     /complete
                     /domains="nrpspksdomains_swnK_AMP-binding.1"
                     /domains="nrpspksdomains_swnK_PCP.1"
                     /locus_tags="swnK"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10924..10965
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0001"
                     /evalue="1.30E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="swnK"
                     /protein_end="114"
                     /protein_start="100"
                     /score="15.3"
                     /tool="antismash"
                     /translation="LAVLKLGAAYVPVD"
     CDS_motif       11155..11214
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0002"
                     /evalue="5.60E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="swnK"
                     /protein_end="197"
                     /protein_start="177"
                     /score="31.1"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVEISH"
     CDS_motif       11704..11793
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0003"
                     /evalue="3.60E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="swnK"
                     /protein_end="390"
                     /protein_start="360"
                     /score="32.1"
                     /tool="antismash"
                     /translation="PMGCEGEVYIGGGSVSNGYRNKAELTHSRF"
     CDS_motif       11875..11937
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0004"
                     /evalue="3.10E-07"
                     /label="NRPS-A_a8"
                     /locus_tag="swnK"
                     /protein_end="438"
                     /protein_start="417"
                     /score="22.8"
                     /tool="antismash"
                     /translation="IGRIDGVVKIRGHRIDVGDIE"
     aSDomain        12226..12429
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnK_PCP.1"
                     /evalue="8.00E-17"
                     /label="swnK_PCP.1"
                     /locus_tag="swnK"
                     /protein_end="602"
                     /protein_start="534"
                     /score="53.1"
                     /tool="antismash"
                     /translation="EQQIQAIWSDILGHNHFGIEDNFFNIGGDSVRIIRMQAALEKQLL
                     RPVPTPKLFEHYTVKALAEYLAG"
     CDS_motif       12418..12474
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0005"
                     /evalue="4.80E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="swnK"
                     /protein_end="617"
                     /protein_start="598"
                     /score="-2.0"
                     /tool="antismash"
                     /translation="YLAGTSDTTCKQESHTVDH"
     aSDomain        12499..13764
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnK_PKS_KS.1"
                     /domain_subtype="Modular-KS"
                     /evalue="1.10E-169"
                     /label="swnK_PKS_KS.1"
                     /locus_tag="swnK"
                     /protein_end="1047"
                     /protein_start="625"
                     /score="556.7"
                     /tool="antismash"
                     /translation="IAVVSMACRLPGGILTPEEFWQLLQSGGDTIVDVPKDRWNADKIY
                     NSDPDVNGTSYCRKGGFLDSIYSFDASFFGISPREAQAMDPMQHLMLELCWEGFERAGY
                     TRGQLSGSTTGIFLGVSNNGTTNSTAPDLEGYSITGSANATMSGRLSYTFGLQGPSLTV
                     DTACSSSLVAAHLASNALRQGECNMVLAGGVSLLLTPGIHIEFSKLRGLSADGRCRAFS
                     EDADGTGFSEGAAIVVLKRLSDAQRDGNAIHAVLRGTAVMHGGHSAGLTAPSIPGQTTL
                     IHNALGRAAMEPGDIDYIEAHGTATRLGDPIEATALAEVFGVGCRSSEPLRLGSAKSNI
                     GHTQAAAGLVGLLKVVLSMQHNTLPKTLHVSEPTRAIDWKSANMELVVANRPWLPNVSR
                     LRRAGVSAFGIGGTNAHIVVEEP"
     aSModule        12499..17754
                     /complete
                     /domains="nrpspksdomains_swnK_PKS_KS.1"
                     /domains="nrpspksdomains_swnK_PKS_AT.1"
                     /domains="nrpspksdomains_swnK_PKS_KR.1"
                     /domains="nrpspksdomains_swnK_ACP.1"
                     /domains="nrpspksdomains_swnK_TD.1"
                     /final_module
                     /locus_tags="swnK"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       12970..13017
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0006"
                     /evalue="6.40E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="swnK"
                     /protein_end="798"
                     /protein_start="782"
                     /score="21.2"
                     /tool="antismash"
                     /translation="GPSLTVDTACSSSLVA"
     CDS_motif       13390..13437
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0007"
                     /evalue="1.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="swnK"
                     /protein_end="938"
                     /protein_start="922"
                     /score="11.2"
                     /tool="antismash"
                     /translation="YIEAHGTATRLGDPIE"
     CDS_motif       13498..13542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0008"
                     /evalue="4.80E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="swnK"
                     /protein_end="973"
                     /protein_start="958"
