BGC0001813: tyrobetaine biosynthetic gene cluster from Streptomyces sp. NRRL WC-3703
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Location: 1,569 - 29,680 nt. (total: 28,112 nt).
This entry is originally from NCBI GenBank NZ_JOCH01000080.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001813
Short description tyrobetaine biosynthetic gene cluster from Streptomyces sp. NRRL WC-3703
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: NZ_JOCH01000080.1
Compounds
  • tyrobetaine
Species Streptomyces sp. NRRL WC-3703 [taxonomy]
References
Chemical products information
tyrobetaine
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IF71_RS1000000149300
  • WP_129820953.1
 1569 - 2357 (-) hypothetical protein
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  • IF71_RS0139170
  • WP_003981341.1
 2546 - 4303 (+) DUF262 domain-containing HNH endonuclease family protein
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  • IF71_RS0139175
  • WP_003981343.1
 4611 - 5087 (-) MSMEG_6728 family protein
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  • IF71_RS0139180
  • WP_003981346.1
 5223 - 15878 (-) non-ribosomal peptide synthetase
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  • IF71_RS1000000145670
  • WP_003981348.1
 16020 - 16751 (+) 4'-phosphopantetheinyl transferase superfamily protein
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  • IF71_RS0139190
  • WP_003981349.1
 16777 - 18420 (-) amino acid adenylation domain-containing protein
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  • IF71_RS0139195
  • WP_003981350.1
 18417 - 19691 (-) MFS transporter
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  • IF71_RS0139200
  • WP_100246535.1
 19688 - 20836 (-) HAD-IIIC family phosphatase
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  • IF71_RS0139205
  • WP_003981353.1
 20842 - 21864 (-) 3-oxoacyl-ACP synthase III
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  • IF71_RS0139210
  • WP_003981355.1
 21861 - 22976 (-) acyl-CoA dehydrogenase family protein
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  • IF71_RS0139215
  • WP_003981357.1
 22973 - 23266 (-) acyl carrier protein
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  • IF71_RS0139220
  • WP_030185022.1
 23263 - 24129 (-) 3-hydroxyacyl-CoA dehydrogenase family protein
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  • IF71_RS0139225
  • WP_030185025.1
 24168 - 27602 (-) thioester reductase domain-containing protein
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  • IF71_RS1000000148350
  • WP_003987412.1
 27599 - 27970 (-) acyl carrier protein
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  • IF71_RS0139235
  • WP_003987413.1
 27996 - 28829 (-) sugar phosphate isomerase/epimerase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
IF71_RS0139180
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Feeding study
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Feeding study
Module ?
Specificity: 3-hydroxyleucine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Feeding study
IF71_RS0139190
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Feeding study
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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