BGC0000001: abyssomicin C biosynthetic gene cluster from Verrucosispora maris AB-18-032
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Location: 1 - 59,320 nt. (total: 59,320 nt).
This entry is originally from NCBI GenBank JF752342.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000001
Short description abyssomicin C biosynthetic gene cluster from Verrucosispora maris AB-18-032
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
JF752342.1
via Knock-out studies
Compounds
  • abyssomicin C
  • atrop-abyssomicin C
Species Verrucosispora maris AB-18-032 [taxonomy]
References
Chemical products information
abyssomicin C Evidence:
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C19H22O6
Chemical database entries
NPAtlas
PubCHEM
ChEMBL
atrop-abyssomicin C Evidence:
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C19H22O6
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEK75490.1
  • orfP
 1 - 1083 (+) protein methyltransferase
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    • AEK75491.1
    		 1208 - 1834 (+) putative hydrolase
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      • AEK75492.1
      • abyR
      		 1887 - 2633 (+) pathway-specific SARP activator
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        • AEK75493.1
        • abyX
        		 2646 - 3836 (-) cytochrome P450
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          • AEK75494.1
          • abyH
          		 3927 - 6596 (-) LuxR family transcriptional regulator
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            • AEK75495.1
            • abyI
            		 6952 - 7710 (+) pathway-specific SARP activator
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              • abyU
              		 7760 - 8182 (-) Diels-Alderase
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                • AEK75496.1
                • abyK
                		 8175 - 10034 (-) YD repeat protein
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                  • AEK75497.1
                  • abyA1
                  		 10118 - 11143 (+) 3-oxoacyl-ACP synthase III
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                    • AEK75498.1
                    • abyA2
                    		 11140 - 13008 (+) phosphatase and glyceryl transferase
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                      • AEK75499.1
                      • abyA3
                      		 13005 - 13241 (+) acyl-carrier protein
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                        • AEK75500.1
                        • abyA4
                        		 13238 - 13993 (+) pyruvate/2-oxoglutarate dehydrogenase
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                          • AEK75501.1
                          • abyA5
                          		 13990 - 15057 (+) AbyA5
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                            • AEK75502.1
                            • abyB1
                            		 15054 - 32399 (+) type 1 polyketide synthase
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                              • AEK75503.1
                              • abyB2
                              		 32476 - 43413 (+) type 1 polyketide synthase
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                                • AEK75504.1
                                • abyB3
                                		 43410 - 46388 (+) type 1 polyketide synthase
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                                  • AEK75505.1
                                  • abyC
                                  		 46457 - 47149 (-) TetR regulatory protein
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                                    • AEK75506.1
                                    • abyD
                                    		 47233 - 48660 (+) EmrB/QacA drug resistance transporter
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                                      • AEK75507.1
                                      • abyE
                                      		 48731 - 49738 (+) luciferase/monooxygenase
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                                        • AEK75508.1
                                        • abyF1
                                        		 49826 - 51442 (+) BC transporter oligopeptide binding protein
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                                          • AEK75509.1
                                          • abyF2
                                          		 51439 - 52374 (+) ABC transporter oligopeptide permease
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                                            • AEK75510.1
                                            • abyF3
                                            		 52371 - 53222 (+) binding-protein dependent ABC transporter
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                                              • AEK75511.1
                                              • abyF4
                                              		 53212 - 54831 (+) ATP-binding ABC peptide transporter
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                                                • AEK75512.1
                                                • abyV
                                                		 54828 - 56015 (+) cytochrome P450
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                                                  • AEK75513.1
                                                  • abyW
                                                  		 55978 - 56229 (+) alcohol dehydrogenase
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                                                    • AEK75514.1
                                                    • abyZ
                                                    		 56230 - 56808 (-) NAD(P)H-depedent FMN-reductase
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                                                      • AEK75515.1
                                                      • abyT
                                                      		 56933 - 57829 (+) type II thioesterase
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                                                        • AEK75516.1
                                                        • orfU
                                                        		 57728 - 58636 (-) Zn-dependent alcohol dehydrogenase
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                                                          • AEK75517.1
                                                          • orfS
                                                          		 58727 - 59320 (+) TetR transcriptional regulator
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                                                            Biosynthesis information

                                                            Biosynthetic modules

                                                            Name
                                                            1
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            abyB1
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                            Name
                                                            2
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            abyB1
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                            Name
                                                            3
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            abyB1
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                            Name
                                                            4
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            abyB1
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                            Name
                                                            5
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            abyB2
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                            Name
                                                            6
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            abyB2
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                            Name
                                                            7
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            abyB3
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                            Annotation changelog

                                                            Entry version: next

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2024-04-23
                                                            MIBiG v4 annotathon
                                                            • (ID: IQDGAEIXNOAWG3AVLVJH6HBZ)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Sorted modules by module number
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2019-10-16
                                                            Updated compound(s) information (MIBiG Annotathon)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2019-10-16
                                                            Updated compound(s) information (NPAtlas curation)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: M2JBIQNJAZIP5YVYS7CZLALR)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            Detailed domain annotation
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                                                            Modifications to original record
                                                            • abyU was added