                     /score="9.8"
                     /tool="antismash"
                     /translation="GSAKSNIGHTQAAAG"
     aSDomain        14089..14991
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnK_PKS_AT.1"
                     /evalue="7.50E-106"
                     /label="swnK_PKS_AT.1"
                     /locus_tag="swnK"
                     /protein_end="1456"
                     /protein_start="1155"
                     /score="345.6"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQRPGMGKDLYAVYPVFRDALDEIAARFTGLESPLLDIM
                     WAEPGSASASLLNRTDFAQPALFALEVSLWRLWQSWGVKPAYLLGHSVGELAAAHVAGA
                     LDLFDACRLVTMRGRLMQAISCHGKMASVEASSTEVAATIRKLGHSDKVEIAGYNTPSQ
                     TVISGDAETVEAVTAHIAQLGRKTKMLDTSHAFHSHHMDGMLDEFKTIVQSVRFSAPKV
                     PIISTMTGRLAVPGELEQAEYWVQQVRNPVRFSDAFQTLAKQGANVFLEIGPSPTLCGL
                     GVACLADAPQVNTILWLPSL"
     CDS_motif       14092..14139
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0009"
                     /evalue="9.40E-06"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="swnK"
                     /protein_end="1172"
                     /protein_start="1156"
                     /score="18.1"
                     /tool="antismash"
                     /translation="FTGQGSQRPGMGKDLY"
     CDS_motif       14260..14328
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0010"
                     /evalue="2.80E-06"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="swnK"
                     /protein_end="1235"
                     /protein_start="1212"
                     /score="20.1"
                     /tool="antismash"
                     /translation="NRTDFAQPALFALEVSLWRLWQS"
     CDS_motif       14332..14454
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0011"
                     /evalue="9.80E-21"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="swnK"
                     /protein_end="1277"
                     /protein_start="1236"
                     /score="66.0"
                     /tool="antismash"
                     /translation="GVKPAYLLGHSVGELAAAHVAGALDLFDACRLVTMRGRLMQ"
     CDS_motif       14815..14850
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0012"
                     /evalue="1.60E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="swnK"
                     /protein_end="1409"
                     /protein_start="1397"
                     /score="15.1"
                     /tool="antismash"
                     /translation="YWVQQVRNPVRF"
     aSDomain        15811..16347
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnK_PKS_KR.1"
                     /evalue="1.60E-50"
                     /label="swnK_PKS_KR.1"
                     /locus_tag="swnK"
                     /protein_end="1908"
                     /protein_start="1729"
                     /score="163.4"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GAVLITGGLGDLGGRVARRLVSSHGICDLVLMSRRGMRSQGAEAF
                     VSELAKLGAKATVVGGDIANFDGLRSVMQMFTADRPLRGVVHAAGVVDSGVLSSLTPQK
                     CATTFASKVDGLWNLHQLTKNMDLDLFMMFSSISGAMGLPGLANYSAANSFVDVLAYLR
                     RAQGLPATSVAYGVWG"
     CDS_motif       15817..15915
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0013"
                     /evalue="1.70E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="swnK"
                     /protein_end="1764"
                     /protein_start="1731"
                     /score="20.7"
                     /tool="antismash"
                     /translation="VLITGGLGDLGGRVARRLVSSHGICDLVLMSRR"
     CDS_motif       16192..16302
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0014"
                     /evalue="2.40E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="swnK"
                     /protein_end="1893"
                     /protein_start="1856"
                     /score="52.3"
                     /tool="antismash"
                     /translation="LDLFMMFSSISGAMGLPGLANYSAANSFVDVLAYLRR"
     aSDomain        16660..16875
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnK_ACP.1"
                     /evalue="1.10E-17"
                     /label="swnK_ACP.1"
                     /locus_tag="swnK"
                     /protein_end="2084"
                     /protein_start="2012"
                     /score="56.0"
                     /tool="antismash"
                     /translation="RMVQATIGKALGYVRVDDVDISRPLQELGIDSLTAVLVRNHLATL
                     TGMTLPPNIALLHPNLKSLSEFLLAQL"
     CDS_motif       17056..17124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_swnK_0015"
                     /evalue="2.70E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="swnK"
                     /protein_end="2167"
                     /protein_start="2144"
                     /score="-2.4"
                     /tool="antismash"
                     /translation="TVFVTGPTGFVGAFMVHELLRRG"
     aSDomain        17059..17754
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_swnK_TD.1"
                     /evalue="7.60E-52"
                     /label="swnK_TD.1"
                     /locus_tag="swnK"
                     /protein_end="2377"
                     /protein_start="2145"
