BGC0001818: vazabitide A biosynthetic gene cluster from Streptomyces sp. SANK 60404
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Location: 1 - 40,455 nt. (total: 40,455 nt).
This entry is originally from NCBI GenBank LC072720.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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NRP
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0001818
Short description vazabitide A biosynthetic gene cluster from Streptomyces sp. SANK 60404
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: LC072720.1
Compounds
  • vazabitide A
Species Streptomyces sp. SANK 60404 [taxonomy]
References
Chemical products information
vazabitide A
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C12H21N3O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAV57436.1
  • vzb0
 2 - 217 (-) putative membrane protein
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  • BAV57437.1
  • vzb1
 353 - 1111 (-) MerR-family transcriptional regulator
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  • BAV57438.1
  • vzb2
 1202 - 2455 (-) putative ligase/carboxylase
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  • BAV57439.1
  • vzb3
 2490 - 2810 (-) branched-chain amino acid transporter
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  • BAV57440.1
  • vzb4
 2812 - 3645 (-) branched-chain amino acid transporter
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  • BAV57441.1
  • vzb5
 3685 - 4836 (-) acyl-CoA dehydrogenase
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  • BAV57442.1
  • vzb6
 4863 - 6014 (-) pimeloyl-CoA dehydrogenase
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  • BAV57443.1
  • vzb7
 6017 - 10186 (-) NRPS (C-A-PCP-TE)
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  • BAV57444.1
  • vzb8
 10164 - 10544 (-) PCP domain protein
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  • BAV57445.1
  • vzb9
 10523 - 11905 (-) Glutamine--scyllo-inositol transaminase
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  • BAV57446.1
  • vzb10
 11902 - 12933 (-) hypothetical protein
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  • BAV57447.1
  • vzb11
 12930 - 13565 (-) hypothetical protein
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  • BAV57448.1
  • vzb12
 13562 - 14491 (-) GCN5-related N-acetyltransferase
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  • BAV57449.1
  • vzb13
 14484 - 15827 (-) peptidase M20
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  • BAV57450.1
  • vzb14
 15824 - 16642 (-) thioesterase
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  • BAV57451.1
  • vzb15
 16639 - 18474 (-) NRPS (A-PCP)
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  • BAV57452.1
  • vzb16
 18510 - 18704 (-) MbtH
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  • BAV57453.1
  • vzb17
 18870 - 19550 (-) LuxR family transcriptional regulator
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  • BAV57454.1
  • vzb18
 19695 - 20984 (-) sulfate adenylyltransferase
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  • BAV57455.1
  • vzb19
 20987 - 22006 (-) sulfate adenylyltransferase
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  • BAV57456.1
  • vzb20
 22014 - 22574 (-) adenylylsulfate kinase
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  • BAV57457.1
  • vzb21
 22629 - 23360 (-) hypothetical protein
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  • BAV57458.1
  • vzb22
 23661 - 23834 (+) LysW
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  • BAV57459.1
  • vzb23
 23831 - 24709 (+) LysX
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  • BAV57460.1
  • vzb24
 24697 - 25734 (+) LysY
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  • BAV57461.1
  • vzb25
 25750 - 26616 (+) LysZ
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  • BAV57462.1
  • vzb26
 26613 - 27731 (+) LysK
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  • BAV57463.1
  • vzb27
 27731 - 28600 (+) Transketolase N-terminal domain protein
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  • BAV57464.1
  • vzb28
 28597 - 29595 (+) Transketolase C-terminal domain protein
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  • BAV57465.1
  • vzb29
 29762 - 30403 (-) transcriptional regulator
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  • BAV57466.1
  • vzb30
 30469 - 31005 (-) hypothetical protein
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  • BAV57467.1
  • vzb31
 31102 - 32559 (-) aldehyde dehydrogenase
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  • BAV57468.1
  • vzb32
 32630 - 33565 (-) helix-turn-helix domain protein
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  • BAV57469.1
  • vzb33
 33653 - 33844 (-) hypothetical protein
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  • BAV57470.1
  • vzb34
 33822 - 34331 (+) regulator
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  • BAV57471.1
  • vzb35
 34395 - 34682 (-) putative regulator
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  • BAV57472.1
  • vzb36
 34882 - 35127 (-) 30S ribosomal protein S18
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  • BAV57473.1
  • vzb37
 35132 - 36256 (-) cobalamin synthesis CobW domain containing protein
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  • BAV57474.1
  • vzb38
 36256 - 36516 (-) 50S ribosomal protein L31 type B
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  • BAV57475.1
  • vzb39
 36525 - 36725 (-) 50S ribosomal protein L33
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  • BAV57476.1
  • vzb40
 36753 - 36989 (+) 50S ribosomal protein L28
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  • BAV57477.1
  • vzb41
 36989 - 37294 (+) 30S ribosomal protein S14
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  • BAV57478.1
  • vzb42
 37236 - 37832 (+) membrane protein
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  • BAV57479.1
  • vzb43
 37829 - 37978 (-) hypothetical protein
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  • BAV57480.1
  • vzb44
 38164 - 39324 (-) hypothetical protein
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  • BAV57481.1
  • vzb45
 39673 - 40440 (+) DNA polymerase I
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
vzb7
Module ?
Specificity: (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
  • Knock-out studies
vzb15
Module ?
Specificity: valine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Merge NRPS substrate specificities from duplicate BGC0001912
Detailed domain annotation
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