                     /score="167.8"
                     /tool="antismash"
                     /translation="VFVTGPTGFVGAFMVHELLRRGITVYCLVRADSLNQAHERLVTTL
                     EQYSLWKPEYEALLNPVVGNLAQPLLGLDEAVFEDLADRVDAVLHSGALVDWMRPLENY
                     VGPNILGTHEILRLASWGRGKAVHFISTISTLPIHVGYGLTELDGEYGYGTSKYLAEKM
                     VVAARFRGAKASSYRLPFVAASATNGHFRLDRGDFLNNLITGSLDLGAFPSLDADLSTV
                     LPVDYLCNTI"
     mRNA            complement(<18447..>19373)
                     /gene="swnR"
                     /product="SwnR"
     gene            complement(<18447..>19373)
                     /gene="swnR"
     CDS             complement(18447..19373)
                     /codon_start=1
                     /gene="swnR"
                     /note="putative NADB Rossmann-fold reductase"
                     /product="SwnR"
                     /protein_id="AQV04222.1"
                     /transl_table=1
                     /translation="MRVAIAGYGDLTRYICEEFTQAGHDLVILTRNHKPQLETQGITQA
                     ITDYTLPSLKTPLSDCDVLISTISDYSPTYTDIHRTLIQACQQSPKCKRIIPAEFATNI
                     ETYPDQPGFYYAPHEPVRETLRNQTDLEWTLVCIGWLADYFVPSKNRHIKDIGVFHPTN
                     WGGSDKIVVPGTGAEPVDFTWARDVVRGLASLVKAPRGSWEPYTFMSGERSCWNDTAEL
                     FRRKYRPDTPIEHVSLRTVAEMIRTAKADDEDTLTLADYYLLSISQACGNPPDKVRRHR
                     EKYFPDIRFRTVQEGLAQFDEYPDSIL"
     mRNA            join(<20237..20341,20401..20639,20695..21050,21106..>21374)
                     /gene="swnN"
                     /product="SwnN"
     gene            <20237..>21374
                     /gene="swnN"
     CDS             join(20237..20341,20401..20639,20695..21050,21106..21374)
                     /codon_start=1
                     /gene="swnN"
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 61.8; E-value: 1.3e-18)"
                     /gene_kind="other"
                     /note="similar to NmrA family reductase"
                     /product="SwnN"
                     /protein_id="AQV04221.1"
                     /transl_table=1
                     /translation="MVVVAIAGGTGGVGRTVLDAIAKSGQHRAVVLSRTAAAATATKGP
                     KRIAVDYTDVEQMKRVLQENNVEVVVSALLLLDESIAQAQINLIRAAAQSGTVTKFIPS
                     EYYIDFHAPIPGSDLFTNFNIEAEEELSRHPQLTWTLIRNGIFLDHLVMPHNPKTTYIS
                     PYWVFVDIDHEQCVLPGDGSYPLVFTHSTDLAAYIERLVGLPAKDWPRESLVASNKLQV
                     GDLATLIKKVTGKEFKVTYDSAGAIHEGRITPLPSNQAVFDDPAKGEMFHEVEQQVMLS
                     MLSKAHDLPGKNLAELFPDVEPTNIEDFFRAGWALKQSTTS"
ORIGIN
        1 gcgtggtgtc aaatctgacc agttcgggcc atataagcct ttgattgcgg gagaggaggc
       61 cgctgtacat cgatcgaaca ttgcggttca gaagagtcgt cagggtgata gcgaaacgac
      121 taagagggtg actagaaccg caagaatcga cagaacacaa aaccttcagt gccactgtcg
      181 tacgtacggt tgtactaagg tcgtctccga aggaacgaca gtagaatttg agcttcactg
      241 gttaacggcg aggtctgagg atcggtgaat cagattttcg taagcaacta tatctagtta
      301 aagatcgctc tgaatgggta gaagactcac aggcctgaat catcttgcaa gctcagagca
      361 caagcagaag atacaataag caaagtgttg ccacggaact tattcgtgaa gtaatggagt
      421 ctcgaaaaga agtttcgtgg tcaatttcaa actccgtttt cattgtctaa gtagcattct
      481 acttagcaat tattgcctat agcatcattt tagtatatat gtgctccagc gttgtaacct
      541 aatgcgtcac actgaacaca tctttgaccg cttcagcaaa gaatcgaaca ccagtgtcca
      601 actccgattc atccgcggtg gcgaatgtga accggaaacc tatctcgttg tccagatgat
      661 gagaaacctg aaacattgat ccattggtga cctggacacc tttctcgtaa gcactggcca
      721 ttattctctc ctcgatagac ctgtgaagtc ctccattctc gacagcacga gaagaaccaa
      781 actcatgatg tttggtgatg ttcacatgga tccagaggaa cagaccatgt ggtggtacag
      841 accaagtaca tagcgtccgt ggcaaatgag tctggcaagc ttgtaccatg atttctcgtc
      901 tttgccggta tctagcagac aggtccgcca accaattcaa aaagcccaaa tgtccccagg
      961 attcctcgag tagcttgtac agcattagct gtgacgggcc gttgacgaat gctgtggaga
     1021 cttcgtggta tgacagaaac ttgtcgatga tgcagtcatt ggcagtaacc cagccagccc
     1081 tcagaccagg cgccagtatc tttgacgtgg agtctagcct tacaactcga ccagacgtgt
     1141 caatggagac atatgaggga ataagactct tcagaaaatc ttgcccgttt ccgccactgg
     1201 tcttgcaaaa gttcagttga aggaagtagt atgggtcgtc ttcgattatg atcagatcat
     1261 gttcctctgc gatactgtaa acttctagtt ttcgttcata tgtctgagaa gtgccagttg
     1321 ggttgtgtcc tgagggtatc gtgtatagca ttgacggttt gcggccgtcc gcttcgttcc
     1381 agttacgtaa tgtcttgctc aaagattcag gcttgatgcc ttcggcatcc atttctatac
     1441 cgcgaactgc cacgcctaac agttctgctg cttctagaaa gcctggatat gtaagctgtt
     1501 cggccagaat cgtgtcgcct cggttgcaga agatccgcaa tgcgatctcc aacgctgatg
     1561 tagacccagc ggagagacag gttccccaat ccgagtatgg cggatcgtga actaattcaa
     1621 cgtgttccgt gatgaaacga agcaactggg gtgccccagc agcatatcca tagtcaagca
     1681 cactggtcag atcgtaaatc ccatcgcgtt tgggaacctt atgggcggca cctccattga
     1741 tggaccaagg ttgaggatca gcaaacttct cattctgaat cacaaggctc tcccaaggaa
     1801 agaattcggc attcggtcgt cccgtaccta gtggaataat gacggaacca ggatttggtg
     1861 ttgccatctt cttgagggac gctcctgaaa actgtcggct ctctttactg agatggcatt
     1921 gtgagatttt tgacgcaggt ttagcgagag aacgtgctga tttgtaggca tcgtattgct
     1981 tgtaggataa agcagcagcg aaggaggagt gagacgctga tctgagcgcc ttcacatcag
     2041 agatgctcat gcggcccatt tcttgaacaa gtatgcaggt tgatattgat accgaagaat
     2101 aaagagctct gaggccgact ttgcctcgat aaagtgaagt atttcatcct ggttcgatcg
     2161 ctgtatggca ttgaacggtt atatggcgac acagaattcg ctggcgtaga actgggtacg
     2221 attgcactca catctcgctt gggcatcccg tagagtggct tttcaatttg tctctgactg
     2281 cccaatcaag ggttcctgtt gtacgtcagt ctgttgcaat taccttgagt tcgaaaagga
     2341 tctgtgttga ggaaagctcg tcaatccagt gatcagccta gtgggtccag cctgctagtg
     2401 cggtagtata atgtaccgta cgtaccgtaa acccctgtaa tgctgcggtc acgcccggga
     2461 agacgccccg gaagccgccc tccggagcga tcaaccatcc aacactaaca ttactaacct
     2521 ttcttcatga tgttgacatc tgcaggtgca agggaggcta aacatcatcc ctggtacgga
     2581 gacacatgct ttgagatcat ctcctctcaa ccttccctct ggtcatacgc aattcacccg
     2641 gttagatagt tcggcccaga gggatgcgag ggtgtccgaa gcgtattcct acagtacctg
     2701 cccgtctacg ataatcatgg ctcatgtaag aaggaacacc tatcagctgc ttttatttat
     2761 catgggacaa catactaact aatctgtcag tgtgatcaca cagtgctgtt ctgacacaga
     2821 aagattgatt ccgtttctaa tacttaccca tttacatggt actgtatgtt gcataaagcg
     2881 cactcctcag gcatcactat ttaatgcact agccatgatt cttctcatcg tgtttagagt
     2941 gccatcgtca tatgtagatg tacgacttat ttgtttggta gcttttaatg actatgtctt
     3001 aactctatgc attcgccata gcaaagacct ctgggaggtt ctctgccggg tcggcgttat
     3061 tgacaatccc aagccaagtt tctggtttct tgtatcctag gagagagagc atagtgtcac
     3121 tcataccaag taccttgctt cgaggaatgg cgaagaattg attctcctca ggacggagtg
     3181 tgcctggaat aaagaagaga ccataaagct tgcgcacttg atcaggaact gtgttgttcc
     3241 cagcgccatg ataaaccgta ccgaggaaaa ccaatgcgga acctggatcc atctctaatc
     3301 atctgttaga cattctctga tccttttagg cccgccacaa caagccctgg gacgaagcaa
     3361 acttgactta cctgcaaagc aaacttcatc agttctggga acccgagtat ggtcccattt
     3421 gtgagaacca gggatagcca ttgttgctcc attcgcacga gtagtcctag acccagcaat
     3481 cataaagcca agcattgttt catttgaaag actatactcg cccttgtggt agataccgtg
     3541 gatcatgtca tctctgtgca gcctctgacg agggccacca tggctgatat ggtatgtcaa
     3601 actgctgttc aacagaggac taatggtgaa ctcttctgtt cggtcttccc atgtggcagt
     3661 gcactttttg gacaagacca gtgtccgtag cttgtcgatt acttcaaatt cggcaatcct
     3721 ggccattgtc ggcgatttcc ctacaacacc aggtaccatt atcgtttgtt tgggacacag
     3781 atcatatgca tcatggtcgt cagctttagc cttttggatg taaggctcga cctcttcgtt
     3841 aatggcagct acgtcttgac ttgaaacgag atccgtcaag atgagtgcgc catctcgttc
     3901 gagaacagca atgatatctt cgattggtgc tgttgctggg attttcgtaa aagagactga
     3961 gggtacatac gatggatcaa taggcggagg aaatgcagcc atctcggtga gtgagttccc
     4021 ggataaacaa gacaagtcga gtctctggaa cgtcggcgga agaggtgttg cgtgagtgag
     4081 cgtgttcagt cgtgaggcag ctgaggcgta gtcacgatga ttccgtccac cagcgaaccc
     4141 taacaaagct cttataagcg ctactgactc ggccacaacg actgttgccc cttcgacttc
     4201 cactgctgga tgctggaagc gctagcgcct gccctagtgt atgactactt tcctaaacgg
     4261 gtaagttaat ccaccatatt acaaactcag aaacctgtct aatagcaatg ttgtagtacg
     4321 tacacctaga aacgcactgg aagccagagc agcatgtatc aaacattgta tcggccatcg
     4381 aacatcaaac aaggaattcg tcagtcagtg aaattccccg gtcagatttt atcacccata
     4441 tttgaccaaa gagaataaag acgcattatt tgcacactcc tactacagct atctcatgat
     4501 acttcccctt gtcgacaaca acacactcta caacgtccgt aagctatagt tcggaaaagt
     4561 agtgatatct gcgacccgtc tgagaagttg tcatacatgt catttcatgt tgcgggtcag
     4621 ctgcattcaa aggcttggtt ggattctatt gaaccatgtc tccgatcctc ggagtctgac
     4681 gactgcactc catgcgctgt gtaatcagtt aatgagtcaa cttgctctac tgcaagccta
     4741 acccgcttca aatatggttc gatagttgag gcattgatcg aactttgcca gggagcgagc
     4801 tccatcaggc atcaccgccg ggaaatcaca catgagacat acctatctag actgatggat
     4861 tggcgccaat ccagacaacc tacagtacga tacgttccat agcggagaca aaataccaag
     4921 cgacagatgc aagttctctc acgtcaccac gacagactgc agatatttcc tgcatggtgc
     4981 actgccaaat cacactgatc atccccaccc accttcgccc ccggagtcag ctgcttggtg
     5041 tttggctgca aggtatgtgg taccctctag tcaatcaagg atcccttaca tacccaaaag
     5101 tcgtccagtt cattctggct gaccatctcc agggcgcttc gttagcgggc gtgtacttta
     5161 agcttccacc cgcccgcttt aagttcaata tcacccactg cctaagaaca gtgggacgtt
     5221 gtccgcattt ggcctcgaac cttagcttat caacccccgg aagatcattt acgtactcaa
     5281 gttcaatcca acccgcctct ttcagggcta ctcgacacat gttttctgct gcgtagcgtt
     5341 cggaagccat ggtaccggta catctcgttg attgcaaccc ggttgctctc caccctgtcg
     5401 ttcgtcgcat cccaacatat gccaggtcag ttgcgccatc caacacatgc agcctgatga
     5461 gtgcgctacg cttgtcggat ccagccaatc gaggcaagca tttatagagc tttagataag
     5521 ctacaacatg tttcggtgtt caaaagttaa atctagctcc atctagctcc ggtcaggcaa
     5581 gcattctgcc attttacagt aagtttacag aactaacccc ccccccaaag cggttactgt
     5641 aaaacaggag gggccgctcc ttggcttaca aggggacaag acaggcggtg gtgtggcagg
     5701 ataggtgctt ctgacgtaac tctaattgac cgtcgaggtt acaaccaagc ctttagtttc
     5761 gccactggtt gcttatcgaa ttgttgatct aggcccctcc tttgctatca tggagttgaa
     5821 gtactgccta aactctgcca atggttgatt gccgactctc acgcgcgaca gcttcaacac
     5881 gaacagaaca gtacgtactc tgtagctagg atccctcaac attcccaaca gcatgaccca
     5941 cgaagcatca caaccggctt cacaggccgg cgtccccaac cggggcagcg caccgtccaa
     6001 aaaactggcg gaaaaagttg acgaacacat gcccagtccg atcgaggagg gtaacatcac
     6061 cgtccagacg cagaagccat tggcattgga tatggagtca ccaacacggc cgttgggata
     6121 ccgatcattc tgagtacagc aatgccgtac gggggatcgc cccaggtctt ctggggcttt
     6181 ctgatacagg cagtcgtcgc cctagctaca gcaacgaccc tcgctgagct gatatccgcc
     6241 atgcctcatc ccggcggcca gtacatctgg gttcacaagc ttgcgccaga gaggtaccga
     6301 agaggcttgt cgtttaccac ggccatgatc gcctggatcg ccgccattgc tgccggttcc
     6361 tctggcaacc tctctgtgcc tgtgaatgcc ttcggtatcg tcacgcttct caatcccaac
     6421 ttcgcctacc agcggtggat gggcttcgtg gtgtttcagg tcatcaacgt gacaacgtgc
     6481 cttggtgctt gtttcgagca tgcgttgcct aaagtgtaaa aagctttgtt gctgttcaat
     6541 gtcgccaccg tgacggtcat cgtcattact ctgttcgcca tggccaaaac ccgcacaagc
     6601 gctgaagact tcttcaaact tgtcaatgtg tccggatggc cagacggagt ggcattcatc
     6661 atcggcatga acggacccaa ctagtgtttc tcctgcctcg atgtcgccac acacctggca
     6721 gaagaaatcc cctcccccag caccaacatc cccaaatctt tgatttggac tgtcatcgtc
     6781 ggaaccagca gcgggcttct gatggtgctg gctattctcg tcaacctagg cgctgtcgac
     6841 actaccgact actcgggcat ttccatcttc caccaaatca ccggcgtcaa gggcgccgcc
     6901 atcggcctgt gggtccccgt cctcttcctg gtctacgcgt ccgtctgggc catccaaacc
     6961 tggcagtccc gcctcgcctg gacgctgagc cgcgagtccg gcttccccct ccaccggcat
     7021 ttcagcaaga tcttcccggc cccgttctac accccgatct ggtctctgat cggctcggcc
     7081 tgcgggaccg ccctattcgg ctgtctctat ctcgcttcgg cgctggcctt caactcgctc
     7141 accgcgacgg gcatcttgct ccagtacgtc agctacagca tccccacggt gctggtcctc
     7201 tggcaaggca gggcgaattt ccgccatggc ccgttttggt atccccggtt gggcctgctc
     7261 gcgaacgtcg tgatgatttc gtggaccgtc gtggcgttcg tgttctactg cttcccggcc
     7321 tattcgcagg ttgttgcgag cgagatgaat tacgtgtctg gagtttttgt tgttattgcc
     7381 ctcctcgtcg cctcgctttg gtttctttat gcgaggggga attatgaggt tatcgagagg
     7441 ctttaggata gaagctacgt atagtatggg ttagttaatg atatatagaa agtacgacct
     7501 agtttcttgg acagaaggta ttaatttcat acttgagcgg gcgagtctca actatcagtc
     7561 aggtcatcat cgactcccaa gtgaaactat catgcaatat aatttcttac tacgctaaca
     7621 ccttctcgta gatagcagca aggtctttcg tcgggtcctc gttctcaacc atacccagcc
     7681 agttagttgc cggcttcttg aaccccagta gactctgcat cttcgggctc atcttgagaa
     7741 ccttgctgcg agggttacac aggaactggt tctcctcggt ccgcagtgtc cctcggcaga
     7801 agaccaggtt catgatcttg cggatctcgc ctgggatggt gttgtatccc gcgccgtgag
     7861 cgacggtgct caggaagatg aaggcgtcgc ctcgatccat ttctagacgt cgcgtgctgt
     7921 ggttagtctt ctggaatgtt tggacggaag gttttacgtg gacttaccga ggaaggaaac
     7981 ctcttctggt ttgccgcggc ggtcgtgctc ccacttgtgg gaaccgagga tgatcatggt
     8041 cccgccgttt tcgcgcgtga ttttggtgcc ggcgaggaaa cagctgaagc cgtcgacttc
     8101 gttgatcttc atgttggggt ggtgcttgct ggcgaagacc atgtcatctc tgtgcagtgc
     8161 ttgacggggc gaaccgtggc cgacgtggaa agccatggcg atgctcacca acgggtccac
     8221 gacgaggtct tcggtatggg tttcgaaaac ggcggggtat cgctccgtta ggatgatctt
     8281 gagaagttgg tctatggtct cgttcgtgtc gatgatgttg gcgatggtgt ccgactttga
     8341 gaccagcccg ggaatgacct gggtcttttt tccgatgaag tcgtcatact gatcgttggc
     8401 gactataggc ttggatgtgt atggctccag ctcggtggca atctgatcca gcgtctcctg
     8461 agaaacaaaa tcggtcaaaa tgactccgcc gtctgcgtca aggtgttcaa gaatggtttc
     8521 cagagaagaa gttgccggaa tcttagggat ggacctggct ggctggtaga acgcgggaat
     8581 aggggttaac aagcgtgtag aggccatctt gtcggattcc attcgtttct ccattttacc
     8641 ttcaattgat gccaatttca cagaattcag ttactgttaa gataaagaag aaggtgtgtt
     8701 gctcgacact tgggtaaaaa gaacgacagc ggagaggggc acagtagcga cggccaatgt
     8761 aattggtgta catatattgt tgagctggct tgtggaataa agttatggta acattatatg
     8821 cctggcaggt ggcccttggc agtaggtgaa tctcaagcgt gatagcttga cttacagtaa
     8881 cacttcagtc caggtcttga cccagagggg ctcgctcaac ttaccacact ttctcggtca
     8941 aagaatggtt ctgatgacat gagatggaca gtacgtatga ccaacatgac ggcccacact
     9001 aatgcgcgtg ggtcggttgt gccgtccaag tacgagtatt gtaggactac ggacagatgt
     9061 agcaccaaga gctgttgaag ccgacatcgg tgtctcccgt ccaagagcga cagtagtgca
     9121 tagatgttgg cacgggaaag actttcttga aaccgctgag atggtcggat cgtccagtca
     9181 actcggtctc gatccatgca ccaccgcaat aagcgtttga gcttgaagtt tcttttccac
     9241 cgaaatcctt gcttgtagta cgcatgggtg gtggggaaga gacgccaatg gacaaggaac
     9301 tgcatggtca attggtgggt gacatcgctt agtagataca tgtcttgcag caagtttcac
     9361 tgtcgtcagc attcccttcc gcggtatgct ttgtgatatc atgcggatag ggcatcgacc
     9421 cacaggactt gttgtccctg cttccgagtc ctcgccaggg tacggtgcag ctttgccacc
     9481 agctagacga aacccttatg cacgatgaaa ccccgatagt gtccgaaggc gggggcggtc
     9541 cgtatcgctt tcaaagactc aaatcatttc ccacctgctg caacgcttgt gccagcgccc
     9601 cgttacggta ccatgagatc cacgttcagg ggttgggttg cctcgaaatg cagggcttcg
     9661 tggcgcttct cgggatgtta tcccgtcggc caagtgagtg tgacagttgg cagacgttgg
     9721 cttgtgttcg tctgtcaagc ttatgtcaat cgactcggtc ccacagagga tctgatcagc
     9781 tccataatct aagacagatt tgttgctcgt attctgttgt tgagacaggc agtgagtatc
     9841 cactgtgacg actcgagacc gctggcgacc agtagtcgtg cgcctgaacg acagtgattg
     9901 gacgtgatgc aggtgtttta ctgtcaaaca ttcacgtaag gttgatatta gaactgacct
     9961 gtcacataat tgttgagacg agtaccggct tgttttacag taccgtacgt tacatacgaa
    10021 aaacacgcta gcttgctctt tcgtaaagtg ccaactcact cgtcatgtcg attttgtata
    10081 gaccatgtgc ctaagggacc aagtaaagtt ctcaaccacc atggaccttc ccacattcaa
    10141 caaaacgtac aggatcatct caacagcgga ttgtaaccag aaggggacaa gttatcccac
    10201 atcacgtctc ctgcttcatt ttgagggtga tgagggtcag tcactcgtga tgaatgatgg
    10261 gtccactgac agagcttact ccgaggagaa cagctaaact tcgcaaaagg taatgtacaa
    10321 tgctcaggct agcgggcgat ctgacaagga acctgatcat ctgcagtgaa actactacaa
    10381 ctagttacat catgctttcg tagtacggcg caagataggc atggatatct gtcaggaagg
    10441 tacaactcag taaactggct ttggtgcagg tagctcaggt tgcttcatgg cccggatact
    10501 gtaatacttt ctctttgtac cggttgcagc gaaactcaac ccctgagaat tagcagtgca
    10561 aaactcggct cttgcaatca atcgatattc tattgacatt cactcattct cactatcttt
    10621 gagatggctt accaaataaa atcgaatgac atctcagacc aagactacca agctctggtc
    10681 aacgacttca atgccacaga tgatacctcg ttattaggca accgtttgga tcagctattt
    10741 gaggaagttg tggacaggtt tccaaacaac gttgctttga ttcacaatgg gactgagata
    10801 tccttcagcg agctcaatgc gtcagcgaat atcctggctc gcagccttgc aaagcgaggg
    10861 ttagaatacg gtgacgtggt cggcctggca gtatcacgct ccgtagacct tgttgttgtg
    10921 atgctagctg tactcaagct aggcgctgct tatgttcctg ttgatccgtc tttcccagcc
    10981 gcacgcatcg accaaatggt agaagatgcc ggtcccaaac ttataatcct cagtggcagt
    11041 ccgaccaagg gcctgacacg ctggaaaggc ctatgcttga gcgtcgacga ggcaagggac
    11101 agctcaatca ccgataagat caaccttaga accgaaattc gaatccaaga tctcgcatat
    11161 gtgatatata cgtctggctc aacaggccga cccaaaggag tcgagattag ccatggagcc
    11221 gccaccaact ttctgagctc gttacgaaag tatgagccag gctgcaatga ggatgatcga
    11281 ttgcttgcaa tcacaaccat ttctttcgat atgtcagctc tagagctatt gttaccaatt
    11341 ctgtccggtg ccacgatgat cattgcaaat gcaagtgcgg tgaaagatcc gcgtgagctc
    11401 atcggtttaa tgagggatta tcaagtcacc attttgcagg cgaccccagc aacgtggaca
    11461 atgctcctag agtctggatg gaaaggagag ccgcgactct ccaaaatcat ctgtggtggt
    11521 gagccactct cgcgccaact tgcagaccgc ctgctcgcct ctgctgattc agtgtggaat
    11581 gtgtacgggc cttccgagac aacgtacgga agcgttggaa aagtcacaga aggtgacatt
    11641 gttgttggaa accctgttgc caatggtcga atatacgttc tcgatgataa tatgttgcct
    11701 gtgcctatgg gctgtgaggg cgaagtatat attggcggtg gcagtgtatc gaacggatat
    11761 cgcaacaaag ctgaactcac acactctcgg tttcttagca atccattcca cgggggaaga
    11821 ttcttccgca ctggtgacct ggctcgattc ataggaccgg gaaaactgca agttataggc
    11881 cgcatagatg gagtggtcaa gatccgcggt caccgcattg atgttggtga tattgaagcg
    11941 atccttgttg atcatcccaa tgtggccgaa gcggttgtta ttagtcgcga tgatcgtcta
    12001 gtggcatact gcgtactctc tgcagcgttt cacggtacaa cctcacttga cggtcatcta
    12061 cggccatggg ttgctgagcg cctcccatta tacatgctgc caacattttt cgtcaagatg
    12121 gatgcgctgc cgctgtcgcc caacgagaag gtcaatcgtg aggccctccc tgatccaata
    12181 gaggcgattc aaagtcagac catgatacaa cctacctccg agttagagca gcaaatacag
    12241 gctatttggt cagacatcct tggccacaac cactttggca tagaagataa cttcttcaac
    12301 attggcggtg actctgtgcg cataatccgc atgcaagcag cattagagaa acagctactc
    12361 cgacctgtgc caacaccaaa acttttcgaa cactacacgg tcaaggcgtt ggccgaatac
    12421 ctggctggta caagtgatac aacttgtaaa caggaatctc atacggtaga tcatggcttt
    12481 accggcagca atgaagatat tgctgtagtt tccatggcgt gtcgattacc tggtggtata
    12541 ttgacaccag aagagttctg gcaactcttg caaagcggcg gcgacacaat tgttgatgta
    12601 cccaaggatc gttggaatgc tgataagata tataattcag accccgatgt taatggcacg
    12661 tcatattgcc gcaaaggcgg cttcctcgac tcaatctact cgtttgacgc atccttcttt
    12721 ggcatatcgc cccgtgaggc acaagcaatg gatccaatgc agcatttaat gttggagctg
    12781 tgctgggaag gtttcgaaag agctggctat accaggggac agctgagcgg cagtacaact
    12841 ggaatttttc ttggtgtcag caacaacgga acaacaaaca gcacagctcc agatcttgag
    12901 ggatattcta taacagggag cgccaatgct accatgtctg gccgtctgtc gtataccttc
    12961 ggtctgcagg gaccgtctct aactgttgat accgcatgtt cctcatctct ggtggccgcg
    13021 caccttgcct ccaatgcctt gcgccagggc gagtgcaaca tggttttagc cggcggtgta
    13081 agccttcttc tcacgccggg tatacacatt gaatttagca agctccgagg tctttcagcg
    13141 gatggccgat gtagagcctt ctccgaggac gcagatggca caggatttag cgagggcgct
    13201 gctatcgtgg tcctgaagcg cctgtctgat gcccagcgcg atggtaacgc cattcacgcc
    13261 gtactgagag gtactgcagt gatgcatgga ggccacagtg ctggtctcac agcgcccagt
    13321 atccccggtc agacaacact aatccataat gccttgggcc gagctgcgat ggagccgggc
    13381 gatatcgact acatcgaggc tcacggcact gctaccaggc tgggtgaccc aattgaagct
    13441 accgcactgg ccgaagtctt tggggtgggt tgtcgaagct cagaacctct aaggctcggc
    13501 tccgctaaat ccaacattgg acatactcaa gccgccgctg gccttgttgg cttgctaaag
    13561 gtagttttgt ccatgcaaca caatactctg cccaaaacgt tacatgtgag cgagcctacc
    13621 agggcaattg attggaagag tgccaatatg gagttggtcg tggcaaatag accgtggttg
    13681 ccaaatgtga gccgacttcg tcgggctggc gtgagcgcgt tcggcattgg tggcacaaat
    13741 gcccacatcg tcgtcgaaga gccacctagt ctcgctgtgg gagaggctgg caacatcaca
    13801 gcacctgaga tcggagcaac tgtcccaatt ttgctgtcag gcaatagtga ctctgctctg
    13861 agggcacagg ccgagaagct tcaattgcac attgacagtg gtatcggaaa gtacgaccgt
    13921 ctgagcgatg tggcctactc gctagccaca tctcgtacgc actttcaccg gagactggta
    13981 gtgacggcag gagacaaggc gcaggtactg cagaaactag cgtccatcag ctcgggttct
    14041 gttaagccgc cccgtatgga tgagaccgac actgcgagct tgggaatgct gttcactggg
    14101 caaggcagcc agcggccagg aatgggcaag gatctatatg ctgtctatcc tgtcttccga
    14161 gatgcactgg acgaaattgc tgccagattc acggggcttg agtcacctct tcttgatatc
    14221 atgtgggccg aaccggggag tgcgagtgct tccttgttga atcgtaccga ttttgcccaa
    14281 cctgctttat ttgctcttga ggtatctttg tggagattat ggcaaagttg gggtgtgaag
    14341 cctgcttatc tactcggaca cagcgtgggc gagcttgcag cagctcacgt tgcaggagct
    14401 ttggatttgt tcgatgcttg ccgacttgtc acgatgcgtg gtcgcctgat gcaagccatt
    14461 tcttgtcatg gaaagatggc gtcggtagaa gcaagcagta cagaggtcgc agcgacgatc
    14521 agaaaactgg gtcatagtga caaggttgaa atcgcgggat ataatacacc ttctcaaact
    14581 gtgatatctg gagatgccga gactgttgag gctgtgacag ctcacatcgc acagctgggc
    14641 cgcaagacta agatgcttga tactagccac gctttccact cacaccacat ggacggtatg
    14701 ctggatgagt tcaagaccat agtccaaagc gttcgattca gtgcaccgaa ggttccgatt
    14761 atcagcacca tgactggtag gctggccgta ccaggtgagc ttgaacaagc cgaatactgg
    14821 gttcaacagg tccgcaatcc tgttcgattc agtgatgcct ttcaaacact cgctaaacag
    14881 ggtgcgaacg tcttcctcga aattggaccc agtccgacac tttgtggctt gggtgtagcg
    14941 tgtctcgcag atgcccctca agtgaacaca attctctggc tgccctcttt gaagccaaag
    15001 aaggaagaag tctcagtaat tcagaacagc attgctgagt tgcatatgcg taatgtgaca
    15061 atcgactggg atgaatactt caagccgttt ggttgccgaa gagtggaact tcccacatat
    15121 gccttccagc gggagacttt ccagcctgca aataaggcca cttggttcag tttcatccca
    15181 caaagcaccg atattgatca cgctccgcag ggtgtagaaa ggatgatgtt cgaattgaat
    15241 tggagtcaag tcaacgtgga cagggttcaa ccacgtggtt catggggtct tgtctgccca
    15301 tcaggggaga cactgtggac aaataaggca cgaaaggcat tatcaaacac aggtatccag
    15361 ttagtgcctg ttacgaagct tcaggaggcc gagcacctcg aaggcgtgct ctctctgtgg
    15421 gactctgatg ctgatgttgt tcagatggca catgacttca ctgcaaaggc attaagtcag
    15481 ttgcaagagg ccatcggaat tggcttcgat atgccagtgg tatgggtcac tcgtcatgct
    15541 gtaggtgctg gcgctggtga ccggcccgtc aaggtcgggg ccggaccact atggggcctg
    15601 atgggaacgg cccgaagtga gcatccagag ttgcatctac gcttgatcga tgtggatgaa
    15661 gaggcggacc tggcgaccat cggcttcgcc ttgatgctgg acgatctgcc agaaattgcc
    15721 atccgcaagg aacagctgct cacaccgcat atggtgcgcg ctgcctcaat tacaccgcga
    15781 ccgattgagc agcctttgct tcgaactgac ggcgccgtac tgatcactgg cgggcttggt
    15841 gatcttggag gtcgtgtagc tcgcagacta gtgagctccc atggaatttg cgacctggtt
    15901 ctgatgtcac gacgcggcat gaggtcccaa ggcgctgaag catttgtaag cgagcttgca
    15961 aagctgggtg ccaaagctac cgtagttggc ggcgacattg caaactttga tggtctccga
    16021 tctgttatgc aaatgtttac agccgaccga cccctacgcg gtgttgttca cgctgctggg
    16081 gtggttgact cgggcgttct ttcatcacta acgccccaaa agtgtgccac gactttcgca
    16141 tcaaaggtag acggtctgtg gaatctgcat caattgacca agaacatgga tttggacctt
    16201 ttcatgatgt tctcctccat ctctggtgct atgggcttac caggactggc aaattactcc
    16261 gctgccaatt cgtttgttga tgtgcttgca tatctgcgac gtgctcaggg cttgccagcc
    16321 acctcagtcg catacggtgt ctggggtgga gacggcatgg caaccactct cgtttcaaca
    16381 actcgtgctc atctttcgca gctcgggatg aattttctcg agccggaagc tgggttggaa
    16441 ttactcgagc aagccgttta ccaaggtcgt gcgtttacca tagctgcgga tcttgatttg
    16501 gaccggctca aggcgtacta tgaagaacaa ggcggtgttc cttccttttt acgctcaatg
    16561 cttggtcaaa gtaaggttga gaagccaatg gacaaagctg taaacttgcg tgacgcattg
    16621 accgacgcgg ctcctgaaca atacggcagc attgtgttgc gcatggtcca agcaaccata
    16681 ggcaaggcct tgggatacgt ccgggtggat gatgtggaca tcagtcgacc cctacaggag
    16741 ttagggattg actccttgac cgcggttctg gtacgcaatc atctagcgac gttgacgggc
    16801 atgacactgc caccgaacat tgccctcctt cacccaaatc tgaagtcact cagcgagttt
    16861 ctgctggccc agttgctgga tgacatcggg agtggctcgt ccagtccatc agagactgac
    16921 gataccacac caaataccga ggcatcagct gcttcgtatg tcgacatggc agccatccgg
    16981 aggggcattc tcgatccctc aatccagttc agtaatatag ttaagcaccc tactgcttgt
    17041 tctggtactc cccggaccgt cttcgtgaca ggtcctacag gctttgttgg cgcgttcatg
    17101 gtacacgagc ttctccgaag aggcatcact gtgtattgtc tcgtacgtgc tgacagcctc
    17161 aatcaggctc acgaacgact ggtcacaaca ctagaacaat acagcctctg gaagcccgag
    17221 tacgaggcac tgcttaatcc ggtggtcggc aatctcgcac agcccctgct cggccttgac
    17281 gaggctgtat ttgaagacct ggcagatcga gttgatgctg ttctccattc cggagctctt
    17341 gttgactgga tgcgcccgct ggaaaactat gtcggtccca acatcctcgg gacccacgag
    17401 atcctgcgtc tcgcctcttg gggccgtggc aaggcagtcc acttcatatc gaccatctcc
    17461 acgttgccca tccatgtagg ctacgggctg actgagctgg atggagagta tggttacggt
    17521 acatcgaagt acctcgcaga aaaaatggtt gtggcagccc gtttccgggg cgccaaggca
    17581 tcatcttatc ggttgccctt tgttgctgcc tcagccacga atggccattt ccgacttgat
    17641 cgtggtgact ttttgaacaa cctcatcact ggaagtctgg acttgggtgc ttttccttca
    17701 ctagacgccg atctatccac cgtgctgccg gttgattatc tgtgcaatac cattgctgct
    17761 atcatgaccg aggaccaaca gcgaattggt gaggattacg acttcattaa ttcacaagcg
    17821 cccacgttca accatttctt caagattatg ggggctgcta gcggtggaat agacactgta
    17881 cccttcaacg agtggtatcg tcgggcactc aagtacgcag gagcccatcc gaagagttca
    17941 ctggctcgca tcaccactat cattgatggt tacaccgatg aaacggcagg tgctttggtg
    18001 aagggaaatc ccgttggcaa gcatgtcttt ggagtggatg actatccagc cccagcgatt
    18061 gatgaggaat atgtgcgcaa gtatttagat tgcattaatg ccgcgaaagc gattacatgt
    18121 gcgtgaatag ctatcagtac acgtgttggg agaatggtat acaatacata tttggctagt
    18181 taattagaac gatggacaat ggtacattta cttttggttg aaaaacttgc ttttggtctc
    18241 agttgtagaa aaccaagact tcgacttgct tctcccgggg gggcacgcta agtagttctc
    18301 gtggttgtat accgtacaga gtggaggtcg gaagcatagc tactaacgga agcactgtag
    18361 attcatttta tctgtcgtat aaataccctg atggcttcca gcaactcatc accctcgcca
    18421 acccgtcaag tacactctcg tctccttcag agtatcgaat ccggatactc gtcaaactgg
    18481 gcaagacctt cctggaccgt ccgaaaccga atgtccggga agtacttctc cctatgccgg
    18541 cggaccttgt ccggcgggtt gccgcacgcc tggctgatgg acaacaggta gtaatcggcc
    18601 agcgtcagcg tgtcctcgtc gtcggctttg gccgtcctga tcatctccgc cacggtgcgc
    18661 agcgagacgt gctcgatcgg cgtgtcgggg cggtacttcc gtctgaagag ctcggccgtg
    18721 tcgttccagc agctgcgctc cccggacatg aacgtgtagg gctcccatga cccccgtggg
    18781 gccttgacca gtgatgctag gcctcgaacc acgtcccgtg cccatgtgaa atcgacgggt
    18841 tcggctcctg ttcctgggac cacgatcttg tcgctaccgc cccagttcgt ggggtggaag
    18901 acgccgatgt ctttgatgtg gcggttcttg gacgggacga agtagtcggc cagccagccg
    18961 atgcagacga gtgtccattc caggtcggtt tggttgcgga gggtctcgcg gacgggctcg
    19021 tgcggggcgt agtagaagcc tggttggtcc gggtaggtct cgatgttcgt ggcgaactcg
    19081 gcggggatga tgcgtttgca tttcgggctc tgctggcagg cttggatgag tgtgcggtgg
    19141 atgtcggtgt aggtggggga gtagtctgag atggttgaga ttaggacgtc gcagtcggat
    19201 aacggcgttt ttagagatgg gagagtgtag tctgtgattg cttgggtgat gccctgggtc
    19261 tcgagttggg gtttgtggtt ccgtgtcagg atgacgaggt cgtggccggc ttgggtgaac
    19321 tcttcacaga tgtaccgtgt taggtcgcca tatccggcga ttgctactcg cattgtgggc
    19381 tgcagtgatg atggtggtat gcgttgcgta cgaagatgag cgaaagggga ggtccctaca
    19441 cgaccaggtt tggtagagtc ggattgagta ttagcgatgg gctgtgctcc cttaaagtac
    19501 ttgtttcaca ctatccgccg aggcaagttt tgtatgcctg tatttctgat acctaatatt
    19561 gctgtgcctt caaattgcaa cactgttagt tatggcttca actagtttat tggcgttggc
    19621 gcggatttct aaattcattc tagttagctt gactcgtatg cctaagagcc aagtcacaat
    19681 agataggttt tgacttgaac gtggtttgat tactgtattg tcagtaccaa gttgtaattc
    19741 aagctgtttt gttgggacca ctagagcgcc atcatctgca cacaatagtc cacggttgca
    19801 accaccgacg acttgagacg atcgatcaca tgcgtcctgc gagcttacga cccttgttcc
    19861 acgatgtggc atttcctgta atggttagga cgaacagtcg gcagaagaat ccacggggtt
    19921 gcagagagtt actgcactat gtgttgcaac gaaccttgcg gtgcatagcg ccggggaagt
    19981 tatcgttgca tgggaggcgt cttagtttgt aatgggttca gtctcgtact gattgcgctc
    20041 cttggtggat gtattgacag attttgacca cttaatggtc ccacgtagca tgacatttgg
    20101 tcagccgaac cgatgaatag catccaagtc ggccgacatc ccggactggt tcgagggtca
    20161 ttgagactgg gggtaccttg cgaacctctc gcgattccca gctacaccaa agtatctatt
    20221 tcctccaact tacacgatgg ttgtcgtcgc cattgcaggt ggcaccggcg gtgtcggtcg
    20281 caccgtgctg gatgccattg cgaagtcagg ccagcataga gctgttgtat tatcgaggac
    20341 agtaagttca ccgataccat cgctcgttac aacgatatca aactcacatt attccaccag
    20401 gcagcagcag caaccgcaac gaaagggccg aaacgtattg ctgtcgatta caccgacgtc
    20461 gagcagatga agcgtgtgct ccaagagaac aatgttgagg ttgttgtatc agctttgctt
    20521 ctgcttgatg agagcatcgc acaggcacag atcaacctga tccgagctgc tgcgcaatca
    20581 ggcaccgtaa ccaaatttat ccccagcgaa tactatatcg acttccatgc tccaatcccg
    20641 tgagatatct ttgaccatac tttcgagcct gcaatgctaa catgtgttgc acagtggttc
    20701 tgatctcttt accaatttca acattgaggc ggaagaggaa ctctcgcgcc atccgcaatt
    20761 gacttggacg ctgatcagaa atggaatctt tcttgaccat cttgtcatgc cacataatcc
    20821 taagacaaca tatattagcc catactgggt gtttgttgat atagaccatg aacaatgtgt
    20881 cttgccaggt gacgggtcat acccacttgt atttacgcac tcaacagacc tcgcggctta
    20941 tattgagcgt ttagtaggcc tgccggccaa ggattggcca cgagaatctc tcgtcgcgtc
    21001 caataaactg caagtaggag accttgcgac actcatcaag aaggtcacag gtaagtagcg
    21061 caatagtcaa ggatggggtc ttcgaaatcc taatgttgat gacagggaag gaatttaaag
    21121 tcacgtacga ctcggcggga gcaattcacg agggccgtat cacacctttg ccttctaacc
    21181 aggctgtgtt tgacgatccc gccaagggtg aaatgtttca cgaggtcgaa cagcaggtca
    21241 tgctttcgat gttgagcaaa gcacacgatc tacctgggaa gaaccttgct gagctgttcc
    21301 ctgatgtcga accaacgaat atcgaagact tctttagagc aggctgggca ctcaagcaga
    21361 gcacaacgtc atagtattga tcgccggttg caaaagaatt ccttgatact caaaagatca
    21421 ggcagatagc tccaatatac tggactttga acgcattata ccaagcaaag taatttgaaa
    21481 atcattaaaa gaagcatgag tttcacagta agtcgatgga tgtgggtagg gataaataat
    21541 aaagtggtac atagtcggtt cgttccttcc gctgcctctt tcgcatattg cacaactgtt
    21601 ttgctcttga aggatacact cgccattagc ggaggaatgt acagcttttg ttggaagaga
    21661 atgttgtcac aatggtagtc ctgatagagt cggcacatgt ggagtaggaa gatgtaacgg
    21721 aaacgtgctt gcccaagttg cagattaatc gatgcaccca ctgatactgg gctgtctaag
    21781 ttggtcatgc gaccacatgt tgaggtcaaa ctccagatca taaccagaag gccgagctca
    21841 cacaaagatg aatatgagca ctcacatcat gtgtagaaga ctgaaggcat ttccaattcc
    21901 accagagtag actcatccgc agcaggagtc tagctggggg cgtgtacgct cccaataggt
    21961 gtccaagcac accgcttata tgaaagatgg tgaaactgag cagccaatcc gaaacaggtt
    22021 gagatacgca tgctctcgta agcatacgcg tcgttaggtg tttctgcgta caatggtggt
    22081 gctagaactc ttgataagct caaaagcgat agacctagat tctgatatca gtagctgcaa
    22141 tcttgagaat aagtggaaca gtaatattac tgtgcttagc agcaagctct ttgatgcctt
    22201 accgtaaagt gatgctcact tgacctgaaa ggatgtctag gaaattcttt ctttatgcag
    22261 ccctggccac ggtatcgaag cagcaagtgg cgtaagattt acatggtaga gacctgaaca
    22321 gcctatgagg cgccctccaa ggccactgtt aaaagttgtt gcaaccttta gagcgatgac
    22381 cacggtgatc tgatgcaatt acttaattga gggccaagat tcaatgcctc ctttattgta
    22441 tcaccctgcc agccgaggtc atttgcaccg cgccagtggc tactcgttag tagtatagtt
    22501 tggaagattc gagataaaca tgggcgtctc aagaagtgtg ttgcctggat agccacagtc
    22561 ttctatcaca gccttgccac acagaccagg ctgcagcctt accggcggcg ggcggacggg
    22621 gcaaggctgg attctttctg attccgcggg cttcacgtca gcaacaggcg gcgagctggt
    22681 gacgtgcagc aaagcaaact gaaccgcgga tctctcgcca agacccgcct gccatctagc
    22741 agtgcagtgc ctgatcattt gaacacttcg gccggagttc ataacactct cttatttcat
    22801 cttgaccatc tccatctctg taatcacact gcaattcctt ttcccgcatt cctccctctc
    22861 tcacaaccat ctcctcgctt ttacccgggg agatcgtcct gccgcaactt catcagatag
    22921 cgggcacctc tgttcctatc tccgaatcag cgtcaacaac ccattctgtc cctcaccaca
    22981 gtcctataac agctcaag
//
